| 1 | INPP5J, KCNE1, KCNQ1
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| Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking.
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| Royal AA, Tinker A, Harmer SC.
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| PLoS One 12(10):e0186293. doi: 10.1371/journal.pone.0186293. eCollection 2017.
2017
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| 2 | AQP2, AQP3, KCNE1
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| Ménière's Disease: Molecular Analysis of Aquaporins 2, 3 and Potassium Channel KCNE1 Genes in Brazilian Patients.
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| Lopes Kde C, Sartorato EL, da Silva-Costa SM, de Macedo Adamov NS, Ganança FF.
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| Otol Neurotol 37(8):1117-21. doi: 10.1097/MAO.0000000000001136.
2016
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| 3 | KCNE1, KCNQ1, SGMS1
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| Regulation of membrane KCNQ1/KCNE1 channel density by sphingomyelin synthase 1.
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| Wu M, Takemoto M, Taniguchi M, Takumi T, Okazaki T, Song WJ.
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| Am J Physiol Cell Physiol 311(1):C15-23. doi: 10.1152/ajpcell.00272.2015. Epub 2016 May 18.
2016
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| 4 | BACE1, KCNE1, KCNQ1
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| BACE1 modulates gating of KCNQ1 (Kv7.1) and cardiac delayed rectifier KCNQ1/KCNE1 (IKs).
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| Agsten M, Hessler S, Lehnert S, Volk T, Rittger A, Hartmann S, Raab C, Kim DY, Groemer TW, Schwake M, Alzheimer C, Huth T.
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| J Mol Cell Cardiol 89(Pt B):335-48. doi: 10.1016/j.yjmcc.2015.10.006. Epub 2015 Oct 8.
2015
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| 5 | KCNE1, KCNQ1, OXSR1, STK39
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| SPAK and OSR1 Sensitive Cell Membrane Protein Abundance and Activity of KCNQ1/E1 K+ Channels.
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| Elvira B, Warsi J, Fezai M, Munoz C, Lang F.
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| Cell Physiol Biochem 37(5):2032-42. doi: 10.1159/000438563. Epub 2015 Nov 20.
2015
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| 6 | KCNE1, KCNE2, KCNQ1
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| Differential modulations of KCNQ1 by auxiliary proteins KCNE1 and KCNE2.
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| Li P, Liu H, Lai C, Sun P, Zeng W, Wu F, Zhang L, Wang S, Tian C, Ding J.
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| Sci Rep 4:4973. doi: 10.1038/srep04973.
2014
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| 7 | KCNE1, KCNQ1, KL
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| Upregulation of KCNQ1/KCNE1 K+ channels by Klotho.
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| Almilaji A, Pakladok T, Muñoz C, Elvira B, Sopjani M, Lang F.
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| Channels (Austin) 8(3):222-9.
2014
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| 8 | KCNE1
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| Structural investigation of the transmembrane domain of KCNE1 in proteoliposomes.
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| Sahu ID, Kroncke BM, Zhang R, Dunagan MM, Smith HJ, Craig A, McCarrick RM, Sanders CR, Lorigan GA.
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| Biochemistry 53(40):6392-401. doi: 10.1021/bi500943p. Epub 2014 Oct 3.
2014
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| 9 | KCNE1, KCNE2
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| Differential modulations of KCNQ1 by auxiliary proteins KCNE1 and KCNE2.
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| Li P, Liu H, Lai C, Sun P, Zeng W, Wu F, Zhang L, Wang S, Tian C, Ding J.
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| Sci Rep 4:4973. doi: 10.1038/srep04973.
2014
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| 10 | BACE1, KCNE1, KCNE2
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| BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels.
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| Sachse CC, Kim YH, Agsten M, Huth T, Alzheimer C, Kovacs DM, Kim DY.
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| FASEB J 27(6):2458-67. doi: 10.1096/fj.12-214056. Epub 2013 Mar 15.
2013
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| 11 | KCNE1, KCNQ1
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| Trafficking of the IKs -complex in MDCK cells: site of subunit assembly and determinants of polarized localization.
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| David JP, Andersen MN, Olesen SP, Rasmussen HB, Schmitt N.
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| Traffic 14(4):399-411. doi: 10.1111/tra.12042. Epub 2013 Feb 13.
2013
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| 12 | KCNE1, KCNQ1
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| KCNQ1 channels do not undergo concerted but sequential gating transitions in both the absence and the presence of KCNE1 protein.
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| Meisel E, Dvir M, Haitin Y, Giladi M, Peretz A, Attali B.
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| J Biol Chem 287(41):34212-24. doi: 10.1074/jbc.M112.364901. Epub 2012 Aug 20.
2012
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| 13 | KCNE1, KCNQ1
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| Regulation of KCNQ1/KCNE1 by β-catenin.
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| Wilmes J, Haddad-Tóvolli R, Alesutan I, Munoz C, Sopjani M, Pelzl L, Bogatikov E, Fedele G, Faggio C, Seebohm G, Föller M, Lang F.
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| Mol Membr Biol 29(3-4):87-94. doi: 10.3109/09687688.2012.678017. Epub 2012 May 14.
2012
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| 14 | KCNE1
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| KCNE1 D85N polymorphism--a sex-specific modifier in type 1 long QT syndrome?
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| Lahtinen AM, Marjamaa A, Swan H, Kontula K.
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| BMC Med Genet 12:11.
2011
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| 15 | KCNE1, KCNQ1
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| Analysis of the interactions between the C-terminal cytoplasmic domains of KCNQ1 and KCNE1 channel subunits.
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| Zheng R, Thompson K, Obeng-Gyimah E, Alessi D, Chen J, Cheng H, McDonald TV.
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| Biochem J 428(1):75-84.PMID: 20196769 2010
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| 16 | KCNE1, KCNQ1
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| KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate.
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| Osteen JD, Gonzalez C, Sampson KJ, Iyer V, Rebolledo S, Larsson HP, Kass RS.
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| Proc Natl Acad Sci U S A 107(52):22710-5. Epub 2010 Dec 13.
2010
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| 17 | KCNE1, KCNQ1
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| Stoichiometry of the KCNQ1 - KCNE1 ion channel complex.
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| Nakajo K, Ulbrich MH, Kubo Y, Isacoff EY.
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| Proc Natl Acad Sci U S A 107(44):18862-7. Epub 2010 Oct 20.
2010
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| 18 | KCNE1, KCNQ1
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| Identification of a protein-protein interaction between KCNE1 and the activation gate machinery of KCNQ1.
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| Lvov A, Gage SD, Berrios VM, Kobertz WR.
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| J Gen Physiol 135(6):607-18. Epub 2010 May 17.
2010
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| 19 | KCNE1, SCN5A
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| Common variants in cardiac ion channel genes are associated with sudden cardiac death.
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| Albert CM, MacRae CA, Chasman DI, VanDenburgh M, Buring JE, Manson JE, Cook NR, Newton-Cheh C.
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| Circ Arrhythm Electrophysiol 3(3):222-9. Epub 2010 Apr 17.
2010
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| 20 | KCNE1, LQT5
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| Mechanisms of disease pathogenesis in long QT syndrome type 5.
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| Harmer SC, Wilson AJ, Aldridge R, Tinker A.
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| Am J Physiol Cell Physiol 298(2):C263-73. Epub 2009 Nov 11.
2010
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| 21 | KCNE1, KCNE2
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| Dynamic partnership between KCNQ1 and KCNE1 and influence on cardiac IKs current amplitude by KCNE2.
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| Jiang M, Xu X, Wang Y, Toyoda F, Liu XS, Zhang M, Robinson RB, Tseng GN.
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| J Biol Chem 284(24):16452-62. Epub 2009 Apr 16.PMID: 19372218 2009
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| 22 | KCNE1, KCNQ1
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| Intracellular domains interactions and gated motions of I(KS) potassium channel subunits.
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| Haitin Y, Wiener R, Shaham D, Peretz A, Cohen EB, Shamgar L, Pongs O, Hirsch JA, Attali B.
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| EMBO J 28(14):1994-2005. Epub 2009 Jun 11.
2009
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| 23 | KCNE1, KCNQ1
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| Functional interactions between KCNE1 C-terminus and the KCNQ1 channel.
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| Chen J, Zheng R, Melman YF, McDonald TV.
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| PLoS One 4(4):e5143. Epub 2009 Apr 2.
2009
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| 24 | CLIC6, DEL21Q22, DSCR, FPDAML, KCNE1, RUNX1
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| Syndromic thrombocytopenia and predisposition to acute myelogenous leukemia caused by constitutional microdeletions on chromosome 21q.
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| Shinawi M, Erez A, Shardy DL, Lee B, Naeem R, Weissenberger G, Chinault AC, Cheung SW, Plon SE.
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| Blood 112(4):1042-7. Epub 2008 May 16. 2008
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| 25 | KCNA1, KCNA5, KCNE1
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| Potassium channels involved in human sperm volume regulation--quantitative studies at the protein and mRNA levels.
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| Yeung CH, Cooper TG.
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| Mol Reprod Dev 75(4):659-68. 2008
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| 26 | KCNE1, KCNQ1
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| Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel.
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| Kang C, Tian C, Sönnichsen FD, Smith JA, Meiler J, George AL Jr, Vanoye CG, Kim HJ, Sanders CR.
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| Biochemistry 47(31):7999-8006. Epub 2008 Jul 9.
2008
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| 27 | KCNE1, KCNE4, KCNQ1
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| KCNE4 can co-associate with the I(Ks) (KCNQ1-KCNE1) channel complex.
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| Manderfield LJ, George AL Jr.
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| FEBS J 275(6):1336-49. Epub 2008 Feb 14.
2008
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| 28 | KCNE1
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| Preparation, functional characterization, and NMR studies of human KCNE1, a voltage-gated potassium channel accessory subunit associated with deafness and long QT syndrome.
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| Tian C, Vanoye CG, Kang C, Welch RC, Kim HJ, George AL Jr, Sanders CR.
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| Biochemistry 46(41):11459-72. Epub 2007 Sep 25. 2007
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| 29 | KCNE1
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| Characterization of the cardiac KCNE1 gene promoter.
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| Mustapha Z, Pang L, Nattel S.
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| Cardiovasc Res 73(1):82-91. Epub 2006 Nov 10. 2007
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| 30 | KCNE1, KCNQ1
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| Regulation of endocytic recycling of KCNQ1/KCNE1 potassium channels.
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| Seebohm G, Strutz-Seebohm N, Birkin R, Dell G, Bucci C, Spinosa MR, Baltaev R, Mack AF, Korniychuk G, Choudhury A, Marks D, Pagano RE, Attali B, Pfeufer A, Kass RS, Sanguinetti MC, Tavare JM, Lang F.
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| Circ Res 100(5):686-92. Epub 2007 Feb 9.
2007
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| 31 | KCNE1
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| Upregulation of KCNE1 induces QT interval prolongation in patients with chronic heart failure.
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| Watanabe E, Yasui K, Kamiya K, Yamaguchi T, Sakuma I, Honjo H, Ozaki Y, Morimoto S, Hishida H, Kodama I.
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| Circ J 71(4):471-8.
2007
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| 32 | KCNE1, KCNE2, KCNH2
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| Differential association between HERG and KCNE1 or KCNE2.
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| Um SY, McDonald TV.
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| PLoS One 2(9):e933.PMID: 17895974 2007
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| 33 | KCNE1, LQT5
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| The role of abnormal trafficking of KCNE1 in long QT syndrome 5.
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| Harmer SC, Tinker A.
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| Biochem Soc Trans 35(Pt 5):1074-6. Review.PMID: 17956282 2007
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| 34 | KCNQ1, LQT1, KCNE1, KCNE2, LQT5, LQT6, SCN5A, LQT3, KCNH2, LQT2
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| Spectrum of pathogenic mutations and associated polymorphisms in a cohort of 44 unrelated patients with long QT syndrome.
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| Millat G, Chevalier P, Restier-Miron L, Da Costa A, Bouvagnet P, Kugener B, Fayol L, Gonzalez Armengod C, Oddou B, Chanavat V, Froidefond E, Perraudin R, Rousson R, Rodriguez-Lafrasse C.
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| Clin Genet 70(3):214-27. 2006
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| 35 | KCNE1, KCNE1L, KCNE2, KCNE3, KCNE4
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| Expression and transcriptional control of human KCNE genes.
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| Lundquist AL, Turner CL, Ballester LY, George AL Jr.
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| Genomics 87(1):119-28. Epub 2005 Nov 21. 2006
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| 36 | KCNE1
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| Possible association of the human KCNE1 (minK) gene and QT interval in healthy subjects: evidence from association and linkage analyses in Israeli families.
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| Friedlander Y, Vatta M, Sotoodehnia N, Sinnreich R, Li H, Manor O, Towbin JA, Siscovick DS, Kark JD.
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| Ann Hum Genet 69(Pt 6):645-56. 2005
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| 37 | KCNQ1, KCNE1, KCNH2, SCN5A
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| Association of KCNQ1, KCNE1, KCNH2 and SCN5A polymorphisms with QTc interval length in a healthy population.
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| Gouas L, Nicaud V, Berthet M, Forhan A, Tiret L, Balkau B, Guicheney P; D.
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| Eur J Hum Genet 13(11):1213-22. 2005
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| 38 | KCNQ1, KCNH2, SCN5A, KCNE1, KCNE2
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| Single nucleotide polymorphism map of five long-QT genes.
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| Aydin A, Bahring S, Dahm S, Guenther UP, Uhlmann R, Busjahn A, Luft FC.
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| J Mol Med 83(2):159-65. Epub 2004 Dec 15. 2005
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| 39 | KCNQ1, KCNE1
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| Impaired KCNQ1-KCNE1 and phosphatidylinositol-4,5-bisphosphate interaction underlies the long QT syndrome.
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| Park KH, Piron J, Dahimene S, Merot J, Baro I, Escande D, Loussouarn G.
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| Circ Res 96(7):730-9. Epub 2005 Mar 3. 2005
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| 40 | KCNE1, KCNQ1, LQT1, LQT5
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| Dominant-negative I(Ks) suppression by KCNQ1-deltaF339 potassium channels linked to Romano-Ward syndrome.
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| Thomas D, Wimmer AB, Karle CA, Licka M, Alter M, Khalil M, Ulmer HE, Kathofer S, Kiehn J, Katus HA, Schoels W, Koenen M, Zehelein J.
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| Cardiovasc Res 67(3):487-97. 2005
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| 41 | KCNE1, LQT5
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| Characterization of a novel Long QT syndrome mutation G52R-KCNE1 in a Chinese family.
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| Ma L, Lin C, Teng S, Chai Y, Bahring R, Vardanyan V, Li L, Pongs O, Hui R.
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| Cardiovasc Res 59(3):612-9. 2003
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| 42 | AKAP9, KCNE1, KCNQ1
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| Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel.
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| Marx SO, Kurokawa J, Reiken S, Motoike H, D'Armiento J, Marks AR, Kass RS.
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| Science 295(5554):496-9. 2002
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| 43 | KCNE1, KCNQ1
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| KCNQ1/KCNE1 potassium channels in mammalian vestibular dark cells.
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| Nicolas M, Dememes D, Martin A, Kupershmidt S, Barhanin J.
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| Hear Res 153(1-2):132-45. 2001
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| 44 | KCNE1, KCNQ1
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| Novel mutations in KvLQT1 that affect Iks activation through interactions with Isk.
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| Chouabe C, Neyroud N, Richard P, Denjoy I, Hainque B, Romey G, Drici MD, Guicheney P, Barhanin J.
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| Cardiovasc Res 45(4):971-80. 2000
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| 45 | KCNE1, KCNH2, KCNQ1, SCN5A
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| Twenty single nucleotide polymorphisms (SNPs) and their allelic frequencies in four genes that are responsible for familial long QT syndrome in the Japanese population.
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| Iwasa H, Itoh T, Nagai R, Nakamura Y, Tanaka T.
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| J Hum Genet 45(3):182-3. 2000
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| 46 | KCNE1, KCNE3, KCNK1
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| A constitutively open potassium channel formed by KCNQ1 and KCNE3.
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| Schroeder BC, Waldegger S, Fehr S, Bleich M, Warth R, Greger R, Jentsch TJ.
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| Nature 403(6766):196-9. 2000
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| 47 | JLNS2, KCNE1, KCNF1, KCNQ1
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| Genomic structure of three long QT syndrome genes : KVLQT1, HERG, and KCNE1.
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| Splawski I, et al.
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| Genomics 51 : 86-97. 1998
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| 48 | JLNS1, JLNS2, KCNQ1, KCNE1
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| IsK and KvLQT1: mutation in either of the two subunits of the slow component of the delayed rectifier potassium channel can cause Jervell and Lange-Nielsen syndrome.
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| Tyson J, Tranebjaerg L, Bellman S, Wren C, Taylor JF, Bathen J, Aslaksen B, Sorland SJ, Lund O, Malcolm S, Pembrey M, Bhattacharya S, Bitner-Glindzicz M.
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| Hum Mol Genet 6(12):2179-85. 1997
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| 49 | JLNS2, KCNE1
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| KCNE1 mutations cause Jervell and Lange-Nielsen syndrome.
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| Schulze-Bahr E, Wang Q, Wedekind H, Haverkamp W, Chen Q, Sun Y, Rubie C, Hordt M, Towbin JA, Borggrefe M, Assmann G, Qu X, Somberg JC, Breithardt G, Oberti C, Funke H.
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| Nat Genet 17(3):267-8. No abstract available. 1997
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| 50 | KCNE1, KCNE2
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| A minK-HERG complex regulates the cardiac potassium current I(Kr).
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| McDonald TV, et al.
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| Nature 388(6639):289-92. 1997
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| 51 | KCNE1, KCNQ1
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| K(V)LQT1 and IsK (minK) proteins associate to form the I(Ks) cardiac potassium current.
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| Barhanin J, et al.
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| Nature 384 : 78-80. 1996
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| 52 | KCNE1, KCNQ1
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| Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel.
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| Sanguinetti MC, et al.
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| Nature 384 : 80-83. 1996
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| 53 | KCNE1
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| Gene assignment by polymerase chain reaction : localization of the human potassium channel I sK gene to the Down's syndrome region of chromosome 21q22.1-q22.2.
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| Malo MS, et al.
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| Gene 159 : 273-275. 1995
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| 54 | KCNE1
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| Polymorphism of the gene encoding a human minimal potassium ion channel (minK).
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| Lai LP, et al.
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| Gene 151 : 339-340. 1994
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| 55 | KCNE1
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| Localization of a potassium channel gene (KCNE1) to 21q22.1-q22.2 by in situ hybridization and somatic cell hybridization.
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| Chevillard C, et al.
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| Genomics 15 : 243-245. 1993
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| 56 | KCNA1, KCNA2, KCNA5, KCNA7, KCNC2, KCNC3, KCNC4, KCNE1
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| Chromosomal localization of 7 potassium channel genes.
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| McPherson JD, et al.
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| (HGM11) Cytogenet Cell Genet 58 : 1979. 1991
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| 57 | KCNE1
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| Molecular cloning and sequence analysis of human genomic DNA encoding a novel membrane protein which exhibits a slowly activating potassium channel activity.
|
| Murai T, et al.
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| Biochem Biophys Res Commun 161(1):176-81. 1989
|