| 1 | KCNJ1
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| Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1/SGK1-dependent phosphorylation of WNK1.
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| Cheng CJ, Huang CL.
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| J Am Soc Nephrol 22(3):460-71. Epub 2011 Feb 25.
2011
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| 2 | KCNJ1, UMOD
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| Tamm-Horsfall glycoprotein interacts with renal outer medullary potassium channel ROMK2 and regulates its function.
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| Renigunta A, Renigunta V, Saritas T, Decher N, Mutig K, Waldegger S.
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| J Biol Chem 286(3):2224-35. Epub 2010 Nov 16.
2011
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| 3 | KCNJ1
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| Hypertension resistance polymorphisms in ROMK (Kir1.1) alter channel function by different mechanisms.
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| Fang L, Li D, Welling PA.
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| Am J Physiol Renal Physiol 299(6):F1359-64. Epub 2010 Oct 6.
2010
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| 4 | KCNJ1, SH3RF1
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| POSH stimulates the ubiquitination and the clathrin-independent endocytosis of ROMK1 channels.
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| Lin DH, Yue P, Pan CY, Sun P, Zhang X, Han Z, Roos M, Caplan M, Giebisch G, Wang WH.
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| J Biol Chem. 284(43):29614-24. 2009
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| 5 | KCNJ1, LDLRAP1
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| The ARH adaptor protein regulates endocytosis of the ROMK potassium secretory channel in mouse kidney.
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| Fang L, Garuti R, Kim BY, Wade JB, Welling PA.
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| J Clin Invest 119(11):3278-89. doi: 10.1172/JCI37950. Epub 2009 Oct 19.
2009
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| 6 | KCNJ1, KL
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| Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho.
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| Cha SK, Hu MC, Kurosu H, Kuro-o M, Moe O, Huang CL.
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| Mol Pharmacol 76(1):38-46. Epub 2009 Apr 6.
2009
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| 7 | KCNJ1
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| Regulation of ROMK channel and K+ homeostasis by kidney-specific WNK1 kinase.
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| Liu Z, Wang HR, Huang CL.
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| J Biol Chem 284(18):12198-206. Epub 2009 Feb 25.
2009
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| 8 | CD63, KCNJ1, PTPRA, SRC
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| Expression of tetraspan protein CD63 activates protein-tyrosine kinase (PTK) and enhances the PTK-induced inhibition of ROMK channels.
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| Lin D, Kamsteeg EJ, Zhang Y, Jin Y, Sterling H, Yue P, Roos M, Duffield A, Spencer J, Caplan M, Wang WH.
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| J Biol Chem 283(12):7674-81. Epub 2008 Jan 22. 2008
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| 9 | CASR, KCNJ1, NR3C2, SCNN1G, SNN1B
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| Common variants in genes underlying monogenic hypertension and hypotension and blood pressure in the general population.
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| Tobin MD, Tomaszewski M, Braund PS, Hajat C, Raleigh SM, Palmer TM, Caulfield M, Burton PR, Samani NJ.
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| Hypertension 51(6):1658-64. Epub 2008 Apr 28.
2008
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| 10 | KCNJ1, SLC12A1, SLCA3
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| Rare independent mutations in renal salt handling genes contribute to blood pressure variation.
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| Ji W, Foo JN, O'Roak BJ, Zhao H, Larson MG, Simon DB, Newton-Cheh C, State MW, Levy D, Lifton RP.
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| Nat Genet 40(5):592-9. Epub 2008 Apr 6.
2008
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| 11 | KCNJ1, PHA2B, WNK4
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| The acidic motif of WNK4 is crucial for its interaction with the K channel ROMK.
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| Murthy M, Cope G, O'Shaughnessy KM.
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| Biochem Biophys Res Commun 375(4):651-4. Epub 2008 Aug 26.
2008
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| 12 | KCNJ1, WNK4
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| Intersectin links WNK kinases to endocytosis of ROMK1.
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| He G, Wang HR, Huang SK, Huang CL.
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| J Clin Invest 117(4):1078-87. Epub 2007 Mar 22.
2007
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| 13 | KCNJ1
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| ROMK1 channel activity is regulated by monoubiquitination.
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| Lin DH, Sterling H, Wang Z, Babilonia E, Yang B, Dong K, Hebert SC, Giebisch G, Wang WH.
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| Proc Natl Acad Sci U S A 102(12):4306-11. Epub 2005 Mar 14. 2005
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| 14 | KCNJ1
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| Phosphorylation-regulated endoplasmic reticulum retention signal in the renal outer-medullary K+ channel (ROMK).
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| O'Connell AD, Leng Q, Dong K, MacGregor GG, Giebisch G, Hebert SC.
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| Proc Natl Acad Sci U S A 102(28):9954-9. Epub 2005 Jun 29. 2005
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| 15 | WNK4, SLC12A3, KCNJ1
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| WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia.
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| ahle KT, Gimenez I, Hassan H, Wilson FH, Wong RD, Forbush B, Aronson PS, Lifton RP.
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| Proc Natl Acad Sci U S A 101(7):2064-9. Epub 2004 Feb 09. 2004
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| 16 | BSND2, KCNJ1
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| Classification and rescue of ROMK mutations underlying hyperprostaglandin E syndrome/antenatal Bartter syndrome.
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| Peters M, Ermert S, Jeck N, Derst C, Pechmann U, Weber S, Schlingmann KP, Seyberth HW, Waldegger S, Konrad M.
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| Kidney Int 64(3):923-32. 2003
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| 17 | KCNJ1
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| Functional heterogeneity of ROMK mutations linked to hyperprostaglandin E syndrome.
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| Jeck N, Derst C, Wischmeyer E, Ott H, Weber S, Rudin C, Seyberth HW, Daut J, Karschin A, Konrad M.
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| Kidney Int 59(5):1803-11. 2001
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| 18 | CLCNKB, KCNJ1, SLC12A1, BSND3
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| Mutations in the chloride channel gene CLCNKB as a cause of classic Bartter syndrome.
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| Konrad M, Vollmer M, Lemmink HH, van den Heuvel LP, Jeck N, Vargas-Poussou R, Lakings A, Ruf R, Deschenes G, Antignac C, Guay-Woodford L, Knoers NV, Seyberth HW, Feldmann D, Hildebrandt F.
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| J Am Soc Nephrol 11(8):1449-59. 2000
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| 19 | BSND2, KCNJ1
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| Functional consequences of ROMK mutants linked to antenatal Bartter's syndrome and implications for treatment.
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| Schwalbe RA, et al.
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| Hum Mol Genet 7 : 975-980. 1998
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| 20 | BSND2, KCNJ1
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| Mutations in the gene encoding the inwardly-rectifying renal potassium channel, ROMK, cause the antenatal variant of Bartter syndrome : evidence for genetic heterogeneity.
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| Karolyi L, et al.
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| Hum Mol Genet 6 : 17-26. 1997
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| 21 | BSND2, KCNJ1
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| Mutations in the ROMK gene in antenatal Bartter syndrome are associated with impaired K+ channel function.
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| Derst C, et al.
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| Biochem Biophys Res Commun 230 : 641-645. 1997
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| 22 | KCNJ1
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| Nucleotide sequence analysis of the human KCNJ1 potassium channel locus.
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| Bock JH, et al.
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| Gene 188 : 9-16. 1997
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| 23 | CLCN6, CLCN7, CLCN8, CLIC1, HTR3B, KCNAB1, KCNB1, KCNJ1, KCNJ2, KCNJ3, KCNJ5, KCNMA1
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| Chromosomal localization of 15 ion channel genes.
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| Russell MWW, et al.
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| Somat Cell Mol Genet 22 : 425-431. 1996
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| 24 | KCNJ1
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| Isolation and chromosomal localization of a human ATP-regulated potassium channel.
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| Krishnan SN, et al.
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| Hum Genet 96 : 155-160. 1995
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| 25 | KCNJ1
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| Cloning and characterization of multiple forms of the human kidney ROM-K potassium channel.
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| Shuck ME, Bock JH, Benjamin CW, Tsai TD, Lee KS, Slightom JL, Bienkowski MJ.
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| J Biol Chem 269(39):24261-70. 1994
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| 26 | KCNJ1
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| Alternative splicing of human inwardly rectifying K+ channel ROMK1 mRNA.
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| Yano H, Philipson LH, Kugler JL, Tokuyama Y, Davis EM, Le Beau MM, Nelson DJ, Bell GI, Takeda J.
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| Mol Pharmacol 45(5):854-60. 1994
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| 27 | KCNJ1
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| Cloning and expression of an inwardly rectifying ATP-regulated potassium channel.
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| Ho K, et al.
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| Nature 362 : 31-38. 1993
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