| 1 | KCNK2
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| Influence of the N terminus on the biophysical properties and pharmacology of TREK1 potassium channels.
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| Veale EL, Al-Moubarak E, Bajaria N, Omoto K, Cao L, Tucker SJ, Stevens EB, Mathie A.
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| Mol Pharmacol 85(5):671-81. doi: 10.1124/mol.113.091199. Epub 2014 Feb 7.
2014
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| 2 | KCNK2
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| The 2-pore domain potassium channel TREK-1 regulates stretch-induced detachment of alveolar epithelial cells.
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| Roan E, Waters CM, Teng B, Ghosh M, Schwingshackl A.
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| PLoS One 9(2):e89429. doi: 10.1371/journal.pone.0089429. eCollection 2014.
2014
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| 3 | KCNK2
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| The purified mechanosensitive channel TREK-1 is directly sensitive to membrane tension.
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| Berrier C, Pozza A, de Lacroix de Lavalette A, Chardonnet S, Mesneau A, Jaxel C, le Maire M, Ghazi A.
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| J Biol Chem 288(38):27307-14. doi: 10.1074/jbc.M113.478321. Epub 2013 Jul 29.
2013
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| 4 | KCNK2
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| Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS.
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| Bittner S, Ruck T, Schuhmann MK, Herrmann AM, Moha ou Maati H, Bobak N, Göbel K, Langhauser F, Stegner D, Ehling P, Borsotto M, Pape HC, Nieswandt B, Kleinschnitz C, Heurteaux C, Galla HJ, Budde T, Wiendl H, Meuth SG.
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| Nat Med 19(9):1161-5. doi: 10.1038/nm.3303. Epub 2013 Aug 11.
2013
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| 5 | KCNK10, KCNK2
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| Expression and effects of modulation of the K2P potassium channels TREK-1 (KCNK2) and TREK-2 (KCNK10) in the normal human ovary and epithelial ovarian cancer.
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| Innamaa A, Jackson L, Asher V, van Schalkwyk G, Warren A, Keightley A, Hay D, Bali A, Sowter H, Khan R.
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| Clin Transl Oncol 15(11):910-8. doi: 10.1007/s12094-013-1022-4. Epub 2013 Mar 12.
2013
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| 6 | KCNK2
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| A role for two-pore potassium (K2P) channels in endometrial epithelial function.
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| Patel SK, Jackson L, Warren AY, Arya P, Shaw RW, Khan RN.
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| J Cell Mol Med 17(1):134-46. doi: 10.1111/j.1582-4934.2012.01656.x. Epub 2013 Jan 11.
2013
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| 7 | KCNK2
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| Involvement of TREK-1 activity in astrocyte function and neuroprotection under simulated ischemia conditions.
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| Wu X, Liu Y, Chen X, Sun Q, Tang R, Wang W, Yu Z, Xie M.
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| J Mol Neurosci 49(3):499-506. doi: 10.1007/s12031-012-9875-5. Epub 2012 Aug 16.
2013
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| 8 | KCNK2
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| Variants of stretch-activated two-pore potassium channel TREK-1 associated with preterm labor in humans.
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| Wu YY, Singer CA, Buxton IL.
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| Biol Reprod 87(4):96. doi: 10.1095/biolreprod.112.099499. Print 2012 Oct.
2012
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| 9 | KCNK2
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| Expression of the two pore domain potassium channel TREK-1 in human intervertebral disc cells.
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| Sharma P, Hughes S, El Haj A, Maffulli N.
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| Curr Stem Cell Res Ther 7(4):266-71.
2012
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| 10 | KCNK2
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| Regulation and function of the two-pore-domain (K2P) potassium channel Trek-1 in alveolar epithelial cells.
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| Schwingshackl A, Teng B, Ghosh M, West AN, Makena P, Gorantla V, Sinclair SE, Waters CM.
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| Am J Physiol Lung Cell Mol Physiol 302(1):L93-L102. doi: 10.1152/ajplung.00078.2011. Epub 2011 Sep 23.
2012
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| 11 | BEST1, GNG4, KCNK2
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| TREK-1 and Best1 channels mediate fast and slow glutamate release in astrocytes upon GPCR activation.
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| Woo DH, Han KS, Shim JW, Yoon BE, Kim E, Bae JY, Oh SJ, Hwang EM, Marmorstein AD, Bae YC, Park JY, Lee CJ.
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| Cell 151(1):25-40. doi: 10.1016/j.cell.2012.09.005.
2012
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| 12 | KCNK2
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| Regional differential expression of TREK-1 at left ventricle in myocardial infarction.
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| Zhao LN, Fu L, Gao QP, Xie RS, Cao JX.
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| Can J Cardiol 27(6):826-33. doi: 10.1016/j.cjca.2011.01.013. Epub 2011 Jun 16.
2011
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| 13 | KCNK10, KCNK2, KCNK4
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| Molecular regulations governing TREK and TRAAK channel functions.
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| Noël J, Sandoz G, Lesage F.
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| Channels (Austin) 5(5):402-9. doi: 10.4161/chan.5.5.16469. Epub 2011 Sep 1. Review.
2011
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| 14 | KCNK2
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| Dominant negative effects of a non-conducting TREK1 splice variant expressed in brain.
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| Veale EL, Rees KA, Mathie A, Trapp S.
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| J Biol Chem 285(38):29295-304. Epub 2010 Jul 6.
2010
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| 15 | KCNK2
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| Expression of stretch-activated two-pore potassium channels in human myometrium in pregnancy and labor.
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| Buxton IL, Singer CA, Tichenor JN.
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| PLoS One 5(8):e12372. doi: 10.1371/journal.pone.0012372.
2010
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| 16 | COPB2, KCNK2
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| Enhancement of TREK1 channel surface expression by protein-protein interaction with beta-COP.
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| Kim E, Hwang EM, Yarishkin O, Yoo JC, Kim D, Park N, Cho M, Lee YS, Sun CH, Yi GS, Yoo J, Kang D, Han J, Hong SG, Park JY.
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| Biochem Biophys Res Commun 395(2):244-50. doi: 10.1016/j.bbrc.2010.03.171. Epub 2010 Apr 1.
2010
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| 17 | KCNK2, KCNK9
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| An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action.
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| Pang DS, Robledo CJ, Carr DR, Gent TC, Vyssotski AL, Caley A, Zecharia AY, Wisden W, Brickley SG, Franks NP.
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| Proc Natl Acad Sci U S A 106(41):17546-51. Epub 2009 Sep 24.PMID: 19805135 2009
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| 18 | KCNK1, KCNK2
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| TWIK-1 and TREK-1 are potassium channels contributing significantly to astrocyte passive conductance in rat hippocampal slices.
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| Zhou M, Xu G, Xie M, Zhang X, Schools GP, Ma L, Kimelberg HK, Chen H.
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| J Neurosci 29(26):8551-64. doi: 10.1523/JNEUROSCI.5784-08.2009.
2009
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| 19 | KCNK10, KCNK2
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| AMP-activated protein kinase inhibits TREK channels.
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| Kréneisz O, Benoit JP, Bayliss DA, Mulkey DK.
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| J Physiol 587(Pt 24):5819-30. doi: 10.1113/jphysiol.2009.180372. Epub .
2009
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| 20 | KCNK10, KCNK2
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| Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue.
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| Sandoz G, Douguet D, Chatelain F, Lazdunski M, Lesage F.
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| Proc Natl Acad Sci U S A 106(34):14628-33. doi: 10.1073/pnas.0906267106. Epub 2009 Aug 10.
2009
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| 21 | KCNK2, KCNK9
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| Both TASK-3 and TREK-1 two-pore loop K channels are expressed in H295R cells and modulate their membrane potential and aldosterone secretion.
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| Brenner T, O'Shaughnessy KM.
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| Am J Physiol Endocrinol Metab 295(6):E1480-6. Epub 2008 Oct 14.PMID: 18854423 2008
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| 22 | KCNK2
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| Expression of the mechanosensitive 2PK+ channel TREK-1 in human osteoblasts.
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| Hughes S, Magnay J, Foreman M, Publicover SJ, Dobson JP, El Haj AJ.
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| J Cell Physiol 206(3):738-48. 2006
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| 23 | KCNK2, KCNK3
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| Expression of TASK and TREK, two-pore domain K+ channels, in human myometrium.
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| Bai X, Bugg GJ, Greenwood SL, Glazier JD, Sibley CP, Baker PN, Taggart MJ, Fyfe GK.
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| Reproduction 129(4):525-30. 2005
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| 24 | KCNK3, KCNK2
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| Localization of TASK and TREK, two-pore domain K+ channels, in human cytotrophoblast cells.
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| Bai X, Greenwood SL, Glazier JD, Baker PN, Sibley CP, Taggart MJ, Fyfe GK.
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| J Soc Gynecol Investig 12(2):77-83. 2005
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| 25 | KCNK2
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| TREK-1 is a heat-activated background K(+) channel.
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| Maingret F, Lauritzen I, Patel AJ, Heurteaux C, Reyes R, Lesage F, Lazdunski M, Honore E.
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| EMBO J 19(11):2483-91. 2000
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| 26 | KCNK2, KCNK3
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| Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23.
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| Lesage F, et al.
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| Genomics 51 : 478-479. 1998
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