| 1 | CDC16, CDC26, LATS1, LATS2
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| LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C
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| Masuda K, Chiyoda T, Sugiyama N, Segura-Cabrera A, Kabe Y, Ueki A, Banno K, Suematsu M, Aoki D, Ishihama Y, Saya H, Kuninaka S.
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| PLoS One. 5 Feb 27;10(2):e0118662. doi: 10.1371/journal.pone.0118662. Erratum in: PLoS One. 2015;10(4):e0125308. Banno, Koji [corrected to 2015
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| 2 | AMOT, LATS1, LATS2
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| Angiomotins link F-actin architecture to Hippo pathway signaling.
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| Mana-Capelli S, Paramasivam M, Dutta S, McCollum D.
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| Mol Biol Cell 25(10):1676-85. doi: 10.1091/mbc.E13-11-0701. Epub 2014 Mar 19.
2014
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| 3 | ESR1, LATS2
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| LATS2 is a modulator of estrogen receptor alpha.
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| Lit LC, Scott S, Zhang H, Stebbing J, Photiou A, Giamas G.
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| Anticancer Res 33(1):53-63.
2013
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| 4 | AMOT, ITCH, LATS1, LATS2, YAP1
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| Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases.
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| Adler JJ, Johnson DE, Heller BL, Bringman LR, Ranahan WP, Conwell MD, Sun Y, Hudmon A, Wells CD.
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| Proc Natl Acad Sci U S A 110(43):17368-73. doi: 10.1073/pnas.1308236110. Epub 2013 Oct 7.
2013
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| 5 | AMOT, LATS1, LATS2
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| Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration, and angiogenesis.
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| Dai X, She P, Chi F, Feng Y, Liu H, Jin D, Zhao Y, Guo X, Jiang D, Guan KL, Zhong TP, Zhao B.
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| J Biol Chem 288(47):34041-51. doi: 10.1074/jbc.M113.518019. Epub 2013 Oct 8.
2013
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| 6 | LATS1, LATS2, NF2
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| Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2.
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| Yin F, Yu J, Zheng Y, Chen Q, Zhang N, Pan D.
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| Cell 154(6):1342-55. doi: 10.1016/j.cell.2013.08.025. Epub 2013 Sep 5.
2013
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| 7 | DMPK, LATS2
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| Phosphorylation target site specificity for AGC kinases DMPK E and Lats2.
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| Gerrits L, Venselaar H, Wieringa B, Wansink DG, Hendriks WJ.
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| J Cell Biochem 113(6):2126-35. doi: 10.1002/jcb.24086.
2012
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| 8 | LATS2, WWC1
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| KIBRA regulates aurora kinase activity and is required for precise chromosome alignment during mitosis.
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| Zhang L, Iyer J, Chowdhury A, Ji M, Xiao L, Yang S, Chen Y, Tsai MY, Dong J.
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| J Biol Chem 287(41):34069-77. doi: 10.1074/jbc.M112.385518.
2012
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| 9 | AMOT, AMOTL2, LATS2, YAP1
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| Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor.
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| Murugan P, Sarkeshik A, Yates JR 3rd, McCollum D.
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| Mol Biol Cell ol Biol Cell. 2011 Aug 10. [Epub ahead of print] 2011
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| 10 | LATS2
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| LATS2 is a tumor suppressor gene of malignant mesothelioma.
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| Murakami H, Mizuno T, Taniguchi T, Fujii M, Ishiguro F, Fukui T, Akatsuka S, Horio Y, Hida T, Kondo Y, Toyokuni S, Osada H, Sekido Y.
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| Cancer Res 71(3):873-83. Epub 2011 Jan 18.
2011
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| 11 | LATS1, LATS2, WWC1
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| KIBRA regulates Hippo signaling activity via interactions with large tumor suppressor kinases.
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| Xiao L, Chen Y, Ji M, Dong J.
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| J Biol Chem 286(10):7788-96. Epub 2011 Jan 13.
2011
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| 12 | FOXP3, LATS2
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| Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers.
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| Li W, Wang L, Katoh H, Liu R, Zheng P, Liu Y.
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| Cancer Res 71(6):2162-71. Epub 2011 Jan 28.
2011
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| 13 | LATS2, SNAI1
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| Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation.
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| Zhang K, Rodriguez-Aznar E, Yabuta N, Owen RJ, Mingot JM, Nojima H, Nieto MA, Longmore GD.
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| EMBO J 31(1):29-43. doi: 10.1038/emboj.2011.357.
2011
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| 14 | LATS2
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| The tumor suppressor Lats2 is pivotal in Aurora A and Aurora B signaling during mitosis.
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| Yabuta N, Mukai S, Okada N, Aylon Y, Nojima H.
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| Cell Cycle 10(16):2724-36. Epub 2011 Aug 15.
2011
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| 15 | LATS2, ZFP36
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| Stability of the LATS2 tumor suppressor gene is regulated by tristetraprolin.
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| Lee HH, Vo MT, Kim HJ, Lee UH, Kim CW, Kim HK, Ko MS, Lee WH, Cha SJ, Min YJ, Choi DH, Suh HS, Lee BJ, Park JW, Cho WJ.
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| J Biol Chem 285(23):17329-37. Epub 2010 Mar 24.PMID: 20335167 2010
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| 16 | HSP90AA1, LATS1, LATS2
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| Heat shock protein 90 inhibition depletes LATS1 and LATS2, two regulators of the mammalian hippo tumor suppressor pathway.
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| Huntoon CJ, Nye MD, Geng L, Peterson KL, Flatten KS, Haluska P, Kaufmann SH, Karnitz LM.
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| Cancer Res 70(21):8642-50. Epub 2010 Sep 14.
2010
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| 17 | LATS2
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| Pig large tumor suppressor 2 (Lats2), a novel gene that may regulate the fat reduction in adipocyte.
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| Liu Q, Gu X, Zhao Y, Zhang J, Zhao Y, Meng Q, Xu G, Hu X, Li N.
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| BMB Rep 43(2):97-102.
2010
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| 18 | LATS2
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| LATS2 tumour specific mutations and down-regulation of the gene in non-small cell carcinoma.
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| Strazisar M, Mlakar V, Glavac D.
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| Lung Cancer 64(3):257-62. Epub 2008 Nov 12.
2009
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| 19 | LATS2
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| Lats2 is a negative regulator of myocyte size in the heart.
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| Matsui Y, Nakano N, Shao D, Gao S, Luo W, Hong C, Zhai P, Holle E, Yu X, Yabuta N, Tao W, Wagner T, Nojima H, Sadoshima J.
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| Circ Res 103(11):1309-18. Epub 2008 Oct 16. Erratum in: Circ Res. 2009 Feb 13;104(3):e27-9.
2008
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| 20 | LATS2
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| Lats2 is an essential mitotic regulator required for the coordination of cell division.
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| Yabuta N, Okada N, Ito A, Hosomi T, Nishihara S, Sasayama Y, Fujimori A, Okuzaki D, Zhao H, Ikawa M, Okabe M, Nojima H.
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| J Biol Chem 282(26):19259-71. Epub 2007 May 3. 2007
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| 21 | LATS1, LATS2
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| Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma.
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| Jiang Z, Li X, Hu J, Zhou W, Jiang Y, Li G, Lu D.
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| Neurosci Res 56(4):450-8. Epub 2006 Oct 17.
2006
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| 22 | TSG13D, LATS2, CRYL1, IFT88, GJB2
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| Molecular genetic evidence supporting a novel human hepatocellular carcinoma tumor suppressor locus at 13q12.11.
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| Chen CF, Yeh SH, Chen DS, Chen PJ, Jou YS.
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| Genes Chromosomes Cancer 44(3):320-8. 2005
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| 23 | LATS1, LATS2, STK3
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| The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1.
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| Chan EH, Nousiainen M, Chalamalasetty RB, Schäfer A, Nigg EA, Silljé HH.
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| Oncogene 24(12):2076-86.
2005
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| 24 | LATS2, AURKA
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| The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.
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| Toji S, Yabuta N, Hosomi T, Nishihara S, Kobayashi T, Suzuki S, Tamai K, Nojima H.
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| Genes Cells 9(5):383-97. 2004
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| 25 | LATS2, AR
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| The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor.
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| Powzaniuk M, McElwee-Witmer S, Vogel RL, Hayami T, Rutledge SJ, Chen F, Harada S, Schmidt A, Rodan GA, Freedman LP, Bai C.
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| Mol Endocrinol 18(8):2011-23. Epub 2004 May 6. 2004
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| 26 | LATS1, LATS2
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| Lats2, a putative tumor suppressor, inhibits G1/S transition.
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| Li Y, Pei J, Xia H, Ke H, Wang H, Tao W.
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| Oncogene 22(28):4398-405. 2003
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| 27 | LATS2
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| Structure, Expression, and Chromosome Mapping of LATS2, a Mammalian Homologue of the Drosophila Tumor Suppressor Gene lats/warts.
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| Yabuta N, Fujii T, Copeland NG, Gilbert DJ, Jenkins NA, Nishiguchi H, Endo Y, Toji S, Tanaka H, Nishimune Y, Nojima H.
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| Genomics 63(2):263-270. 2000
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| 28 | LATS2
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| Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction.
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| St John MA, Tao W, Fei X, Fukumoto R, Carcangiu ML, Brownstein DG, Parlow AF, McGrath J, Xu T.
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| Nat Genet 21(2):182-6 1999
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| 29 | CDK1, LATS2
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| Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity.
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| Tao W, Zhang S, Turenchalk GS, Stewart RA, St John MA, Chen W, Xu T.
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| Nat Genet 21(2):177-81 1999
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| 30 | LATS2
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| The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation.
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| Justice RW, Zilian O, Woods DF, Noll M, Bryant PJ.
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| Genes Dev 9(5):534-46 1995
|