| 1 | KLRK1
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| NKG2D blockade inhibits poly(I:C)-triggered fetal loss in wild type but not in IL-10-/- mice.
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| Thaxton JE, Nevers T, Lippe EO, Blois SM, Saito S, Sharma S.
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| J Immunol 190(7):3639-47. doi: 10.4049/jimmunol.1203488. Epub 2013 Mar 1.
2013
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| 2 | KLRK1, RAET1L
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| The genotype of RAET1L (ULBP6), a ligand for human NKG2D (KLRK1), markedly influences the clinical outcome of allogeneic stem cell transplantation.
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| Antoun A, Vekaria D, Salama RA, Pratt G, Jobson S, Cook M, Briggs D, Moss P.
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| Br J Haematol 159(5):589-98. doi: 10.1111/bjh.12072. Epub 2012 Oct 1. 2012
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| 3 | IL4, KLRK1
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| Negative regulation of NKG2D expression by IL-4 in memory CD8 T cells.
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| Ventre E, Brinza L, Schicklin S, Mafille J, Coupet CA, Marçais A, Djebali S, Jubin V, Walzer T, Marvel J.
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| J Immunol 189(7):3480-9. Epub 2012 Aug 31. 2012
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| 4 | KLRK1
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| A dual function of NKG2D ligands in NK-cell activation.
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| Cheney EE, Wise EL, Bui JD, Schreiber RD, Carayannopoulos LN, Spitzer D, Zafirova B, Polic B, Shaw AS, Markiewicz MA.
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| Eur J Immunol 42(9):2452-8. doi: 10.1002/eji.201141849. Epub 2012 Jul 27.
2012
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| 5 | KLRK1
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| NKG2D signaling on CD8⁺ T cells represses T-bet and rescues CD4-unhelped CD8⁺ T cell memory recall but not effector responses.
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| Zloza A, Kohlhapp FJ, Lyons GE, Schenkel JM, Moore TV, Lacek AT, O'Sullivan JA, Varanasi V, Williams JW, Jagoda MC, Bellavance EC, Marzo AL, Thomas PG, Zafirova B, Polić B, Al-Harthi L, Sperling AI, Guevara-Patiño JA.
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| Nat Med 18(3):422-8. doi: 10.1038/nm.2683.
2012
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| 6 | KLRK1, MICA, MICB
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| Expression of MICA, MICB and NKG2D in human leukemkic myelomonocytic and cervical cancer cells.
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| Weiss-Steider B, Soto-Cruz I, Martinez-Campos CA, Mendoza-Rincon JF.
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| J Exp Clin Cancer Res 30(1):37. [Epub ahead of print]
2011
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| 7 | HCST, KLRK1
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| Expression, signaling proficiency, and stimulatory function of the NKG2D lymphocyte receptor in human cancer cells.
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| Benitez AC, Dai Z, Mann HH, Reeves RS, Margineantu DH, Gooley TA, Groh V, Spies T.
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| Proc Natl Acad Sci U S A 108(10):4081-6. Epub 2011 Feb 14.
2011
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| 8 | KLRK1
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| NKG2D receptor regulates human effector T-cell cytokine production.
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| Barber A, Sentman CL.
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| Blood 117(24):6571-81. Epub 2011 Apr 25.
2011
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| 9 | CEACAM1, KLRK1
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| CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells.
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| Chen Z, Chen L, Baker K, Olszak T, Zeissig S, Huang YH, Kuo TT, Mandelboim O, Beauchemin N, Lanier LL, Blumberg RS.
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| J Exp Med 208(13):2633-40. Epub 2011 Dec 5. 2011
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| 10 | KLRK1, MICA
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| The intraepithelial T cell response to NKG2D-ligands links lymphoid stress surveillance to atopy.
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| Strid J, Sobolev O, Zafirova B, Polic B, Hayday A.
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| Science 334(6060):1293-7. doi: 10.1126/science.1211250.
2011
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| 11 | HCST, KLRK1
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| Complex regulation of human NKG2D-DAP10 cell surface expression: opposing roles of the γc cytokines and TGF-β1.
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| Park YP, Choi SC, Kiesler P, Gil-Krzewska A, Borrego F, Weck J, Krzewski K, Coligan JE.
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| Blood 118(11):3019-27. doi: 10.1182/blood-2011-04-346825. Epub 2011 Aug 3.
2011
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| 12 | HCST, HMBOX1, KLRK1
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| HMBOX1 negatively regulates NK cell functions by suppressing the NKG2D/DAP10 signaling pathway.
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| Wu L, Zhang C, Zhang J.
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| Cell Mol Immunol 8(5):433-40. doi: 10.1038/cmi.2011.20. Epub 2011 Jun 27.
2011
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| 13 | KLRK1, MICA
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| MICA polymorphism identified by whole genome array associated with NKG2D-mediated cytotoxicity in T-cell large granular lymphocyte leukemia.
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| Viny AD, Clemente MJ, Jasek M, Askar M, Ishwaran H, Nowacki A, Zhang A, Maciejewski JP.
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| Haematologica 95(10):1713-21. Epub 2010 May 11.
2010
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| 14 | KLRK1, MICA, MICB, ULBP2
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| The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia.
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| Nückel H, Switala M, Sellmann L, Horn PA, Dürig J, Dührsen U, Küppers R, Grosse-Wilde H, Rebmann V.
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| Leukemia 24(6):1152-9. Epub 2010 Apr 29.
2010
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| 15 | KLRD1, KLRK1
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| NKG2D and CD94 bind to heparin and sulfate-containing polysaccharides.
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| Higai K, Imaizumi Y, Suzuki C, Azuma Y, Matsumoto K.
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| Biochem Biophys Res Commun 386(4):709-14. Epub 2009 Jun 23.
2009
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| 16 | KLRC1, KLRC2, KLRD1, KLRK1
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| NKG2D and CD94 bind to multimeric alpha2,3-linked N-acetylneuraminic acid.
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| Imaizumi Y, Higai K, Suzuki C, Azuma Y, Matsumoto K.
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| Biochem Biophys Res Commun 382(3):604-8. Epub 2009 Mar 19.
2009
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| 17 | KLRK1, RAET1E
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| The NKG2D ligand ULBP4 binds to TCRgamma9/delta2 and induces cytotoxicity to tumor cells through both TCRgammadelta and NKG2D.
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| Kong Y, Cao W, Xi X, Ma C, Cui L, He W.
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| Blood 114(2):310-7. Epub 2009 May 12.
2009
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| 18 | KLRK1, MICA
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| NKG2D ligand MICA is retained in the cis-Golgi apparatus by human cytomegalovirus protein UL142.
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| Ashiru O, Bennett NJ, Boyle LH, Thomas M, Trowsdale J, Wills MR.
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| J Virol 83(23):12345-54. Epub 2009 Sep 30.
2009
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| 19 | HCST, KLRK1
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| The traffic of the NKG2D/Dap10 receptor complex during natural killer (NK) cell activation.
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| Roda-Navarro P, Reyburn HT.
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| J Biol Chem 284(24):16463-72. Epub 2009 Mar 26.
2009
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| 20 | KLRK1, RAET1L
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| ULBP6/RAET1L is an additional human NKG2D ligand.
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| Eagle RA, Traherne JA, Hair JR, Jafferji I, Trowsdale J.
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| Eur J Immunol 39(11):3207-16. 2009
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| 21 | KLRF1, KLRK1
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| Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
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| Thomas M, Boname JM, Field S, Nejentsev S, Salio M, Cerundolo V, Wills M, Lehner PJ.
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| Proc Natl Acad Sci U S A 105(5):1656-61. Epub 2008 Jan 29.PMID: 18230726 2008
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| 22 | KLRK1, RAET1E, RAET1G
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| Four novel ULBP splice variants are ligands for human NKG2D.
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| Cao W, Xi X, Wang Z, Dong L, Hao Z, Cui L, Ma C, He W.
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| Int Immunol 20(8):981-91. Epub 2008 Jun 10. 2008
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| 23 | KLRK1
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| Phosphatidylinositol 3-kinase activation is required to form the NKG2D immunological synapse.
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| Giurisato E, Cella M, Takai T, Kurosaki T, Feng Y, Longmore GD, Colonna M, Shaw AS.
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| Mol Cell Biol 27(24):8583-99. Epub 2007 Oct 8. 2007
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| 24 | KLRK1, MICA, MICB
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| Promoter region architecture and transcriptional regulation of the genes for the MHC class I-related chain A and B ligands of NKG2D.
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| Venkataraman GM, Suciu D, Groh V, Boss JM, Spies T.
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| J Immunol 178(2):961-9.
2007
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| 25 | HCST, KLRK1
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| NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway.
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| Horng T, Bezbradica JS, Medzhitov R.
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| Nat Immunol 8(12):1345-52. Epub 2007 Oct 21.
2007
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| 26 | KLRK1, RAET1E
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| Regulation of NKG2D ligand gene expression.
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| Eagle RA, Traherne JA, Ashiru O, Wills MR, Trowsdale J.
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| Hum Immunol 67(3):159-69. Epub 2006 Apr 17.
2006
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| 27 | KLRK1, ATR, ATM, CHEK1
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| The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor.
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| Gasser S, Orsulic S, Brown EJ, Raulet DH.
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| Nature 436(7054):1186-90. Epub 2005 Jul 3. 2005
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| 28 | KLRK1
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| NKG2D function protects the host from tumor initiation.
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| Smyth MJ, Swann J, Cretney E, Zerafa N, Yokoyama WM, Hayakawa Y.
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| J Exp Med 202(5):583-8. Epub 2005 Aug 29. 2005
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| 29 | KLRC3, KLRF1, KLRK1
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| Molecular and functional characterization of NKG2D, NKp80, and NKG2C triggering NK cell receptors in rhesus and cynomolgus macaques: monitoring of NK cell function during simian HIV infection.
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| Biassoni R, Fogli M, Cantoni C, Costa P, Conte R, Koopman G, Cafaro A, Ensoli B, Moretta A, Moretta L, De Maria A.
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| J Immunol 174(9):5695-705.PMID: 15843571 2005
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| 30 | KLRK1, KLRC1, KLRC2, KLRC3, KLRC4, TYROBP
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| Human NKG2F is expressed and can associate with DAP12.
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| Kim DK, Kabat J, Borrego F, Sanni TB, You CH, Coligan JE.
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| Mol Immunol 41(1):53-62. 2004
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| 31 | KLRK1, RAET1E
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| ULBP4 is a novel ligand for human NKG2D.
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| Jan Chalupny N, Sutherland CL, Lawrence WA, Rein-Weston A, Cosman D.
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| Biochem Biophys Res Commun 305(1):129-35. 2003
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| 32 | KLRK1, RAET1E
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| ULBP4 is a novel ligand for human NKG2D.
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| Chalupny NJ, Sutherland CL, Lawrence WA, Rein-Weston A, Cosman D.
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| Biochem Biophys Res Commun 305(1):129-35.
2003
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| 33 | KLRK1
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| UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells.
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| Sutherland CL, Chalupny NJ, Schooley K, VandenBos T, Kubin M, Cosman D.
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| J Immunol 168(2):671-9. 2002
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| 34 | KLRK1, MICA, MICB
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| Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation.
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| Groh V, Wu J, Yee C, Spies T.
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| Nature 419(6908):734-8. 2002
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| 35 | KLRK1
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| Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family.
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| Steinle A, Li P, Morris DL, Groh V, Lanier LL, Strong RK, Spies T.
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| Immunogenetics 53(4):279-87. 2001
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| 36 | KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, KLRK1
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| Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes.
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| Plougastel B, Trowsdale J.
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| Genomics 49(2):193-9. 1998
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| 37 | KLRC2, KLRC3, KLRC4, KLRD1, KLRK1
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| The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex.
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| Glienke J, Sobanov Y, Brostjan C, Steffens C, Nguyen C, Lehrach H, HoferE, Francis F.
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| Immunogenetics 48(3):163-73. 1998
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| 38 | KLRK1
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| DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells.
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| Houchins JP, Yabe T, McSherry C, Bach FH.
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| J Exp Med 173(4):1017-20. 1991
|