| 1 | BRAF, KSR1, RAF1
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| Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF.
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| Hu J, Yu H, Kornev AP, Zhao J, Filbert EL, Taylor SS, Shaw AS.
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| Proc Natl Acad Sci U S A 108(15):6067-72. Epub 2011 Mar 25.
2011
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| 2 | KSR1
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| KSR1 is overexpressed in endometrial carcinoma and regulates proliferation and TRAIL-induced apoptosis by modulating FLIP levels.
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| Llobet D, Eritja N, Domingo M, Bergada L, Mirantes C, Santacana M, Pallares J, Maciā A, Yeramian A, Encinas M, Moreno-Bueno G, Palacios J, Lewis RE, Matias-Guiu X, Dolcet X.
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| Am J Pathol 178(4):1529-43.
2011
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| 3 | KSR1, MAP2K1
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| KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1.
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| Goettel JA, Liang D, Hilliard VC, Edelblum KL, Broadus MR, Gould KL, Hanks SK, Polk DB.
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| Exp Cell Res 317(4):452-63. Epub 2010 Dec 7.
2011
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| 4 | KSR1, PPARGC1A
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| Kinase suppressor of ras 1 (KSR1) regulates PGC1α and estrogen-related receptor α to promote oncogenic Ras-dependent anchorage-independent growth.
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| Fisher KW, Das B, Kortum RL, Chaika OV, Lewis RE.
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| Mol Cell Biol 31(12):2453-61. Epub 2011 Apr 25. 2011
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| 5 | KSR1
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| Kinase suppressor of Ras 1 is required for full ERK activation in thymocytes but not for thymocyte selection.
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| Filbert EL, Nguyen A, Markiewicz MA, Fowlkes BJ, Huang YH, Shaw AS.
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| Eur J Immunol 40(11):3226-34. doi: 10.1002/eji.201040349. Epub 2010 Sep 24.
2010
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| 6 | EGFR, IQGAP1, KSR1, MAPK1, MAPK3, PLA2G4A
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| Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins.
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| Casar B, Arozarena I, Sanz-Moreno V, Pinto A, Agudo-Ibáņez L, Marais R, Lewis RE, Berciano MT, Crespo P.
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| Mol Cell Biol 29(5):1338-53. Epub 2008 Dec 29.
2009
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| 7 | KSR1
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| The mitogen-activated protein kinase scaffold KSR1 is required for recruitment of extracellular signal-regulated kinase to the immunological synapse.
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| Giurisato E, Lin J, Harding A, Cerutti E, Cella M, Lewis RE, Colonna M, Shaw AS.
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| Mol Cell Biol 29(6):1554-64. Epub 2009 Jan 12.
2009
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| 8 | KSR1
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| KSR1 is required for cell cycle reinitiation following DNA damage.
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| Razidlo GL, Johnson HJ, Stoeger SM, Cowan KH, Bessho T, Lewis RE.
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| J Biol Chem 284(11):6705-15. Epub 2009 Jan 15.
2009
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| 9 | KSR1
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| KSR1 modulates the sensitivity of mitogen-activated protein kinase pathway activation in T cells without altering fundamental system outputs.
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| Lin J, Harding A, Giurisato E, Shaw AS.
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| Mol Cell Biol 29(8):2082-91. Epub 2009 Feb 2.
2009
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| 10 | KSR1
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| Signaling dynamics of the KSR1 scaffold complex.
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| McKay MM, Ritt DA, Morrison DK.
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| Proc Natl Acad Sci U S A 106(27):11022-7. Epub 2009 Jun 18.
2009
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| 11 | KSR1
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| The molecular scaffold kinase suppressor of Ras 1 (KSR1) regulates adipogenesis.
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| Kortum RL, Costanzo DL, Haferbier J, Schreiner SJ, Razidlo GL, Wu MH, Volle DJ, Mori T, Sakaue H, Chaika NV, Chaika OV, Lewis RE.
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| Mol Cell Biol 25(17):7592-604. 2005
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| 12 | BRAP, KSR1
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| Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP.
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| Matheny SA, Chen C, Kortum RL, Razidlo GL, Lewis RE, White MA.
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| Nature 427(6971):256-60. 2004
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| 13 | KSR1
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| Inflammatory bowel disease reveals the kinase activity of KSR1.
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| Kolesnick R, Xing HR.
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| J Clin Invest 114(9):1233-7. Review. 2004
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| 14 | KSR1
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| C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1.
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| Muller J, Ory S, Copeland T, Piwnica-Worms H, Morrison DK.
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| Mol Cell 8(5):983-93. 2001
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| 15 | KSR1
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| Epidermal growth factor treatment enhances the kinase activity of kinase suppressor of Ras.
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| Xing HR, Lozano J, Kolesnick R.
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| J Biol Chem 275(23):17276-80. 2000
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| 16 | KSR1
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| KSR, a novel protein kinase required for RAS signal transduction.
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| Therrien M, Chang HC, Solomon NM, Karim FD, Wassarman DA, Rubin GM.
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| Cell 83(6):879-88. 1995
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