| 1 | F2R, KLK6
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| KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease.
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| Billi AC, Ludwig JE, Fritz Y, Rozic R, Swindell WR, Tsoi LC, Gruszka D, Abdollahi-Roodsaz S, Xing X, Diaconu D, Uppala R, Camhi MI, Klenotic PA, Sarkar MK, Husni ME, Scher JU, McDonald C, Kahlenberg JM, Midura RJ, Gudjonsson JE, Ward NL.
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| J Clin Invest Clin Invest. 2020 Mar 10. pii: 133159. doi: 10.1172/JCI133159. [Epub ahead of print]
2020
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| 2 | KLK10, KLK6
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| Kallikrein-related peptidases 6 and 10 are elevated in cerebrospinal fluid of patients with Alzheimer's disease and associated with CSF-TAU and FDG-PET.
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| Goldhardt O, Warnhoff I, Yakushev I, Begcevic I, Förstl H, Magdolen V, Soosaipillai A, Diamandis E, Alexopoulos P, Grimmer T.
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| Transl Neurodegener 8:25. doi: 10.1186/s40035-019-0168-6. eCollection 2019.
2019
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| 3 | KLK6
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| Kallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein.
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| Chen H, Sells E, Pandey R, Abril ER, Hsu CH, Krouse RS, Nagle RB, Pampalakis G, Sotiropoulou G, Ignatenko NA.
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| Oncotarget 10(58):6062-6078. doi: 10.18632/oncotarget.27153. eCollection 2019 Oct 22.
2019
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| 4 | KLK6
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| A proinflammatory role of KLK6 protease in Netherton syndrome.
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| Zingkou E, Pampalakis G, Charla E, Nauroy P, Kiritsi D, Sotiropoulou G.
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| J Dermatol Sci 95(1):28-35. doi: 10.1016/j.jdermsci.2019.06.004. Epub 2019 Jun 16.
2019
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| 5 | KLK6
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| Biochemical pathways mediated by KLK6 protease in breast cancer.
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| Pampalakis G, Zingkou E, Sidiropoulos KG, Diamandis EP, Zoumpourlis V, Yousef GM, Sotiropoulou G.
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| Mol Oncol 13(11):2329-2343. doi: 10.1002/1878-0261.12493. Epub 2019 Sep 30.
2019
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| 6 | KLK10, KLK15, KLK2, KLK3, KLK6, KLK7, KLK8
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| Diagnostic and prognostic biomarker potential of kallikrein family genes in different cancer types.
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| Tailor PD, Kodeboyina SK, Bai S, Patel N, Sharma S, Ratnani A, Copland JA, She JX, Sharma A.
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| Oncotarget 9(25):17876-17888. doi: 10.18632/oncotarget.24947. eCollection 2018 Apr 3.
2018
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| 7 | KLK6
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| KLK6 Promotes Growth, Migration, and Invasion of Gastric Cancer Cells.
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| Zhu S, Shi J, Zhang S, Li Z.
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| J Gastric Cancer 18(4):356-367. doi: 10.5230/jgc.2018.18.e35. Epub 2018 Nov 14.
2018
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| 8 | KLK6
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| KLK6 protease accelerates skin tumor formation and progression.
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| Khoury N, Zingkou E, Pampalakis G, Sofopoulos M, Zoumpourlis V, Sotiropoulou G.
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| Carcinogenesis 39(12):1529-1536. doi: 10.1093/carcin/bgy110.
2018
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| 9 | KLK6
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| Kallikrein-related peptidase 6 orchestrates astrocyte form and function through proteinase activated receptor-dependent mechanisms.
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| Yoon H, Radulovic M, Scarisbrick IA.
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| Biol Chem 399(9):1041-1052. doi: 10.1515/hsz-2018-0122.
2018
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| 10 | KLK1, KLK10, KLK13, KLK14, KLK6
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| Functional interrelationships between the kallikrein-related peptidases family and the classical kinin system in the human neutrophil.
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| Ehrenfeld P, Bhoola KD, Matus CE, Figueroa CD.
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| Biol Chem 399(9):925-935. doi: 10.1515/hsz-2017-0338. Review.
2018
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| 11 | KLK5, KLK6, KLK7, KLK8, KLK9
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| Molecular cloning of novel transcripts of human kallikrein-related peptidases 5, 6, 7, 8 and 9 (KLK5 - KLK9), using Next-generation sequencing.
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| Adamopoulos PG, Kontos CK, Scorilas A.
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| Sci Rep 7(1):17299. doi: 10.1038/s41598-017-16269-6.
2017
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| 12 | KLK6
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| Germline Mutations in the Kallikrein 6 Region and Predisposition for Aggressive Prostate Cancer.
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| Briollais L, Ozcelik H, Xu J, Kwiatkowski M, Lalonde E, Sendorek DH, Fleshner NE, Recker F, Kuk C, Olkhov-Mitsel E, Savas S, Hanna S, Juvet T, Hunter GA, Friedlander M, Li H, Chadwick K, Prassas I, Soosaipillai A, Randazzo M, Trachtenberg J, Toi A, Shiah YJ, Fraser M, van der Kwast T, Bristow RG, Bapat B, Diamandis EP, Boutros PC, Zlotta AR.
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| J Natl Cancer Inst 109(4). doi: 10.1093/jnci/djw258.
2017
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| 13 | KLK6
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| Activity of human kallikrein-related peptidase 6 (KLK6) on substrates containing sequences of basic amino acids. Is it a processing protease?
|
| Silva RN, Oliveira LCG, Parise CB, Oliveira JR, Severino B, Corvino A, di Vaio P, Temussi PA, Caliendo G, Santagada V, Juliano L, Juliano MA.
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| Biochim Biophys Acta Proteins Proteom 1865(5):558-564. doi: 10.1016/j.bbapap.2017.02.017. Epub 2017 Feb 28.
2017
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| 14 | KLK6, KLK7, KLK9
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| Prognostic significance of multiple kallikreins in high-grade astrocytoma.
|
| Drucker KL, Gianinni C, Decker PA, Diamandis EP, Scarisbrick IA.
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| BMC Cancer 15:565. doi: 10.1186/s12885-015-1566-5.
2015
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| 15 | KLK10, KLK6
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| Evaluation of human tissue kallikrein-related peptidases 6 and 10 expression in early gastroesophageal adenocarcinoma.
|
| Grin A, Samaan S, Tripathi M, Rotondo F, Kovacs K, Bassily MN, Yousef GM.
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| Hum Pathol 46(4):541-8. doi: 10.1016/j.humpath.2014.12.005. Epub 2014 Dec 31.
2015
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| 16 | KLK6
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| Kallikrein-related peptidase 6 regulates epithelial-to-mesenchymal transition and serves as prognostic biomarker for head and neck squamous cell carcinoma patients.
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| Schrader CH, Kolb M, Zaoui K, Flechtenmacher C, Grabe N, Weber KJ, Hielscher T, Plinkert PK, Hess J.
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| Mol Cancer 14:107. doi: 10.1186/s12943-015-0381-6.
2015
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| 17 | KLK10, KLK6
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| Prognostic significance of human tissue kallikrein-related peptidases 6 and 10 in gastric cancer.
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| Kolin DL, Sy K, Rotondo F, Bassily MN, Kovacs K, Brezden-Masley C, Streutker CJ, Yousef GM.
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| Biol Chem 395(9):1087-93. doi: 10.1515/hsz-2014-0143.
2014
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| 18 | BDRKB1, KLK1, KLK11, kLK6
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| Bioregulation of kallikrein-related peptidases 6, 10 and 11 by the kinin B₁ receptor in breast cancer cells.
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| Ehrenfeld P, Manso L, Pavicic MF, Matus CE, Borquez C, Lizama A, Sarmiento J, Poblete MT, Bhoola KD, Naran A, Figueroa CD.
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| Anticancer Res 34(12):6925-38.
2014
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| 19 | KLK6
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| Prognostic significance of human tissue kallikrein-related peptidases 6 and 10 in gastric cancer.
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| Kolin DL, Sy K, Rotondo F, Bassily MN, Kovacs K, Brezden-Masley C, Streutker CJ, Yousef GM.
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| Biol Chem 395(9):1087-93. doi: 10.1515/hsz-2014-0143.
2014
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| 20 | F2R, F2RL1, KLK6
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| Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity.
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| Yoon H, Radulovic M, Wu J, Blaber SI, Blaber M, Fehlings MG, Scarisbrick IA.
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| J Neurochem 127(2):283-98. doi: 10.1111/jnc.12293. Epub 2013 May 27.
2013
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| 21 | KLK6
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| In vivo analysis of kallikrein-related peptidase 6 (KLK6) function in oligodendrocyte development and the expression of myelin proteins.
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| Murakami K, Jiang YP, Tanaka T, Bando Y, Mitrovic B, Yoshida S.
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| Neuroscience 236:1-11. doi: 10.1016/j.neuroscience.2012.12.073. Epub 2013 Jan 31.
2013
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| 22 | KLK6
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| Kallikrein 6 as a serum prognostic marker in patients with aneurysmal subarachnoid hemorrhage.
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| Martínez-Morillo E, Diamandis A, Romaschin AD, Diamandis EP.
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| PLoS One 7(9):e45676. doi: 10.1371/journal.pone.0045676. Epub 2012 Sep 25.
2012
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| 23 | KLK6
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| Kallikrein 6 is a novel molecular trigger of reactive astrogliosis.
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| Scarisbrick IA, Radulovic M, Burda JE, Larson N, Blaber SI, Giannini C, Blaber M, Vandell AG.
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| Biol Chem 393(5):355-67. doi: 10.1515/hsz-2011-0241.
2012
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| 24 | KLK6
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| Kallikrein-related peptidase 6 (KLK6)gene expression in intracranial tumors.
|
| Talieri M, Zoma M, Devetzi M, Scorilas A, Ardavanis A.
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| Tumour Biol 33(5):1375-83. doi: 10.1007/s13277-012-0385-4. Epub 2012 Apr 3.
2012
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| 25 | KLK6
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| Kallikrein 6 regulates early CNS demyelination in a viral model of multiple sclerosis.
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| Scarisbrick IA, Yoon H, Panos M, Larson N, Blaber SI, Blaber M, Rodriguez M.
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| Brain Pathol 22(5):709-22. doi: 10.1111/j.1750-3639.2012.00577.x. Epub 2012 Mar 21.
2012
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| 26 | KLK6, KLK8
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| Kallikrein-related peptidase 8-dependent skin wound healing is associated with upregulation of kallikrein-related peptidase 6 and PAR2.
|
| Kishibe M, Bando Y, Tanaka T, Ishida-Yamamoto A, Iizuka H, Yoshida S.
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| J Invest Dermatol 132(6):1717-24. doi: 10.1038/jid.2012.18. Epub 2012 Feb 23.
2012
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| 27 | KLK10, KLK6
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| The association with age, human tissue kallikreins 6 and 10 and hemostatic markers for survival outcome from epithelial ovarian cancer.
|
| Koh SC, Razvi K, Chan YH, Narasimhan K, Ilancheran A, Low JJ, Choolani M; Ovarian Cancer Research Consortium of SE Asia.
|
| Arch Gynecol Obstet 284(1):183-90. doi: 10.1007/s00404-010-1605-z. Epub 2010 Aug 1.
2011
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| 28 | KLK1, KLK15, KLK6, KLK7
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| Immunohistochemical analysis of kallikrein-related peptidases in the normal kidney and renal tumors: potential clinical implications.
|
| Gabril M, White NM, Moussa M, Chow TF, Metias SM, Fatoohi E, Yousef GM.
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| Biol Chem iol Chem. 2010 Feb 3. [Epub ahead of print]PMID: 20128686 2010
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| 29 | KLK13, KLK6
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| KLK6 and KLK13 predict tumor recurrence in epithelial ovarian carcinoma.
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| White NM, Mathews M, Yousef GM, Prizada A, Popadiuk C, Doré JJ.
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| Br J Cancer 101(7):1107-13.PMID: 19707197 2009
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| 30 | KLK6
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| High Kallikrein-Related Peptidase 6 in Non-Small Cell Lung Cancer Cells: an indicator of tumor proliferation and poor prognosis.
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| Nathalie HV, Chris P, Serge G, Catherine C, Benjamin B, Claire B, Christelle P, Briollais L, Pascale R, Marie-Lise J, Yves C.
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| J Cell Mol Med Cell Mol Med. 2009 May 1. [Epub ahead of print]PMID: 19426157 2009
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| 31 | KLK1, KLK13, KLK14, KLK2, KLK5, KLK6
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| Association between kallikrein-related peptidases (KLKs) and macroscopic indicators of semen analysis: their relation to sperm motility.
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| Emami N, Scorilas A, Soosaipillai A, Earle T, Mullen B, Diamandis EP.
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| Biol Chem 390(9):921-9.PMID: 19558318 2009
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| 32 | KLK6, KRAS
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| Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells.
|
| Henkhaus RS, Gerner EW, Ignatenko NA.
|
| Biol Chem 389(6):757-64.PMID: 18627290 2008
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| 33 | KLK4, KLK5, KLK6, KLK7
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| Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7.
|
| Debela M, Beaufort N, Magdolen V, Schechter NM, Craik CS, Schmitt M, Bode W, Goettig P.
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| Biol Chem 389(6):623-32. Review.PMID: 18627343 2008
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| 34 | KLK1, KLK5, KLK6, KLK13, KLK14
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| A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation.
|
| Borgono CA, Michael IP, Komatsu N, Jayakumar A, Kapadia R, Clayman GL, Sotiropoulou G, Diamandis EP.
|
| J Biol Chem 282(6):3640-52. Epub 2006 Dec 11. 2007
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| 35 | KLK5, KLK6, KLK8, KLK9
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| Association of KLK5 overexpression with invasiveness of urinary bladder carcinoma cells.
|
| Shinoda Y, Kozaki K, Imoto I, Obara W, Tsuda H, Mizutani Y, Shuin T, Fujioka T, Miki T, Inazawa J.
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| Cancer Sci 98(7):1078-86. Epub 2007 Apr 24.PMID: 17459052 2007
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| 36 | KLK13, KLK2, KLK3, KLK5, KLK6, KLK7, KLK8
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| Distribution of 15 human kallikreins in tissues and biological fluids.
|
| Shaw JL, Diamandis EP.
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| Clin Chem 53(8):1423-32. Epub 2007 Jun 15.PMID: 17573418 2007
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| 37 | KLK6
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| Cloning and characterization of novel isoforms of the human kallikrein 6 gene.
|
| Pampalakis G, Kurlender L, Diamandis EP, Sotiropoulou G.
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| Biochem Biophys Res Commun 320(1):54-61. 2004
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| 38 | KLK6
|
| Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells.
|
| Ghosh MC, Grass L, Soosaipillai A, Sotiropoulou G, Diamandis EP.
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| Tumour Biol 25(4):193-9. 2004
|
| 39 | KLK6
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| Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors.
|
| Magklara A, Mellati AA, Wasney GA, Little SP, Sotiropoulou G, Becker GW, Diamandis EP.
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| Biochem Biophys Res Commun 307(4):948-55. 2003
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| 40 | KLK6
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| The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein family.
|
| Gomis-Ruth FX, Bayes A, Sotiropoulou G, Pampalakis G, Tsetsenis T, Villegas V, Aviles FX, Coll M.
|
| J Biol Chem 277(30):27273-81. Epub 2002 May 16. 2002
|
| 41 | KLK10, KLK11, KLK12, KLK13, KLK14, KLK4, KLK5, KLK6, KLK7, KLK8, KLK9
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| The New Human Kallikrein Gene Family: Implications in Carcinogenesis.
|
| Diamandis EP, Yousef GM, Luo I, Magklara I, Obiezu CV.
|
| Trends Endocrinol Metab 11(2):54-60. 2000
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| 42 | KLK12, KLK13, KLK14, KLK6
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| Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues.
|
| Yousef GM, Chang A, Diamandis EP.
|
| J Biol Chem 275(16):11891-8. 2000
|
| 43 | KLK6
|
| Human kallikrein 6 as a biomarker of alzheimer's disease.
|
| Diamandis EP, Yousef GM, Petraki C, Soosaipillai AR.
|
| Clin Biochem 33(8):663-7. 2000
|
| 44 | KLK1, KLK10, KLK11, KLK12, KLK13, KLK2, KLK3, KLK4, KLK5, KLK6, KLK7, KLK8, KLK9
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| Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4.
|
| Harvey TJ, Hooper JD, Myers SA, Stephenson SA, Ashworth LK, Clements JA.
|
| J Biol Chem 275(48):37397-406.
2000
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| 45 | KLK6
|
| Molecular characterization of zyme/protease M/neurosin (PRSS9), a hormonally regulated kallikrein-like serine protease.
|
| Yousef GM, Luo LY, Scherer SW, Sotiropoulou G, Diamandis EP.
|
| Genomics 62(2):251-9 1999
|
| 46 | KLK6
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| Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain.
|
| Yamashiro K, et al.
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| Biochim Biophys Acta 1350 : 11-14. 1997
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| 47 | KLK6
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| A novel protease homolog differentially expressed in breast and ovarian cancer.
|
| Anisowicz A, et al.
|
| Mol Med 2 : 624-636 1996
|