| 1 | CD6, LAT, SH2D2A
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| CD6 and Linker of Activated T Cells are Potential Interaction Partners for T Cell-Specific Adaptor Protein.
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| Hem CD, Ekornhol M, Granum S, Sundvold-Gjerstad V, Spurkland A.
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| Scand J Immunol 85(2):104-112. doi: 10.1111/sji.12513.
2017
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| 2 | IMD52, LAT
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| Mutations in linker for activation of T cells (LAT) lead to a novel form of severe combined immunodeficiency.
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| Bacchelli C, Moretti FA, Carmo M, Adams S, Stanescu HC, Pearce K, Madkaikar M, Gilmour KC, Nicholas AK, Woods CG, Kleta R, Beales PL, Qasim W, Gaspar HB.
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| J Allergy Clin Immunol 139(2):634-642.e5. doi: 10.1016/j.jaci.2016.05.036. Epub 2016 Jul 15.
2017
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| 3 | CD247, LAT, ZAP70
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| The Immune Signaling Adaptor LAT Contributes to the Neuroanatomical Phenotype of 16p11.2 BP2-BP3 CNVs.
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| Loviglio MN, Arbogast T, Jønch AE, Collins SC, Popadin K, Bonnet CS, Giannuzzi G, Maillard AM, Jacquemont S; 16p11.
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| Am J Hum Genet 101(4):564-577. doi: 10.1016/j.ajhg.2017.08.016. Epub 2017 Sep 28.
2017
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| 4 | IFT20, LAT
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| IFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo.
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| Vivar OI, Masi G, Carpier JM, Magalhaes JG, Galgano D, Pazour GJ, Amigorena S, Hivroz C, Baldari CT.
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| Proc Natl Acad Sci U S A 113(2):386-91. doi: 10.1073/pnas.1513601113. Epub 2015 Dec 29.
2016
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| 5 | IMD52, LAT
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| Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.
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| Keller B, Zaidman I, Yousefi OS, Hershkovitz D, Stein J, Unger S, Schachtrup K, Sigvardsson M, Kuperman AA, Shaag A, Schamel WW, Elpeleg O, Warnatz K, Stepensky P.
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| J Exp Med 213(7):1185-99. doi: 10.1084/jem.20151110. Epub 2016 May 30. Erratum in: J Exp Med. 2017 Jun 1;:.
2016
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| 6 | LAT
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| The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity.
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| O'Brien SA, Zhu M, Zhang W.
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| J Immunol 195(2):695-705. doi: 10.4049/jimmunol.1403187. Epub 2015 Jun 1.
2015
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| 7 | LAT
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| Low level of LAT-PLC-γ1 interaction is associated with Th2 polarized differentiation: a contributing factor to the etiology of asthma.
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| Peng X, Cui Z, Gu W, Xu W, Guo X.
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| Cell Immunol 290(1):131-7. doi: 10.1016/j.cellimm.2014.05.012. Epub 2014 Jun 18.
2014
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| 8 | GRAP2, GRB2, LAT, PLCG1
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| The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis.
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| Sullivan SA, Zhu M, Bao S, Lewis CA, Ou-Yang CW, Zhang W.
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| J Immunol 192(6):2865-74. doi: 10.4049/jimmunol.1302493. Epub 2014 Feb 12.
2014
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| 9 | GRB2, LAT, SOS1
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| The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo.
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| Kortum RL, Balagopalan L, Alexander CP, Garcia J, Pinski JM, Merrill RK, Nguyen PH, Li W, Agarwal I, Akpan IO, Sommers CL, Samelson LE.
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| Sci Signal 6(301):ra99. doi: 10.1126/scisignal.2004494.
2013
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| 10 | LAT, TRAF6
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| TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapter.
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| Xie JJ, Liang JQ, Diao LH, Altman A, Li Y.
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| J Immunol 190(8):4027-36. doi: 10.4049/jimmunol.1202742. Epub 2013 Mar 20.
2013
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| 11 | FAS, LAT
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| The membrane adaptor LAT is proteolytically cleaved following Fas engagement in a tyrosine phosphorylation-dependent fashion.
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| García-Blesa A, Klossowicz M, López-Osuna C, Martínez-Florensa M, Malissen B, García-Cózar FJ, Miazek A, Aguado E.
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| Biochem J 450(3):511-21. doi: 10.1042/BJ20121135.
2013
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| 12 | LAT
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| Role of LAT in the granule-mediated cytotoxicity of CD8 T cells.
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| Ou-Yang CW, Zhu M, Fuller DM, Sullivan SA, Chuck MI, Ogden S, Li QJ, Zhang W.
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| Mol Cell Biol 32(14):2674-84. doi: 10.1128/MCB.00356-12. Epub 2012 May 7.
2012
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| 13 | LAT, TNFSF11
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| The transmembrane adaptor protein, linker for activation of T cells (LAT), regulates RANKL-induced osteoclast differentiation.
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| Kim K, Kim JH, Moon JB, Lee J, Kwak HB, Park YW, Kim N.
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| Mol Cells 33(4):401-6. doi: 10.1007/s10059-012-0009-2. Epub 2012 Feb 28.
2012
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| 14 | LAT, PLCG1, STK11
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| LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection.
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| Cao Y, Li H, Liu H, Zhang M, Hua Z, Ji H, Liu X.
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| EMBO J 30(10):2083-93. doi: 10.1038/emboj.2011.116. Epub 2011 Apr 12.
2011
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| 15 | LAT
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| Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation.
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| Balagopalan L, Ashwell BA, Bernot KM, Akpan IO, Quasba N, Barr VA, Samelson LE.
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| Proc Natl Acad Sci U S A 108(7):2885-90. doi: 10.1073/pnas.1007098108. Epub 2011 Jan 31. 2011
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| 16 | LAT, LCK
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| T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells.
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| Dong S, Corre B, Nika K, Pellegrini S, Michel F.
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| PLoS One 5(11):e15114. doi: 10.1371/journal.pone.0015114.
2010
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| 17 | LAT
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| The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage.
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| Shen S, Zhu M, Lau J, Chuck M, Zhang W.
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| J Immunol 182(9):5596-604.PMID: 1938080 2009
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| 18 | LAT, LAT2
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| Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire.
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| Whittaker GC, Burshtyn DN, Orr SJ, Quigley L, Hodge DL, Pascal V, Zhang W, McVicar DW.
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| Blood 112(7):2869-77. doi: 10.1182/blood-2007-11-121590. Epub 2008 Jul 21.
2008
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| 19 | CBL, LAT
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| c-Cbl-mediated regulation of LAT-nucleated signaling complexes.
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| Balagopalan L, Barr VA, Sommers CL, Barda-Saad M, Goyal A, Isakowitz MS, Samelson LE.
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| Mol Cell Biol 27(24):8622-36. Epub 2007 Oct 15.PMID: 17938199 2007
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| 20 | LAT, LCK
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| Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes.
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| Jiang Y, Cheng H.
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| Leuk Res 31(4):541-5. Epub 2006 Aug 30.PMID: 16938345 2007
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| 21 | LAT, LAT2
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| LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival.
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| Yamasaki S, Ishikawa E, Sakuma M, Kanagawa O, Cheng AM, Malissen B, Saito T.
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| Mol Cell Biol 27(12):4406-15. Epub 2007 Apr 9.
2007
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| 22 | LAT, SOS1, GRB2
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| Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1.
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| Houtman JC, Yamaguchi H, Barda-Saad M, Braiman A, Bowden B, Appella E, Schuck P, Samelson LE.
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| Nat Struct Mol Biol 13(9):798-805. Epub 2006 Aug 13. 2006
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| 23 | ELF1, LAT
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| Regulation of the human LAT gene by the Elf-1 transcription factor.
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| Finco TS, Justice-Healy GE, Patel SJ, Hamilton VE.
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| BMC Mol Biol 7:4.PMID: 16464244 2006
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| 24 | LAT, LAT2
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| NTAL/LAB and LAT: a balancing act in mast-cell activation and function.
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| Rivera J.
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| Trends Immunol 26(3):119-22. Review. No abstract available.
2005
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| 25 | LAT
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| Induction of T helper type 2 immunity by a point mutation in the LAT adaptor.
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| Aguado E, Richelme S, Nunez-Cruz S, Miazek A, Mura AM, Richelme M, Guo XJ, Sainty D, He HT, Malissen B, Malissen M.
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| Science 296(5575):2036-40. 2002
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| 26 | LAT
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| A LAT mutation that inhibits T cell development yet induces lymphoproliferation.
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| Sommers CL, Park CS, Lee J, Feng C, Fuller CL, Grinberg A, Hildebrand JA, Lacana E, Menon RK, Shores EW, Samelson LE, Love PE.
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| Science 296(5575):2040-3. 2002
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| 27 | LAT
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| Chromosomal localization and genomic organization of the human Linker for Activation of T cells (LAT) gene.
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| Windpassinger C, Kroisel PM, Wagner K, Petek E.
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| Cytogenet Genome Res 97(3-4):155-7. 2002
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| 28 | LAT, SLC7A8
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| Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains.
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| Bröer A, Friedrich B, Wagner CA, Fillon S, Ganapathy V, Lang F, Bröer S.
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| Biochem J 355(Pt 3):725-31.
2001
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