| 1 | KCNJ11, KCNJ14, KCNJ2, KCNJ4, KCNJ5, kCNJ8
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| Molecular and functional characterization of inwardly rectifying K+ currents in murine proximal colon.2018 Dec 27. PMID:
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| Huang X, Lee SH, Lu H, Sanders KM, Koh SD.
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| J Physiol. Feb 1;596(3):379-391. doi: 10.1113/JP275234. Epub 2017 2018
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| 2 | DUSP1, KCNJ2
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| DUSP1 and KCNJ2 mRNA upregulation can serve as a biomarker of mechanical asphyxia-induced death in cardiac tissue.
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| Zeng Y, Tao L, Ma J, Han L, Lv Y, Hui P, Zhang H, Ma K, Xiao B, Shi Q, Xu H, Chen L.
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| Int J Legal Med. May;132(3):655-665. doi: 10.1007/s00414-017-1616-4. Epub 2017 Jun 17. 2018
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| 3 | KCNJ2, PPKCA
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| Characterization of a Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Model for the Study of Variant Pathogenicity: Validation of a KCNJ2 Mutation.
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| Gélinas R, El Khoury N, Chaix MA, Beauchamp C, Alikashani A, Ethier N, Boucher G, Villeneuve L, Robb L, Latour F, Mondesert B, Rivard L, Goyette P, Talajic M, Fiset C, Rioux JD.
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| Circ Cardiovasc Genet 10(5). pii: e001755. doi: 10.1161/CIRCGENETICS.117.001755.
2017
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| 4 | KCNJ2, PPKCA
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| Characterization of a novel KCNJ2 sequence variant detected in Andersen-Tawil syndrome patients.
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| Scheiper S, Hertel B, Beckmann BM, Kääb S, Thiel G, Kauferstein S.
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| BMC Med Genet 18(1):113. doi: 10.1186/s12881-017-0472-x.
2017
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| 5 | KCNJ2, SQT3
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| Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria.
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| Whittaker DG, Ni H, El Harchi A, Hancox JC, Zhang H.
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| PLoS Comput Biol 13(6):e1005593. doi: 10.1371/journal.pcbi.1005593. eCollection 2017 Jun.
2017
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| 6 | KCNJ2
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| Three pairs of weak interactions precisely regulate the G-loop gate of Kir2.1 channel.
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| Li J, Xiao S, Xie X, Zhou H, Pang C, Li S, Zhang H, Logothetis DE, Zhan Y, An H.
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| Proteins 84(12):1929-1937. doi: 10.1002/prot.25176. Epub 2016 Oct 25.
2016
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| 7 | KCNJ2
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| Kir2.1 regulates rat smooth muscle cell proliferation, migration, and post-injury carotid neointimal formation.
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| Qiao Y, Tang C, Wang Q, Wang D, Yan G, Zhu B.
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| Biochem Biophys Res Commun 477(4):774-780. doi: 10.1016/j.bbrc.2016.06.134. Epub 2016 Jul 5.
2016
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| 8 | CDON, KCNJ2
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| Cdo Regulates Surface Expression of Kir2.1 K+ Channel in Myoblast Differentiation.
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| Leem YE, Jeong HJ, Kim HJ, Koh J, Kang K, Bae GU, Cho H, Kang JS.
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| PLoS One 11(7):e0158707. doi: 10.1371/journal.pone.0158707. eCollection 2016.
2016
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| 9 | KCNJ2
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| Hypoxic stress up-regulates Kir2.1 expression and facilitates cell proliferation in brain capillary endothelial cells.
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| Yamamura H, Suzuki Y, Yamamura H, Asai K, Imaizumi Y.
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| Biochem Biophys Res Commun 476(4):386-392. doi: 10.1016/j.bbrc.2016.05.131. Epub 2016 May 26.
2016
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| 10 | KCNJ2
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| Role of Kir2.1 in human monocyte-derived foam cell maturation.
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| Zhang W, Lei XJ, Wang YF, Wang DQ, Yuan ZY.
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| J Cell Mol Med 20(3):403-12. doi: 10.1111/jcmm.12705. Epub 2015 Dec 22.
2016
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| 11 | KCNJ2, KIT
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| Effects of BKCa and Kir2.1 Channels on Cell Cycling Progression and Migration in Human Cardiac c-kit+ Progenitor Cells.
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| Zhang YY, Li G, Che H, Sun HY, Xiao GS, Wang Y, Li GR.
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| PLoS One 10(9):e0138581. doi: 10.1371/journal.pone.0138581. eCollection 2015.
2015
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| 12 | KCNJ2
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| The inward rectifier potassium channel Kir2.1 is expressed in mouse neutrophils from bone marrow and liver.
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| Masia R, Krause DS, Yellen G.
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| Am J Physiol Cell Physiol 308(3):C264-76. doi: 10.1152/ajpcell.00176.2014. Epub 2014 Dec 3.
2015
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| 13 | KCNJ2
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| The inward rectifier potassium channel Kir2.1 is required for osteoblastogenesis.
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| Sacco S, Giuliano S, Sacconi S, Desnuelle C, Barhanin J, Amri EZ, Bendahhou S.
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| Hum Mol Genet 24(2):471-9. doi: 10.1093/hmg/ddu462. Epub 2014 Sep 8.
2015
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| 14 | KCNJ2, OXSR1, STK39
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| SPAK and OSR1 Sensitive Kir2.1 K+ Channels.
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| Fezai M, Ahmed M, Hosseinzadeh Z, Elvira B, Lang F.
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| Neurosignals 23(1):20-33. doi: 10.1159/000442601. Epub 2015 Dec 17.
2015
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| 15 | KCNJ2
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| KCNJ2 mutation causes an adrenergic-dependent rectification abnormality with calcium sensitivity and ventricular arrhythmia.
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| Kalscheur MM, Vaidyanathan R, Orland KM, Abozeid S, Fabry N, Maginot KR, January CT, Makielski JC, Eckhardt LL.
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| Heart Rhythm 11(5):885-94. doi: 10.1016/j.hrthm.2014.02.015. Epub 2014 Feb 21.
2014
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| 16 | KCNJ2
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| Functional expression of a Kir2.1-like inwardly rectifying potassium channel in mouse mammary secretory cells.
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| Kamikawa A, Ishikawa T.
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| Am J Physiol Cell Physiol 306(3):C230-40. doi: 10.1152/ajpcell.00219.2013. Epub 2013 Nov 20.
2014
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| 17 | KCNJ2
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| ESCRT regulates surface expression of the Kir2.1 potassium channel.
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| Kolb AR, Needham PG, Rothenberg C, Guerriero CJ, Welling PA, Brodsky JL.
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| Mol Biol Cell 25(2):276-89. doi: 10.1091/mbc.E13-07-0394. Epub 2013 Nov 13.
2014
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| 18 | KCNJ2, KCNMA1, TRPV1
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| Identification of novel cholesterol-binding regions in Kir2 channels.
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| Rosenhouse-Dantsker A, Noskov S, Durdagi S, Logothetis DE, Levitan I.
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| J Biol Chem 288(43):31154-64. doi: 10.1074/jbc.M113.496117. Epub 2013 Sep 9.
2013
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| 19 | KCNJ2
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| A potential molecular target for morphological defects of fetal alcohol syndrome: Kir2.1.
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| Bates EA.
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| Curr Opin Genet Dev 23(3):324-9. doi: 10.1016/j.gde.2013.05.001. Epub 2013 Jun 4. Review.
2013
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| 20 | KCNJ2
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| Regulated neuronal neuromodulation via spinal cord expression of the gene for the inwardly rectifying potassium channel 2.1 (Kir2.1).
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| Boulis NM, Handy CR, Krudy CA, Donnelly EM, Federici T, Franz CK, Barrow EM, Teng Q, Kumar P, Cress D.
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| Neurosurgery 72(4):653-61; discussion 661. doi: 10.1227/NEU.0b013e318283f59a.
2013
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| 21 | KCNJ2, PPKCA
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| An inwardly rectifying K+ channel is required for patterning.
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| Dahal GR, Rawson J, Gassaway B, Kwok B, Tong Y, Ptácek LJ, Bates E.
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| Development 139(19):3653-64. doi: 10.1242/dev.078592.
2012
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| 22 | KCNJ2, PPKCA
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| Inhibition of Kir2.1 (KCNJ2) by the AMP-activated protein kinase.
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| Alesutan I, Munoz C, Sopjani M, Dërmaku-Sopjani M, Michael D, Fraser S, Kemp BE, Seebohm G, Föller M, Lang F.
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| Biochem Biophys Res Commun 408(4):505-10. Epub 2011 Apr 9.
2011
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| 23 | KCNJ2, PPKCA
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| Golgi export of the Kir2.1 channel is driven by a trafficking signal located within its tertiary structure.
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| Ma D, Taneja TK, Hagen BM, Kim BY, Ortega B, Lederer WJ, Welling PA.
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| Cell 145(7):1102-15.
2011
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| 24 | KCNJ12, KCNJ2
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| Dual-mode phospholipid regulation of human inward rectifying potassium channels.
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| Cheng WW, D'Avanzo N, Doyle DA, Nichols CG.
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| Biophys J 100(3):620-8.
2011
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| 25 | EDA, HMGA2, HOXB2, IGF2BP1, KCNJ2, MSRB3, RAD51B
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| Genome-wide association study reveals multiple loci associated with primary tooth development during infancy.
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| Pillas D, Hoggart CJ, Evans DM, O'Reilly PF, Sipilä K, Lähdesmäki R, Millwood IY, Kaakinen M, Netuveli G, Blane D, Charoen P, Sovio U, Pouta A, Freimer N, Hartikainen AL, Laitinen J, Vaara S, Glaser B, Crawford P, Timpson NJ, Ring SM, Deng G, Zhang W, McCarthy MI, Deloukas P, Peltonen L, Elliott P, Coin LJ, Smith GD, Jarvelin MR.
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| PLoS Genet 6(2):e1000856. 2010
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| 26 | KCNJ2, PPKCA
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| A novel neuropsychiatric phenotype of KCNJ2 mutation in one Taiwanese family with Andersen-Tawil syndrome.
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| Chan HF, Chen ML, Su JJ, Ko LC, Lin CH, Wu RM.
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| J Hum Genet 55(3):186-8. Epub 2010 Jan 29.
2010
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| 27 | KCNJ2
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| Nitric oxide increases cardiac IK1 by nitrosylation of cysteine 76 of Kir2.1 channels.
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| Gómez R, Caballero R, Barana A, Amorós I, Calvo E, López JA, Klein H, Vaquero M, Osuna L, Atienza F, Almendral J, Pinto A, Tamargo J, Delpón E.
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| Circ Res 105(4):383-92. Epub 2009 Jul 16.PMID: 19608980 2009
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| 28 | KCNJ2
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| Human Kir2.1 channel carries a transient outward potassium current with inward rectification.
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| Zhang DY, Lau CP, Li GR.
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| Pflugers Arch 457(6):1275-85. Epub 2008 Nov 11.PMID: 19002489 2009
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| 29 | KCNJ2
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| Topological and developmental expression gradients of Kir2.1, an inward rectifier K+ channel, in spiral ganglion and cochlear hair cells of mouse inner ear.
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| Ruan Q, Chen D, Wang Z, Chi F, Yin S, Wang J.
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| Dev Neurosci 30(6):374-88. Epub 2008 Oct 15.PMID: 18854645 2008
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| 30 | PPKCA, KCNJ2
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| An andersen-Tawil syndrome mutation in Kir2.1 (V302M) alters the G-loop cytoplasmic K+ conduction pathway.
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| Ma D, Tang XD, Rogers TB, Welling PA.
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| J Biol Chem 282(8):5781-9. Epub 2006 Dec 13. 2007
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| 31 | PPKCA, KCNJ2
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| Mutations of KCNJ2 gene associated with Andersen-Tawil syndrome in Korean families.
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| Choi BO, Kim J, Suh BC, Yu JS, Sunwoo IN, Kim SJ, Kim GH, Chung KW.
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| J Hum Genet 52(3):280-3. Epub 2007 Jan 9. 2007
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| 32 | KCNJ2,SOX9, PRS
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| Pierre Robin sequence may be caused by dysregulation of SOX9 and KCNJ2.
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| Jakobsen LP, Ullmann R, Christensen SB, Jensen KE, Molsted K, Henriksen KF, Hansen C, Knudsen MA, Larsen LA, Tommerup N, Tumer Z.
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| J Med Genet 44(6):381-6. 2007
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| 33 | KCNJ2, PPKCA
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| Functional and clinical characterization of a mutation in KCNJ2 associated with Andersen-Tawil syndrome.
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| Lu CW, Lin JH, Rajawat YS, Jerng H, Rami TG, Sanchez X, DeFreitas G, Carabello B, DeMayo F, Kearney DL, Miller G, Li H, Pfaffinger PJ, Bowles NE, Khoury DS, Towbin JA.
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| J Med Genet 43(8):653-9. Epub 2006 Mar 29. 2006
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| 34 | KCNJ2, PPKCA
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| Andersen's syndrome mutation effects on the structure and assembly of the cytoplasmic domains of Kir2.1.
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| Pegan S, Arrabit C, Slesinger PA, Choe S.
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| Biochemistry 45(28):8599-606. 2006
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| 35 | KCNJ2, PPKCA
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| Short QT syndrome or Andersen syndrome: Yin and Yang of Kir2.1 channel dysfunction.
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| Schulze-Bahr E.
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| Circ Res 96(7):703-4. No abstract available. 2005
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| 36 | SQT3, KCNJ2
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| A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene.
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| Priori SG, Pandit SV, Rivolta I, Berenfeld O, Ronchetti E, Dhamoon A, Napolitano C, Anumonwo J, di Barletta MR, Gudapakkam S, Bosi G, Stramba-Badiale M, Jalife J.
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| Circ Res 96(7):800-7. Epub 2005 Mar 10. 2005
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| 37 | ATFB9, KCNJ2
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| A Kir2.1 gain-of-function mutation underlies familial atrial fibrillation.
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| Xia M, Jin Q, Bendahhou S, He Y, Larroque MM, Chen Y, Zhou Q, Yang Y, Liu Y, Liu B, Zhu Q, Zhou Y, Lin J, Liang B, Li L, Dong X, Pan Z, Wang R, Wan H, Qiu W, Xu W, Eurlings P, Barhanin J, Chen Y.
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| Biochem Biophys Res Commun 332(4):1012-9. 2005
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| 38 | KCNJ2, PPKCA
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| Loss-of-function mutations of the K(+) channel gene KCNJ2 constitute a rare cause of long QT syndrome.
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| Fodstad H, Swan H, Auberson M, Gautschi I, Loffing J, Schild L, Kontula K.
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| J Mol Cell Cardiol 37(2):593-602. 2004
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| 39 | DLG2, KCNJ2
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| An alternatively spliced isoform of PSD-93/chapsyn 110 binds to the inwardly rectifying potassium channel, Kir2.1.
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| Leyland ML, Dart C.
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| J Biol Chem 279(42):43427-36. Epub 2004 Aug 10.
2004
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| 40 | KCNE4, KCNQ1, KCNJ2
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| Novel gene hKCNE4 slows the activation of the KCNQ1 channel
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| Teng S, Ma L, Zhen Y, Lin C, Bahring R, Vardanyan V, Pongs O, Hui R.
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| Biochem Biophys Res Commun 303(3):808-13. 2003
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| 41 | PPKCA, KCNJ2
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| Function, subcellular localization and assembly of a novel mutation of KCNJ2 in Andersen's syndrome.
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| Hosaka Y, Hanawa H, Washizuka T, Chinushi M, Yamashita F, Yoshida T, Komura S, Watanabe H, Aizawa Y.
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| J Mol Cell Cardiol 35(4):409-15. 2003
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| 42 | KCNJ2, PPKCA
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| KCNJ2 mutation results in Andersen syndrome with sex-specific cardiac and skeletal muscle phenotypes.
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| Andelfinger G, Tapper AR, Welch RC, Vanoye CG, George AL Jr, Benson DW.
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| Am J Hum Genet 71(3):663-8. 2002
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| 43 | KCNJ2
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| Inward rectifier K(+) current in human bronchial smooth muscle cells: inhibition with antisense oligonucleotides targeted to Kir2.1 mRNA.
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| Oonuma H, Iwasawa K, Iida H, Nagata T, Imuta H, Morita Y, Yamamoto K, Nagai R, Omata M, Nakajima T.
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| Am J Respir Cell Mol Biol 26(3):371-9. 2002
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| 44 | KCNJ2, PPKCA
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| Novel KCNJ2 mutation in familial periodic paralysis with ventricular dysrhythmia.
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| Ai T, Fujiwara Y, Tsuji K, Otani H, Nakano S, Kubo Y, Horie M.
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| Circulation 105(22):2592-4. 2002
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| 45 | PPKCA, KCNJ2
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| Functional and clinical characterization of KCNJ2 mutations associated with LQT7 (Andersen syndrome).
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| Tristani-Firouzi M, Jensen JL, Donaldson MR, Sansone V, Meola G, Hahn A, Bendahhou S, Kwiecinski H, Fidzianska A, Plaster N, Fu YH, Ptacek LJ, Tawil R.
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| J Clin Invest 110(3):381-8. 2002
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| 46 | KCNJ2, PPKCA
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| Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome.
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| Plaster NM, Tawil R, Tristani-Firouzi M, Canun S, Bendahhou S, Tsunoda A, Donaldson MR, Iannaccone ST, Brunt E, Barohn R, Clark J, Deymeer F, George AL Jr, Fish FA, Hahn A, Nitu A, Ozdemir C, Serdaroglu P, Subramony SH, Wolfe G, Fu YH, Ptacek LJ.
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| Cell 105(4):511-9. 2001
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| 47 | KCNJ16, KCNJ2
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| Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits.
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| Derst C, Karschin C, Wischmeyer E, Hirsch JR, Preisig-Muller R, Rajan S, Engel H, Grzeschik K, Daut J, Karschin A.
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| FEBS Lett 491(3):305-11. 2001
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| 48 | BICRA, DHX34, GLTSCR2, KCNJ2, SEPW1, SYNGR4, TSG19A
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| A transcript map of the chromosome 19q-Arm glioma tumor suppressor region.
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| Smith JS, Tachibana I, Pohl U, Lee HK, Thanarajasingam U, Portier BP, Ueki K, Ramaswamy S, Billings SJ, Mohrenweiser HW, Louis DN, Jenkins RB.
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| Genomics 64(1):44-50. 2000
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| 49 | KCNJ2
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| Kir2.1 Potassium channels and corneal epithelia.
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| Rae JL, Shepard AR.
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| Curr Eye Res 20(2):144-52. 2000
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| 50 | KCNJ2
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| Detection of a high-frequency silent polymorphism (C-->T) in the kir2.1 (KCNJ2) inwardly rectifying potassium channel gene by polymerase chain reaction and single strand conformation polymorphism.
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| Mylona P, Gokhale DA, Taylor GM, Sibley CP.
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| Mol Cell Probes 12 : 331-333. 1998
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| 51 | CLCN6, CLCN7, CLCN8, CLIC1, HTR3B, KCNAB1, KCNB1, KCNJ1, KCNJ2, KCNJ3, KCNJ5, KCNMA1
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| Chromosomal localization of 15 ion channel genes.
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| Russell MWW, et al.
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| Somat Cell Mol Genet 22 : 425-431. 1996
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| 52 | KCNJ2
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| Cloning, localization, and functional expression of a human brain inward rectifier potassium channel (hIRK1).
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| Tang W, et al.
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| Receptors Channels 3 : 175-183. 1995
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| 53 | KCNJ2
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| Cloning and functional expression of a human gene, hIRK1, encoding the heart inward rectifier K+ -channel.
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| Wood LS, et al.
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| Gene 163 : 313-317. 1995
|