1 | KLF1
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| Does the Novel KLF1 Gene Mutation Lead to a Delay in Fetal Hemoglobin Switch?
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| Hariharan P, Gorivale M, Colah R, Ghosh K, Nadkarni A.
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| Ann Hum Genet 81(3):125-128. doi: 10.1111/ahg.12191. Epub 2017 Mar 31.
2017
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2 | KLF1
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| Changes in HbA2 and HbF in alpha thalassemia carriers with KLF1 mutation.
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| Satta S, Paglietti ME, Sollaino MC, Barella S, Moi P, Desogus MF, Demartis FR, Manunza L, Origa R.
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| Blood Cells Mol Dis 64:30-32. doi: 10.1016/j.bcmd.2017.03.007. Epub 2017 Mar 18.
2017
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3 | CDAN4, KLF1
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| A case of congenital dyserythropoietic anemia type IV.
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| de-la-Iglesia-Iņigo S, Moreno-Carralero MI, Lemes-Castellano A, Molero-Labarta T, Méndez M, Morán-Jiménez MJ.
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| Clin Case Rep 5(3):248-252. doi: 10.1002/ccr3.825. eCollection 2017 Mar.
2017
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4 | KLF1
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| Orchestration of late events in erythropoiesis by KLF1/EKLF.
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| Gnanapragasam MN, Bieker JJ.
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| Curr Opin Hematol 24(3):183-190. doi: 10.1097/MOH.0000000000000327.
2017
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5 | KLF1
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| Activation of KLF1 Enhances the Differentiation and Maturation of Red Blood Cells from Human Pluripotent Stem Cells.
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| Yang CT, Ma R, Axton RA, Jackson M, Taylor AH, Fidanza A, Marenah L, Frayne J, Mountford JC, Forrester LM.
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| Stem Cells 35(4):886-897. doi: 10.1002/stem.2562. Epub 2017 Jan 19.
2017
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6 | BCL11A, HBB, KLF1
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| Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts.
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| Vinjamur DS, Alhashem YN, Mohamad SF, Amin P, Williams DC Jr, Lloyd JA.
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| PLoS One 11(2):e0146802. doi: 10.1371/journal.pone.0146802. eCollection 2016. 2016
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7 | GATA1, KLF1, TAL1
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| KLF1 stabilizes GATA-1 and TAL1 occupancy in the human β-globin locus.
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| Kang Y, Kim YW, Yun J, Shin J, Kim A.
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| Biochim Biophys Acta 1849(3):282-9. doi: 10.1016/j.bbagrm.2014.12.010. Epub 2014 Dec 17.
2015
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8 | KLF1
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| Alternative splicing of EKLF/KLF1 in murine primary erythroid tissues.
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| Yien YY, Gnanapragasam MN, Gupta R, Rivella S, Bieker JJ.
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| Exp Hematol 43(1):65-70. doi: 10.1016/j.exphem.2014.08.007. Epub 2014 Oct 2.
2015
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9 | KLF1, PIAS3
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| Transcriptional activity of erythroid Kruppel-like factor (EKLF/KLF1) modulated by PIAS3 (protein inhibitor of activated STAT3).
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| Siatecka M, Soni S, Planutis A, Bieker JJ.
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| J Biol Chem 290(15):9929-40. doi: 10.1074/jbc.M114.610246. Epub 2015 Feb 24.
2015
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10 | DEK, KLF1
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| The DEK Oncoprotein Is a Critical Component of the EKLF/KLF1 Enhancer in Erythroid Cells.
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| Lohmann F, Dangeti M, Soni S, Chen X, Planutis A, Baron MH, Choi K, Bieker JJ.
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| Mol Cell Biol 35(21):3726-38. doi: 10.1128/MCB.00382-15. Epub 2015 Aug 24.
2015
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11 | FOXM1, KLF1, KLF2
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| Krϋppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation.
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| Vinjamur DS, Wade KJ, Mohamad SF, Haar JL, Sawyer ST, Lloyd JA.
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| Haematologica aematologica. 2014 Aug 22. pii: haematol.2014.104943. [Epub ahead of print] 2014
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12 | DOK2, KLF1
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| Dok2 likely down-regulates Klf1 in mouse erythroleukemia cells.
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| Tanaka Y, Kulkeaw K, Inoue T, Tan KS, Nakanishi Y, Shirasawa S, Sugiyama D.
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| Anticancer Res 34(8):4561-7.
2014
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13 | KLF1, PGF
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| Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor.
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| Wang X, Mendelsohn L, Rogers H, Leitman S, Raghavachari N, Yang Y, Yau YY, Tallack M, Perkins A, Taylor JG 6th, Noguchi CT, Kato GJ.
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| Blood 124(6):946-54. doi: 10.1182/blood-2013-11-539718. Epub 2014 Jun 10.
2014
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14 | KLF1
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| Extrinsic and intrinsic control by EKLF (KLF1) within a specialized erythroid niche.
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| Xue L, Galdass M, Gnanapragasam MN, Manwani D, Bieker JJ.
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| Development 141(11):2245-54. doi: 10.1242/dev.103960.
2014
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15 | GATA1, HBB, HIRA, KLF1
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| Transcription factor EKLF (KLF1) recruitment of the histone chaperone HIRA is essential for β-globin gene expression.
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| Soni S, Pchelintsev N, Adams PD, Bieker JJ.
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| Proc Natl Acad Sci U S A 111(37):13337-42. doi: 10.1073/pnas.1405422111. Epub 2014 Sep 2.
2014
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16 | FLI1, KLF1
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| Transcription factors Fli1 and EKLF in the differentiation of megakaryocytic and erythroid progenitor in 5q- syndrome and in Diamond-Blackfan anemia.
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| Neuwirtova R, Fuchs O, Holicka M, Vostry M, Kostecka A, Hajkova H, Jonasova A, Cermak J, Cmejla R, Pospisilova D, Belickova M, Siskova M, Hochova I, Vondrakova J, Sponerova D, Kadlckova E, Novakova L, Brezinova J, Michalova K.
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| Ann Hematol 92(1):11-8. doi: 10.1007/s00277-012-1568-1. Epub 2012 Sep 11.
2013
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17 | KLF1
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| Three fingers on the switch: Krüppel-like factor 1 regulation of γ-globin to β-globin gene switching.
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| Tallack MR, Perkins AC.
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| Curr Opin Hematol 20(3):193-200. doi: 10.1097/MOH.0b013e32835f59ba. Review.
2013
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18 | KLF1
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| Functional analysis of a novel KLF1 gene promoter variation associated with hereditary persistence of fetal hemoglobin.
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| Radmilovic M, Zukic B, Petrovic MS, Bartsakoulia M, Stankovic B, Kotur N, Dokmanovic L, Georgitsi M, Patrinos GP, Pavlovic S.
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| Ann Hematol 92(1):53-8. doi: 10.1007/s00277-012-1625-9. Epub 2012 Nov 18.
2013
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19 | BCL11A, HBG1, HBG2, KLF1
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| Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice.
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| Esteghamat F, Gillemans N, Bilic I, van den Akker E, Cantų I, van Gent T, Klingmüller U, van Lom K, von Lindern M, Grosveld F, Bryn van Dijk T, Busslinger M, Philipsen S.
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| Blood 121(13):2553-62. doi: 10.1182/blood-2012-06-434530. Epub 2013 Jan 29.
2013
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20 | KLF1, PPM1B
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| Functional interactions between erythroid Krüppel-like factor (EKLF/KLF1) and protein phosphatase PPM1B/PP2Cβ.
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| Yien YY, Bieker JJ.
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| J Biol Chem 287(19):15193-204. doi: 10.1074/jbc.M112.350496. Epub 2012 Mar 5.
2012
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21 | KLF1, KLF2, MYC
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| Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesis.
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| Pang CJ, Lemsaddek W, Alhashem YN, Bondzi C, Redmond LC, Ah-Son N, Dumur CI, Archer KJ, Haar JL, Lloyd JA, Trudel M.
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| Mol Cell Biol 32(13):2628-44. doi: 10.1128/MCB.00104-12. Epub 2012 May 7.
2012
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22 | KLF1, KLF15, KLF2, KLF4, KLF5
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| Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF).
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| Mas C, Lussier-Price M, Soni S, Morse T, Arseneault G, Di Lello P, Lafrance-Vanasse J, Bieker JJ, Omichinski JG.
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| Proc Natl Acad Sci U S A 108(26):10484-9. Epub 2011 Jun 13.
2011
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23 | HBE1, HBG1, HBG2, KLF1, KLF2
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| Transcription factors KLF1 and KLF2 positively regulate embryonic and fetal beta-globin genes through direct promoter binding.
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| Alhashem YN, Vinjamur DS, Basu M, Klingmüller U, Gaensler KM, Lloyd JA.
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| J Biol Chem 286(28):24819-27. Epub 2011 May 24. 2011
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24 | CDAN4, KLF, KLF1
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| Mutations in the second zinc finger of human EKLF reduce promoter affinity but give rise to benign and disease phenotypes.
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| Singleton BK, Lau W, Fairweather VS, Burton NM, Wilson MC, Parsons SF, Richardson BM, Trakarnsanga K, Brady RL, Anstee DJ, Frayne J.
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| Blood 118(11):3137-45. Epub 2011 Jul 21. 2011
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25 | EP300, GTF2H1, KLF1
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| Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF).
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| Mas C, Lussier-Price M, Soni S, Morse T, Arseneault G, Di Lello P, Lafrance-Vanasse J, Bieker JJ, Omichinski JG.
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| Proc Natl Acad Sci U S A 108(26):10484-9. doi: 10.1073/pnas.1017029108. Epub 2011 Jun 13.
2011
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26 | CDKN1A, KLF1
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| EKLF directly activates the p21WAF1/CIP1 gene by proximal promoter and novel intronic regulatory regions during erythroid differentiation.
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| Siatecka M, Lohmann F, Bao S, Bieker JJ.
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| Mol Cell Biol 30(11):2811-22. Epub 2010 Apr 5.PMID: 20368355 2010
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27 | CDAN4, KLF1
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| A dominant mutation in the gene encoding the erythroid transcription factor KLF1 causes a congenital dyserythropoietic anemia.
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| Arnaud L, Saison C, Helias V, Lucien N, Steschenko D, Giarratana MC, Prehu C, Foliguet B, Montout L, de Brevern AG, Francina A, Ripoche P, Fenneteau O, Da Costa L, Peyrard T, Coghlan G, Illum N, Birgens H, Tamary H, Iolascon A, Delaunay J, Tchernia G, Cartron JP.
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| Am J Hum Genet 87(5):721-7. Epub 2010 Nov 4.PMID: 21055716 2010
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28 | BCL11A, KLF1
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| KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching.
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| Zhou D, Liu K, Sun CW, Pawlik KM, Townes TM.
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| Nat Genet 42(9):742-4. Epub 2010 Aug 1.
2010
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29 | KLF1
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| Mutation in erythroid specific transcription factor KLF1 causes Hereditary Spherocytosis in the Nan hemolytic anemia mouse model.
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| Heruth DP, Hawkins T, Logsdon DP, Gibson MI, Sokolovsky IV, Nsumu NN, Major SL, Fegley B, Woods GM, Lewing KB, Neville KA, Cornetta K, Peterson KR, White RA.
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| Genomics 96(5):303-7. Epub 2010 Aug 5.
2010
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30 | KLF1, TAF9
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| Distinct modes of gene regulation by a cell-specific transcriptional activator.
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| Sengupta T, Cohet N, Morlé F, Bieker JJ.
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| Proc Natl Acad Sci U S A 106(11):4213-8. Epub 2009 Feb 27.
2009
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31 | KLF1
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| Erythroid Kruppel-like factor (EKLF) is recruited to the gamma-globin gene promoter as a co-activator and is required for gamma-globin gene induction by short-chain fatty acid derivatives.
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| Perrine SP, Mankidy R, Boosalis MS, Bieker JJ, Faller DV.
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| Eur J Haematol 82(6):466-76. Epub 2009 Feb 5.
2009
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32 | KLF1
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| EKLF restricts megakaryocytic differentiation at the benefit of erythrocytic differentiation.
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| Bouilloux F, Juban G, Cohet N, Buet D, Guyot B, Vainchenker W, Louache F, Morlé F.
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| Blood 112(3):576-84. Epub 2008 Jun 3.
2008
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33 | KLF1
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| Mutations in EKLF/KLF1 form the molecular basis of the rare blood group In(Lu) phenotype.
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| Singleton BK, Burton NM, Green C, Brady RL, Anstee DJ.
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| Blood 112(5):2081-8. Epub 2008 May 16.
2008
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34 | KLF1, KLF3
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| Erythroid Krüppel-like factor directly activates the basic Krüppel-like factor gene in erythroid cells.
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| Funnell AP, Maloney CA, Thompson LJ, Keys J, Tallack M, Perkins AC, Crossley M.
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| Mol Cell Biol 27(7):2777-90. Epub 2007 Feb 5.PMID: 17283065 2007
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35 | SP1, SP2, SP3, SP4, SP5, SP6, SP7, SP8, SP9, KLF1, KLF2, KLF3, KLF4, KLF5, KLF6, KLF7, KLF8, KLF9, KLF10, KLF11, KLF12, KLF13, KLF14, KLF15, KLF16
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| Mammalian SP/KLF transcription factors: bring in the family.
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| Suske G, Bruford E, Philipsen S.
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| Genomics 85(5):551-6. 2005
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36 | KLF1
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| Basic residues within the Kruppel zinc finger DNA binding domains are the critical nuclear localization determinants of EKLF/KLF-1.
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| Pandya K, Townes TM.
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| J Biol Chem 277(18):16304-12. 2002
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37 | CTBP1, KLF1, KLF3
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| Basic Kruppel-like factor functions within a network of interacting haematopoietic transcription factors.
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| Turner J, Crossley M.
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| Int J Biochem Cell Biol 31(10):1169-74. Review. 1999
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38 | KLF1
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| Chromatin structure and transcriptional control elements of the erythroid Kruppel-like factor (EKLF) gene.
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| Chen X, et al.
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| J Biol Chem 273 : 25031-25040. 1998
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39 | KLF1, LCR-HB-B@
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| Altered DNA-binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of the beta-globin locus control region in vivo.
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| Gillemans N, Tewari R, Lindeboom F, Rottier R, de Wit T, Wijgerde M, Grosveld F, Philipsen S.
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| Genes Dev 12(18):2863-73. 1998
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40 | KLF1, SMARCB1, SMARCC1, SMARCC2
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| A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro.
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| Armstrong JA, Bieker JJ, Emerson BM.
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| Cell 95(1):93-104. 1998
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41 | KLF1
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| The human erythroid-specific transcription factor EKLF localizes to chromosome 19p13.12-p13.13.
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| Van Ree JH, et al.
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| Genomics 39 : 393-395. 1997
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42 | KLF1
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| The role of EKLF in human beta-globin gene competition.
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| Wijgerde M, et al.
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| Genes Dev 10 : 2894-2902. 1996
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43 | KLF1
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| Isolation, genomic structure, and expression of human erythroid Krppel-like factor (EKLF).
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| Bieker JJ.
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| DNA Cell Biol 15 : 347-352. 1996
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44 | KLF1, KLF2
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| Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Kruppel-like factor: identification of a new multigene family.
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| Anderson KP, Kern CB, Crable SC, Lingrel JB.
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| Mol Cell Biol 15(11):5957-65 1995
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