| 1 | KDM6A, UTY
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| Target sequencing and CRISPR/Cas editing reveal simultaneous loss of UTX and UTY in urothelial bladder cancer.
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| Ahn J, Kim KH, Park S, Ahn YH, Kim HY, Yoon H, Lee JH, Bang D, Lee DH.
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| Oncotarget ncotarget. 2016 Aug 11. doi: 10.18632/oncotarget.11207. [Epub ahead of print]
2016
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| 2 | KABUK1, KDM6A, KMS3, KMT2D
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| Mutation Update for Kabuki Syndrome Genes KMT2D and KDM6A and Further Delineation of X-Linked Kabuki Syndrome Subtype 2.
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| Bögershausen N, Gatinois V, Riehmer V, Kayserili H, Becker J, Thoenes M, Simsek-Kiper PÖ, Barat-Houari M, Elcioglu NH, Wieczorek D, Tinschert S, Sarrabay G, Strom TM, Fabre A, Baynam G, Sanchez E, Nürnberg G, Altunoglu U, Capri Y, Isidor B, Lacombe D, Corsini C, Cormier-Daire V, Sanlaville D, Giuliano F, Le Quan Sang KH, Kayirangwa H, Nürnberg P, Meitinger T, Boduroglu K, Zoll B, Lyonnet S, Tzschach A, Verloes A, Di Donato N, Touitou I, Netzer C, Li Y, Geneviève D, Yigit G, Wollnik B.
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| Hum Mutat 37(9):847-64. doi: 10.1002/humu.23026.
2016
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| 3 | KDM6A
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| UTX demethylase activity is required for satellite cell-mediated muscle regeneration.
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| Faralli H, Wang C, Nakka K, Benyoucef A, Sebastian S, Zhuang L, Chu A, Palii CG, Liu C, Camellato B, Brand M, Ge K, Dilworth FJ.
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| J Clin Invest 126(4):1555-65. doi: 10.1172/JCI83239.
2016
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| 4 | KDM6A, KDM6B
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| Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation.
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| Manna S, Kim JK, Baugé C, Cam M, Zhao Y, Shetty J, Vacchio MS, Castro E, Tran B, Tessarollo L, Bosselut R.
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| Nat Commun 6:8152. doi: 10.1038/ncomms9152.
2015
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| 5 | KDM6A, KMS3
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| Novel KDM6A (UTX) mutations and a clinical and molecular review of the X-linked Kabuki syndrome (KS2).
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| Banka S, Lederer D, Benoit V, Jenkins E, Howard E, Bunstone S, Kerr B, McKee S, Chris Lloyd I, Shears D, Stewart H, White SM, Savarirayan R, Mancini GM, Beysen D, Cohn RD, Grisart B, Maystadt I, Donnai D.
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| Clin Genet lin Genet. 2014 Feb 14. doi: 10.1111/cge.12363. [Epub ahead of print]
2014
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| 6 | EZH2, KDM6A
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| EZH2 and KDM6A Act as an Epigenetic Switch to Regulate Mesenchymal Stem Cell Lineage Specification.
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| Hemming S, Cakouros D, Isenmann S, Cooper L, Menicanin D, Zannettino A, Gronthos S.
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| Stem Cells 32(3):802-15. doi: 10.1002/stem.1573.
2014
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| 7 | KDM6A, KDM6B
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| KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development.
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| Shpargel KB, Starmer J, Yee D, Pohlers M, Magnuson T.
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| PLoS Genet 10(8):e1004507. doi: 10.1371/journal.pgen.1004507.
2014
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| 8 | KDM6A, KDM6B, UTY
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| Human UTY(KDM6C) is a male-specific Nϵ-methyl lysyl demethylase.
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| Walport LJ, Hopkinson RJ, Vollmar M, Madden SK, Gileadi C, Oppermann U, Schofield CJ, Johansson C.
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| J Biol Chem 289(26):18302-13. doi: 10.1074/jbc.M114.555052.
2014
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| 9 | KDM6A
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| Haploinsufficiency of KDM6A is associated with severe psychomotor retardation, global growth restriction, seizures and cleft palate.
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| Lindgren AM, Hoyos T, Talkowski ME, Hanscom C, Blumenthal I, Chiang C, Ernst C, Pereira S, Ordulu Z, Clericuzio C, Drautz JM, Rosenfeld JA, Shaffer LG, Velsher L, Pynn T, Vermeesch J, Harris DJ, Gusella JF, Liao EC, Morton CC.
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| Hum Genet 132(5):537-52. doi: 10.1007/s00439-013-1263-x. Epub 2013 Jan 25.
2013
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| 10 | KABUK1, KDM6A, KMS3, KMT2D
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| MLL2 and KDM6A mutations in patients with Kabuki syndrome.
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| Miyake N, Koshimizu E, Okamoto N, Mizuno S, Ogata T, Nagai T, Kosho T, Ohashi H, Kato M, Sasaki G, Mabe H, Watanabe Y, Yoshino M, Matsuishi T, Takanashi J, Shotelersuk V, Tekin M, Ochi N, Kubota M, Ito N, Ihara K, Hara T, Tonoki H, Ohta T, Saito K, Matsuo M, Urano M, Enokizono T, Sato A, Tanaka H, Ogawa A, Fujita T, Hiraki Y, Kitanaka S, Matsubara Y, Makita T, Taguri M, Nakashima M, Tsurusaki Y, Saitsu H, Yoshiura K, Matsumoto N, Niikawa N.
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| Am J Med Genet A 161(9):2234-43. doi: 10.1002/ajmg.a.36072. Epub 2013 Aug 2. 2013
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| 11 | KDM6A
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| Female bias in Rhox6 and 9 regulation by the histone demethylase KDM6A.
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| Berletch JB, Deng X, Nguyen DK, Disteche CM.
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| PLoS Genet 9(5):e1003489. doi: 10.1371/journal.pgen.1003489. Epub 2013 May 2.
2013
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| 12 | KDM6A, KMS3
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| KDM6A point mutations cause Kabuki syndrome.
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| Miyake N, Mizuno S, Okamoto N, Ohashi H, Shiina M, Ogata K, Tsurusaki Y, Nakashima M, Saitsu H, Niikawa N, Matsumoto N.
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| Hum Mutat 34(1):108-10. doi: 10.1002/humu.22229. Epub 2012 Oct 17.
2013
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| 13 | DKK1, KDM6A, KDM6B, WNT3
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| Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway.
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| Jiang W, Wang J, Zhang Y.
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| Cell Res 23(1):122-30. doi: 10.1038/cr.2012.119. Epub 2012 Aug 21.
2013
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| 14 | KDM6A, POLR2A, SUPT6H
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| The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis.
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| Wang AH, Zare H, Mousavi K, Wang C, Moravec CE, Sirotkin HI, Ge K, Gutierrez-Cruz G, Sartorelli V.
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| EMBO J 32(8):1075-86. doi: 10.1038/emboj.2013.54.
2013
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| 15 | KABUK1, KDM6A, KMS3, KMT2D
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| Deletion of KDM6A, a Histone Demethylase Interacting with MLL2, in Three Patients with Kabuki Syndrome.
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| Lederer D, Grisart B, Digilio MC, Benoit V, Crespin M, Ghariani SC, Maystadt I, Dallapiccola B, Verellen-Dumoulin C.
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| Am J Hum Genet 90(1):119-24. Epub 2011 Dec 22. 2012
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| 16 | EP300, KDM5A, KDM6A, KDM6B, KLF4, POU5F1
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| The EP300, KDM5A, KDM6A and KDM6B chromatin regulators cooperate with KLF4 in the transcriptional activation of POU5F1.
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| Wang WP, Tzeng TY, Wang JY, Lee DC, Lin YH, Wu PC, Chen YP, Chiu IM, Chi YH.
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| PLoS One 7(12):e52556. doi: 10.1371/journal.pone.0052556. Epub 2012 Dec 18.
2012
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| 17 | KDM6A
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| UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program.
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| Lee S, Lee JW, Lee SK.
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| Dev Cell 22(1):25-37. doi: 10.1016/j.devcel.2011.11.009. Epub 2011 Dec 20.
2012
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| 18 | KDM6A
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| The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming.
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| Mansour AA, Gafni O, Weinberger L, Zviran A, Ayyash M, Rais Y, Krupalnik V, Zerbib M, Amann-Zalcenstein D, Maza I, Geula S, Viukov S, Holtzman L, Pribluda A, Canaani E, Horn-Saban S, Amit I, Novershtern N, Hanna JH.
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| Nature 488(7411):409-13. doi: 10.1038/nature11272.
2012
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| 19 | KDM6A
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| X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner.
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| Welstead GG, Creyghton MP, Bilodeau S, Cheng AW, Markoulaki S, Young RA, Jaenisch R.
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| Proc Natl Acad Sci U S A 109(32):13004-9. doi: 10.1073/pnas.1210787109. Epub 2012 Jul 23.
2012
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| 20 | KDM6A, KDM6B
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| A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.
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| Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H, Eberhard D, Hutchinson S, Jones E, Katso R, Leveridge M, Mander PK, Mosley J, Ramirez-Molina C, Rowland P, Schofield CJ, Sheppard RJ, Smith JE, Swales C, Tanner R, Thomas P, Tumber A, Drewes G, Oppermann U, Patel DJ, Lee K, Wilson DM.
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| Nature 488(7411):404-8. doi: 10.1038/nature11262.
2012
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| 21 | KDM6A, T, UTY
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| UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity.
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| Wang C, Lee JE, Cho YW, Xiao Y, Jin Q, Liu C, Ge K.
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| Proc Natl Acad Sci U S A 109(38):15324-9.
2012
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| 22 | DNMT3A, EZH2, KDM6A
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| Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.
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| Jankowska AM, Makishima H, Tiu RV, Szpurka H, Huang Y, Traina F, Visconte V, Sugimoto Y, Prince C, O'Keefe C, Hsi ED, List A, Sekeres MA, Rao A, McDevitt MA, Maciejewski JP.
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| Blood 118(14):3932-41. doi: 10.1182/blood-2010-10-311019. Epub 2011 Aug 9.
2011
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| 23 | KDM6A
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| Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A.
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| Sengoku T, Yokoyama S.
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| Genes Dev 25(21):2266-77. doi: 10.1101/gad.172296.111. Epub 2011 Oct 14.
2011
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| 24 | KDM6A
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| UTX mediates demethylation of H3K27me3 at muscle-specific genes during myogenesis.
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| Seenundun S, Rampalli S, Liu QC, Aziz A, Palii C, Hong S, Blais A, Brand M, Ge K, Dilworth FJ.
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| EMBO J 29(8):1401-11. Epub 2010 Mar 18.
2010
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| 25 | KDM6A
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| The histone demethylase UTX enables RB-dependent cell fate control.
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| Wang JK, Tsai MC, Poulin G, Adler AS, Chen S, Liu H, Shi Y, Chang HY.
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| Genes Dev 24(4):327-32. Epub 2010 Feb 1.
2010
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| 26 | KDM6A, RB1, RBL2
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| The tumor suppressor Rb and its related Rbl2 genes are regulated by Utx histone demethylase.
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| Terashima M, Ishimura A, Yoshida M, Suzuki Y, Sugano S, Suzuki T.
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| Biochem Biophys Res Commun 399(2):238-44. Epub 2010 Jul 30.PMID: 20650264 2010
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| 27 | KDM6A, KDM6B
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| Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression.
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| Miller SA, Mohn SE, Weinmann AS.
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| Mol Cell 40(4):594-605.
2010
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| 28 | KDM6A
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| Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.
|
| van Haaften G, Dalgliesh GL, Davies H, Chen L, Bignell G, Greenman C, Edkins S, Hardy C, O'Meara S, Teague J, Butler A, Hinton J, Latimer C, Andrews J, Barthorpe S, Beare D, Buck G, Campbell PJ, Cole J, Forbes S, Jia M, Jones D, Kok CY, Leroy C, Lin ML, McBride DJ, Maddison M, Maquire S, McLay K, Menzies A, Mironenko T, Mulderrig L, Mudie L, Pleasance E, Shepherd R, Smith R, Stebbings L, Stephens P, Tang G, Tarpey PS, Turner R, Turrell K, Varian J, West S, Widaa S, Wray P, Collins VP, Ichimura K, Law S, Wong J, Yuen ST, Leung SY, Tonon G, DePinho RA, Tai YT, Anderson KC, Kahnoski RJ, Massie A, Khoo SK, Teh BT, Stratton MR, Futreal PA.
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| Nat Genet 41(5):521-3. Epub 2009 Mar 29.
2009
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| 29 | KDM6A, UTY
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| Sex-specific differences in expression of histone demethylases Utx and Uty in mouse brain and neurons.
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| Xu J, Deng X, Watkins R, Disteche CM.
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| J Neurosci 28(17):4521-7.PMID: 18434530 2008
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| 30 | KDM6A, KDM6B
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| UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development.
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| Agger K, Cloos PA, Christensen J, Pasini D, Rose S, Rappsilber J, Issaeva I, Canaani E, Salcini AE, Helin K.
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| Nature 449(7163):731-4. Epub 2007 Aug 22. 2007
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| 31 | KDM6A, KDM6B
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| Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases.
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| Hong S, Cho YW, Yu LR, Yu H, Veenstra TD, Ge K.
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| Proc Natl Acad Sci U S A 104(47):18439-44. Epub 2007 Nov 14. 2007
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| 32 | KDM6A, KDM6B
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| A histone H3 lysine 27 demethylase regulates animal posterior development.
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| Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y.
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| Nature 449(7163):689-94. Epub 2007 Sep 12. 2007
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| 33 | KDM6A
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| Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.
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| Lee MG, Villa R, Trojer P, Norman J, Yan KP, Reinberg D, Di Croce L, Shiekhattar R.
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| Science 318(5849):447-50. Epub 2007 Aug 30. 2007
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| 34 | KDM6A
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| The UTX gene escapes X inactivation in mice and humans.
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| Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, Steiner K, Tam PP, Monaco AP, Willard HF, Koopman P.
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| Hum Mol Genet 7(4):737-42. 1998
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| 35 | BPY2, CDY1, CDY2A, DDX3Y, EIF1AY, KDM6A, PRY, PTPRY2, PTPRY3, TMSB4Y, TTTY1, TTTY2, USP9Y, UTY, VCY, VCY1B, XGPY, XKRY
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| Functional coherence of the human Y chromosome.
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| Lahn BT, Page DC.
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| Science 278(5338):675-80. 1997
|