Citations for
1KLK5, KLK7, SPINK5
Toll-like receptor signaling induces the expression of lympho-epithelial Kazal-type inhibitor in epidermal keratinocytes.
Sugimoto S, Morizane S, Nomura H, Kobashi M, Sugihara S, Iwatsuki K.
J Dermatol Sci 92(2):181-187. doi: 10.1016/j.jdermsci.2018.09.001. Epub 2018 Sep 15. 2018
2KLK14, KLK5, KLK7, SERPINA12
Kallikrein-related peptidase 14 is the second KLK protease targeted by the serpin vaspin.
Ulbricht D, Tindall CA, Oertwig K, Hanke S, Sträter N, Heiker JT.
Biol Chem 399(9):1079-1084. doi: 10.1515/hsz-2018-0108. 2018
3CCL14, KLK5, KLK8
Kallikrein-related peptidases are activators of the CC chemokine CCL14.
Grünberg M, Quandt D, Cynis H, Demuth HU, Kindermann A, Magdolen V, Forssmann WG, Seliger B, Mägert HJ.
Eur J Immunol 48(9):1592-1594. doi: 10.1002/eji.201747452. Epub 2018 Aug 22. 2018
4KLK5, KLK7
KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype.
Kasparek P, Ileninova Z, Zbodakova O, Kanchev I, Benada O, Chalupsky K, Brattsand M, Beck IM, Sedlacek R.
PLoS Genet 13(1):e1006566. doi: 10.1371/journal.pgen.1006566. eCollection 2017 Jan. 2017
5KLK5, KLK7, PI3, SPINK5
Attenuated kallikrein-related peptidase activity disrupts desquamation and leads to stratum corneum thickening in human skin equivalent models.
McGovern JA, Meinert C, de Veer SJ, Hollier BG, Parker TJ, Upton Z.
Br J Dermatol 176(1):145-158. doi: 10.1111/bjd.14879. Epub 2016 Dec 22. 2017
6KLK5, KLK6, KLK7, KLK8, KLK9
Molecular cloning of novel transcripts of human kallikrein-related peptidases 5, 6, 7, 8 and 9 (KLK5 - KLK9), using Next-generation sequencing.
Adamopoulos PG, Kontos CK, Scorilas A.
Sci Rep 7(1):17299. doi: 10.1038/s41598-017-16269-6. 2017
7KLK5, kLK7
Attenuated kallikrein-related peptidase activity disrupts desquamation and leads to stratum corneum thickening in human skin equivalent models.
McGovern JA, Meinert C, de Veer SJ, Hollier BG, Parker TJ, Upton Z.
Br J Dermatol 176(1):145-158. doi: 10.1111/bjd.14879. Epub 2016 Dec 22. 2017
8KLK14, KLK5, KLK7
Selective Substrates and Inhibitors for Kallikrein-Related Peptidase 7 (KLK7) Shed Light on KLK Proteolytic Activity in the Stratum Corneum.
de Veer SJ, Furio L, Swedberg JE, Munro CA, Brattsand M, Clements JA, Hovnanian A, Harris JM.
J Invest Dermatol 137(2):430-439. doi: 10.1016/j.jid.2016.09.017. Epub 2016 Sep 30. 2017
9KLK12, KLK5
Cleavage activation of human-adapted influenza virus subtypes by kallikrein-related peptidases 5 and 12.
Hamilton BS, Whittaker GR.
J Biol Chem 288(24):17399-407. doi: 10.1074/jbc.M112.440362. Epub 2013 Apr 23. 2013
10DSG1, KLK5
Kallikrein-5 promotes cleavage of desmoglein-1 and loss of cell-cell cohesion in oral squamous cell carcinoma.
Jiang R, Shi Z, Johnson JJ, Liu Y, Stack MS.
J Biol Chem 286(11):9127-35. Epub 2010 Dec 16. 2011
11KLK10, KLK5, KLK7, KLK8
Multiple kallikrein (KLK 5, 7, 8, and 10) expression in squamous cell carcinoma of the oral cavity.
Pettus JR, Johnson JJ, Shi Z, Davis JW, Koblinski J, Ghosh S, Liu Y, Ravosa MJ, Frazier S, Stack MS.
Histol Histopathol 24(2):197-207. 2009
12KLK5, KLK7
Parallel underexpression of kallikrein 5 and kallikrein 7 mRNA in breast malignancies.
Li X, Liu J, Wang Y, Zhang L, Ning L, Feng Y.
Cancer Sci 100(4):601-7.PMID: 19453546 2009
13KLK1, KLK13, KLK14, KLK2, KLK5, KLK6
Association between kallikrein-related peptidases (KLKs) and macroscopic indicators of semen analysis: their relation to sperm motility.
Emami N, Scorilas A, Soosaipillai A, Earle T, Mullen B, Diamandis EP.
Biol Chem 390(9):921-9.PMID: 19558318 2009
14HGFAC, KLK4, KLK5
Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases.
Mukai S, Fukushima T, Naka D, Tanaka H, Osada Y, Kataoka H.
FEBS J 275(5):1003-17. Epub 2008 Jan 25. 2008
15KLK4, KLK5, KLK6, KLK7
Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7.
Debela M, Beaufort N, Magdolen V, Schechter NM, Craik CS, Schmitt M, Bode W, Goettig P.
Biol Chem 389(6):623-32. Review.PMID: 18627343 2008
16KLK1, KLK5, KLK6, KLK13, KLK14
A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation.
Borgono CA, Michael IP, Komatsu N, Jayakumar A, Kapadia R, Clayman GL, Sotiropoulou G, Diamandis EP.
J Biol Chem 282(6):3640-52. Epub 2006 Dec 11. 2007
17KLK5, SPINK5
LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction.
Deraison C, Bonnart C, Lopez F, Besson C, Robinson R, Jayakumar A, Wagberg F, Brattsand M, Hachem JP, Leonardsson G, Hovnanian A.
Mol Biol Cell 18(9):3607-19. Epub 2007 Jun 27. 2007
18KLK5, KLK6, KLK8, KLK9
Association of KLK5 overexpression with invasiveness of urinary bladder carcinoma cells.
Shinoda Y, Kozaki K, Imoto I, Obara W, Tsuda H, Mizutani Y, Shuin T, Fujioka T, Miki T, Inazawa J.
Cancer Sci 98(7):1078-86. Epub 2007 Apr 24.PMID: 17459052 2007
19KLK13, KLK2, KLK3, KLK5, KLK6, KLK7, KLK8
Distribution of 15 human kallikreins in tissues and biological fluids.
Shaw JL, Diamandis EP.
Clin Chem 53(8):1423-32. Epub 2007 Jun 15.PMID: 17573418 2007
20KLK5, KLK7, KLK14
Kallikrein-related peptidase 14 may be a major contributor to trypsin-like proteolytic activity in human stratum corneum.
Stefansson K, Brattsand M, Ny A, Glas B, Egelrud T.
Biol Chem 387(6):761-8. 2006
21SPINK5, KLK5, KLK7
LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum.
Ishida-Yamamoto A, Deraison C, Bonnart C, Bitoun E, Robinson R, O'Brien TJ, Wakamatsu K, Ohtsubo S, Takahashi H, Hashimoto Y, Dopping-Hepenstal PJ, McGrath JA, Iizuka H, Richard G, Hovnanian A.
J Invest Dermatol 124(2):360-6. 2005
22KLK5, KLK7
KLK5 and KLK7, two members of the human tissue kallikrein family, are differentially expressed in lung cancer.
Planque C, de Monte M, Guyetant S, Rollin J, Desmazes C, Panel V, Lemarie E, Courty Y.
Biochem Biophys Res Commun 329(4):1260-6. 2005
23KLK5
The human kallikrein protein 5 (hK5) is enzymatically active, glycosylated and forms complexes with two protease inhibitors in ovarian cancer fluids.
Yousef GM, Kapadia C, Polymeris ME, Borgono C, Hutchinson S, Wasney GA, Soosaipillai A, Diamandis EP.
Biochim Biophys Acta 1628(2):88-96. 2003
24KLK5, NT5C3A, RP9
Mutations in a protein target of the Pim-1 kinase associated with the RP9 form of autosomal dominant retinitis pigmentosa.
Keen TJ, Hims MM, McKie AB, Moore AT, Doran RM, Mackey DA, Mansfield DC, Mueller RF, Bhattacharya SS, Bird AC, Markham AF, Inglehearn CF.
Eur J Hum Genet 10(4):245-9. 2002
25KLK10, KLK11, KLK12, KLK13, KLK14, KLK4, KLK5, KLK6, KLK7, KLK8, KLK9
The New Human Kallikrein Gene Family: Implications in Carcinogenesis.
Diamandis EP, Yousef GM, Luo I, Magklara I, Obiezu CV.
Trends Endocrinol Metab 11(2):54-60. 2000
26KLK1, KLK10, KLK11, KLK12, KLK13, KLK2, KLK3, KLK4, KLK5, KLK6, KLK7, KLK8, KLK9
Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4.
Harvey TJ, Hooper JD, Myers SA, Stephenson SA, Ashworth LK, Clements JA.
J Biol Chem 275(48):37397-406. 2000
27KLK5
The new kallikrein-like gene, KLK-L2. Molecular characterization, mapping, tissue expression, and hormonal regulation.
Yousef GM, Diamandis EP.
J Biol Chem 274(53):37511-6. 1999
28KLK5
Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation.
Brattsand M, Egelrud T.
J Biol Chem 274(42):30033-40. 1999