Citations for
1CD6, LAT, SH2D2A
CD6 and Linker of Activated T Cells are Potential Interaction Partners for T Cell-Specific Adaptor Protein.
Hem CD, Ekornhol M, Granum S, Sundvold-Gjerstad V, Spurkland A.
Scand J Immunol 85(2):104-112. doi: 10.1111/sji.12513. 2017
2IMD52, LAT
Mutations in linker for activation of T cells (LAT) lead to a novel form of severe combined immunodeficiency.
Bacchelli C, Moretti FA, Carmo M, Adams S, Stanescu HC, Pearce K, Madkaikar M, Gilmour KC, Nicholas AK, Woods CG, Kleta R, Beales PL, Qasim W, Gaspar HB.
J Allergy Clin Immunol 139(2):634-642.e5. doi: 10.1016/j.jaci.2016.05.036. Epub 2016 Jul 15. 2017
3CD247, LAT, ZAP70
The Immune Signaling Adaptor LAT Contributes to the Neuroanatomical Phenotype of 16p11.2 BP2-BP3 CNVs.
Loviglio MN, Arbogast T, Jønch AE, Collins SC, Popadin K, Bonnet CS, Giannuzzi G, Maillard AM, Jacquemont S; 16p11.
Am J Hum Genet 101(4):564-577. doi: 10.1016/j.ajhg.2017.08.016. Epub 2017 Sep 28. 2017
4IFT20, LAT
IFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo.
Vivar OI, Masi G, Carpier JM, Magalhaes JG, Galgano D, Pazour GJ, Amigorena S, Hivroz C, Baldari CT.
Proc Natl Acad Sci U S A 113(2):386-91. doi: 10.1073/pnas.1513601113. Epub 2015 Dec 29. 2016
5IMD52, LAT
Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.
Keller B, Zaidman I, Yousefi OS, Hershkovitz D, Stein J, Unger S, Schachtrup K, Sigvardsson M, Kuperman AA, Shaag A, Schamel WW, Elpeleg O, Warnatz K, Stepensky P.
J Exp Med 213(7):1185-99. doi: 10.1084/jem.20151110. Epub 2016 May 30. Erratum in: J Exp Med. 2017 Jun 1;:. 2016
6LAT
The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity.
O'Brien SA, Zhu M, Zhang W.
J Immunol 195(2):695-705. doi: 10.4049/jimmunol.1403187. Epub 2015 Jun 1. 2015
7LAT
Low level of LAT-PLC-γ1 interaction is associated with Th2 polarized differentiation: a contributing factor to the etiology of asthma.
Peng X, Cui Z, Gu W, Xu W, Guo X.
Cell Immunol 290(1):131-7. doi: 10.1016/j.cellimm.2014.05.012. Epub 2014 Jun 18. 2014
8GRAP2, GRB2, LAT, PLCG1
The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis.
Sullivan SA, Zhu M, Bao S, Lewis CA, Ou-Yang CW, Zhang W.
J Immunol 192(6):2865-74. doi: 10.4049/jimmunol.1302493. Epub 2014 Feb 12. 2014
9GRB2, LAT, SOS1
The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo.
Kortum RL, Balagopalan L, Alexander CP, Garcia J, Pinski JM, Merrill RK, Nguyen PH, Li W, Agarwal I, Akpan IO, Sommers CL, Samelson LE.
Sci Signal 6(301):ra99. doi: 10.1126/scisignal.2004494. 2013
10LAT, TRAF6
TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapter.
Xie JJ, Liang JQ, Diao LH, Altman A, Li Y.
J Immunol 190(8):4027-36. doi: 10.4049/jimmunol.1202742. Epub 2013 Mar 20. 2013
11FAS, LAT
The membrane adaptor LAT is proteolytically cleaved following Fas engagement in a tyrosine phosphorylation-dependent fashion.
García-Blesa A, Klossowicz M, López-Osuna C, Martínez-Florensa M, Malissen B, García-Cózar FJ, Miazek A, Aguado E.
Biochem J 450(3):511-21. doi: 10.1042/BJ20121135. 2013
12LAT
Role of LAT in the granule-mediated cytotoxicity of CD8 T cells.
Ou-Yang CW, Zhu M, Fuller DM, Sullivan SA, Chuck MI, Ogden S, Li QJ, Zhang W.
Mol Cell Biol 32(14):2674-84. doi: 10.1128/MCB.00356-12. Epub 2012 May 7. 2012
13LAT, TNFSF11
The transmembrane adaptor protein, linker for activation of T cells (LAT), regulates RANKL-induced osteoclast differentiation.
Kim K, Kim JH, Moon JB, Lee J, Kwak HB, Park YW, Kim N.
Mol Cells 33(4):401-6. doi: 10.1007/s10059-012-0009-2. Epub 2012 Feb 28. 2012
14LAT, PLCG1, STK11
LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection.
Cao Y, Li H, Liu H, Zhang M, Hua Z, Ji H, Liu X.
EMBO J 30(10):2083-93. doi: 10.1038/emboj.2011.116. Epub 2011 Apr 12. 2011
15LAT
Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation.
Balagopalan L, Ashwell BA, Bernot KM, Akpan IO, Quasba N, Barr VA, Samelson LE.
Proc Natl Acad Sci U S A 108(7):2885-90. doi: 10.1073/pnas.1007098108. Epub 2011 Jan 31. 2011
16LAT, LCK
T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells.
Dong S, Corre B, Nika K, Pellegrini S, Michel F.
PLoS One 5(11):e15114. doi: 10.1371/journal.pone.0015114. 2010
17LAT
The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage.
Shen S, Zhu M, Lau J, Chuck M, Zhang W.
J Immunol 182(9):5596-604.PMID: 1938080 2009
18LAT, LAT2
Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire.
Whittaker GC, Burshtyn DN, Orr SJ, Quigley L, Hodge DL, Pascal V, Zhang W, McVicar DW.
Blood 112(7):2869-77. doi: 10.1182/blood-2007-11-121590. Epub 2008 Jul 21. 2008
19CBL, LAT
c-Cbl-mediated regulation of LAT-nucleated signaling complexes.
Balagopalan L, Barr VA, Sommers CL, Barda-Saad M, Goyal A, Isakowitz MS, Samelson LE.
Mol Cell Biol 27(24):8622-36. Epub 2007 Oct 15.PMID: 17938199 2007
20LAT, LCK
Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes.
Jiang Y, Cheng H.
Leuk Res 31(4):541-5. Epub 2006 Aug 30.PMID: 16938345 2007
21LAT, LAT2
LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival.
Yamasaki S, Ishikawa E, Sakuma M, Kanagawa O, Cheng AM, Malissen B, Saito T.
Mol Cell Biol 27(12):4406-15. Epub 2007 Apr 9. 2007
22LAT, SOS1, GRB2
Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1.
Houtman JC, Yamaguchi H, Barda-Saad M, Braiman A, Bowden B, Appella E, Schuck P, Samelson LE.
Nat Struct Mol Biol 13(9):798-805. Epub 2006 Aug 13. 2006
23ELF1, LAT
Regulation of the human LAT gene by the Elf-1 transcription factor.
Finco TS, Justice-Healy GE, Patel SJ, Hamilton VE.
BMC Mol Biol 7:4.PMID: 16464244 2006
24LAT, LAT2
NTAL/LAB and LAT: a balancing act in mast-cell activation and function.
Rivera J.
Trends Immunol 26(3):119-22. Review. No abstract available. 2005
25LAT
Induction of T helper type 2 immunity by a point mutation in the LAT adaptor.
Aguado E, Richelme S, Nunez-Cruz S, Miazek A, Mura AM, Richelme M, Guo XJ, Sainty D, He HT, Malissen B, Malissen M.
Science 296(5575):2036-40. 2002
26LAT
A LAT mutation that inhibits T cell development yet induces lymphoproliferation.
Sommers CL, Park CS, Lee J, Feng C, Fuller CL, Grinberg A, Hildebrand JA, Lacana E, Menon RK, Shores EW, Samelson LE, Love PE.
Science 296(5575):2040-3. 2002
27LAT
Chromosomal localization and genomic organization of the human Linker for Activation of T cells (LAT) gene.
Windpassinger C, Kroisel PM, Wagner K, Petek E.
Cytogenet Genome Res 97(3-4):155-7. 2002
28LAT, SLC7A8
Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains.
Bröer A, Friedrich B, Wagner CA, Fillon S, Ganapathy V, Lang F, Bröer S.
Biochem J 355(Pt 3):725-31. 2001