| 1 | LCK, PTPRC
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| Membrane-cytoskeleton interactions in cholesterol-dependent domain formation.
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| Byrum JN, Rodgers W.
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| Essays Biochem 57:177-87. doi: 10.1042/bse0570177. Review.
2015
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| 2 | CBL, LCK
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| Regulation of T cell development by c-Cbl: essential role of Lck.
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| Chiang YJ, Hodes RJ.
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| Int Immunol 27(5):245-51. doi: 10.1093/intimm/dxu105. Epub 2014 Dec 4.
2015
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| 3 | LCK, ZAP70
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| The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.
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| Sjölin-Goodfellow H, Frushicheva MP, Ji Q, Cheng DA, Kadlecek TA, Cantor AJ, Kuriyan J, Chakraborty AK, Salomon AR, Weiss A.
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| Sci Signal 8(377):ra49. doi: 10.1126/scisignal.2005596.
2015
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| 4 | GADD45GIP1, LCK
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| Lymphocyte-specific protein tyrosine kinase (Lck) interacts with CR6-interacting factor 1 (CRIF1) in mitochondria to repress oxidative phosphorylation.
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| Vahedi S, Chueh FY, Chandran B, Yu CL.
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| BMC Cancer 15:551. doi: 10.1186/s12885-015-1520-6.
2015
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| 5 | GADD45GIP1, LCK
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| Nuclear lymphocyte-specific protein tyrosine kinase and its interaction with CR6-interacting factor 1 promote the survival of human leukemic T cells.
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| Vahedi S, Chueh FY, Dutta S, Chandran B, Yu CL.
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| Oncol Rep 34(1):43-50. doi: 10.3892/or.2015.3990. Epub 2015 May 19.
2015
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| 6 | LCK
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| The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.
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| Granum S, Sundvold-Gjerstad V, Gopalakrishnan RP, Berge T, Koll L, Abrahamsen G, Sřrlie M, Spurkland A.
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| Sci Signal 7(355):ra118. doi: 10.1126/scisignal.2005384.
2014
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| 7 | LCK, PTPRC
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| Phosphatase CD45 both positively and negatively regulates T cell receptor phosphorylation in reconstituted membrane protein clusters.
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| Furlan G, Minowa T, Hanagata N, Kataoka-Hamai C, Kaizuka Y.
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| J Biol Chem 289(41):28514-25. doi: 10.1074/jbc.M114.574319. Epub 2014 Aug 15.
2014
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| 8 | IGF2R, LCK
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| The late endosomal transporter CD222 directs the spatial distribution and activity of Lck.
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| Pfisterer K, Forster F, Paster W, Supper V, Ohradanova-Repic A, Eckerstorfer P, Zwirzitz A, Donner C, Boulegue C, Schiller HB, Ondrovičová G, Acuto O, Stockinger H, Leksa V.
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| J Immunol 193(6):2718-32. doi: 10.4049/jimmunol.1303349. Epub 2014 Aug 15.
2014
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| 9 | LCK, SH2D1A, SLAMF6
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| SAP facilitates recruitment and activation of LCK at NTB-A receptors during restimulation-induced cell death.
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| Katz G, Krummey SM, Larsen SE, Stinson JR, Snow AL.
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| J Immunol 192(9):4202-9. doi: 10.4049/jimmunol.1303070. Epub 2014 Mar 31.
2014
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| 10 | LCK, LGALS1, PTPRC
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| GM1 controlled lateral segregation of tyrosine kinase Lck predispose T-cells to cell-derived galectin-1-induced apoptosis.
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| Novák J, Kriston-Pál É, Czibula Á, Deák M, Kovács L, Monostori É, Fajka-Boja R.
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| Mol Immunol 57(2):302-9. doi: 10.1016/j.molimm.2013.10.010. Epub 2013 Nov 12.
2014
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| 11 | FOXP3, LCK, MMP9, SKP2, VEGFA
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| Phosphorylation of FOXP3 by LCK downregulates MMP9 expression and represses cell invasion.
|
| Nakahira K, Morita A, Kim NS, Yanagihara I.
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| PLoS One 8(10):e77099. doi: 10.1371/journal.pone.0077099. eCollection 2013.
2013
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| 12 | LCK, PTK2
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| Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor.
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| Chapman NM, Connolly SF, Reinl EL, Houtman JC.
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| J Immunol 191(12):6208-21. doi: 10.4049/jimmunol.1301587. Epub 2013 Nov 13.
2013
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| 13 | LCK
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| LCK is an important mediator of B-cell receptor signaling in chronic lymphocytic leukemia cells.
|
| Talab F, Allen JC, Thompson V, Lin K, Slupsky JR.
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| Mol Cancer Res 11(5):541-54. doi: 10.1158/1541-7786.MCR-12-0415-T. Epub 2013 Mar 15.
2013
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| 14 | JAK2, LCK, LMO2
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| Nuclear localization of lymphocyte-specific protein tyrosine kinase (Lck) and its role in regulating LIM domain only 2 (Lmo2) gene.
|
| Venkitachalam S, Chueh FY, Yu CL.
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| Biochem Biophys Res Commun 417(3):1058-62. doi: 10.1016/j.bbrc.2011.12.095. Epub 2011 Dec 27.
2012
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| 15 | DLG1, LCK
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| Subcellular distribution of Lck during CD4 T-cell maturation in the thymic medulla regulates the T-cell activation threshold.
|
| Stephen TL, Wilson BS, Laufer TM.
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| Proc Natl Acad Sci U S A 109(19):7415-20. doi: 10.1073/pnas.1119272109. Epub 2012 Apr 23.
2012
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| 16 | IMD22, LCK
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| Primary T-cell immunodeficiency with immunodysregulation caused by autosomal recessive LCK deficiency.
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| Hauck F, Randriamampita C, Martin E, Gerart S, Lambert N, Lim A, Soulier J, Maciorowski Z, Touzot F, Moshous D, Quartier P, Heritier S, Blanche S, Rieux-Laucat F, Brousse N, Callebaut I, Veillette A, Hivroz C, Fischer A, Latour S, Picard C.
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| J Allergy Clin Immunol 130(5):1144-1152.e11. doi: 10.1016/j.jaci.2012.07.029. Epub 2012 Sep 15.
2012
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| 17 | LCK
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| Centrosome docking at the immunological synapse is controlled by Lck signaling.
|
| Tsun A, Qureshi I, Stinchcombe JC, Jenkins MR, de la Roche M, Kleczkowska J, Zamoyska R, Griffiths GM.
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| J Cell Biol 192(4):663-74.
2011
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| 18 | LCK, SOCS1, SOCS3
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| Suppressor of cytokine signaling 1 interacts with oncogenic lymphocyte-specific protein tyrosine kinase.
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| Venkitachalam S, Chueh FY, Leong KF, Pabich S, Yu CL.
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| Oncol Rep 25(3):677-83. doi: 10.3892/or.2011.1144. Epub 2011 Jan 13. 2011
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| 19 | LCK, RHOH
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| RhoH modulates pre-TCR and TCR signalling by regulating LCK.
|
| Wang H, Zeng X, Fan Z, Lim B.
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| Cell Signal 23(1):249-58. Epub 2010 Sep 16.
2011
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| 20 | ITGB2, LCK, ZAP70
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| The integrin LFA-1 signals through ZAP-70 to regulate expression of high-affinity LFA-1 on T lymphocytes.
|
| Evans R, Lellouch AC, Svensson L, McDowall A, Hogg N.
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| Blood 117(12):3331-42. doi: 10.1182/blood-2010-06-289140. Epub 2011 Jan 3.
2011
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| 21 | LCK, SOCS6
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| SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradation.
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| Choi YB, Son M, Park M, Shin J, Yun Y.
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| J Biol Chem 285(10):7271-80. Epub 2009 Dec 10. 2010
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| 22 | LCK, RASSF5
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| Functional interaction of the Ras effector RASSF5 with the tyrosine kinase Lck: critical role in nucleocytoplasmic transport and cell cycle regulation.
|
| Kumari G, Singhal PK, Suryaraja R, Mahalingam S.
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| J Mol Biol 397(1):89-109. Epub 2010 Jan 11.
2010
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| 23 | LCK
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| Role of lymphocyte-specific protein tyrosine kinase (LCK) in the expansion of glioma-initiating cells by fractionated radiation.
|
| Kim RK, Yoon CH, Hyun KH, Lee H, An S, Park MJ, Kim MJ, Lee SJ.
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| Biochem Biophys Res Commun 402(4):631-6. Epub 2010 Oct 29.
2010
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| 24 | LCK
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| Th2-specific immunity and function of peripheral T cells is regulated by the p56Lck Src homology 3 domain.
|
| McCoy ME, Finkelman FD, Straus DB.
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| J Immunol 185(6):3285-94. Epub 2010 Aug 20.
2010
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| 25 | LCK
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| Plasma membrane subdomain partitioning of Lck in primary human T lymphocytes.
|
| Irles C, Arias-Martinez J, Guzmán-Bárcenas J, Ortega A.
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| Can J Physiol Pharmacol 88(4):487-96.
2010
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| 26 | LCK
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| Inhibition of Lck enhances glucocorticoid sensitivity and apoptosis in lymphoid cell lines and in chronic lymphocytic leukemia.
|
| Harr MW, Caimi PF, McColl KS, Zhong F, Patel SN, Barr PM, Distelhorst CW.
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| Cell Death Differ 17(9):1381-91. Epub 2010 Mar 19.
2010
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| 27 | ITK, LCK, SH2D2A
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| T cell specific adapter protein (TSAd) interacts with Tec kinase ITK to promote CXCL12 induced migration of human and murine T cells.
|
| Berge T, Sundvold-Gjerstad V, Granum S, Andersen TC, Holthe GB, Claesson-Welsh L, Andreotti AH, Inngjerdingen M, Spurkland A.
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| PLoS One 5(3):e9761. doi: 10.1371/journal.pone.0009761.
2010
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| 28 | LAT, LCK
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| T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells.
|
| Dong S, Corre B, Nika K, Pellegrini S, Michel F.
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| PLoS One 5(11):e15114. doi: 10.1371/journal.pone.0015114.
2010
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| 29 | LCK, PRKD2
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| PKD2 interacts with Lck and regulates NFAT activity in T cells.
|
| Li Q, Sun X, Wu J, Lin Z, Luo Y.
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| BMB Rep 42(1):35-40. 2009
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| 30 | LCK
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| The Src kinase Lck facilitates assembly of HIV-1 at the plasma membrane.
|
| Strasner AB, Natarajan M, Doman T, Key D, August A, Henderson AJ.
|
| J Immunol 181(5):3706-13.
2008
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| 31 | LCK
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| Modulation of Lck function through multisite docking to T cell-specific adapter protein.
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| Granum S, Andersen TC, Sřrlie M, Jřrgensen M, Koll L, Berge T, Lea T, Fleckenstein B, Spurkland A, Sundvold-Gjerstad V.
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| J Biol Chem 283(32):21909-19. Epub 2008 Jun 9.
2008
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| 32 | LCK, PTPN12
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| TCR-induced downregulation of protein tyrosine phosphatase PEST augments secondary T cell responses.
|
| Arimura Y, Vang T, Tautz L, Williams S, Mustelin T.
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| Mol Immunol 45(11):3074-84. doi: 10.1016/j.molimm.2008.03.019. Epub 2008 May 5.
2008
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| 33 | LAT, LCK
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| Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes.
|
| Jiang Y, Cheng H.
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| Leuk Res 31(4):541-5. Epub 2006 Aug 30.PMID: 16938345 2007
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| 34 | LCK,TNFRSF13C
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| The differential expression of LCK and BAFF-receptor and their role in apoptosis in human lymphomas.
|
| Paterson JC, Tedoldi S, Craxton A, Jones M, Hansmann ML, Collins G, Roberton H, Natkunam Y, Pileri S, Campo E, Clark EA, Mason DY, Marafioti T.
|
| Haematologica 91(6):772-80. 2006
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| 35 | LCK, LCP2
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| A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function.
|
| Kumar L, Feske S, Rao A, Geha RS.
|
| Proc Natl Acad Sci U S A 102(52):19063-8. Epub 2005 Dec 14. 2005
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| 36 | CBL, LCK
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| Negative regulation of Lck by Cbl ubiquitin ligase.
|
| Rao N, Miyake S, Reddi AL, Douillard P, Ghosh AK, Dodge IL, Zhou P, Fernandes ND, Band H.
|
| Proc Natl Acad Sci U S A 99(6):3794-9. 2002
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| 37 | CD4, LCK, VAV1
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| CD4-Lck through TCR and in the absence of Vav exchange factor induces Bax increase and mitochondrial damage.
|
| Tuosto L, Marinari B, Piccolella E.
|
| J Immunol 168(12):6106-12. 2002
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| 38 | CD4, LCK
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| p56Lck anchors CD4 to distinct microdomains on microvilli.
|
| Foti M, Phelouzat MA, Holm A, Rasmusson BJ, Carpentier JL.
|
| Proc Natl Acad Sci U S A 99(4):2008-13. 2002
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| 39 | IMD22, LCK
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| Defect of lck in a patient with common variable immunodeficiency.
|
| Sawabe T, Horiuchi T, Nakamura M, Tsukamoto H, Nakahara K, Harashima SI, Tsuchiya T, Nakano S.
|
| Int J Mol Med 7(6):609-14.
2001
|
| 40 | DOK1, DOK2, LCK
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| Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling.
|
| Nemorin JG, Duplay P.
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| J Biol Chem 275(19):14590-7. 2000
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| 41 | LCK
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| Defective expression of p56lck in an infant with severe combined immunodeficiency.
|
| Goldman FD, Ballas ZK, Schutte BC, Kemp J, Hollenback C, Noraz N, Taylor N.
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| J Clin Invest 102(2):421-9. 1998
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| 42 | LCK
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| Subregional mapping of the human lymphocyte-specific protein tyrosine kinase gene (LCK) to 1p35-p34.3 and its position relative to the 1p marker D1S57.
|
| Volpi EV, et al.
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| Cytogenet Cell Genet 67 : 187-189. 1994
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| 43 | LCK, TAL3, TRB@
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| Molecular analysis of the T-cell acute lymphoblastic leukemia-associated t(1;7)(p34;q34) that fuses LCK and TCRB.
|
| Burnett RC, et al.
|
| Blood 84 : 1232-1236. 1994
|
| 44 | LCK,TAL3,TRB@
|
| Chromosomal translocations joining LCK and TCRB loci in human T cell leukemia.
|
| Tycko B, et al.
|
| J Exp Med 174 : 867-873. 1991
|
| 45 | LCK, TAL3, TRB@
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| The LCK gene is involved in the t(1;7)(p34;q34) in the T-cell acute lymphoblastic leukemia derived cell line, HSB-2.
|
| Burnett RC, et al.
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| Genes Chromosomes Cancer 3 : 461-467. 1991
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| 46 | LCK
|
| Localization of a lymphocyte-specific protein tyrosine kinase gene (LCK) at a site of frequent chromosomal abnormalities in human lymphomas.
|
| Marth JD, et al.
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| Proc Natl Acad Sci U S A 83 : 7400-7404. 1986
|