1 | DGKE, KL, KLF15
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| Diacylglycerol kinase epsilon protects against renal ischemia/reperfusion injury in mice through Krüppel-like factor 15/klotho pathway.
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| Wang Z, Zhou Z, Zhang Y, Zuo F, Du J, Wang M, Hu M, Sun Y, Wang X, Liu M, Zhang Y, Tang W, Yi F.
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| Ren Fail. Dec;44(1):902-913. doi: 10.1080/0886022X.2022.2079524. 2022
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2 | FGF23, KL
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| FGF23-klotho signaling axis in the kidney.
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| Erben RG, Andrukhova O.
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| Bone one. 2016 Sep 10. pii: S8756-3282(16)30256-3. doi: 10.1016/j.bone.2016.09.010. [Epub ahead of print] Review.
2016
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3 | KL, SIRT1
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| Activation of SIRT1 Attenuates Klotho Deficiency-Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity.
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| Gao D, Zuo Z, Tian J, Ali Q, Lin Y, Lei H, Sun Z.
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| Hypertension ypertension. 2016 Sep 12. pii: HYPERTENSIONAHA.116.07709. [Epub ahead of print]
2016
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4 | KL
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| Differential Regulatory Role of Soluble Klothos on Cardiac Fibrogenesis in Hypertension.
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| Liu X, Chen Y, McCoy CW, Zhao T, Quarles DL, Pi M, Bhattacharya SK, King G, Sun Y.
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| Am J Hypertens 29(10):1140-7. doi: 10.1093/ajh/hpw062. Epub 2016 Aug 19.
2016
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5 | FGF23, KL
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| Soluble Klotho and fibroblast growth factor 23 levels in diabetic nephropathy with different stages of albuminuria.
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| Inci A, Sari F, Coban M, Olmaz R, Dolu S, Sarıkaya M, Yılmaz N.
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| J Investig Med 64(6):1128-33. doi: 10.1136/jim-2016-000142. Epub 2016 Jun 20.
2016
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6 | KL
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| In vivo evidence for a limited role of proximal tubular Klotho in renal phosphate handling.
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| Ide N, Olauson H, Sato T, Densmore MJ, Wang H, Hanai J, Larsson TE, Lanske B.
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| Kidney Int 90(2):348-62. doi: 10.1016/j.kint.2016.04.009. Epub 2016 Jun 9.
2016
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7 | KL
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| Role of Klotho in migration and proliferation of human dermal microvascular endothelial cells.
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| Markiewicz M, Panneerselvam K, Marks N.
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| Microvasc Res 107:76-82. doi: 10.1016/j.mvr.2016.05.005. Epub 2016 May 31.
2016
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8 | KL
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| Klotho gene silencing promotes pathology in the mdx mouse model of Duchenne muscular dystrophy.
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| Wehling-Henricks M, Li Z, Lindsey C, Wang Y, Welc SS, Ramos JN, Khanlou N, Kuro-O M, Tidball JG.
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| Hum Mol Genet um Mol Genet. 2016 May 6. pii: ddw111. [Epub ahead of print]
2016
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9 | KL, SLC1A2, SLC1A3
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| Up-Regulation of Excitatory Amino Acid Transporters EAAT1 and EAAT2 by ß-Klotho.
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| Warsi J, Abousaab A, Lang F.
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| Neurosignals 23(1):59-70. doi: 10.1159/000442604. Epub 2015 Dec 19.
2015
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10 | KL
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| Klotho Ameliorates Kidney Injury and Fibrosis and Normalizes Blood Pressure by Targeting the Renin-Angiotensin System.
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| Zhou L, Mo H, Miao J, Zhou D, Tan RJ, Hou FF, Liu Y.
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| Am J Pathol 185(12):3211-23. doi: 10.1016/j.ajpath.2015.08.004. Epub 2015 Oct 24.
2015
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11 | KL
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| Klotho, stem cells, and aging.
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| Bian A, Neyra JA, Zhan M, Hu MC.
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| Clin Interv Aging 10:1233-43. doi: 10.2147/CIA.S84978. eCollection 2015. Review.
2015
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12 | KL
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| α-Klotho Expression in Human Tissues.
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| Lim K, Groen A, Molostvov G, Lu T, Lilley KS, Snead D, James S, Wilkinson IB, Ting S, Hsiao LL, Hiemstra TF, Zehnder D.
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| J Clin Endocrinol Metab 100(10):E1308-18. doi: 10.1210/jc.2015-1800. Epub 2015 Aug 17.
2015
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13 | CDKN2A, KL
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| Ablation of the p16(INK4a) tumour suppressor reverses ageing phenotypes of klotho mice.
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| Sato S, Kawamata Y, Takahashi A, Imai Y, Hanyu A, Okuma A, Takasugi M, Yamakoshi K, Sorimachi H, Kanda H, Ishikawa Y, Sone S, Nishioka Y, Ohtani N, Hara E.
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| Nat Commun 6:7035. doi: 10.1038/ncomms8035.
2015
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14 | KL
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| Molecular basis of Klotho: from gene to function in aging.
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| Xu Y, Sun Z.
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| Endocr Rev 36(2):174-93. doi: 10.1210/er.2013-1079. Epub 2015 Feb 19. Review.
2015
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15 | KL
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| Intracellular signaling of the aging suppressor protein Klotho.
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| Sopjani M, Rinnerthaler M, Kruja J, Dermaku-Sopjani M.
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| Curr Mol Med 15(1):27-37. Review.
2015
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16 | KL, MTOR
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| Mammalian target of rapamycin signaling inhibition ameliorates vascular calcification via Klotho upregulation.
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| Zhao Y, Zhao MM, Cai Y, Zheng MF, Sun WL, Zhang SY, Kong W, Gu J, Wang X, Xu MJ.
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| Kidney Int 88(4):711-21. doi: 10.1038/ki.2015.160. Epub 2015 Jun 10.
2015
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17 | B3GAT1, KL
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| α-Klotho mice demonstrate increased expression of the non-sulfated N-glycan form of the HNK-1 glyco-epitope in kidney tissue.
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| Akasaka-Manya K, Manya H, Kizuka Y, Oka S, Endo T.
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| J Biochem 156(2):107-13. doi: 10.1093/jb/mvu024. Epub 2014 Apr 9.
2014
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18 | KL, SLC6A8
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| Upregulation of the creatine transporter Slc6A8 by Klotho.
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| Almilaji A, Sopjani M, Elvira B, Borras J, Dërmaku-Sopjani M, Munoz C, Warsi J, Lang UE, Lang F.
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| Kidney Blood Press Res 39(6):516-25. doi: 10.1159/000368462. Epub 2014 Nov 29.
2014
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19 | KL
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| The role of klotho on vascular calcification and endothelial function in chronic kidney disease.
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| Vervloet MG, Adema AY, Larsson TE, Massy ZA.
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| Semin Nephrol 34(6):578-85. doi: 10.1016/j.semnephrol.2014.09.003. Review.
2014
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20 | KL
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| Regulation of cellular transport by klotho protein.
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| Sopjani M, Rinnerthaler M, Almilaji A, Ahmeti S, Dermaku-Sopjani M.
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| Curr Protein Pept Sci 15(8):828-35. Review.
2014
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21 | KL
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| Alpha Klotho and phosphate homeostasis.
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| Bian A, Xing C, Hu MC.
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| J Endocrinol Invest 37(11):1121-6. doi: 10.1007/s40618-014-0158-6. Epub 2014 Sep 7. Review. No abstract available.
2014
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22 | KL
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| α-Klotho protects against oxidative damage in pulmonary epithelia.
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| Ravikumar P, Ye J, Zhang J, Pinch SN, Hu MC, Kuro-o M, Hsia CC, Moe OW.
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| Am J Physiol Lung Cell Mol Physiol 307(7):L566-75. doi: 10.1152/ajplung.00306.2013. Epub 2014 Jul 25.
2014
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23 | KL
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| Klotho deficiency disrupts hematopoietic stem cell development and erythropoiesis.
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| Vadakke Madathil S, Coe LM, Casu C, Sitara D.
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| Am J Pathol 184(3):827-41. doi: 10.1016/j.ajpath.2013.11.016. Epub 2014 Jan 8.
2014
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24 | KL
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| Reduced Klotho is associated with the presence and severity of coronary artery disease.
|
| Navarro-González JF, Donate-Correa J, Muros de Fuentes M, Pérez-Hernández H, Martínez-Sanz R, Mora-Fernández C.
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| Heart 100(1):34-40. doi: 10.1136/heartjnl-2013-304746. Epub 2013 Oct 28.
2014
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25 | KCNE1, KCNQ1, KL
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| Upregulation of KCNQ1/KCNE1 K+ channels by Klotho.
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| Almilaji A, Pakladok T, Muńoz C, Elvira B, Sopjani M, Lang F.
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| Channels (Austin) 8(3):222-9.
2014
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26 | FGF23, FGFR3, KL
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| FGF23 suppresses chondrocyte proliferation in the presence of soluble α-Klotho both in vitro and in vivo.
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| Kawai M, Kinoshita S, Kimoto A, Hasegawa Y, Miyagawa K, Yamazaki M, Ohata Y, Ozono K, Michigami T.
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| J Biol Chem 288(4):2414-27. doi: 10.1074/jbc.M112.410043. Epub 2012 Dec 12.
2013
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27 | FGF23, KL, TRPV5
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| The epithelial calcium channel TRPV5 is regulated differentially by klotho and sialidase.
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| Leunissen EH, Nair AV, Büll C, Lefeber DJ, van Delft FL, Bindels RJ, Hoenderop JG.
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| J Biol Chem 288(41):29238-46. doi: 10.1074/jbc.M113.473520. Epub 2013 Aug 22.
2013
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28 | KL
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| Elevated Klotho promoter methylation is associated with severity of chronic kidney disease.
|
| Chen J, Zhang X, Zhang H, Lin J, Zhang C, Wu Q, Ding X.
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| PLoS One 8(11):e79856. doi: 10.1371/journal.pone.0079856. eCollection 2013.
2013
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29 | KL
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| Klotho regulates retinal pigment epithelial functions and protects against oxidative stress.
|
| Kokkinaki M, Abu-Asab M, Gunawardena N, Ahern G, Javidnia M, Young J, Golestaneh N.
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| J Neurosci 33(41):16346-59. doi: 10.1523/JNEUROSCI.0402-13.2013.
2013
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30 | KL
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| The age-regulating protein klotho is vital to sustain retinal function.
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| Reish NJ, Maltare A, McKeown AS, Laszczyk AM, Kraft TW, Gross AK, King GD.
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| Invest Ophthalmol Vis Sci 54(10):6675-85. doi: 10.1167/iovs.13-12550.
2013
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31 | KL, SLC1A1, SLC1A6
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| Klotho sensitivity of the neuronal excitatory amino acid transporters EAAT3 and EAAT4.
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| Almilaji A, Munoz C, Pakladok T, Alesutan I, Feger M, Föller M, Lang UE, Shumilina E, Lang F.
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| PLoS One 8(7):e70988. doi: 10.1371/journal.pone.0070988. Print 2013.
2013
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32 | KL
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| Retinitis Pigmentosa: over-expression of anti-ageing protein Klotho in degenerating photoreceptors.
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| Farinelli P, Arango-Gonzalez B, Völkl J, Alesutan I, Lang F, Zrenner E, Paquet-Durand F, Ekström PA.
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| J Neurochem 127(6):868-79. doi: 10.1111/jnc.12353. Epub 2013 Jul 22.
2013
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33 | KL
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| Klotho ameliorates chemically induced endoplasmic reticulum (ER) stress signaling.
|
| Banerjee S, Zhao Y, Sarkar PS, Rosenblatt KP, Tilton RG, Choudhary S.
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| Cell Physiol Biochem 31(4-5):659-72. doi: 10.1159/000350085. Epub 2013 May 8.
2013
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34 | KL
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| The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS.
|
| Chen CD, Sloane JA, Li H, Aytan N, Giannaris EL, Zeldich E, Hinman JD, Dedeoglu A, Rosene DL, Bansal R, Luebke JI, Kuro-o M, Abraham CR.
|
| J Neurosci 33(5):1927-39. doi: 10.1523/JNEUROSCI.2080-12.2013.
2013
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35 | KL
|
| Klotho modulates the stress response in human senescent endothelial cells.
|
| Carracedo J, Buendía P, Merino A, Madueńo JA, Peralbo E, Ortiz A, Martín-Malo A, Aljama P, Rodríguez M, Ramírez R.
|
| Mech Ageing Dev 133(11-12):647-54. doi: 10.1016/j.mad.2012.09.002. Epub 2012 Sep 21.
2012
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36 | FGF23, KL
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| Targeted deletion of Klotho in kidney distal tubule disrupts mineral metabolism.
|
| Olauson H, Lindberg K, Amin R, Jia T, Wernerson A, Andersson G, Larsson TE.
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| J Am Soc Nephrol 23(10):1641-51. Epub 2012 Aug 9.
2012
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37 | KL
|
| Re: Klotho: a novel regulator of calcium and phosphorus homeostasis.
|
| Assimos D.
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| J Urol 187(4):1298-9. No abstract available.
2012
|
38 | DDX58, KL
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| Klotho suppresses RIG-I-mediated senescence-associated inflammation.
|
| Liu F, Wu S, Ren H, Gu J.
|
| Nat Cell Biol 13(3):254-62. Epub 2011 Feb 20. Erratum in: Nat Cell Biol. 2011 Apr;13(4):487.
2011
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39 | KL
|
| Regulation of the Na+/K+ ATPase by Klotho.
|
| Sopjani M, Alesutan I, Dërmaku-Sopjani M, Gu S, Zelenak C, Munoz C, Velic A, Föller M, Rosenblatt KP, Kuro-o M, Lang F.
|
| FEBS Lett 585(12):1759-64. Epub 2011 May 19.
2011
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40 | KL
|
| Functional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin.
|
| Wolf I, Laitman Y, Rubinek T, Abramovitz L, Novikov I, Beeri R, Kuro-O M, Koeffler HP, Catane R, Freedman LS, Levy-Lahad E, Karlan BY, Friedman E, Kaufman B.
|
| Oncogene 29(1):26-33. Epub 2009 Oct 5.PMID: 19802015 2010
|
41 | KL, KLB
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| Relevant use of Klotho in FGF19 subfamily signaling system in vivo.
|
| Tomiyama K, Maeda R, Urakawa I, Yamazaki Y, Tanaka T, Ito S, Nabeshima Y, Tomita T, Odori S, Hosoda K, Nakao K, Imura A, Nabeshima Y.
|
| Proc Natl Acad Sci U S A 107(4):1666-71. Epub 2010 Jan 8.PMID: 20080590 2010
|
42 | KDR, KL, TRPC1
|
| Klotho is associated with VEGF receptor-2 and the transient receptor potential canonical-1 Ca2+ channel to maintain endothelial integrity.
|
| Kusaba T, Okigaki M, Matui A, Murakami M, Ishikawa K, Kimura T, Sonomura K, Adachi Y, Shibuya M, Shirayama T, Tanda S, Hatta T, Sasaki S, Mori Y, Matsubara H.
|
| Proc Natl Acad Sci U S A 107(45):19308-13. Epub 2010 Oct 21.
2010
|
43 | KCNJ1, KL
|
| Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho.
|
| Cha SK, Hu MC, Kurosu H, Kuro-o M, Moe O, Huang CL.
|
| Mol Pharmacol 76(1):38-46. Epub 2009 Apr 6.
2009
|
44 | FGF19, KL, KLB
|
| C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors.
|
| Wu X, Lemon B, Li X, Gupte J, Weiszmann J, Stevens J, Hawkins N, Shen W, Lindberg R, Chen JL, Tian H, Li Y.
|
| J Biol Chem 283(48):33304-9. Epub 2008 Oct 1.
2008
|
45 | BCL2, DLEC1, HOXA1, HOXA10, KL, NR3C1, SEZ6L, SFRP4, SFRP5, SMAD9, TWIST1
|
| DNA methylation profiles of gastric carcinoma characterized by quantitative DNA methylation analysis.
|
| Kang GH, Lee S, Cho NY, Gandamihardja T, Long TI, Weisenberger DJ, Campan M, Laird PW.
|
| Lab Invest 88(2):161-70. Epub 2007 Dec 24.
2008
|
46 | KL
|
| Klotho as a regulator of oxidative stress and senescence.
|
| Kuro-o M.
|
| Biol Chem 389(3):233-41. Review.PMID: 18177265 2008
|
47 | KL
|
| alpha-Klotho as a regulator of calcium homeostasis.
|
| Imura A, Tsuji Y, Murata M, Maeda R, Kubota K, Iwano A, Obuse C, Togashi K, Tominaga M, Kita N, Tomiyama K, Iijima J, Nabeshima Y, Fujioka M, Asato R, Tanaka S, Kojima K, Ito J, Nozaki K, Hashimoto N, Ito T, Nishio T, Uchiyama T, Fujimori T, Nabeshima Y.
|
| Science 316(5831):1615-8. 2007
|
48 | KL, ADAM10, ADAM17
|
| Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17.
|
| Chen CD, Podvin S, Gillespie E, Leeman SE, Abraham CR.
|
| Proc Natl Acad Sci U S A 104(50):19796-801. Epub 2007 Dec 3. 2007
|
49 | KL
|
| Klotho gene polymorphism and male bone mass.
|
| Zarrabeitia MT, Hernández JL, Valero C, Zarrabeitia AL, Ortiz F, Gonzalez-Macias J, Riancho JA.
|
| Calcif Tissue Int 80(1):10-4. Epub 2007 Jan 4.
2007
|
50 | FGF23, KL
|
| Klotho converts canonical FGF receptor into a specific receptor for FGF23.
|
| Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, Fujita T, Fukumoto S, Yamashita T.
|
| Nature 444(7120):770-4. Epub 2006 Oct 29. 2006
|
51 | KL
|
| Relationship between polymorphisms G395A in promoter and C1818T in exon 4 of the KLOTHO gene with glucose metabolism and cardiovascular risk factors in Korean women.
|
| Rhee EJ, Oh KW, Yun EJ, Jung CH, Lee WY, Kim SW, Baek KH, Kang MI, Park SW.
|
| J Endocrinol Invest 29(7):613-8. 2006
|
52 | KL
|
| Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway.
|
| de Oliveira RM.
|
| FEBS Lett 580(24):5753-8. Epub 2006 Sep 27. 2006
|
53 | KL
|
| Klotho protein promotes adipocyte differentiation.
|
| Chihara Y, Rakugi H, Ishikawa K, Ikushima M, Maekawa Y, Ohta J, Kida I, Ogihara T.
|
| Endocrinology 147(8):3835-42. Epub 2006 May 18. 2006
|
54 | KL
|
| Klotho is a genetic risk factor for ischemic stroke caused by cardioembolism in Korean females.
|
| Kim Y, Kim JH, Nam YJ, Kong M, Kim YJ, Yu KH, Lee BC, Lee C.
|
| Neurosci Lett 407(3):189-94. Epub 2006 Sep 14.
2006
|
55 | KL
|
| The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel.
|
| Chang Q, Hoefs S, van der Kemp AW, Topala CN, Bindels RJ, Hoenderop JG.
|
| Science 310(5747):490-3. 2005
|
56 | KL
|
| Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis.
|
| Baldwin C, Nolan VG, Wyszynski DF, Ma QL, Sebastiani P, Embury SH, Bisbee A, Farrell J, Farrer L, Steinberg MH.
|
| Blood 106(1):372-5. Epub 2005 Mar 22. 2005
|
57 | KL
|
| Klotho gene polymorphisms are associated with osteocalcin levels but not bone density of aged postmenopausal women.
|
| Mullin BH, Wilson SG, Islam FM, Calautti M, Dick IM, Devine A, Prince RL.
|
| Calcif Tissue Int 77(3):145-51. Epub 2005 Sep 8. 2005
|
58 | KL
|
| Genetic influences on life span and survival among elderly African-Americans, Caribbean Hispanics, and Caucasians.
|
| Lee JH, Flaquer A, Costa R, Andrews H, Cross P, Lantigua R, Schupf N, Tang MX, Mayeux R.
|
| Am J Med Genet 128A(2):159-64. 2004
|
59 | KL
|
| KLOTHO allele status and the risk of early-onset occult coronary artery disease.
|
| Arking DE, Becker DM, Yanek LR, Fallin D, Judge DP, Moy TF, Becker LC, Dietz HC.
|
| Am J Hum Genet 72(5):1154-61. Epub 2003 Mar 31. 2003
|
60 | KL, STC1, STC2
|
| Regulation of stanniocalcin 1 and 2 expression in the kidney by klotho gene.
|
| Yahata K, Mori K, Mukoyama M, Sugawara A, Suganami T, Makino H, Nagae T, Fujinaga Y, Nabeshima Y, Nakao K.
|
| Biochem Biophys Res Commun 310(1):128-34. 2003
|
61 | KL
|
| Association of klotho gene polymorphism with bone density and spondylosis of the lumbar spine in postmenopausal women.
|
| Ogata N, Matsumura Y, Shiraki M, Kawano K, Koshizuka Y, Hosoi T, Nakamura K, Kuro-O M, Kawaguchi H.
|
| Bone 31(1):37-42. 2002
|
62 | KL
|
| Klotho gene polymorphisms associated with bone density of aged postmenopausal women.
|
| Kawano K, Ogata N, Chiano M, Molloy H, Kleyn P, Spector TD, Uchida M, Hosoi T, Suzuki T, Orimo H, Inoue S, Nabeshima Y, Nakamura K, Kuro-o M, Kawaguchi H.
|
| J Bone Miner Res 17(10):1744-51. 2002
|
63 | KL
|
| Klotho protein deficiency leads to overactivation of mu-calpain.
|
| Manya H, Inomata M, Fujimori T, Dohmae N, Sato Y, Takio K, Nabeshima Y, Endo T.
|
| J Biol Chem 277(38):35503-8. Epub 2002 Jul 15. 2002
|
64 | KL
|
| Regulation of angiogenesis by the aging suppressor gene klotho.
|
| Fukino K, Suzuki T, Saito Y, Shindo T, Amaki T, Kurabayashi M, Nagai R.
|
| Biochem Biophys Res Commun 293(1):332-7. 2002
|
65 | KL
|
| Association of human aging with a functional variant of klotho.
|
| Arking DE, Krebsova A, Macek M Sr, Macek M Jr, Arking A, Mian IS, Fried L, Hamosh A, Dey S, McIntosh I, Dietz HC.
|
| Proc Natl Acad Sci U S A 99(2):856-61. Epub 2002 Jan 15. 2002
|
66 | KL
|
| Severely reduced production of klotho in human chronic renal failure kidney.
|
| Koh N, Fujimori T, Nishiguchi S, Tamori A, Shiomi S, Nakatani T, Sugimura K, Kishimoto T, Kinoshita S, Kuroki T, Nabeshima Y.
|
| Biochem Biophys Res Commun 280(4):1015-20. 2001
|
67 | KL
|
| Disruption of klotho gene causes an abnormal energy homeostasis in mice.
|
| Mori K, Yahata K, Mukoyama M, Suganami T, Makino H, Nagae T, Masuzaki H, Ogawa Y, Sugawara A, Nabeshima Y, Nakao K.
|
| Biochem Biophys Res Commun 278(3):665-70. 2000
|
68 | KL
|
| Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein.
|
| Matsumura Y, et al.
|
| Biochem Biophys Res Commun 242(3):626-30. 1998
|
69 | KL
|
| Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
|
| Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima YI.
|
| Nature 390(6655):45-51. 1997
|