| 1 | KDM6B, NEDCFSA
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| The clinical and molecular spectrum of the KDM6B-related neurodevelopmental disorder.
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| Rots D, Jakub TE, Keung C, Jackson A, Banka S, Pfundt R, de Vries BBA, van Jaarsveld RH, Hopman SMJ, van Binsbergen E, Valenzuela I, Hempel M, Bierhals T, Kortüm F, Lecoquierre F, Goldenberg A, Hertz JM, Andersen CB, Kibćk M, Prijoles EJ, Stevenson RE, Everman DB, Patterson WG, Meng L, Gijavanekar C, De Dios K, Lakhani S, Levy T, Wagner M, Wieczorek D, Benke PJ, Lopez Garcia MS, Perrier R, Sousa SB, Almeida PM, Simőes MJ, Isidor B, Deb W, Schmanski AA, Abdul-Rahman O, Philippe C, Bruel AL, Faivre L, Vitobello A, Thauvin C, Smits JJ, Garavelli L, Caraffi SG, Peluso F, Davis-Keppen L, Platt D, Royer E, Leeuwen L, Sinnema M, Stegmann APA, Stumpel CTRM, Tiller GE, Bosch DGM, Potgieter ST, Joss S, Splitt M, Holden S, Prapa M, Foulds N, Douzgou S, Puura K, Waltes R, Chiocchetti AG, Freitag CM, Satterstrom FK, De Rubeis S, Buxbaum J, Gelb BD, Branko A, Kushima I, Howe J, Scherer SW, Arado A, Baldo C, Patat O, Bénédicte D, Lopergolo D, Santorelli FM, Haack TB, Dufke A, Bertrand M, Falb RJ, Rieß A, Krieg P, Spranger S, Bedeschi MF, Iascone M, Josephi-Taylor S, Roscioli T, Buckley MF, Liebelt J, Dagli AI, Aten E, Hurst ACE, Hicks A, Suri M, Aliu E, Naik S, Sidlow R, Coursimault J, Nicolas G, Küpper H, Petit F, Ibrahim V, Top D, Di Cara F; Genomics England Research Consortium; Louie RJ, Stolerman E, Brunner HG, Vissers LELM, Kramer JM, Kleefstra T
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| Am J Hum Genet. Jun 1;110(6):963-978. doi: 10.1016/j.ajhg.2023.04.008. Epub 2023 May 16. 2023
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| 2 | KDM6B
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| The ERα/KDM6B regulatory axis modulates osteogenic differentiation in human mesenchymal stem cells.
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| Liu Z, Lee HL, Suh JS, Deng P, Lee CR, Bezouglaia O, Mirnia M, Chen V, Zhou M, Cui ZK, Kim RH, Lee M, Aghaloo T, Hong C, Wang CY.
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| Bone Res. Jan 7;10(1):3. doi: 10.1038/s41413-021-00171-z. 2022
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| 3 | KDM6B
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| KDM6B (JMJD3) and its dual role in cancer. 2021 PMID:
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| Lagunas-Rangel FA.
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| Biochimie. May;184:63-71. doi: 10.1016/j.biochi.2021.02.005. Epub 2021 Feb 11. 2021
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| 4 | CEBPB, KDM6B
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| KDM6B promotes ESCC cell proliferation and metastasis by facilitating C/EBPβ transcription
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| Qin M, Han F, Wu J, Gao FX, Li Y, Yan DX, He XM, Long Y, Tang XP, Ren DL, Gao Y, Dai TY.
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| BMC Cancer. May 17;21(1):559. doi: 10.1186/s12885-021-08282-w. Erratum in: BMC Cancer. 2021 Aug 5;21(1):893. 2021
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| 5 | KDM6B
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| Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms.
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| Davis FM, Tsoi LC, Melvin WJ, denDekker A, Wasikowski R, Joshi AD, Wolf S, Obi AT, Billi AC, Xing X, Audu C, Moore BB, Kunkel SL, Daugherty A, Lu HS, Gudjonsson JE, Gallagher KA.
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| J Exp Med. Jun 7;218(6):e20201839. doi: 10.1084/jem.20201839. 2021
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| 6 | KDM6B, KLF4
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| JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency.
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| Huang Y, Zhang H, Wang L, Tang C, Qin X, Wu X, Pan M, Tang Y, Yang Z, Babarinde IA, Lin R, Ji G, Lai Y, Xu X, Su J, Wen X, Satoh T, Ahmed T, Malik V, Ward C, Volpe G, Guo L, Chen J, Sun L, Li Y, Huang X, Bao X, Gao F, Liu B, Zheng H, Jauch R, Lai L, Pan G, Chen J, Testa G, Akira S, Hu J, Pei D, Hutchins AP, Esteban MA, Qin B.
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| Nat Commun. Oct 8;11(1):5061. doi: 10.1038/s41467-020-18900-z. 2020
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| 7 | KDM6B, NEDCFSA
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| Genetic variants in the KDM6B gene are associated with neurodevelopmental delays and dysmorphic features
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| Stolerman ES, Francisco E, Stallworth JL, Jones JR, Monaghan KG, Keller-Ramey J, Person R, Wentzensen IM, McWalter K, Keren B, Heron B, Nava C, Heron D, Kim K, Burton B, Al-Musafri F, O'Grady L, Sahai I, Escobar LF, Meuwissen M, Reyniers E, Kooy F, Lacassie Y, Gunay-Aygun M, Schatz KS, Hochstenbach R, Zwijnenburg PJG, Waisfisz Q, van Slegtenhorst M, Mancini GMS, Louie RJ.
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| Am J Med Genet A. Jul;179(7):1276-1286. doi: 10.1002/ajmg.a.61173. Epub 2019 May 23. 2019
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| 8 | KDM6B
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| Histone demethylase KDM6B regulates human podocyte differentiation in vitro
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| Guo Y, Xiong Z, Guo X.
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| Biochem J. Jun 26;476(12):1741-1751. doi: 10.1042/BCJ20180968. 2019
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| 9 | KDM6B
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| Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiation
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| Yang L, Zha Y, Ding J, Ye B, Liu M, Yan C, Dong Z, Cui H, Ding HF.
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| Oncogenesis. Jan 4;8(1):3. doi: 10.1038/s41389-018-0112-0. 2019
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| 10 | KDM6B
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| The histone demethylase Kdm6b regulates a mature gene expression program in differentiating cerebellar granule neurons
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| Wijayatunge R, Liu F, Shpargel KB, Wayne NJ, Chan U, Boua JV, Magnuson T, West AE.
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| Mol Cell Neurosci. Mar;87:4-17. doi: 10.1016/j.mcn.2017.11.005. Epub 2017 Dec 15. 2018
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| 11 | KDM6B
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| Kdm6b regulates cartilage development and homeostasis through anabolic metabolism
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| Dai J, Yu D, Wang Y, Chen Y, Sun H, Zhang X, Zhu S, Pan Z, Heng BC, Zhang S, Ouyang H.
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| Ann Rheum Dis. Jul;76(7):1295-1303. doi: 10.1136/annrheumdis-2016-210407. Epub 2017 Mar 17. 2017
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| 12 | KDM6B
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| The Prognostic Significance of Histone Lysine Demethylase JMJD3/KDM6B in Colorectal Cancer
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| Tokunaga R, Sakamoto Y, Nakagawa S, Miyake K, Izumi D, Kosumi K, Taki K, Higashi T, Imamura Y, Ishimoto T, Iwatsuki M, Baba Y, Miyamoto Y, Yoshida N, Oki E, Watanabe M, Baba H.
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| Ann Surg Oncol. Feb;23(2):678-85. doi: 10.1245/s10434-015-4879-3. Epub 2015 Sep 28. 2016
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| 13 | KDM6B
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| The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation.
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| Liu Z, Cao W, Xu L, Chen X, Zhan Y, Yang Q, Liu S, Chen P, Jiang Y, Sun X, Tao Y, Hu Y, Li C, Wang Q, Wang Y, Chen CD, Shi Y, Zhang X.
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| J Mol Cell Biol Mol Cell Biol. 2015 Apr 3. pii: mjv022. [Epub ahead of print]
2015
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| 14 | KDM6B, RB1
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| JMJD3 promotes SAHF formation in senescent WI38 cells by triggering an interplay between demethylation and phosphorylation of RB protein.
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| Zhao L, Zhang Y, Gao Y, Geng P, Lu Y, Liu X, Yao R, Hou P, Liu D, Lu J, Huang B.
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| Cell Death Differ ell Death Differ. 2015 Feb 20. doi: 10.1038/cdd.2015.6. [Epub ahead of print]
2015
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| 15 | KDM6B, RUNX2
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| JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice.
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| Zhang F, Xu L, Xu L, Xu Q, Li D, Yang Y, Karsenty G, Chen CD.
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| J Mol Cell Biol 7(1):23-34. doi: 10.1093/jmcb/mjv003. Epub 2015 Jan 13.
2015
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| 16 | KDM6A, KDM6B
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| Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation.
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| Manna S, Kim JK, Baugé C, Cam M, Zhao Y, Shetty J, Vacchio MS, Castro E, Tran B, Tessarollo L, Bosselut R.
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| Nat Commun 6:8152. doi: 10.1038/ncomms9152.
2015
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| 17 | KDM6B
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| Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation.
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| Li Q, Zou J, Wang M, Ding X, Chepelev I, Zhou X, Zhao W, Wei G, Cui J, Zhao K, Wang HY, Wang RF.
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| Nat Commun 5:5780. doi: 10.1038/ncomms6780.
2014
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| 18 | KDM6B
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| Stage-dependent and locus-specific role of histone demethylase Jumonji D3 (JMJD3) in the embryonic stages of lung development.
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| Li Q, Wang HY, Chepelev I, Zhu Q, Wei G, Zhao K, Wang RF.
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| PLoS Genet 10(7):e1004524. doi: 10.1371/journal.pgen.1004524. eCollection 2014 Jul.
2014
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| 19 | KDM6B
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| The histone lysine demethylase Kdm6b is required for activity-dependent preconditioning of hippocampal neuronal survival.
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| Wijayatunge R, Chen LF, Cha YM, Zannas AS, Frank CL, West AE.
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| Mol Cell Neurosci 61:187-200. doi: 10.1016/j.mcn.2014.06.008. Epub 2014 Jun 28.
2014
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| 20 | KDM6A, KDM6B
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| KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development.
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| Shpargel KB, Starmer J, Yee D, Pohlers M, Magnuson T.
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| PLoS Genet 10(8):e1004507. doi: 10.1371/journal.pgen.1004507.
2014
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| 21 | KDM6A, KDM6B, UTY
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| Human UTY(KDM6C) is a male-specific Nϵ-methyl lysyl demethylase.
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| Walport LJ, Hopkinson RJ, Vollmar M, Madden SK, Gileadi C, Oppermann U, Schofield CJ, Johansson C.
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| J Biol Chem 289(26):18302-13. doi: 10.1074/jbc.M114.555052.
2014
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| 22 | KDM6B, PHF20, TRIM26
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| Jmjd3 inhibits reprogramming by upregulating expression of INK4a/Arf and targeting PHF20 for ubiquitination.
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| Zhao W, Li Q, Ayers S, Gu Y, Shi Z, Zhu Q, Chen Y, Wang HY, Wang RF.
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| Cell 152(5):1037-50. doi: 10.1016/j.cell.2013.02.006.
2013
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| 23 | DKK1, KDM6A, KDM6B, WNT3
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| Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway.
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| Jiang W, Wang J, Zhang Y.
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| Cell Res 23(1):122-30. doi: 10.1038/cr.2012.119. Epub 2012 Aug 21.
2013
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| 24 | BGLAP, IBSP, KDM6B, RUNX2, SP7
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| Histone demethylase Jmjd3 regulates osteoblast differentiation via transcription factors Runx2 and osterix.
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| Yang D, Okamura H, Nakashima Y, Haneji T.
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| J Biol Chem 288(47):33530-41. doi: 10.1074/jbc.M113.497040. Epub 2013 Oct 8.
2013
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| 25 | KDM6B
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| H3K27 demethylase, JMJD3, regulates fragmentation of spermatogonial cysts.
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| Iwamori N, Iwamori T, Matzuk MM.
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| PLoS One 8(8):e72689. doi: 10.1371/journal.pone.0072689. eCollection 2013.
2013
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| 26 | KDM6B
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| Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells.
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| Ohtani K, Zhao C, Dobreva G, Manavski Y, Kluge B, Braun T, Rieger MA, Zeiher AM, Dimmeler S.
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| Circ Res 113(7):856-62. doi: 10.1161/CIRCRESAHA.113.302035. Epub 2013 Jul 15.
2013
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| 27 | KDM6B
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| RNA polymerase II progression through H3K27me3-enriched gene bodies requires JMJD3 histone demethylase.
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| Estarás C, Fueyo R, Akizu N, Beltrán S, Martínez-Balbás MA.
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| Mol Biol Cell 24(3):351-60. doi: 10.1091/mbc.E12-07-0561. Epub 2012 Dec 14.
2013
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| 28 | KDM6B
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| EED and KDM6B coordinate the first mammalian cell lineage commitment to ensure embryo implantation
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| Saha B, Home P, Ray S, Larson M, Paul A, Rajendran G, Behr B, Paul S.
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| Mol Cell Biol. Jul;33(14):2691-705. doi: 10.1128/MCB.00069-13. Epub 2013 May 13. 2013
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| 29 | KDM4B, KDM6B
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| Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs.
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| Ye L, Fan Z, Yu B, Chang J, Al Hezaimi K, Zhou X, Park NH, Wang CY.
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| Cell Stem Cell 11(1):50-61. doi: 10.1016/j.stem.2012.04.009.
2012
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| 30 | EP300, KDM5A, KDM6A, KDM6B, KLF4, POU5F1
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| The EP300, KDM5A, KDM6A and KDM6B chromatin regulators cooperate with KLF4 in the transcriptional activation of POU5F1.
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| Wang WP, Tzeng TY, Wang JY, Lee DC, Lin YH, Wu PC, Chen YP, Chiu IM, Chi YH.
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| PLoS One 7(12):e52556. doi: 10.1371/journal.pone.0052556. Epub 2012 Dec 18.
2012
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| 31 | KDM6B
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| Histone demethylase KDM6B promotes epithelial-mesenchymal transition.
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| Ramadoss S, Chen X, Wang CY.
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| J Biol Chem 287(53):44508-17. doi: 10.1074/jbc.M112.424903. Epub 2012 Nov 14.
2012
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| 32 | KDM6A, KDM6B
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| A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.
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| Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H, Eberhard D, Hutchinson S, Jones E, Katso R, Leveridge M, Mander PK, Mosley J, Ramirez-Molina C, Rowland P, Schofield CJ, Sheppard RJ, Smith JE, Swales C, Tanner R, Thomas P, Tumber A, Drewes G, Oppermann U, Patel DJ, Lee K, Wilson DM.
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| Nature 488(7411):404-8. doi: 10.1038/nature11262.
2012
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| 33 | KDM6B, KDM7A, SUPT16H, SUPT6H
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| The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation.
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| Chen S, Ma J, Wu F, Xiong LJ, Ma H, Xu W, Lv R, Li X, Villen J, Gygi SP, Liu XS, Shi Y.
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| Genes Dev 26(12):1364-75. doi: 10.1101/gad.186056.111.
2012
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| 34 | ITGA2B, KDM6B, MPL
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| Itga2b regulation at the onset of definitive hematopoiesis and commitment to differentiation.
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| Dumon S, Walton DS, Volpe G, Wilson N, Dassé E, Del Pozzo W, Landry JR, Turner B, O'Neill LP, Göttgens B, Frampton J.
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| PLoS One 7(8):e43300. doi: 10.1371/journal.pone.0043300. Epub 2012 Aug 28.
2012
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| 35 | KDM6B, NFATC1
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| Epigenetic regulation of osteoclast differentiation: possible involvement of Jmjd3 in the histone demethylation of Nfatc1.
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| Yasui T, Hirose J, Tsutsumi S, Nakamura K, Aburatani H, Tanaka S.
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| J Bone Miner Res 26(11):2665-71. doi: 10.1002/jbmr.464.
2011
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| 36 | KDM6A, KDM6B
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| Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression.
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| Miller SA, Mohn SE, Weinmann AS.
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| Mol Cell 40(4):594-605.
2010
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| 37 | KDM6B
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| Jmjd3 contributes to the control of gene expression in LPS-activated macrophages.
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| De Santa F, Narang V, Yap ZH, Tusi BK, Burgold T, Austenaa L, Bucci G, Caganova M, Notarbartolo S, Casola S, Testa G, Sung WK, Wei CL, Natoli G.
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| EMBO J 28(21):3341-52. Epub 2009 Sep 24.PMID: 19779457 2009
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| 38 | KDM6B
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| Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3.
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| Sen GL, Webster DE, Barragan DI, Chang HY, Khavari PA.
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| Genes Dev 22(14):1865-70.PMID: 18628393 2008
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| 39 | HOXA11, KDM6B, RBBP5
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| The Histone H3 Lysine-27 Demethylase Jmjd3 Links Inflammation to Inhibition of Polycomb-Mediated Gene Silencing.
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| De Santa F, Totaro MG, Prosperini E, Notarbartolo S, Testa G, Natoli G.
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| Cell 130(6):1083-1094. Epub 2007 Sep 6. 2007
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| 40 | KDM6A, KDM6B
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| UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development.
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| Agger K, Cloos PA, Christensen J, Pasini D, Rose S, Rappsilber J, Issaeva I, Canaani E, Salcini AE, Helin K.
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| Nature 449(7163):731-4. Epub 2007 Aug 22. 2007
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| 41 | KDM6A, KDM6B
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| Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases.
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| Hong S, Cho YW, Yu LR, Yu H, Veenstra TD, Ge K.
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| Proc Natl Acad Sci U S A 104(47):18439-44. Epub 2007 Nov 14. 2007
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| 42 | KDM6A, KDM6B
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| A histone H3 lysine 27 demethylase regulates animal posterior development.
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| Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y.
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| Nature 449(7163):689-94. Epub 2007 Sep 12. 2007
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| 43 | ALOX12, ATP1B2, CD68, CHD3, CHRNB1, EIF4A1, FGF11, FXR2, GUCY2D, KDM6B, NEUROD2, SHBG, TNFSF12, TNFSF13, TP53
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| Physical Map of 17p13 and the Genes Adjacent to p53.
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| Cousin P, Billotte J, Chaubert P, Shaw P.
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| Genomics 63(1):60-68. 2000
|