Citations for
1KLF1
Does the Novel KLF1 Gene Mutation Lead to a Delay in Fetal Hemoglobin Switch?
Hariharan P, Gorivale M, Colah R, Ghosh K, Nadkarni A.
Ann Hum Genet 81(3):125-128. doi: 10.1111/ahg.12191. Epub 2017 Mar 31. 2017
2KLF1
Changes in HbA2 and HbF in alpha thalassemia carriers with KLF1 mutation.
Satta S, Paglietti ME, Sollaino MC, Barella S, Moi P, Desogus MF, Demartis FR, Manunza L, Origa R.
Blood Cells Mol Dis 64:30-32. doi: 10.1016/j.bcmd.2017.03.007. Epub 2017 Mar 18. 2017
3CDAN4, KLF1
A case of congenital dyserythropoietic anemia type IV.
de-la-Iglesia-Iņigo S, Moreno-Carralero MI, Lemes-Castellano A, Molero-Labarta T, Méndez M, Morán-Jiménez MJ.
Clin Case Rep 5(3):248-252. doi: 10.1002/ccr3.825. eCollection 2017 Mar. 2017
4KLF1
Orchestration of late events in erythropoiesis by KLF1/EKLF.
Gnanapragasam MN, Bieker JJ.
Curr Opin Hematol 24(3):183-190. doi: 10.1097/MOH.0000000000000327. 2017
5KLF1
Activation of KLF1 Enhances the Differentiation and Maturation of Red Blood Cells from Human Pluripotent Stem Cells.
Yang CT, Ma R, Axton RA, Jackson M, Taylor AH, Fidanza A, Marenah L, Frayne J, Mountford JC, Forrester LM.
Stem Cells 35(4):886-897. doi: 10.1002/stem.2562. Epub 2017 Jan 19. 2017
6BCL11A, HBB, KLF1
Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts.
Vinjamur DS, Alhashem YN, Mohamad SF, Amin P, Williams DC Jr, Lloyd JA.
PLoS One 11(2):e0146802. doi: 10.1371/journal.pone.0146802. eCollection 2016. 2016
7GATA1, KLF1, TAL1
KLF1 stabilizes GATA-1 and TAL1 occupancy in the human β-globin locus.
Kang Y, Kim YW, Yun J, Shin J, Kim A.
Biochim Biophys Acta 1849(3):282-9. doi: 10.1016/j.bbagrm.2014.12.010. Epub 2014 Dec 17. 2015
8KLF1
Alternative splicing of EKLF/KLF1 in murine primary erythroid tissues.
Yien YY, Gnanapragasam MN, Gupta R, Rivella S, Bieker JJ.
Exp Hematol 43(1):65-70. doi: 10.1016/j.exphem.2014.08.007. Epub 2014 Oct 2. 2015
9KLF1, PIAS3
Transcriptional activity of erythroid Kruppel-like factor (EKLF/KLF1) modulated by PIAS3 (protein inhibitor of activated STAT3).
Siatecka M, Soni S, Planutis A, Bieker JJ.
J Biol Chem 290(15):9929-40. doi: 10.1074/jbc.M114.610246. Epub 2015 Feb 24. 2015
10DEK, KLF1
The DEK Oncoprotein Is a Critical Component of the EKLF/KLF1 Enhancer in Erythroid Cells.
Lohmann F, Dangeti M, Soni S, Chen X, Planutis A, Baron MH, Choi K, Bieker JJ.
Mol Cell Biol 35(21):3726-38. doi: 10.1128/MCB.00382-15. Epub 2015 Aug 24. 2015
11FOXM1, KLF1, KLF2
Krϋppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation.
Vinjamur DS, Wade KJ, Mohamad SF, Haar JL, Sawyer ST, Lloyd JA.
Haematologica aematologica. 2014 Aug 22. pii: haematol.2014.104943. [Epub ahead of print] 2014
12DOK2, KLF1
Dok2 likely down-regulates Klf1 in mouse erythroleukemia cells.
Tanaka Y, Kulkeaw K, Inoue T, Tan KS, Nakanishi Y, Shirasawa S, Sugiyama D.
Anticancer Res 34(8):4561-7. 2014
13KLF1, PGF
Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor.
Wang X, Mendelsohn L, Rogers H, Leitman S, Raghavachari N, Yang Y, Yau YY, Tallack M, Perkins A, Taylor JG 6th, Noguchi CT, Kato GJ.
Blood 124(6):946-54. doi: 10.1182/blood-2013-11-539718. Epub 2014 Jun 10. 2014
14KLF1
Extrinsic and intrinsic control by EKLF (KLF1) within a specialized erythroid niche.
Xue L, Galdass M, Gnanapragasam MN, Manwani D, Bieker JJ.
Development 141(11):2245-54. doi: 10.1242/dev.103960. 2014
15GATA1, HBB, HIRA, KLF1
Transcription factor EKLF (KLF1) recruitment of the histone chaperone HIRA is essential for β-globin gene expression.
Soni S, Pchelintsev N, Adams PD, Bieker JJ.
Proc Natl Acad Sci U S A 111(37):13337-42. doi: 10.1073/pnas.1405422111. Epub 2014 Sep 2. 2014
16FLI1, KLF1
Transcription factors Fli1 and EKLF in the differentiation of megakaryocytic and erythroid progenitor in 5q- syndrome and in Diamond-Blackfan anemia.
Neuwirtova R, Fuchs O, Holicka M, Vostry M, Kostecka A, Hajkova H, Jonasova A, Cermak J, Cmejla R, Pospisilova D, Belickova M, Siskova M, Hochova I, Vondrakova J, Sponerova D, Kadlckova E, Novakova L, Brezinova J, Michalova K.
Ann Hematol 92(1):11-8. doi: 10.1007/s00277-012-1568-1. Epub 2012 Sep 11. 2013
17KLF1
Three fingers on the switch: Krüppel-like factor 1 regulation of γ-globin to β-globin gene switching.
Tallack MR, Perkins AC.
Curr Opin Hematol 20(3):193-200. doi: 10.1097/MOH.0b013e32835f59ba. Review. 2013
18KLF1
Functional analysis of a novel KLF1 gene promoter variation associated with hereditary persistence of fetal hemoglobin.
Radmilovic M, Zukic B, Petrovic MS, Bartsakoulia M, Stankovic B, Kotur N, Dokmanovic L, Georgitsi M, Patrinos GP, Pavlovic S.
Ann Hematol 92(1):53-8. doi: 10.1007/s00277-012-1625-9. Epub 2012 Nov 18. 2013
19BCL11A, HBG1, HBG2, KLF1
Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice.
Esteghamat F, Gillemans N, Bilic I, van den Akker E, Cantų I, van Gent T, Klingmüller U, van Lom K, von Lindern M, Grosveld F, Bryn van Dijk T, Busslinger M, Philipsen S.
Blood 121(13):2553-62. doi: 10.1182/blood-2012-06-434530. Epub 2013 Jan 29. 2013
20KLF1, PPM1B
Functional interactions between erythroid Krüppel-like factor (EKLF/KLF1) and protein phosphatase PPM1B/PP2Cβ.
Yien YY, Bieker JJ.
J Biol Chem 287(19):15193-204. doi: 10.1074/jbc.M112.350496. Epub 2012 Mar 5. 2012
21KLF1, KLF2, MYC
Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesis.
Pang CJ, Lemsaddek W, Alhashem YN, Bondzi C, Redmond LC, Ah-Son N, Dumur CI, Archer KJ, Haar JL, Lloyd JA, Trudel M.
Mol Cell Biol 32(13):2628-44. doi: 10.1128/MCB.00104-12. Epub 2012 May 7. 2012
22KLF1, KLF15, KLF2, KLF4, KLF5
Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF).
Mas C, Lussier-Price M, Soni S, Morse T, Arseneault G, Di Lello P, Lafrance-Vanasse J, Bieker JJ, Omichinski JG.
Proc Natl Acad Sci U S A 108(26):10484-9. Epub 2011 Jun 13. 2011
23HBE1, HBG1, HBG2, KLF1, KLF2
Transcription factors KLF1 and KLF2 positively regulate embryonic and fetal beta-globin genes through direct promoter binding.
Alhashem YN, Vinjamur DS, Basu M, Klingmüller U, Gaensler KM, Lloyd JA.
J Biol Chem 286(28):24819-27. Epub 2011 May 24. 2011
24CDAN4, KLF, KLF1
Mutations in the second zinc finger of human EKLF reduce promoter affinity but give rise to benign and disease phenotypes.
Singleton BK, Lau W, Fairweather VS, Burton NM, Wilson MC, Parsons SF, Richardson BM, Trakarnsanga K, Brady RL, Anstee DJ, Frayne J.
Blood 118(11):3137-45. Epub 2011 Jul 21. 2011
25EP300, GTF2H1, KLF1
Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF).
Mas C, Lussier-Price M, Soni S, Morse T, Arseneault G, Di Lello P, Lafrance-Vanasse J, Bieker JJ, Omichinski JG.
Proc Natl Acad Sci U S A 108(26):10484-9. doi: 10.1073/pnas.1017029108. Epub 2011 Jun 13. 2011
26CDKN1A, KLF1
EKLF directly activates the p21WAF1/CIP1 gene by proximal promoter and novel intronic regulatory regions during erythroid differentiation.
Siatecka M, Lohmann F, Bao S, Bieker JJ.
Mol Cell Biol 30(11):2811-22. Epub 2010 Apr 5.PMID: 20368355 2010
27CDAN4, KLF1
A dominant mutation in the gene encoding the erythroid transcription factor KLF1 causes a congenital dyserythropoietic anemia.
Arnaud L, Saison C, Helias V, Lucien N, Steschenko D, Giarratana MC, Prehu C, Foliguet B, Montout L, de Brevern AG, Francina A, Ripoche P, Fenneteau O, Da Costa L, Peyrard T, Coghlan G, Illum N, Birgens H, Tamary H, Iolascon A, Delaunay J, Tchernia G, Cartron JP.
Am J Hum Genet 87(5):721-7. Epub 2010 Nov 4.PMID: 21055716 2010
28BCL11A, KLF1
KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching.
Zhou D, Liu K, Sun CW, Pawlik KM, Townes TM.
Nat Genet 42(9):742-4. Epub 2010 Aug 1. 2010
29KLF1
Mutation in erythroid specific transcription factor KLF1 causes Hereditary Spherocytosis in the Nan hemolytic anemia mouse model.
Heruth DP, Hawkins T, Logsdon DP, Gibson MI, Sokolovsky IV, Nsumu NN, Major SL, Fegley B, Woods GM, Lewing KB, Neville KA, Cornetta K, Peterson KR, White RA.
Genomics 96(5):303-7. Epub 2010 Aug 5. 2010
30KLF1, TAF9
Distinct modes of gene regulation by a cell-specific transcriptional activator.
Sengupta T, Cohet N, Morlé F, Bieker JJ.
Proc Natl Acad Sci U S A 106(11):4213-8. Epub 2009 Feb 27. 2009
31KLF1
Erythroid Kruppel-like factor (EKLF) is recruited to the gamma-globin gene promoter as a co-activator and is required for gamma-globin gene induction by short-chain fatty acid derivatives.
Perrine SP, Mankidy R, Boosalis MS, Bieker JJ, Faller DV.
Eur J Haematol 82(6):466-76. Epub 2009 Feb 5. 2009
32KLF1
EKLF restricts megakaryocytic differentiation at the benefit of erythrocytic differentiation.
Bouilloux F, Juban G, Cohet N, Buet D, Guyot B, Vainchenker W, Louache F, Morlé F.
Blood 112(3):576-84. Epub 2008 Jun 3. 2008
33KLF1
Mutations in EKLF/KLF1 form the molecular basis of the rare blood group In(Lu) phenotype.
Singleton BK, Burton NM, Green C, Brady RL, Anstee DJ.
Blood 112(5):2081-8. Epub 2008 May 16. 2008
34KLF1, KLF3
Erythroid Krüppel-like factor directly activates the basic Krüppel-like factor gene in erythroid cells.
Funnell AP, Maloney CA, Thompson LJ, Keys J, Tallack M, Perkins AC, Crossley M.
Mol Cell Biol 27(7):2777-90. Epub 2007 Feb 5.PMID: 17283065 2007
35SP1, SP2, SP3, SP4, SP5, SP6, SP7, SP8, SP9, KLF1, KLF2, KLF3, KLF4, KLF5, KLF6, KLF7, KLF8, KLF9, KLF10, KLF11, KLF12, KLF13, KLF14, KLF15, KLF16
Mammalian SP/KLF transcription factors: bring in the family.
Suske G, Bruford E, Philipsen S.
Genomics 85(5):551-6. 2005
36KLF1
Basic residues within the Kruppel zinc finger DNA binding domains are the critical nuclear localization determinants of EKLF/KLF-1.
Pandya K, Townes TM.
J Biol Chem 277(18):16304-12. 2002
37CTBP1, KLF1, KLF3
Basic Kruppel-like factor functions within a network of interacting haematopoietic transcription factors.
Turner J, Crossley M.
Int J Biochem Cell Biol 31(10):1169-74. Review. 1999
38KLF1
Chromatin structure and transcriptional control elements of the erythroid Kruppel-like factor (EKLF) gene.
Chen X, et al.
J Biol Chem 273 : 25031-25040. 1998
39KLF1, LCR-HB-B@
Altered DNA-binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of the beta-globin locus control region in vivo.
Gillemans N, Tewari R, Lindeboom F, Rottier R, de Wit T, Wijgerde M, Grosveld F, Philipsen S.
Genes Dev 12(18):2863-73. 1998
40KLF1, SMARCB1, SMARCC1, SMARCC2
A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro.
Armstrong JA, Bieker JJ, Emerson BM.
Cell 95(1):93-104. 1998
41KLF1
The human erythroid-specific transcription factor EKLF localizes to chromosome 19p13.12-p13.13.
Van Ree JH, et al.
Genomics 39 : 393-395. 1997
42KLF1
The role of EKLF in human beta-globin gene competition.
Wijgerde M, et al.
Genes Dev 10 : 2894-2902. 1996
43KLF1
Isolation, genomic structure, and expression of human erythroid KrŸppel-like factor (EKLF).
Bieker JJ.
DNA Cell Biol 15 : 347-352. 1996
44KLF1, KLF2
Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Kruppel-like factor: identification of a new multigene family.
Anderson KP, Kern CB, Crable SC, Lingrel JB.
Mol Cell Biol 15(11):5957-65 1995