Citations for
1CDC16, CDC26, LATS1, LATS2
LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C
Masuda K, Chiyoda T, Sugiyama N, Segura-Cabrera A, Kabe Y, Ueki A, Banno K, Suematsu M, Aoki D, Ishihama Y, Saya H, Kuninaka S.
PLoS One. 5 Feb 27;10(2):e0118662. doi: 10.1371/journal.pone.0118662. Erratum in: PLoS One. 2015;10(4):e0125308. Banno, Koji [corrected to 2015
2AMOT, LATS1, LATS2
Angiomotins link F-actin architecture to Hippo pathway signaling.
Mana-Capelli S, Paramasivam M, Dutta S, McCollum D.
Mol Biol Cell 25(10):1676-85. doi: 10.1091/mbc.E13-11-0701. Epub 2014 Mar 19. 2014
3ESR1, LATS2
LATS2 is a modulator of estrogen receptor alpha.
Lit LC, Scott S, Zhang H, Stebbing J, Photiou A, Giamas G.
Anticancer Res 33(1):53-63. 2013
4AMOT, ITCH, LATS1, LATS2, YAP1
Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases.
Adler JJ, Johnson DE, Heller BL, Bringman LR, Ranahan WP, Conwell MD, Sun Y, Hudmon A, Wells CD.
Proc Natl Acad Sci U S A 110(43):17368-73. doi: 10.1073/pnas.1308236110. Epub 2013 Oct 7. 2013
5AMOT, LATS1, LATS2
Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration, and angiogenesis.
Dai X, She P, Chi F, Feng Y, Liu H, Jin D, Zhao Y, Guo X, Jiang D, Guan KL, Zhong TP, Zhao B.
J Biol Chem 288(47):34041-51. doi: 10.1074/jbc.M113.518019. Epub 2013 Oct 8. 2013
6LATS1, LATS2, NF2
Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2.
Yin F, Yu J, Zheng Y, Chen Q, Zhang N, Pan D.
Cell 154(6):1342-55. doi: 10.1016/j.cell.2013.08.025. Epub 2013 Sep 5. 2013
7DMPK, LATS2
Phosphorylation target site specificity for AGC kinases DMPK E and Lats2.
Gerrits L, Venselaar H, Wieringa B, Wansink DG, Hendriks WJ.
J Cell Biochem 113(6):2126-35. doi: 10.1002/jcb.24086. 2012
8LATS2, WWC1
KIBRA regulates aurora kinase activity and is required for precise chromosome alignment during mitosis.
Zhang L, Iyer J, Chowdhury A, Ji M, Xiao L, Yang S, Chen Y, Tsai MY, Dong J.
J Biol Chem 287(41):34069-77. doi: 10.1074/jbc.M112.385518. 2012
9AMOT, AMOTL2, LATS2, YAP1
Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor.
Murugan P, Sarkeshik A, Yates JR 3rd, McCollum D.
Mol Biol Cell ol Biol Cell. 2011 Aug 10. [Epub ahead of print] 2011
10LATS2
LATS2 is a tumor suppressor gene of malignant mesothelioma.
Murakami H, Mizuno T, Taniguchi T, Fujii M, Ishiguro F, Fukui T, Akatsuka S, Horio Y, Hida T, Kondo Y, Toyokuni S, Osada H, Sekido Y.
Cancer Res 71(3):873-83. Epub 2011 Jan 18. 2011
11LATS1, LATS2, WWC1
KIBRA regulates Hippo signaling activity via interactions with large tumor suppressor kinases.
Xiao L, Chen Y, Ji M, Dong J.
J Biol Chem 286(10):7788-96. Epub 2011 Jan 13. 2011
12FOXP3, LATS2
Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers.
Li W, Wang L, Katoh H, Liu R, Zheng P, Liu Y.
Cancer Res 71(6):2162-71. Epub 2011 Jan 28. 2011
13LATS2, SNAI1
Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation.
Zhang K, Rodriguez-Aznar E, Yabuta N, Owen RJ, Mingot JM, Nojima H, Nieto MA, Longmore GD.
EMBO J 31(1):29-43. doi: 10.1038/emboj.2011.357. 2011
14LATS2
The tumor suppressor Lats2 is pivotal in Aurora A and Aurora B signaling during mitosis.
Yabuta N, Mukai S, Okada N, Aylon Y, Nojima H.
Cell Cycle 10(16):2724-36. Epub 2011 Aug 15. 2011
15LATS2, ZFP36
Stability of the LATS2 tumor suppressor gene is regulated by tristetraprolin.
Lee HH, Vo MT, Kim HJ, Lee UH, Kim CW, Kim HK, Ko MS, Lee WH, Cha SJ, Min YJ, Choi DH, Suh HS, Lee BJ, Park JW, Cho WJ.
J Biol Chem 285(23):17329-37. Epub 2010 Mar 24.PMID: 20335167 2010
16HSP90AA1, LATS1, LATS2
Heat shock protein 90 inhibition depletes LATS1 and LATS2, two regulators of the mammalian hippo tumor suppressor pathway.
Huntoon CJ, Nye MD, Geng L, Peterson KL, Flatten KS, Haluska P, Kaufmann SH, Karnitz LM.
Cancer Res 70(21):8642-50. Epub 2010 Sep 14. 2010
17LATS2
Pig large tumor suppressor 2 (Lats2), a novel gene that may regulate the fat reduction in adipocyte.
Liu Q, Gu X, Zhao Y, Zhang J, Zhao Y, Meng Q, Xu G, Hu X, Li N.
BMB Rep 43(2):97-102. 2010
18LATS2
LATS2 tumour specific mutations and down-regulation of the gene in non-small cell carcinoma.
Strazisar M, Mlakar V, Glavac D.
Lung Cancer 64(3):257-62. Epub 2008 Nov 12. 2009
19LATS2
Lats2 is a negative regulator of myocyte size in the heart.
Matsui Y, Nakano N, Shao D, Gao S, Luo W, Hong C, Zhai P, Holle E, Yu X, Yabuta N, Tao W, Wagner T, Nojima H, Sadoshima J.
Circ Res 103(11):1309-18. Epub 2008 Oct 16. Erratum in: Circ Res. 2009 Feb 13;104(3):e27-9. 2008
20LATS2
Lats2 is an essential mitotic regulator required for the coordination of cell division.
Yabuta N, Okada N, Ito A, Hosomi T, Nishihara S, Sasayama Y, Fujimori A, Okuzaki D, Zhao H, Ikawa M, Okabe M, Nojima H.
J Biol Chem 282(26):19259-71. Epub 2007 May 3. 2007
21LATS1, LATS2
Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma.
Jiang Z, Li X, Hu J, Zhou W, Jiang Y, Li G, Lu D.
Neurosci Res 56(4):450-8. Epub 2006 Oct 17. 2006
22TSG13D, LATS2, CRYL1, IFT88, GJB2
Molecular genetic evidence supporting a novel human hepatocellular carcinoma tumor suppressor locus at 13q12.11.
Chen CF, Yeh SH, Chen DS, Chen PJ, Jou YS.
Genes Chromosomes Cancer 44(3):320-8. 2005
23LATS1, LATS2, STK3
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1.
Chan EH, Nousiainen M, Chalamalasetty RB, Schäfer A, Nigg EA, Silljé HH.
Oncogene 24(12):2076-86. 2005
24LATS2, AURKA
The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.
Toji S, Yabuta N, Hosomi T, Nishihara S, Kobayashi T, Suzuki S, Tamai K, Nojima H.
Genes Cells 9(5):383-97. 2004
25LATS2, AR
The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor.
Powzaniuk M, McElwee-Witmer S, Vogel RL, Hayami T, Rutledge SJ, Chen F, Harada S, Schmidt A, Rodan GA, Freedman LP, Bai C.
Mol Endocrinol 18(8):2011-23. Epub 2004 May 6. 2004
26LATS1, LATS2
Lats2, a putative tumor suppressor, inhibits G1/S transition.
Li Y, Pei J, Xia H, Ke H, Wang H, Tao W.
Oncogene 22(28):4398-405. 2003
27LATS2
Structure, Expression, and Chromosome Mapping of LATS2, a Mammalian Homologue of the Drosophila Tumor Suppressor Gene lats/warts.
Yabuta N, Fujii T, Copeland NG, Gilbert DJ, Jenkins NA, Nishiguchi H, Endo Y, Toji S, Tanaka H, Nishimune Y, Nojima H.
Genomics 63(2):263-270. 2000
28LATS2
Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction.
St John MA, Tao W, Fei X, Fukumoto R, Carcangiu ML, Brownstein DG, Parlow AF, McGrath J, Xu T.
Nat Genet 21(2):182-6 1999
29CDK1, LATS2
Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity.
Tao W, Zhang S, Turenchalk GS, Stewart RA, St John MA, Chen W, Xu T.
Nat Genet 21(2):177-81 1999
30LATS2
The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation.
Justice RW, Zilian O, Woods DF, Noll M, Bryant PJ.
Genes Dev 9(5):534-46 1995