| 1 | BAP1, KLF5, WWP1
|
| BAP1 antagonizes WWP1-mediated transcription factor KLF5 ubiquitination and inhibits autophagy to promote melanoma progression
|
| Jia X, Chen H, Ren Y, Dejizhuoga, Gesangyuzhen, Gao N, Feng H, Huang W, Liao Y, Yu H.
|
| Exp Cell Res. May 1;402(1):112506. doi: 10.1016/j.yexcr.2021.112506. Epub 2021 Jan 29. 2021
|
| 2 | CDX1, CDX2, KLF5
|
| CDX1/2 and KLF5 Expression and Epigenetic Modulation of Sonic Hedgehog Signaling in Gastric Adenocarcinoma.
|
| Samadani AA, Nikbakhsh N, Taheri H, Shafaee S, Fattahi S, Pilehchian Langroudi M, Hajian K, Akhavan-Niaki H.
|
| Pathol Oncol Res 25(3):1215-1222. doi: 10.1007/s12253-019-00594-4. Epub 2019 Jan 26.
2019
|
| 3 | KLF5, TNFRSF11A
|
| KLF5 promotes cervical cancer proliferation, migration and invasion in a manner partly dependent on TNFRSF11a expression.
|
| Ma D, Chang LY, Zhao S, Zhao JJ, Xiong YJ, Cao FY, Yuan L, Zhang Q, Wang XY, Geng ML, Zheng HY, Li O.
|
| Sci Rep 7(1):15683. doi: 10.1038/s41598-017-15979-1.
2017
|
| 4 | KLF5, NOS2
|
| iNOS-derived peroxynitrite mediates high glucose-induced inflammatory gene expression in vascular smooth muscle cells through promoting KLF5 expression and nitration.
|
| Zhang ML, Zheng B, Tong F, Yang Z, Wang ZB, Yang BM, Sun Y, Zhang XH, Zhao YL, Wen JK.
|
| Biochim Biophys Acta Mol Basis Dis 1863(11):2821-2834. doi: 10.1016/j.bbadis.2017.07.004. Epub 2017 Jul 12.
2017
|
| 5 | KLF5, WWTR1
|
| TAZ antagonizes the WWP1-mediated KLF5 degradation and promotes breast cell proliferation and tumorigenesis.
|
| Zhao D, Zhi X, Zhou Z, Chen C.
|
| Carcinogenesis 33(1):59-67. Epub 2011 Oct 31.
2012
|
| 6 | KLF5
|
| The granulocyte-associated transcription factor Krüppel-like factor 5 is silenced by hypermethylation in acute myeloid leukemia.
|
| Diakiw SM, Kok CH, To LB, Lewis ID, Brown AL, D'Andrea RJ.
|
| Leuk Res 36(1):110-6. Epub 2011 Oct 11.
2012
|
| 7 | KLF5, YAP1
|
| YAP promotes breast cell proliferation and survival partially through stabilizing the KLF5 transcription factor.
|
| Zhi X, Zhao D, Zhou Z, Liu R, Chen C.
|
| Am J Pathol 180(6):2452-61. doi: 10.1016/j.ajpath.2012.02.025.
2012
|
| 8 | CDX1, KLF5, SALL4
|
| CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemness-associated reprogramming factors SALL4 and KLF5.
|
| Fujii Y, Yoshihashi K, Suzuki H, Tsutsumi S, Mutoh H, Maeda S, Yamagata Y, Seto Y, Aburatani H, Hatakeyama M.
|
| Proc Natl Acad Sci U S A 109(50):20584-9. doi: 10.1073/pnas.1208651109. Epub 2012 Oct 29. 2012
|
| 9 | DHCR24, KLF5
|
| Promoter analysis of the DHCR24 (3β-hydroxysterol Δ(24)-reductase) gene: characterization of SREBP (sterol-regulatory-element-binding protein)-mediated activation.
|
| Daimiel LA, Fernández-Suárez ME, Rodríguez-Acebes S, Crespo L, Lasunción MA, Gómez-Coronado D, Martínez-Botas J.
|
| Biosci Rep 33(1):57-69. doi: 10.1042/BSR20120095.
2012
|
| 10 | KLF5, TRIM25
|
| Oestrogen causes degradation of KLF5 by inducing the E3 ubiquitin ligase EFP in ER-positive breast cancer cells.
|
| Zhao KW, Sikriwal D, Dong X, Guo P, Sun X, Dong JT.
|
| Biochem J 437(2):323-33.
2011
|
| 11 | KLF5, SMURF2
|
| The E3 ubiquitin ligase SMAD ubiquitination regulatory factor 2 negatively regulates Krüppel-like factor 5 protein.
|
| Du JX, Hagos EG, Nandan MO, Bialkowska AB, Yu B, Yang VW.
|
| J Biol Chem 286(46):40354-64. Epub 2011 Sep 27.
2011
|
| 12 | KLF5
|
| Kruppel-like factor 5 is required for formation and differentiation of the bladder urothelium.
|
| Bell SM, Zhang L, Mendell A, Xu Y, Haitchi HM, Lessard JL, Whitsett JA.
|
| Dev Biol 358(1):79-90. Epub 2011 Jul 22.
2011
|
| 13 | KLF1, KLF15, KLF2, KLF4, KLF5
|
| Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF).
|
| Mas C, Lussier-Price M, Soni S, Morse T, Arseneault G, Di Lello P, Lafrance-Vanasse J, Bieker JJ, Omichinski JG.
|
| Proc Natl Acad Sci U S A 108(26):10484-9. Epub 2011 Jun 13.
2011
|
| 14 | KLF5
|
| Loss of transcription factor KLF5 in the context of p53 ablation drives invasive progression of human squamous cell cancer.
|
| Yang Y, Nakagawa H, Tetreault MP, Billig J, Victor N, Goyal A, Sepulveda AR, Katz JP.
|
| Cancer Res 71(20):6475-84. doi: 10.1158/0008-5472.CAN-11-1702. Epub 2011 Aug 25.
2011
|
| 15 | KLF5
|
| Regulation of Krüpple-like factor 5 by targeted protein degradation.
|
| Chen C.
|
| Methods Mol Biol 647:267-77.
2010
|
| 16 | FBXW7, KLF5
|
| The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation.
|
| Zhao D, Zheng HQ, Zhou Z, Chen C.
|
| Cancer Res 70(11):4728-38. Epub 2010 May 18.
2010
|
| 17 | KLF5
|
| Kruppel-like factor 5 shows proliferation-specific roles in vascular remodeling, direct stimulation of cell growth, and inhibition of apoptosis.
|
| Suzuki T, Sawaki D, Aizawa K, Munemasa Y, Matsumura T, Ishida J, Nagai R.
|
| J Biol Chem 284(14):9549-57. Epub 2009 Feb 3.
2009
|
| 18 | KLF5
|
| Opposing effects of KLF5 on the transcription of MYC in epithelial proliferation in the context of transforming growth factor beta.
|
| Guo P, Dong XY, Zhao K, Sun X, Li Q, Dong JT.
|
| J Biol Chem 284(41):28243-52. Epub 2009 Aug 14.
2009
|
| 19 | FGFBP1, KLF5
|
| Krüppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor binding protein 1.
|
| Zheng HQ, Zhou Z, Huang J, Chaudhury L, Dong JT, Chen C.
|
| Oncogene 28(42):3702-13. Epub 2009 Aug 10.
2009
|
| 20 | KLF5
|
| Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases.
|
| Dong JT, Chen C.
|
| Cell Mol Life Sci 66(16):2691-706. Epub 2009 May 16. Review.
2009
|
| 21 | KLF5
|
| Pro-proliferative factor KLF5 becomes anti-proliferative in epithelial homeostasis upon signaling-mediated modification.
|
| Guo P, Dong XY, Zhang X, Zhao KW, Sun X, Li Q, Dong JT.
|
| J Biol Chem 284(10):6071-8. Epub 2008 Dec 4.
2009
|
| 22 | DUSP1, FGFBP1, KLF5
|
| KLF5 promotes breast cell survival partially through fibroblast growth factor-binding protein 1-pERK-mediated dual specificity MKP-1 protein phosphorylation and stabilization.
|
| Liu R, Zheng HQ, Zhou Z, Dong JT, Chen C.
|
| J Biol Chem 284(25):16791-8. Epub 2009 May 1.
2009
|
| 23 | KLF5, MMP9
|
| Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9.
|
| Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H.
|
| J Biol Chem 283(36):24682-9. Epub 2008 Jul 10. 2008
|
| 24 | KLF5, PPARD
|
| SUMOylation of Krppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta.
|
| Oishi Y, Manabe I, Tobe K, Ohsugi M, Kubota T, Fujiu K, Maemura K, Kubota N, Kadowaki T, Nagai R.
|
| Nat Med 14(6):656-66. Epub 2008 May 25. 2008
|
| 25 | ANP32B, KLF5
|
| Promoter region-specific histone incorporation by the novel histone chaperone ANP32B and DNA-binding factor KLF5.
|
| Munemasa Y, Suzuki T, Aizawa K, Miyamoto S, Imai Y, Matsumura T, Horikoshi M, Nagai R.
|
| Mol Cell Biol 28(3):1171-81. Epub 2007 Nov 26.
2008
|
| 26 | AUTS2, PIBF1, KLF5, LYZL4
|
| Mutations in autism susceptibility candidate 2 (AUTS2) in patients with mental retardation.
|
| Kalscheuer VM, Fitzpatrick D, Tommerup N, Bugge M, Niebuhr E, Neumann LM, Tzschach A, Shoichet SA, Menzel C, Erdogan F, Arkesteijn G, Ropers HH, Ullmann R.
|
| Hum Genet 121(3-4):501-9. Epub 2007 Jan 9. 2007
|
| 27 | KLF5
|
| Krüppel-like factor 5 activates MEK/ERK signaling via EGFR in primary squamous epithelial cells.
|
| Yang Y, Goldstein BG, Nakagawa H, Katz JP.
|
| FASEB J 21(2):543-50. Epub 2006 Dec 8.
2007
|
| 28 | KLF5
|
| The deacetylase HDAC1 negatively regulates the cardiovascular transcription factor Kruppel-like factor 5 through direct interaction.
|
| Matsumura T, Suzuki T, Aizawa K, Munemasa Y, Muto S, Horikoshi M, Nagai R.
|
| J Biol Chem 280(13):12123-9. Epub 2005 Jan 24. 2005
|
| 29 | KLF5
|
| Kruppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation.
|
| Oishi Y, Manabe I, Tobe K, Tsushima K, Shindo T, Fujiu K, Nishimura G, Maemura K, Yamauchi T, Kubota N, Suzuki R, Kitamura T, Akira S, Kadowaki T, Nagai R.
|
| Cell metabolism 1(1):27-39. 2005
|
| 30 | SP1, SP2, SP3, SP4, SP5, SP6, SP7, SP8, SP9, KLF1, KLF2, KLF3, KLF4, KLF5, KLF6, KLF7, KLF8, KLF9, KLF10, KLF11, KLF12, KLF13, KLF14, KLF15, KLF16
|
| Mammalian SP/KLF transcription factors: bring in the family.
|
| Suske G, Bruford E, Philipsen S.
|
| Genomics 85(5):551-6. 2005
|
| 31 | WWP1, KLF5
|
| Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells.
|
| Chen C, Sun X, Guo P, Dong XY, Sethi P, Cheng X, Zhou J, Ling J, Simons JW, Lingrel JB, Dong JT.
|
| J Biol Chem 280(50):41553-61. Epub 2005 Oct 13. 2005
|
| 32 | KLF5
|
| Intestinal tumor progression is associated with altered function of KLF5.
|
| Bateman NW, Tan D, Pestell RG, Black JD, Black AR.
|
| J Biol Chem 279(13):12093-101. Epub 2004 Jan 15. 2004
|
| 33 | KLF5
|
| All-trans retinoic acid inhibits proliferation of intestinal epithelial cells by inhibiting expression of the gene encoding Kruppel-like factor 5.
|
| Chanchevalap S, Nandan MO, Merlin D, Yang VW.
|
| FEBS Lett 578(1-2):99-105. 2004
|
| 34 | KLF5
|
| Regulation of KLF5 involves the Sp1 transcription factor in human epithelial cells.
|
| Chen C, Zhou Y, Zhou Z, Sun X, Otto KB, Uht RM, Dong JT.
|
| Gene 330:133-42. 2004
|
| 35 | KLF5, KLF6, KLF4
|
| KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer.
|
| Chen C, Bhalala HV, Vessella RL, Dong JT.
|
| Prostate 55(2):81-8. 2003
|
| 36 | KLF5
|
| Regulation of T-cell receptor D beta 1 promoter by KLF5 through reiterated GC-rich motifs.
|
| Yang XO, Doty RT, Hicks JS, Willerford DM.
|
| Blood 101(11):4492-9. Epub 2003 Feb 6. 2003
|
| 37 | KLF5
|
| Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling.
|
| Shindo T, Manabe I, Fukushima Y, Tobe K, Aizawa K, Miyamoto S, Kawai-Kowase K, Moriyama N, Imai Y, Kawakami H, Nishimatsu H, Ishikawa T, Suzuki T, Morita H, Maemura K, Sata M, Hirata Y, Komukai M, Kagechika H, Kadowaki T, Kurabayashi M, Nagai R.
|
| Nat Med 8(8):856-63. 2002
|
| 38 | KLF5
|
| Intestinal-enriched Kruppel-like factor (Kruppel-like factor 5) is a positive regulator of cellular proliferation.
|
| Sun R, Chen X, Yang VW.
|
| J Biol Chem 276(10):6897-900. 2001
|
| 39 | KLF5
|
| A gene encoding an intestinal-enriched member of the Kruppel-like factor family expressed in intestinal epithelial cells.
|
| Conkright MD, Wani MA, Anderson KP, Lingrel JB.
|
| Nucleic Acids Res 27(5):1263-70. 1999
|
| 40 | KLF5
|
| Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter.
|
| Shi H, Zhang Z, Wang X, Liu S, Teng CT.
|
| Nucleic Acids Res 27(24):4807-15. 1999
|
| 41 | KLF5
|
| cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2.
|
| Sogawa K, Imataka H, Yamasaki Y, Kusume H, Abe H, Fujii-Kuriyama Y.
|
| Nucleic Acids Res 21(7):1527-32. 1993
|