| 1 | HRAS, KRAS, LZTR1, MRAS, NRAS
|
| LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases.
|
| Abe T, Umeki I, Kanno SI, Inoue SI, Niihori T, Aoki Y.
|
| Cell Death Differ. Mar;27(3):1023-1035. doi: 10.1038/s41418-019-0395-5. Epub 2019 Jul 23 2020
|
| 2 | HK1, KRAS
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| KRAS4A directly regulates hexokinase 1.
|
| Amendola CR, Mahaffey JP, Parker SJ, Ahearn IM, Chen WC, Zhou M, Court H, Shi J, Mendoza SL, Morten MJ, Rothenberg E, Gottlieb E, Wadghiri YZ, Possemato R, Hubbard SR, Balmain A, Kimmelman AC, Philips MR.
|
| Nature Dec;576(7787):482-486. doi: 10.1038/s41586-019-1832-9. Epub 2019 Dec 11. 2019
|
| 3 | KRAS, SOS2
|
| Oncogenic RAS isoforms show a hierarchical requirement for the guanine nucleotide exchange factor SOS2 to mediate cell transformation.
|
| Sheffels E, Sealover NE, Wang C, Kim DH, Vazirani IA, Lee E, M Terrell E, Morrison DK, Luo J, Kortum RL.
|
| Sci Signal 11(546). pii: eaar8371. doi: 10.1126/scisignal.aar8371.
2018
|
| 4 | HRAS, KRAS, LZTR1
|
| LZTR1 is a regulator of RAS ubiquitination and signaling.
|
| Bigenzahn JW, Collu GM, Kartnig F, Pieraks M, Vladimer GI, Heinz LX, Sedlyarov V, Schischlik F, Fauster A, Rebsamen M, Parapatics K, Blomen VA, Müller AC, Winter GE, Kralovics R, Brummelkamp TR, Mlodzik M, Superti-Furga G.
|
| Science Dec 7;362(6419):1171-1177. doi: 10.1126/science.aap8210. Epub 2018 Nov 15 2018
|
| 5 | AGO2, KRAS
|
| KRAS Engages AGO2 to Enhance Cellular Transformation.
|
| Shankar S, Pitchiaya S, Malik R, Kothari V, Hosono Y, Yocum AK, Gundlapalli H, White Y, Firestone A, Cao X, Dhanasekaran SM, Stuckey JA, Bollag G, Shannon K, Walter NG, Kumar-Sinha C, Chinnaiyan AM.
|
| Cell Rep 14(6):1448-1461. doi: 10.1016/j.celrep.2016.01.034. Epub 2016 Feb 4.
2016
|
| 6 | KRAS, RALA, RALB
|
| Ral GTPase down-regulation stabilizes and reactivates p53 to inhibit malignant transformation.
|
| Tecleab A, Zhang X, Sebti SM.
|
| J Biol Chem 289(45):31296-309. doi: 10.1074/jbc.M114.565796. Epub 2014 Sep 10.
2014
|
| 7 | KRAS, RNF7
|
| Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis.
|
| Li H, Tan M, Jia L, Wei D, Zhao Y, Chen G, Xu J, Zhao L, Thomas D, Beer DG, Sun Y.
|
| J Clin Invest. Feb;124(2):835-46. doi: 10.1172/JCI70297. Epub 2014 Jan 16. 2014
|
| 8 | GOT1, KRAS
|
| Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.
|
| Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, DePinho RA, Cantley LC, Kimmelman AC.
|
| Nature 496(7443):101-5. doi: 10.1038/nature12040. Epub 2013 Mar 27. Erratum in: Nature. 2013 Jul 25;499(7459):504.
2013
|
| 9 | CD44, KRAS
|
| CD44 promotes Kras-dependent lung adenocarcinoma.
|
| Zhao P, Damerow MS, Stern P, Liu AH, Sweet-Cordero A, Siziopikou K, Neilson JR, Sharp PA, Cheng C.
|
| Oncogene 32(43):5186-90. doi: 10.1038/onc.2012.542. Epub 2012 Dec 3.
2013
|
| 10 | CFC5, KRAS, NS3
|
| Diverging gain-of-function mechanisms of two novel KRAS mutations associated with Noonan and cardio-facio-cutaneous syndromes.
|
| Cirstea IC, Gremer L, Dvorsky R, Zhang SC, Piekorz RP, Zenker M, Ahmadian MR.
|
| Hum Mol Genet 22(2):262-70. doi: 10.1093/hmg/dds426. Epub 2012 Oct 11.
2013
|
| 11 | BIRC5, KRAS
|
| Depletion of K-Ras promotes proteasome degradation of survivin.
|
| Tecleab A, Sebti SM.
|
| Cell Cycle 12(3):522-32. doi: 10.4161/cc.23407. Epub 2013 Jan 16.
2013
|
| 12 | CAV1, KRAS
|
| Caveolin-1 is a novel regulator of K-RAS-dependent migration in colon carcinogenesis.
|
| Basu Roy UK, Henkhaus RS, Loupakis F, Cremolini C, Gerner EW, Ignatenko NA.
|
| Int J Cancer 133(1):43-57. doi: 10.1002/ijc.28001. Epub 2013 Feb 12. Erratum in: Int J Cancer. 2015 Oct 15;137(8):E18.
2013
|
| 13 | APC, KRAS
|
| Dietary heme iron and the risk of colorectal cancer with specific mutations in KRAS and APC.
|
| Gilsing AM, Fransen F, de Kok TM, Goldbohm AR, Schouten LJ, de Bruďne AP, van Engeland M, van den Brandt PA, de Goeij AF, Weijenberg MP.
|
| Carcinogenesis 34(12):2757-66. doi: 10.1093/carcin/bgt290. Epub 2013 Aug 27.
2013
|
| 14 | HRAS, KRAS
|
| Interplay between oncogenic K-Ras and wild-type H-Ras in Caco2 cell transformation.
|
| Ikonomou G, Kostourou V, Shirasawa S, Sasazuki T, Samiotaki M, Panayotou G.
|
| J Proteomics 75(17):5356-69. doi: 10.1016/j.jprot.2012.06.038. Epub 2012 Jul 16.
2012
|
| 15 | KRAS, MAP3K7
|
| TAK1 inhibition promotes apoptosis in KRAS-dependent colon cancers.
|
| Singh A, Sweeney MF, Yu M, Burger A, Greninger P, Benes C, Haber DA, Settleman J.
|
| Cell 148(4):639-50. doi: 10.1016/j.cell.2011.12.033.
2012
|
| 16 | KRAS, NS1, PTPN11, RASA1
|
| Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature.
|
| De Rocca Serra-Nédélec A, Edouard T, Tréguer K, Tajan M, Araki T, Dance M, Mus M, Montagner A, Tauber M, Salles JP, Valet P, Neel BG, Raynal P, Yart A.
|
| Proc Natl Acad Sci U S A 109(11):4257-62. doi: 10.1073/pnas.1119803109. Epub 2012 Feb 27.
2012
|
| 17 | KRAS
|
| Regulation of RAS oncogenicity by acetylation.
|
| Yang MH, Nickerson S, Kim ET, Liot C, Laurent G, Spang R, Philips MR, Shan Y, Shaw DE, Bar-Sagi D, Haigis MC, Haigis KM.
|
| Proc Natl Acad Sci U S A 109(27):10843-8. doi: 10.1073/pnas.1201487109. Epub 2012 Jun 18.
2012
|
| 18 | HRAS, KRAS, SMPS1, SMPS2
|
| Postzygotic HRAS and KRAS mutations cause nevus sebaceous and Schimmelpenning syndrome.
|
| Groesser L, Herschberger E, Ruetten A, Ruivenkamp C, Lopriore E, Zutt M, Langmann T, Singer S, Klingseisen L, Schneider-Brachert W, Toll A, Real FX, Landthaler M, Hafner C.
|
| Nat Genet at Genet. 2012 2012
|
| 19 | AXIN2, FOXM1, KRAS
|
| Foxm1 mediates cross talk between Kras/mitogen-activated protein kinase and canonical Wnt pathways during development of respiratory epithelium.
|
| Wang IC, Snyder J, Zhang Y, Lander J, Nakafuku Y, Lin J, Chen G, Kalin TV, Whitsett JA, Kalinichenko VV.
|
| Mol Cell Biol 32(19):3838-50. doi: 10.1128/MCB.00355-12. Epub 2012 Jul 23.
2012
|
| 20 | KRAS
|
| KRAS gene mutation in colorectal cancer is correlated with increased proliferation and spontaneous apoptosis.
|
| Liu X, Jakubowski M, Hunt JL.
|
| Am J Clin Pathol 135(2):245-52.
2011
|
| 21 | CFC5, KRAS, NS3
|
| Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders.
|
| Gremer L, Merbitz-Zahradnik T, Dvorsky R, Cirstea IC, Kratz CP, Zenker M, Wittinghofer A, Ahmadian MR.
|
| Hum Mutat 32(1):33-43. doi: 10.1002/humu.21377. Epub 2010 Dec 9.
2011
|
| 22 | KRAS
|
| Autoimmune lymphoproliferative syndrome-like disease with somatic KRAS mutation.
|
| Takagi M, Shinoda K, Piao J, Mitsuiki N, Takagi M, Matsuda K, Muramatsu H, Doisaki S, Nagasawa M, Morio T, Kasahara Y, Koike K, Kojima S, Takao A, Mizutani S.
|
| Blood 117(10):2887-90. Epub 2010 Nov 9.
2011
|
| 23 | KRAS, MYC, NFE2L2
|
| Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis.
|
| DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES, Scrimieri F, Winter JM, Hruban RH, Iacobuzio-Donahue C, Kern SE, Blair IA, Tuveson DA.
|
| Nature 475(7354):106-9. doi: 10.1038/nature10189.
2011
|
| 24 | BRIP1, HRAS, KRAS
|
| Oncogenic RAS regulates BRIP1 expression to induce dissociation of BRCA1 from chromatin, inhibit DNA repair, and promote senescence.
|
| Tu Z, Aird KM, Bitler BG, Nicodemus JP, Beeharry N, Xia B, Yen TJ, Zhang R.
|
| Dev Cell 21(6):1077-91. doi: 10.1016/j.devcel.2011.10.010. Epub 2011 Dec 1.
2011
|
| 25 | AURKA, KRAS, RASSF5
|
| Growth and tumor suppressor NORE1A is a regulatory node between Ras signaling and microtubule nucleation.
|
| Bee C, Moshnikova A, Mellor CD, Molloy JE, Koryakina Y, Stieglitz B, Khokhlatchev A, Herrmann C.
|
| J Biol Chem 285(21):16258-66. Epub 2010 Mar 25.
2010
|
| 26 | CALM1, KRAS
|
| K-Ras4B phosphorylation at Ser181 is inhibited by calmodulin and modulates K-Ras activity and function.
|
| Alvarez-Moya B, López-Alcalá C, Drosten M, Bachs O, Agell N.
|
| Oncogene 29(44):5911-22. Epub 2010 Aug 30.
2010
|
| 27 | KRAS
|
| Multiple cellular proteins modulate the dynamics of K-ras association with the plasma membrane.
|
| Bhagatji P, Leventis R, Rich R, Lin CJ, Silvius JR.
|
| Biophys J 99(10):3327-35.
2010
|
| 28 | KRAS
|
| Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1α and HIF-2α target genes.
|
| Chun SY, Johnson C, Washburn JG, Cruz-Correa MR, Dang DT, Dang LH.
|
| Mol Cancer 9:293.
2010
|
| 29 | KRAS
|
| Clinical relevance of KRAS in human cancers.
|
| Jancík S, Drábek J, Radzioch D, Hajdúch M.
|
| J Biomed Biotechnol 2010:150960. Epub 2010 Jun 7. Review.
2010
|
| 30 | KRAS
|
| Genomic and biological characterization of exon 4 KRAS mutations in human cancer.
|
| Janakiraman M, Vakiani E, Zeng Z, Pratilas CA, Taylor BS, Chitale D, Halilovic E, Wilson M, Huberman K, Ricarte Filho JC, Persaud Y, Levine DA, Fagin JA, Jhanwar SC, Mariadason JM, Lash A, Ladanyi M, Saltz LB, Heguy A, Paty PB, Solit DB.
|
| Cancer Res 70(14):5901-11. Epub 2010 Jun 22.
2010
|
| 31 | KRAS
|
| Analysis of k-ras nuclear expression in fibroblasts and mesangial cells.
|
| Fuentes-Calvo I, Blázquez-Medela AM, Santos E, López-Novoa JM, Martínez-Salgado C.
|
| PLoS One 5(1):e8703.
2010
|
| 32 | DUSP4, KRAS, SMYD3
|
| Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas.
|
| Gaedcke J, Grade M, Jung K, Camps J, Jo P, Emons G, Gehoff A, Sax U, Schirmer M, Becker H, Beissbarth T, Ried T, Ghadimi BM.
|
| Genes Chromosomes Cancer 49(11):1024-34.
2010
|
| 33 | KRAS, RPS6KB1, STK33
|
| Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells.
|
| Scholl C, Fröhling S, Dunn IF, Schinzel AC, Barbie DA, Kim SY, Silver SJ, Tamayo P, Wadlow RC, Ramaswamy S, Döhner K, Bullinger L, Sandy P, Boehm JS, Root DE, Jacks T, Hahn WC, Gilliland DG.
|
| Cell 137(5):821-34. 2009
|
| 34 | KRAS
|
| Prognostic significance of alterations in KRAS isoforms KRAS-4A/4B and KRAS mutations in colorectal carcinoma.
|
| Abubaker J, Bavi P, Al-Haqawi W, Sultana M, Al-Harbi S, Al-Sanea N, Abduljabbar A, Ashari LH, Alhomoud S, Al-Dayel F, Uddin S, Al-Kuraya KS.
|
| J Pathol 219(4):435-45.
2009
|
| 35 | KRAS
|
| Presence of activating KRAS mutations correlates significantly with expression of tumour suppressor genes DCN and TPM1 in colorectal cancer.
|
| Mlakar V, Berginc G, Volavsek M, Stor Z, Rems M, Glavac D.
|
| BMC Cancer 9:282.
2009
|
| 36 | CALM1, KRAS
|
| The hypervariable region of K-Ras4B is responsible for its specific interactions with calmodulin.
|
| Abraham SJ, Nolet RP, Calvert RJ, Anderson LM, Gaponenko V.
|
| Biochemistry 48(32):7575-83.
2009
|
| 37 | KRAS
|
| Novel multiple, monoallelic KRAS mutations at codon 12 and 13.
|
| Keller G, Geist B, Slotta-Huspenina J, Langer R, Nagl F, Fend F, Höfler H, Perren A.
|
| Int J Cancer 125(11):2744-5. No abstract available.
2009
|
| 38 | KRAS, MKI67
|
| Prognostic value of KRAS mutations and Ki-67 expression in stage I lung adenocarcinomas.
|
| Woo T, Okudela K, Yazawa T, Wada N, Ogawa N, Ishiwa N, Tajiri M, Rino Y, Kitamura H, Masuda M.
|
| Lung Cancer 65(3):355-62. Epub 2009 Jan 21.
2009
|
| 39 | FLT3, NRAS, KRAS, PTPN11
|
| Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia.
|
| Paulsson K, Horvat A, Strmbeck B, Nilsson F, Heldrup J, Behrendtz M, Forestier E, Andersson A, Fioretos T, Johansson B.
|
| Genes Chromosomes Cancer 47(1):26-33. 2008
|
| 40 | HRAS, KRAS, BRAF, CFC2, COSTS, CFC3, MAP2K1, MAP2K2, CFC4, CFC5
|
| Mutation and phenotypic spectrum in patients with cardio-facio-cutaneous and Costello syndrome.
|
| Schulz AL, Albrecht B, Arici C, van der Burgt I, Buske A, Gillessen-Kaesbach G, Heller R, Horn D, Hbner CA, Korenke GC, Knig R, Kress W, Krger G, Meinecke P, Mcke J, Plecko B, Rossier E, Schinzel A, Schulze A, Seemanova E, Seidel H, Spranger S, Tuysuz B, Uhrig S, Wieczorek D, Kutsche K, Zenker M.
|
| Clin Genet 73(1):62-70. Epub 2007 Nov 27. 2008
|
| 41 | ESX1, KRAS
|
| Anti-tumor activity of ESX1 on cancer cells harboring oncogenic K-ras mutation.
|
| Nakajima J, Ishikawa S, Hamada J, Yanagihara M, Koike T, Hatakeyama M.
|
| Biochem Biophys Res Commun 370(1):189-94. Epub 2008 Mar 24. 2008
|
| 42 | KRAS, NRAS
|
| Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.
|
| Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, Glickman JN, Niwa-Kawakita M, Sweet-Cordero A, Sebolt-Leopold J, Shannon KM, Settleman J, Giovannini M, Jacks T.
|
| Nat Genet 40(5):600-8. Epub 2008 Mar 30. 2008
|
| 43 | BRAF, CFC2, CFC3, CFC4, CFC5, COSTS, HRAS, KRAS, MAP2K1, MAP2K2, NS3
|
| The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders.
|
| Aoki Y, Niihori T, Narumi Y, Kure S, Matsubara Y.
|
| Hum Mutat 29(8):992-1006.
2008
|
| 44 | BRAF, CFC2, CFC3, COSTS, HRAS, KRAS, LEOPS, MAP2K1, MAPK1, MTOR, NF1, NFNS, NS1, NS3, NS4, NS5, PTPN11, RAF1, SOS1
|
| Oncogenes on my mind: ERK and MTOR signaling in cognitive diseases.
|
| Krab LC, Goorden SM, Elgersma Y.
|
| Trends Genet 24(10):498-510. Epub 2008 Sep 4. 2008
|
| 45 | HRAS, KRAS, NRAS
|
| Kras and Hras--what is the difference?
|
| Berns A.
|
| Nat Genet 40(10):1149-50. No abstract available.
2008
|
| 46 | CFC3, CFC4, CFC5, KRAS, MAP2K1, MAP2K2, NS3, NS5, RAF1
|
| Noonan and cardio-facio-cutaneous syndromes: two clinically and genetically overlapping disorders.
|
| Nyström AM, Ekvall S, Berglund E, Björkqvist M, Braathen G, Duchen K, Enell H, Holmberg E, Holmlund U, Olsson-Engman M, Annerén G, Bondeson ML.
|
| J Med Genet 45(8):500-6. Epub 2008 May 2.
2008
|
| 47 | CFC5, COSTS, HRAS, KRAS, NS3
|
| Clinical and molecular aspects of RAS related disorders.
|
| Denayer E, de Ravel T, Legius E.
|
| J Med Genet 45(11):695-703. Epub 2008 Jun 11. Review.
2008
|
| 48 | KRAS, NS1, NS3, NS4, NS5, PTPN11, RAF1, SOS1
|
| PTPN11, SOS1, KRAS, and RAF1 gene analysis, and genotype-phenotype correlation in Korean patients with Noonan syndrome.
|
| Ko JM, Kim JM, Kim GH, Yoo HW.
|
| J Hum Genet 53(11-12):999-1006. Epub 2008 Nov 20.
2008
|
| 49 | KLK6, KRAS
|
| Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells.
|
| Henkhaus RS, Gerner EW, Ignatenko NA.
|
| Biol Chem 389(6):757-64.PMID: 18627290 2008
|
| 50 | NS3, KRAS, COSTS, HRAS
|
| The neoplastic risk in children with Noonan syndrome and Costello syndrome.
|
| Lopez-Rangel E.
|
| Clin Genet 71(1):44-5. 2007
|
| 51 | KRAS, NS3, CFC5
|
| Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations.
|
| Zenker M, Lehmann K, Schulz AL, Barth H, Hansmann D, Koenig R, Korinthenberg R, Kreiss-Nachtsheim M, Meinecke P, Morlot S, Mundlos S, Quante AS, Raskin S, Schnabel D, Wehner LE, Kratz CP, Horn D, Kutsche K.
|
| J Med Genet 44(2):131-5. Epub 2006 Oct 20. 2007
|
| 52 | CFC2, CFC3, CFC4, CFC5, KRAS, MAP2K1, MAP2K2, BRAF, COSTS, HRAS
|
| Molecular and clinical characterization of cardio-facio-cutaneous (CFC) syndrome: overlapping clinical manifestations with Costello syndrome.
|
| Narumi Y, Aoki Y, Niihori T, Neri G, Cave H, Verloes A, Nava C, Kavamura MI, Okamoto N, Kurosawa K, Hennekam RC, Wilson LC, Gillessen-Kaesbach G, Wieczorek D, Lapunzina P, Ohashi H, Makita Y, Kondo I, Tsuchiya S, Ito E, Sameshima K, Kato K, Kure S, Matsubara Y.
|
| Am J Med Genet A 143(8):799-807. 2007
|
| 53 | KRAS,NS3
|
| Further evidence of genetic heterogeneity in Costello syndrome: involvement of the KRAS gene.
|
| Bertola DR, Pereira AC, Brasil AS, Albano LM, Kim CA, Krieger JE.
|
| J Hum Genet 52(6):521-6. Epub 2007 Apr 28. 2007
|
| 54 | CFC2, BRAF, CFC3, MAP21K1, CFC3, MAP2K2, CFC5, KRAS, COSTS, HRAS
|
| Cardio-facio-cutaneous and Noonan syndromes due to mutations in the RAS/MAPK signalling pathway: genotype-phenotype relationships and overlap with Costello syndrome.
|
| Nava C, Hanna N, Michot C, Pereira S, Pouvreau N, Niihori T, Aoki Y, Matsubara Y, Arveiler B, Lacombe D, Pasmant E, Parfait B, Baumann C, Hron D, Sigaudy S, Toutain A, Rio M, Goldenberg A, Leheup B, Verloes A, Cav H.
|
| J Med Genet 44(12):763-71. Epub 2007 Aug 17. 2007
|
| 55 | KRAS, BRAF, CFC2
|
| Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome.
|
| Niihori T, Aoki Y, Narumi Y, Neri G, Cave H, Verloes A, Okamoto N, Hennekam RC, Gillessen-Kaesbach G, Wieczorek D, Kavamura MI, Kurosawa K, Ohashi H, Wilson L, Heron D, Bonneau D, Corona G, Kaname T, Naritomi K, Baumann C, Matsumoto N, Kato K, Kure S, Matsubara Y.
|
| Nat Genet 38(3):294-6. Epub 2006 Feb 12. 2006
|
| 56 | NS3, KRAS
|
| Germline KRAS mutations cause Noonan syndrome.
|
| Schubbert S, Zenker M, Rowe SL, Boll S, Klein C, Bollag G, van der Burgt I, Musante L, Kalscheuer V, Wehner LE, Nguyen H, West B, Zhang KY, Sistermans E, Rauch A, Niemeyer CM, Shannon K, Kratz CP.
|
| Nat Genet 38(3):331-6. Epub 2006 Feb 12. 2006
|
| 57 | KRAS
|
| Germline Missense Mutations Affecting KRAS Isoform B Are Associated with a Severe Noonan Syndrome Phenotype.
|
| Carta C, Pantaleoni F, Bocchinfuso G, Stella L, Vasta I, Sarkozy A, Digilio C, Palleschi A, Pizzuti A, Grammatico P, Zampino G, Dallapiccola B, Gelb BD, Tartaglia M.
|
| Am J Hum Genet 79(1):129-35. Epub 2006 May 1. 2006
|
| 58 | KRAS, NCL
|
| K-Ras4B proteins are expressed in the nucleolus: Interaction with nucleolin.
|
| Birchenall-Roberts MC, Fu T, Kim SG, Huang YK, Dambach M, Resau JH, Ruscetti FW.
|
| Biochem Biophys Res Commun 348(2):540-9. Epub 2006 Jul 28. 2006
|
| 59 | KRAS, NRAS
|
| Structural and functional consequences of c-N-Ras constitutively associated with intact mitochondria.
|
| Wolfman JC, Planchon SM, Liao J, Wolfman A.
|
| Biochim Biophys Acta 1763(10):1108-24. Epub 2006 Aug 12.
2006
|
| 60 | BAX, KRAS, MOAP1, RASSF1
|
| The RASSF1A tumor suppressor activates Bax via MOAP-1.
|
| Vos MD, Dallol A, Eckfeld K, Allen NP, Donninger H, Hesson LB, Calvisi D, Latif F, Clark GJ.
|
| J Biol Chem 281(8):4557-63. Epub 2005 Dec 12.
2006
|
| 61 | BRAF, ICMT, KRAS
|
| Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.
|
| Bergo MO, Gavino BJ, Hong C, Beigneux AP, McMahon M, Casey PJ, Young SG.
|
| J Clin Invest 113(4):539-50.
2004
|
| 62 | NRAS, KRAS, HRAS
|
| ras mutations are associated with aggressive tumor phenotypes and poor prognosis in thyroid cancer.
|
| Garcia-Rostan G, Zhao H, Camp RL, Pollan M, Herrero A, Pardo J, Wu R, Carcangiu ML, Costa J, Tallini G.
|
| J Clin Oncol 21(17):3226-35. 2003
|
| 63 | HRAS, KRAS, RCE1
|
| Human Ras converting enzyme endoproteolytic specificity at the P2' and P3' positions of K-Ras-derived peptides.
|
| Hollander IJ, Frommer E, Aulabaugh A, Mallon R.
|
| Biochim Biophys Acta 1649(1):24-9.
2003
|
| 64 | APC, KRAS, TP53, FAP
|
| Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer.
|
| Smith G, Carey FA, Beattie J, Wilkie MJ, Lightfoot TJ, Coxhead J, Garner RC, Steele RJ, Wolf CR.
|
| Proc Natl Acad Sci U S A 99(14):9433-8. 2002
|
| 65 | BRAF, KRAS
|
| Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status.
|
| Rajagopalan H, Bardelli A, Lengauer C, Kinzler KW, Vogelstein B, Velculescu VE.
|
| Nature 418(6901):934. 2002
|
| 66 | RASSF1, KRAS
|
| K-ras mutations and RASSF1A promoter methylation in colorectal cancer.
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| Oncogene 21(23):3792-5. 2002
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| 67 | KRAS, RAC1, RAP1GDS1, RHOA
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| Oncogene 21(15):2425-32.PMID: 11948427 2002
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| 68 | KRAS
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| Genotypic and phenotypic progression in endometrial tumorigenesis : determining when defects in DNA mismatch repair and KRAS2 occur.
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| Genes Chromosomes Cancer 32 : 295-301. 2001
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| 69 | KRAS, NRAS
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| High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis.
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| Hum Mutat 18(3):212-24. 2001
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| 70 | KRAS
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| The K-ras gene regulates vascular endothelial growth factor gene expression in non-small cell lung cancers.
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| Konishi T, Huang CL, Adachi M, Taki T, Inufusa H, Kodama K, Kohno N, Miyake M.
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| Int J Oncol 16(3):501-11. 2000
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| 71 | KRAS, TP53
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| Differences in patterns of TP53 and KRAS2 mutations in a large series of endometrial carcinomas with or without microsatellite instability.
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| Cancer 85(1):119-26. 1999
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| 72 | KRAS
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| Prognostic significance of K-ras codon 12 mutations in patients with resected stage I and II non-small-cell lung cancer.
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| Graziano SL, et al.
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| J Clin Oncol 17(2):668-75. 1999
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| 73 | BUB1, KRAS, MAD2L1
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| Mutational inactivation of mitotic checkpoint genes, hsMAD2 and hBUB1, is rare in sporadic digestive tract cancers.
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| Imai Y, Shiratori Y, Kato N, Inoue T, Omata M.
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| Jpn J Cancer Res 90(8):837-40 1999
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| 74 | KRAS
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| Ki-ras codon 12 point mutation and p53 mutation in pancreatic diseases.
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| Yamaguchi K, Chijiiwa K, Noshiro H, Torata N, Kinoshita M, Tanaka M.
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| Hepatogastroenterology 46(28):2575-81 1999
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| 75 | KRAS
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| A relationship between K-ras gene mutations and some clinical and histologic variables in patients with primary colorectal carcinoma.
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| Beranek M, Bures J, Palicka V, Jandik P, Langr F, Nejedla E.
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| Clin Chem Lab Med 37(7):723-7 1999
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| 76 | KRAS
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| Specific K-ras2 mutations in human sporadic colorectal adenomas are associated with DNA near-diploid aneuploidy and inhibition of proliferation.
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| Giaretti W, et al.
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| Am J Pathol 153 : 1201-1209. 1998
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| 77 | KRAS
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| Correlation of genetic instability and apoptosis in the presence of oncogenic Ki-Ras.
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| Chen CY, et al.
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| Cell Death Differ 5 : 984-995. 1998
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| 78 | ITPR2, SSPN, KRAS
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| Coamplification in tumors of KRAS2, type 2 inositol 1,4,5 triphosphate receptor gene, and a novel human gene, KRAG.
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| Heighway J, et al.
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| Genomics 35 : 207-214. 1996
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| 79 | KRAS
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| Studies on ras oncogene activation in endometrial carcinoma.
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| Fujimoto I, et al.
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| Gynecol Oncol 48 : 196-202. 1993
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| 80 | KRAS
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| K-ras mutations in human adenocarcinoma of the lung : association with smoking and occupational exposure to asbestos.
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| Husgafvel-Pursiainen K, et al.
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| Int J Cancer 53 : 250-256. 1993
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| 81 | NRAS, KRAS
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| Analysis of karyotype, SCE, and point mutation of RAS oncogene in Indian MDS patients.
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| Mansoor AM, et al.
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| Cancer Genet Cytogenet 65 : 12-20. 1993
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| 82 | NRAS, KRAS
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| Mutational status of codons 12 and 13 of the N- and K-ras genes in tissue and cell lines derived from primary and metastatic prostate carcinomas.
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| Pergolizzi RG, et al.
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| Cancer Invest 11 : 25-32. 1993
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| 83 | KRAS
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| Primitive neuroectodermal tumors after prophylatic central nervous system iradiation in children.
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| Brstle O, et al.
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| Cancer 69 : 2385-2392. 1992
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| 84 | HRAS, KRAS, NRAS
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| Infrequent point mutations in codons 12 and 61 of ras oncogenes in human hepatocellular carcinomas.
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| Challen C, et al.
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| J Hepatol 14 : 342-346. 1992
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| 85 | KRAS
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| c-Ki-ras mutations in dysplastic fields and cancers in ulcerative colitis.
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| Chen J, et al.
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| Gastroenterology 102 : 1983-1987. 1992
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| 86 | KRAS
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| Infrequent mutation of the ras genes in skin tumors of xeroderma pigmentosum patients in Japan.
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| Ishizaki K, et al.
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| Int J Cancer 50 : 382-385. 1992
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| 87 | KRAS
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| Stability of K-ras mutations throughout the natural history of human colorectal cancer.
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| Losi L, et al.
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| Eur J Cancer 28A : 1115-1120. 1992
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| 88 | KRAS
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| Clinical implications of K-ras mutations in malignant epithelial tumors of the endometrium.
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| Mizuuchi H, et al.
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| Cancer Res 52 : 2777-2781. 1992
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| 89 | KRAS
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| Detection of K-ras mutations by denaturing gradient gel electrophoresis (DGGE) : a study on pancreatic cancer.
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| Pellegata NS, et al.
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| Anticancer Res 12 : 1731-1736. 1992
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| 90 | NRAS, KRAS
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| Multiple point mutation of N-ras and K-ras oncogenes in myelodysplastic syndrome and acute myelogenous leukemia.
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| Nakagawa T, et al.
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| Oncology 49 : 114-122. 1992
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| 91 | KRAS
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| A point mutation of C-KI-RAS gene was found in human esophageal carcinoma cell lines but not in primary esophageal carcinomas.
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| Shiga C, et al.
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| Biochem Biophys Res Commun 187 : 515-521. 1992
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| 92 | KRAS
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| Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors.
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| Sidransky D, et al.
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| Science 256 : 102-104. 1992
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| 93 | KRAS, NRAS
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| ras gene mutations as a prognostic marker in adenocarcinoma of the human lung without lymph node metastasis.
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| Sugio K, et al.
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| Cancer Res 52 : 2903-2906. 1992
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| 94 | KRAS
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| High incidence of ras gene mutation in intrahepatic cholangiocarcinoma.
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| Tada M, et al.
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| Cancer 69 : 1115-1118. 1992
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| 95 | KRAS
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| Specific cytogenetic abnormalities and k-ras mutation in two new human colorectal-adenoma-derived cell lines.
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| Williams AC, et al.
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| Int J Cancer 52 : 785-790. 1992
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| 96 | KRAS
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| Primers for detection of StuI and BstXI polymorphisms in a fragment co-amplified with c-Ki-ras 2 (KRAS2).
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| Heighway J.
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| Nucleic Acids Res 19 : 3162. 1991
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| 97 | KRAS
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| PCR assay for a polymorphic TaqI site in the human K-ras-2 gene on chromosome 12p (KRAS2).
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| Abrams ES, et al.
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| Nucleic Acids Res 19 : 4795. 1991
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| 98 | KRAS
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| DdeI polymorphism within sequence encoding 3' untranslated region of c-Ki-ras2 (KRAS2).
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| Heighway J.
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| Nucleic Acids Res 19 : 5092. 1991
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| 99 | KRAS
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| PCR primers to convert c-Ki-ras to a four allele RsaI system (KRAS2).
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| Heighway J.
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| Nucleic Acids Res 19 : 6966. 1991
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| 100 | KRAS
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| Higher frequency of point mutations in the c-K-ras 2 gene in human colorectal adenomas with severe atypia than in carcinomas.
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| Ando M, et al.
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| Jpn J Cancer Res 82 : 245-249. 1991
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| 101 | KRAS
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| Point mutation of c-Ki-ras oncogene in gastric adenoma and adenocarcinoma with tubular differentiation.
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| Kihana T, et al.
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| Jpn J Cancer Res 82 : 308-314. 1991
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| 102 | KRAS
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| Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique.
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| Levi S, et al.
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| Cancer Res 51 : 3497-3502. 1991
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| 103 | KRAS
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| RsaI polymorphism in c-Ki-ras.
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| Heighway J.
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| Nucleic Acids Res 19 : 968. 1991
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| 104 | KRAS
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| Mutations in the KRAS2 oncogene during progressive stages of human colon carcinoma.
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| Burmer GC, et al.
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| Proc Natl Acad Sci U S A 86 : 2403-2407. 1989
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| 105 | KRAS
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| Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse.
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| You M, et al.
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| Proc Natl Acad Sci U S A 86 : 3070-3074. 1989
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| 106 | HRAS, KRAS
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| Analysis of RAS oncogene mutations in human lymphoid malignancies.
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| Neri A, et al.
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| Proc Natl Acad Sci U S A 85 : 9268-9272. 1988
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| 107 | KRAS1P, KRAS
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| Viral K-ras detects two Taqi polymorphisms, one for KRAS1 on chromosome 6 and the other for KRAS2 on chromosome 12.
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| Okamoto M, et al.
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| Nucleic Acids Res 16 : 2363. 1988
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| 108 | KRAS
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| A new polymorphism at the KRAS locus and linkage with known KRAS polymorphisms.
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| Zuppan P, et al.
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| (HGM9) Cytogenet Cell Genet 46 : 727. 1987
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| 109 | NRAS, KRAS1P, KRAS
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| Prevalence of ras gene mutations in human colorectal cancers.
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| Bos JL, et al.
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| Nature 327 : 293-297. 1987
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| 110 | KRAS1P, KRAS
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| Detection of high incidence of K- ras oncogenes during human colon tumorigenesis.
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| Forrester K, et al.
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| Nature 327 : 298-303. 1987
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| 111 | KRAS
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| An EcoRI restriction fragment length polymorphism at the KRAS2 locus on mouse chromosome 6.
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| Ryan J, et al.
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| Nucleic Acids Res 14 : 9222. 1986
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| 112 | KRAS
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| c-K-ras Codon 12 GGT-GGT point mutation : an infrequent event in human lung cancer.
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| Milici A, et al.
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| Biochem Biophys Res Commun 140 : 699-705. 1986
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| 113 | KRAS
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| Anonymous genomic fragment co-amplified with c-Ki-ras 2 detects frequent polymorphism (pK42).
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| Heighway J, et al.
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| Nucleic Acids Res 14 : 8700. 1986
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| 114 | NRAS, KRAS
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| Chromosomal localization of three human ras genes by in situ molecularhybridization.
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| Popescu NC, et al.
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| Somat Cell Mol Genet 11 : 149-155. 1985
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| 115 | KRAS1P, KRAS
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| Regional localization of two human cellular Kirsten ras genes on chromosomes 6 and 12.
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| Sakaguchi AY, et al.
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| Mol Cell Biol 4 : 989-993. 1984
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| 116 | HRAS, ERAS, KRAS1P, KRAS
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| Dispersion of the ras family of transforming genes to four different chromosomes in man.
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| O'Brien SJ, et al.
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| Nature 302 : 839-842. 1983
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| 117 | KRAS
|
| Human c-Ki-ras2 proto-oncogene on chromosome 12.
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| Sakaguchi AY, et al.
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| Science 219 : 1081-1082. 1983
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| 118 | KRAS1P, KRAS, NRAS
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| Regional chromosomal localization of N-ras, K-ras-1, Kras-2 and myb oncogenes in human cells.
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| McBride OW, et al.
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| Nucleic Acids Res 11 : 8221-8236. 1983
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