Citations for
1KDM6B
The ERα/KDM6B regulatory axis modulates osteogenic differentiation in human mesenchymal stem cells.
Liu Z, Lee HL, Suh JS, Deng P, Lee CR, Bezouglaia O, Mirnia M, Chen V, Zhou M, Cui ZK, Kim RH, Lee M, Aghaloo T, Hong C, Wang CY.
Bone Res. Jan 7;10(1):3. doi: 10.1038/s41413-021-00171-z. 2022
2KDM6B
KDM6B (JMJD3) and its dual role in cancer. 2021 PMID:
Lagunas-Rangel FA.
Biochimie. May;184:63-71. doi: 10.1016/j.biochi.2021.02.005. Epub 2021 Feb 11. 2021
3CEBPB, KDM6B
KDM6B promotes ESCC cell proliferation and metastasis by facilitating C/EBPβ transcription
Qin M, Han F, Wu J, Gao FX, Li Y, Yan DX, He XM, Long Y, Tang XP, Ren DL, Gao Y, Dai TY.
BMC Cancer. May 17;21(1):559. doi: 10.1186/s12885-021-08282-w. Erratum in: BMC Cancer. 2021 Aug 5;21(1):893. 2021
4KDM6B
Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms.
Davis FM, Tsoi LC, Melvin WJ, denDekker A, Wasikowski R, Joshi AD, Wolf S, Obi AT, Billi AC, Xing X, Audu C, Moore BB, Kunkel SL, Daugherty A, Lu HS, Gudjonsson JE, Gallagher KA.
J Exp Med. Jun 7;218(6):e20201839. doi: 10.1084/jem.20201839. 2021
5KDM6B, KLF4
JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency.
Huang Y, Zhang H, Wang L, Tang C, Qin X, Wu X, Pan M, Tang Y, Yang Z, Babarinde IA, Lin R, Ji G, Lai Y, Xu X, Su J, Wen X, Satoh T, Ahmed T, Malik V, Ward C, Volpe G, Guo L, Chen J, Sun L, Li Y, Huang X, Bao X, Gao F, Liu B, Zheng H, Jauch R, Lai L, Pan G, Chen J, Testa G, Akira S, Hu J, Pei D, Hutchins AP, Esteban MA, Qin B.
Nat Commun. Oct 8;11(1):5061. doi: 10.1038/s41467-020-18900-z. 2020
6KDM6B, NEDCFSA
Genetic variants in the KDM6B gene are associated with neurodevelopmental delays and dysmorphic features
Stolerman ES, Francisco E, Stallworth JL, Jones JR, Monaghan KG, Keller-Ramey J, Person R, Wentzensen IM, McWalter K, Keren B, Heron B, Nava C, Heron D, Kim K, Burton B, Al-Musafri F, O'Grady L, Sahai I, Escobar LF, Meuwissen M, Reyniers E, Kooy F, Lacassie Y, Gunay-Aygun M, Schatz KS, Hochstenbach R, Zwijnenburg PJG, Waisfisz Q, van Slegtenhorst M, Mancini GMS, Louie RJ.
Am J Med Genet A. Jul;179(7):1276-1286. doi: 10.1002/ajmg.a.61173. Epub 2019 May 23. 2019
7KDM6B
Histone demethylase KDM6B regulates human podocyte differentiation in vitro
Guo Y, Xiong Z, Guo X.
Biochem J. Jun 26;476(12):1741-1751. doi: 10.1042/BCJ20180968. 2019
8KDM6B
Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiation
Yang L, Zha Y, Ding J, Ye B, Liu M, Yan C, Dong Z, Cui H, Ding HF.
Oncogenesis. Jan 4;8(1):3. doi: 10.1038/s41389-018-0112-0. 2019
9KDM6B
The histone demethylase Kdm6b regulates a mature gene expression program in differentiating cerebellar granule neurons
Wijayatunge R, Liu F, Shpargel KB, Wayne NJ, Chan U, Boua JV, Magnuson T, West AE.
Mol Cell Neurosci. Mar;87:4-17. doi: 10.1016/j.mcn.2017.11.005. Epub 2017 Dec 15. 2018
10KDM6B
Kdm6b regulates cartilage development and homeostasis through anabolic metabolism
Dai J, Yu D, Wang Y, Chen Y, Sun H, Zhang X, Zhu S, Pan Z, Heng BC, Zhang S, Ouyang H.
Ann Rheum Dis. Jul;76(7):1295-1303. doi: 10.1136/annrheumdis-2016-210407. Epub 2017 Mar 17. 2017
11KDM6B
The Prognostic Significance of Histone Lysine Demethylase JMJD3/KDM6B in Colorectal Cancer
Tokunaga R, Sakamoto Y, Nakagawa S, Miyake K, Izumi D, Kosumi K, Taki K, Higashi T, Imamura Y, Ishimoto T, Iwatsuki M, Baba Y, Miyamoto Y, Yoshida N, Oki E, Watanabe M, Baba H.
Ann Surg Oncol. Feb;23(2):678-85. doi: 10.1245/s10434-015-4879-3. Epub 2015 Sep 28. 2016
12KDM6B
The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation.
Liu Z, Cao W, Xu L, Chen X, Zhan Y, Yang Q, Liu S, Chen P, Jiang Y, Sun X, Tao Y, Hu Y, Li C, Wang Q, Wang Y, Chen CD, Shi Y, Zhang X.
J Mol Cell Biol Mol Cell Biol. 2015 Apr 3. pii: mjv022. [Epub ahead of print] 2015
13KDM6B, RB1
JMJD3 promotes SAHF formation in senescent WI38 cells by triggering an interplay between demethylation and phosphorylation of RB protein.
Zhao L, Zhang Y, Gao Y, Geng P, Lu Y, Liu X, Yao R, Hou P, Liu D, Lu J, Huang B.
Cell Death Differ ell Death Differ. 2015 Feb 20. doi: 10.1038/cdd.2015.6. [Epub ahead of print] 2015
14KDM6B, RUNX2
JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice.
Zhang F, Xu L, Xu L, Xu Q, Li D, Yang Y, Karsenty G, Chen CD.
J Mol Cell Biol 7(1):23-34. doi: 10.1093/jmcb/mjv003. Epub 2015 Jan 13. 2015
15KDM6A, KDM6B
Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation.
Manna S, Kim JK, Baugé C, Cam M, Zhao Y, Shetty J, Vacchio MS, Castro E, Tran B, Tessarollo L, Bosselut R.
Nat Commun 6:8152. doi: 10.1038/ncomms9152. 2015
16KDM6B
Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation.
Li Q, Zou J, Wang M, Ding X, Chepelev I, Zhou X, Zhao W, Wei G, Cui J, Zhao K, Wang HY, Wang RF.
Nat Commun 5:5780. doi: 10.1038/ncomms6780. 2014
17KDM6B
Stage-dependent and locus-specific role of histone demethylase Jumonji D3 (JMJD3) in the embryonic stages of lung development.
Li Q, Wang HY, Chepelev I, Zhu Q, Wei G, Zhao K, Wang RF.
PLoS Genet 10(7):e1004524. doi: 10.1371/journal.pgen.1004524. eCollection 2014 Jul. 2014
18KDM6B
The histone lysine demethylase Kdm6b is required for activity-dependent preconditioning of hippocampal neuronal survival.
Wijayatunge R, Chen LF, Cha YM, Zannas AS, Frank CL, West AE.
Mol Cell Neurosci 61:187-200. doi: 10.1016/j.mcn.2014.06.008. Epub 2014 Jun 28. 2014
19KDM6A, KDM6B
KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development.
Shpargel KB, Starmer J, Yee D, Pohlers M, Magnuson T.
PLoS Genet 10(8):e1004507. doi: 10.1371/journal.pgen.1004507. 2014
20KDM6A, KDM6B, UTY
Human UTY(KDM6C) is a male-specific Nϵ-methyl lysyl demethylase.
Walport LJ, Hopkinson RJ, Vollmar M, Madden SK, Gileadi C, Oppermann U, Schofield CJ, Johansson C.
J Biol Chem 289(26):18302-13. doi: 10.1074/jbc.M114.555052. 2014
21KDM6B, PHF20, TRIM26
Jmjd3 inhibits reprogramming by upregulating expression of INK4a/Arf and targeting PHF20 for ubiquitination.
Zhao W, Li Q, Ayers S, Gu Y, Shi Z, Zhu Q, Chen Y, Wang HY, Wang RF.
Cell 152(5):1037-50. doi: 10.1016/j.cell.2013.02.006. 2013
22DKK1, KDM6A, KDM6B, WNT3
Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway.
Jiang W, Wang J, Zhang Y.
Cell Res 23(1):122-30. doi: 10.1038/cr.2012.119. Epub 2012 Aug 21. 2013
23BGLAP, IBSP, KDM6B, RUNX2, SP7
Histone demethylase Jmjd3 regulates osteoblast differentiation via transcription factors Runx2 and osterix.
Yang D, Okamura H, Nakashima Y, Haneji T.
J Biol Chem 288(47):33530-41. doi: 10.1074/jbc.M113.497040. Epub 2013 Oct 8. 2013
24KDM6B
H3K27 demethylase, JMJD3, regulates fragmentation of spermatogonial cysts.
Iwamori N, Iwamori T, Matzuk MM.
PLoS One 8(8):e72689. doi: 10.1371/journal.pone.0072689. eCollection 2013. 2013
25KDM6B
Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells.
Ohtani K, Zhao C, Dobreva G, Manavski Y, Kluge B, Braun T, Rieger MA, Zeiher AM, Dimmeler S.
Circ Res 113(7):856-62. doi: 10.1161/CIRCRESAHA.113.302035. Epub 2013 Jul 15. 2013
26KDM6B
RNA polymerase II progression through H3K27me3-enriched gene bodies requires JMJD3 histone demethylase.
Estarás C, Fueyo R, Akizu N, Beltrán S, Martínez-Balbás MA.
Mol Biol Cell 24(3):351-60. doi: 10.1091/mbc.E12-07-0561. Epub 2012 Dec 14. 2013
27KDM6B
EED and KDM6B coordinate the first mammalian cell lineage commitment to ensure embryo implantation
Saha B, Home P, Ray S, Larson M, Paul A, Rajendran G, Behr B, Paul S.
Mol Cell Biol. Jul;33(14):2691-705. doi: 10.1128/MCB.00069-13. Epub 2013 May 13. 2013
28KDM4B, KDM6B
Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs.
Ye L, Fan Z, Yu B, Chang J, Al Hezaimi K, Zhou X, Park NH, Wang CY.
Cell Stem Cell 11(1):50-61. doi: 10.1016/j.stem.2012.04.009. 2012
29EP300, KDM5A, KDM6A, KDM6B, KLF4, POU5F1
The EP300, KDM5A, KDM6A and KDM6B chromatin regulators cooperate with KLF4 in the transcriptional activation of POU5F1.
Wang WP, Tzeng TY, Wang JY, Lee DC, Lin YH, Wu PC, Chen YP, Chiu IM, Chi YH.
PLoS One 7(12):e52556. doi: 10.1371/journal.pone.0052556. Epub 2012 Dec 18. 2012
30KDM6B
Histone demethylase KDM6B promotes epithelial-mesenchymal transition.
Ramadoss S, Chen X, Wang CY.
J Biol Chem 287(53):44508-17. doi: 10.1074/jbc.M112.424903. Epub 2012 Nov 14. 2012
31KDM6A, KDM6B
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.
Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H, Eberhard D, Hutchinson S, Jones E, Katso R, Leveridge M, Mander PK, Mosley J, Ramirez-Molina C, Rowland P, Schofield CJ, Sheppard RJ, Smith JE, Swales C, Tanner R, Thomas P, Tumber A, Drewes G, Oppermann U, Patel DJ, Lee K, Wilson DM.
Nature 488(7411):404-8. doi: 10.1038/nature11262. 2012
32KDM6B, KDM7A, SUPT16H, SUPT6H
The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation.
Chen S, Ma J, Wu F, Xiong LJ, Ma H, Xu W, Lv R, Li X, Villen J, Gygi SP, Liu XS, Shi Y.
Genes Dev 26(12):1364-75. doi: 10.1101/gad.186056.111. 2012
33ITGA2B, KDM6B, MPL
Itga2b regulation at the onset of definitive hematopoiesis and commitment to differentiation.
Dumon S, Walton DS, Volpe G, Wilson N, Dassé E, Del Pozzo W, Landry JR, Turner B, O'Neill LP, Göttgens B, Frampton J.
PLoS One 7(8):e43300. doi: 10.1371/journal.pone.0043300. Epub 2012 Aug 28. 2012
34KDM6B, NFATC1
Epigenetic regulation of osteoclast differentiation: possible involvement of Jmjd3 in the histone demethylation of Nfatc1.
Yasui T, Hirose J, Tsutsumi S, Nakamura K, Aburatani H, Tanaka S.
J Bone Miner Res 26(11):2665-71. doi: 10.1002/jbmr.464. 2011
35KDM6A, KDM6B
Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression.
Miller SA, Mohn SE, Weinmann AS.
Mol Cell 40(4):594-605. 2010
36KDM6B
Jmjd3 contributes to the control of gene expression in LPS-activated macrophages.
De Santa F, Narang V, Yap ZH, Tusi BK, Burgold T, Austenaa L, Bucci G, Caganova M, Notarbartolo S, Casola S, Testa G, Sung WK, Wei CL, Natoli G.
EMBO J 28(21):3341-52. Epub 2009 Sep 24.PMID: 19779457 2009
37KDM6B
Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3.
Sen GL, Webster DE, Barragan DI, Chang HY, Khavari PA.
Genes Dev 22(14):1865-70.PMID: 18628393 2008
38HOXA11, KDM6B, RBBP5
The Histone H3 Lysine-27 Demethylase Jmjd3 Links Inflammation to Inhibition of Polycomb-Mediated Gene Silencing.
De Santa F, Totaro MG, Prosperini E, Notarbartolo S, Testa G, Natoli G.
Cell 130(6):1083-1094. Epub 2007 Sep 6. 2007
39KDM6A, KDM6B
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development.
Agger K, Cloos PA, Christensen J, Pasini D, Rose S, Rappsilber J, Issaeva I, Canaani E, Salcini AE, Helin K.
Nature 449(7163):731-4. Epub 2007 Aug 22. 2007
40KDM6A, KDM6B
Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases.
Hong S, Cho YW, Yu LR, Yu H, Veenstra TD, Ge K.
Proc Natl Acad Sci U S A 104(47):18439-44. Epub 2007 Nov 14. 2007
41KDM6A, KDM6B
A histone H3 lysine 27 demethylase regulates animal posterior development.
Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y.
Nature 449(7163):689-94. Epub 2007 Sep 12. 2007
42ALOX12, ATP1B2, CD68, CHD3, CHRNB1, EIF4A1, FGF11, FXR2, GUCY2D, KDM6B, NEUROD2, SHBG, TNFSF12, TNFSF13, TP53
Physical Map of 17p13 and the Genes Adjacent to p53.
Cousin P, Billotte J, Chaubert P, Shaw P.
Genomics 63(1):60-68. 2000