Citations for
1LCK, PTPRC
Membrane-cytoskeleton interactions in cholesterol-dependent domain formation.
Byrum JN, Rodgers W.
Essays Biochem 57:177-87. doi: 10.1042/bse0570177. Review. 2015
2CBL, LCK
Regulation of T cell development by c-Cbl: essential role of Lck.
Chiang YJ, Hodes RJ.
Int Immunol 27(5):245-51. doi: 10.1093/intimm/dxu105. Epub 2014 Dec 4. 2015
3LCK, ZAP70
The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.
Sjölin-Goodfellow H, Frushicheva MP, Ji Q, Cheng DA, Kadlecek TA, Cantor AJ, Kuriyan J, Chakraborty AK, Salomon AR, Weiss A.
Sci Signal 8(377):ra49. doi: 10.1126/scisignal.2005596. 2015
4GADD45GIP1, LCK
Lymphocyte-specific protein tyrosine kinase (Lck) interacts with CR6-interacting factor 1 (CRIF1) in mitochondria to repress oxidative phosphorylation.
Vahedi S, Chueh FY, Chandran B, Yu CL.
BMC Cancer 15:551. doi: 10.1186/s12885-015-1520-6. 2015
5GADD45GIP1, LCK
Nuclear lymphocyte-specific protein tyrosine kinase and its interaction with CR6-interacting factor 1 promote the survival of human leukemic T cells.
Vahedi S, Chueh FY, Dutta S, Chandran B, Yu CL.
Oncol Rep 34(1):43-50. doi: 10.3892/or.2015.3990. Epub 2015 May 19. 2015
6LCK
The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.
Granum S, Sundvold-Gjerstad V, Gopalakrishnan RP, Berge T, Koll L, Abrahamsen G, Sřrlie M, Spurkland A.
Sci Signal 7(355):ra118. doi: 10.1126/scisignal.2005384. 2014
7LCK, PTPRC
Phosphatase CD45 both positively and negatively regulates T cell receptor phosphorylation in reconstituted membrane protein clusters.
Furlan G, Minowa T, Hanagata N, Kataoka-Hamai C, Kaizuka Y.
J Biol Chem 289(41):28514-25. doi: 10.1074/jbc.M114.574319. Epub 2014 Aug 15. 2014
8IGF2R, LCK
The late endosomal transporter CD222 directs the spatial distribution and activity of Lck.
Pfisterer K, Forster F, Paster W, Supper V, Ohradanova-Repic A, Eckerstorfer P, Zwirzitz A, Donner C, Boulegue C, Schiller HB, Ondrovičová G, Acuto O, Stockinger H, Leksa V.
J Immunol 193(6):2718-32. doi: 10.4049/jimmunol.1303349. Epub 2014 Aug 15. 2014
9LCK, SH2D1A, SLAMF6
SAP facilitates recruitment and activation of LCK at NTB-A receptors during restimulation-induced cell death.
Katz G, Krummey SM, Larsen SE, Stinson JR, Snow AL.
J Immunol 192(9):4202-9. doi: 10.4049/jimmunol.1303070. Epub 2014 Mar 31. 2014
10LCK, LGALS1, PTPRC
GM1 controlled lateral segregation of tyrosine kinase Lck predispose T-cells to cell-derived galectin-1-induced apoptosis.
Novák J, Kriston-Pál É, Czibula Á, Deák M, Kovács L, Monostori É, Fajka-Boja R.
Mol Immunol 57(2):302-9. doi: 10.1016/j.molimm.2013.10.010. Epub 2013 Nov 12. 2014
11FOXP3, LCK, MMP9, SKP2, VEGFA
Phosphorylation of FOXP3 by LCK downregulates MMP9 expression and represses cell invasion.
Nakahira K, Morita A, Kim NS, Yanagihara I.
PLoS One 8(10):e77099. doi: 10.1371/journal.pone.0077099. eCollection 2013. 2013
12LCK, PTK2
Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor.
Chapman NM, Connolly SF, Reinl EL, Houtman JC.
J Immunol 191(12):6208-21. doi: 10.4049/jimmunol.1301587. Epub 2013 Nov 13. 2013
13LCK
LCK is an important mediator of B-cell receptor signaling in chronic lymphocytic leukemia cells.
Talab F, Allen JC, Thompson V, Lin K, Slupsky JR.
Mol Cancer Res 11(5):541-54. doi: 10.1158/1541-7786.MCR-12-0415-T. Epub 2013 Mar 15. 2013
14JAK2, LCK, LMO2
Nuclear localization of lymphocyte-specific protein tyrosine kinase (Lck) and its role in regulating LIM domain only 2 (Lmo2) gene.
Venkitachalam S, Chueh FY, Yu CL.
Biochem Biophys Res Commun 417(3):1058-62. doi: 10.1016/j.bbrc.2011.12.095. Epub 2011 Dec 27. 2012
15DLG1, LCK
Subcellular distribution of Lck during CD4 T-cell maturation in the thymic medulla regulates the T-cell activation threshold.
Stephen TL, Wilson BS, Laufer TM.
Proc Natl Acad Sci U S A 109(19):7415-20. doi: 10.1073/pnas.1119272109. Epub 2012 Apr 23. 2012
16IMD22, LCK
Primary T-cell immunodeficiency with immunodysregulation caused by autosomal recessive LCK deficiency.
Hauck F, Randriamampita C, Martin E, Gerart S, Lambert N, Lim A, Soulier J, Maciorowski Z, Touzot F, Moshous D, Quartier P, Heritier S, Blanche S, Rieux-Laucat F, Brousse N, Callebaut I, Veillette A, Hivroz C, Fischer A, Latour S, Picard C.
J Allergy Clin Immunol 130(5):1144-1152.e11. doi: 10.1016/j.jaci.2012.07.029. Epub 2012 Sep 15. 2012
17LCK
Centrosome docking at the immunological synapse is controlled by Lck signaling.
Tsun A, Qureshi I, Stinchcombe JC, Jenkins MR, de la Roche M, Kleczkowska J, Zamoyska R, Griffiths GM.
J Cell Biol 192(4):663-74. 2011
18LCK, SOCS1, SOCS3
Suppressor of cytokine signaling 1 interacts with oncogenic lymphocyte-specific protein tyrosine kinase.
Venkitachalam S, Chueh FY, Leong KF, Pabich S, Yu CL.
Oncol Rep 25(3):677-83. doi: 10.3892/or.2011.1144. Epub 2011 Jan 13. 2011
19LCK, RHOH
RhoH modulates pre-TCR and TCR signalling by regulating LCK.
Wang H, Zeng X, Fan Z, Lim B.
Cell Signal 23(1):249-58. Epub 2010 Sep 16. 2011
20ITGB2, LCK, ZAP70
The integrin LFA-1 signals through ZAP-70 to regulate expression of high-affinity LFA-1 on T lymphocytes.
Evans R, Lellouch AC, Svensson L, McDowall A, Hogg N.
Blood 117(12):3331-42. doi: 10.1182/blood-2010-06-289140. Epub 2011 Jan 3. 2011
21LCK, SOCS6
SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradation.
Choi YB, Son M, Park M, Shin J, Yun Y.
J Biol Chem 285(10):7271-80. Epub 2009 Dec 10. 2010
22LCK, RASSF5
Functional interaction of the Ras effector RASSF5 with the tyrosine kinase Lck: critical role in nucleocytoplasmic transport and cell cycle regulation.
Kumari G, Singhal PK, Suryaraja R, Mahalingam S.
J Mol Biol 397(1):89-109. Epub 2010 Jan 11. 2010
23LCK
Role of lymphocyte-specific protein tyrosine kinase (LCK) in the expansion of glioma-initiating cells by fractionated radiation.
Kim RK, Yoon CH, Hyun KH, Lee H, An S, Park MJ, Kim MJ, Lee SJ.
Biochem Biophys Res Commun 402(4):631-6. Epub 2010 Oct 29. 2010
24LCK
Th2-specific immunity and function of peripheral T cells is regulated by the p56Lck Src homology 3 domain.
McCoy ME, Finkelman FD, Straus DB.
J Immunol 185(6):3285-94. Epub 2010 Aug 20. 2010
25LCK
Plasma membrane subdomain partitioning of Lck in primary human T lymphocytes.
Irles C, Arias-Martinez J, Guzmán-Bárcenas J, Ortega A.
Can J Physiol Pharmacol 88(4):487-96. 2010
26LCK
Inhibition of Lck enhances glucocorticoid sensitivity and apoptosis in lymphoid cell lines and in chronic lymphocytic leukemia.
Harr MW, Caimi PF, McColl KS, Zhong F, Patel SN, Barr PM, Distelhorst CW.
Cell Death Differ 17(9):1381-91. Epub 2010 Mar 19. 2010
27ITK, LCK, SH2D2A
T cell specific adapter protein (TSAd) interacts with Tec kinase ITK to promote CXCL12 induced migration of human and murine T cells.
Berge T, Sundvold-Gjerstad V, Granum S, Andersen TC, Holthe GB, Claesson-Welsh L, Andreotti AH, Inngjerdingen M, Spurkland A.
PLoS One 5(3):e9761. doi: 10.1371/journal.pone.0009761. 2010
28LAT, LCK
T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells.
Dong S, Corre B, Nika K, Pellegrini S, Michel F.
PLoS One 5(11):e15114. doi: 10.1371/journal.pone.0015114. 2010
29LCK, PRKD2
PKD2 interacts with Lck and regulates NFAT activity in T cells.
Li Q, Sun X, Wu J, Lin Z, Luo Y.
BMB Rep 42(1):35-40. 2009
30LCK
The Src kinase Lck facilitates assembly of HIV-1 at the plasma membrane.
Strasner AB, Natarajan M, Doman T, Key D, August A, Henderson AJ.
J Immunol 181(5):3706-13. 2008
31LCK
Modulation of Lck function through multisite docking to T cell-specific adapter protein.
Granum S, Andersen TC, Sřrlie M, Jřrgensen M, Koll L, Berge T, Lea T, Fleckenstein B, Spurkland A, Sundvold-Gjerstad V.
J Biol Chem 283(32):21909-19. Epub 2008 Jun 9. 2008
32LCK, PTPN12
TCR-induced downregulation of protein tyrosine phosphatase PEST augments secondary T cell responses.
Arimura Y, Vang T, Tautz L, Williams S, Mustelin T.
Mol Immunol 45(11):3074-84. doi: 10.1016/j.molimm.2008.03.019. Epub 2008 May 5. 2008
33LAT, LCK
Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes.
Jiang Y, Cheng H.
Leuk Res 31(4):541-5. Epub 2006 Aug 30.PMID: 16938345 2007
34LCK,TNFRSF13C
The differential expression of LCK and BAFF-receptor and their role in apoptosis in human lymphomas.
Paterson JC, Tedoldi S, Craxton A, Jones M, Hansmann ML, Collins G, Roberton H, Natkunam Y, Pileri S, Campo E, Clark EA, Mason DY, Marafioti T.
Haematologica 91(6):772-80. 2006
35LCK, LCP2
A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function.
Kumar L, Feske S, Rao A, Geha RS.
Proc Natl Acad Sci U S A 102(52):19063-8. Epub 2005 Dec 14. 2005
36CBL, LCK
Negative regulation of Lck by Cbl ubiquitin ligase.
Rao N, Miyake S, Reddi AL, Douillard P, Ghosh AK, Dodge IL, Zhou P, Fernandes ND, Band H.
Proc Natl Acad Sci U S A 99(6):3794-9. 2002
37CD4, LCK, VAV1
CD4-Lck through TCR and in the absence of Vav exchange factor induces Bax increase and mitochondrial damage.
Tuosto L, Marinari B, Piccolella E.
J Immunol 168(12):6106-12. 2002
38CD4, LCK
p56Lck anchors CD4 to distinct microdomains on microvilli.
Foti M, Phelouzat MA, Holm A, Rasmusson BJ, Carpentier JL.
Proc Natl Acad Sci U S A 99(4):2008-13. 2002
39IMD22, LCK
Defect of lck in a patient with common variable immunodeficiency.
Sawabe T, Horiuchi T, Nakamura M, Tsukamoto H, Nakahara K, Harashima SI, Tsuchiya T, Nakano S.
Int J Mol Med 7(6):609-14. 2001
40DOK1, DOK2, LCK
Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling.
Nemorin JG, Duplay P.
J Biol Chem 275(19):14590-7. 2000
41LCK
Defective expression of p56lck in an infant with severe combined immunodeficiency.
Goldman FD, Ballas ZK, Schutte BC, Kemp J, Hollenback C, Noraz N, Taylor N.
J Clin Invest 102(2):421-9. 1998
42LCK
Subregional mapping of the human lymphocyte-specific protein tyrosine kinase gene (LCK) to 1p35-p34.3 and its position relative to the 1p marker D1S57.
Volpi EV, et al.
Cytogenet Cell Genet 67 : 187-189. 1994
43LCK, TAL3, TRB@
Molecular analysis of the T-cell acute lymphoblastic leukemia-associated t(1;7)(p34;q34) that fuses LCK and TCRB.
Burnett RC, et al.
Blood 84 : 1232-1236. 1994
44LCK,TAL3,TRB@
Chromosomal translocations joining LCK and TCRB loci in human T cell leukemia.
Tycko B, et al.
J Exp Med 174 : 867-873. 1991
45LCK, TAL3, TRB@
The LCK gene is involved in the t(1;7)(p34;q34) in the T-cell acute lymphoblastic leukemia derived cell line, HSB-2.
Burnett RC, et al.
Genes Chromosomes Cancer 3 : 461-467. 1991
46LCK
Localization of a lymphocyte-specific protein tyrosine kinase gene (LCK) at a site of frequent chromosomal abnormalities in human lymphomas.
Marth JD, et al.
Proc Natl Acad Sci U S A 83 : 7400-7404. 1986