Citations for
1ERCC3, GTF2H1, KAT2A
Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression.
Sandoz J, Nagy Z, Catez P, Caliskan G, Geny S, Renaud JB, Concordet JP, Poterszman A, Tora L, Egly JM, Le May N, Coin F.
Nat Commun 10(1):1288. doi: 10.1038/s41467-019-09270-2. 2019
2KAT2A, KAT2B
Kat2a and Kat2b Acetyltransferase Activity Regulates Craniofacial Cartilage and Bone Differentiation in Zebrafish and Mice.
Sen R, Pezoa SA, Carpio Shull L, Hernandez-Lagunas L, Niswander LA, Artinger KB.
J Dev Biol 6(4). pii: E27. doi: 10.3390/jdb6040027. 2018
3KAT2A
Histone Acetyltransferase KAT2A Stabilizes Pluripotency with Control of Transcriptional Heterogeneity.
Moris N, Edri S, Seyres D, Kulkarni R, Domingues AF, Balayo T, Frontini M, Pina C.
Stem Cells 36(12):1828-1838. doi: 10.1002/stem.2919. Epub 2018 Oct 17. 2018
4KAT2A
GCN5 Regulates FGF Signaling and Activates Selective MYC Target Genes during Early Embryoid Body Differentiation.
Wang L, Koutelou E, Hirsch C, McCarthy R, Schibler A, Lin K, Lu Y, Jeter C, Shen J, Barton MC, Dent SYR.
Stem Cell Reports 10(1):287-299. doi: 10.1016/j.stemcr.2017.11.009. Epub 2017 Dec 14. 2018
5KAT2A
Declining histone acetyltransferase GCN5 represses BMSC-mediated angiogenesis during osteoporosis.
Jing H, Liao L, Su X, Shuai Y, Zhang X, Deng Z, Jin Y.
FASEB J 31(10):4422-4433. doi: 10.1096/fj.201700118R. Epub 2017 Jun 22. 2017
6KAT2A
The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation.
Gao B, Kong Q, Zhang Y, Yun C, Dent SYR, Song J, Zhang DD, Wang Y, Li X, Fang D.
J Immunol 198(10):3927-3938. doi: 10.4049/jimmunol.1600312. Epub 2017 Apr 19. 2017
7KAT2A
Diencephalic Size Is Restricted by a Novel Interplay Between GCN5 Acetyltransferase Activity and Retinoic Acid Signaling.
Wilde JJ, Siegenthaler JA, Dent SY, Niswander LA.
J Neurosci 37(10):2565-2579. doi: 10.1523/JNEUROSCI.2121-16.2017. Epub 2017 Feb 2. 2017
8KAT2A, KAT2B, PLK4
KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification.
Fournier M, Orpinell M, Grauffel C, Scheer E, Garnier JM, Ye T, Chavant V, Joint M, Esashi F, Dejaegere A, G÷nczy P, Tora L.
Nat Commun 7:13227. doi: 10.1038/ncomms13227. 2016
9KAT2A
GCN5 modulates osteogenic differentiation of periodontal ligament stem cells through DKK1 acetylation in inflammatory microenvironment.
Li B, Sun J, Dong Z, Xue P, He X, Liao L, Yuan L, Jin Y.
Sci Rep 6:26542. doi: 10.1038/srep26542. 2016
10KAT2A, ORC5
Orc5 induces large-scale chromatin decondensation in a GCN5-dependent manner.
Giri S, Chakraborty A, Sathyan KM, Prasanth KV, Prasanth SG.
J Cell Sci 129(2):417-29. doi: 10.1242/jcs.178889. Epub 2015 Dec 7. 2016
11KAT2A
Histone Acetyltransferase GCN5 Regulates Osteogenic Differentiation of Mesenchymal Stem Cells by Inhibiting NF-κB.
Zhang P, Liu Y, Jin C, Zhang M, Tang F, Zhou Y.
J Bone Miner Res 31(2):391-402. doi: 10.1002/jbmr.2704. Epub 2015 Sep 30. 2016
12KAT2A, LAMTOR5
The oncoprotein HBXIP promotes migration of breast cancer cells via GCN5-mediated microtubule acetylation.
Li L, Liu B, Zhang X, Ye L.
Biochem Biophys Res Commun 458(3):720-725. doi: 10.1016/j.bbrc.2015.02.036. Epub 2015 Feb 14. 2015
13EBF1, KAT2A, PRKCQ
Protein kinase Cθ gene expression is oppositely regulated by GCN5 and EBF1 in immature B cells.
Kikuchi H, Nakayama M, Kuribayashi F, Imajoh-Ohmi S, Nishitoh H, Takami Y, Nakayama T.
FEBS Lett EBS Lett. 2014 Mar 19. pii: S0014-5793(14)00230-0. doi: 10.1016/j.febslet.2014.03.025. [Epub ahead of print] 2014
14KAT2A, MYC, TRRAP
MYC interacts with the human STAGA coactivator complex via multivalent contacts with the GCN5 and TRRAP subunits.
Zhang N, Ichikawa W, Faiola F, Lo SY, Liu X, Martinez E.
Biochim Biophys Acta 1839(5):395-405. doi: 10.1016/j.bbagrm.2014.03.017. Epub 2014 Apr 3. 2014
15ATXN7, KAT2A
Direct inhibition of Gcn5 protein catalytic activity by polyglutamine-expanded ataxin-7.
Burke TL, Miller JL, Grant PA.
J Biol Chem 288(47):34266-75. doi: 10.1074/jbc.M113.487538. Epub 2013 Oct 15. 2013
16KAT2A, SUPT20H
The p38-interacting protein (p38IP) regulates G2/M progression by promoting α-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5.
Liu X, Xiao W, Wang XD, Li YF, Han J, Li Y.
J Biol Chem. Dec 20;288(51):36648-61. doi: 10.1074/jbc.M113.486910. Epub 2013 Nov 12. PMID: 24220028 Free PMC article. 2013
17KAT2A, WDHD1
And-1 is required for the stability of histone acetyltransferase Gcn5.
Li Y, Jaramillo-Lambert AN, Yang Y, Williams R, Lee NH, Zhu W.
Oncogene 31(5):643-52. doi: 10.1038/onc.2011.261. Epub 2011 Jul 4. 2012
18ATAT1, KAT2A
Structure of the α-tubulin acetyltransferase, αTAT1, and implications for tubulin-specific acetylation.
Friedmann DR, Aguilar A, Fan J, Nachury MV, Marmorstein R.
Proc Natl Acad Sci U S A 109(48):19655-60. doi: 10.1073/pnas.1209357109. Epub 2012 Oct 15. 2012
19HSF1, KAT2A, PTGES3
The p23 molecular chaperone and GCN5 acetylase jointly modulate protein-DNA dynamics and open chromatin status.
Zelin E, Zhang Y, Toogun OA, Zhong S, Freeman BC.
Mol Cell 48(3):459-70. doi: 10.1016/j.molcel.2012.08.026. Epub 2012 Sep 27. 2012
20BTK, KAT2A, SYK
GCN5 regulates the activation of PI3K/Akt survival pathway in B cells exposed to oxidative stress via controlling gene expressions of Syk and Btk.
Kikuchi H, Kuribayashi F, Takami Y, Imajoh-Ohmi S, Nakayama T.
Biochem Biophys Res Commun 405(4):657-61. Epub 2011 Jan 31. 2011
21BRD4, KAT2A, KAT5, NUT
Perturbation of BRD4 protein function by BRD4-NUT protein abrogates cellular differentiation in NUT midline carcinoma.
Yan J, Diaz J, Jiao J, Wang R, You J.
J Biol Chem 286(31):27663-75. Epub 2011 Jun 7. 2011
22DTL, KAT2A, WDHD1
The stability of histone acetyltransferase general control non-derepressible (Gcn) 5 is regulated by Cullin4-RING E3 ubiquitin ligase.
Li Y, Jaramillo-Lambert A, Hao J, Yang Y, Zhu W.
J Biol Chem 286(48):41344-52. doi: 10.1074/jbc.M111.290767. Epub 2011 Oct 10. 2011
23KAT2A
Gcn5 regulates the dissociation of SWI/SNF from chromatin by acetylation of Swi2/Snf2.
Kim JH, Saraf A, Florens L, Washburn M, Workman JL.
Genes Dev 24(24):2766-71. 2010
24GCN5, KAT2A
The STAGA subunit ADA2b is an important regulator of human GCN5 catalysis.
Gamper AM, Kim J, Roeder RG.
Mol Cell Biol. 29(1):266-80 2009
25KAT2A, RELA
GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA.
Mao X, Gluck N, Li D, Maine GN, Li H, Zaidi IW, Repaka A, Mayo MW, Burstein E.
Genes Dev 23(7):849-61. 2009
26CDC6, KAT2A
Acetylation by GCN5 regulates CDC6 phosphorylation in the S phase of the cell cycle.
Paolinelli R, Mendoza-Maldonado R, Cereseto A, Giacca M.
Nat Struct Mol Biol 16(4):412-20. Epub 2009 Apr 3. 2009
27CHEK1, KAT2A
Chk1 Is a Histone H3 Threonine 11 Kinase that Regulates DNA Damage-Induced Transcriptional Repression.
Shimada M, Niida H, Zineldeen DH, Tagami H, Tanaka M, Saito H, Nakanishi M.
Cell 132(2):221-32. 2008
28KAT2A, SUPT3H, SUPT7L, TADA1, TAF9
Multivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damage.
Gamper AM, Roeder RG.
Mol Cell Biol 28(8):2517-27. Epub 2008 Feb 4.PMID: 18250150 2008
29KAT2A, SUPT3H, SUPT7L, TADA1, TAF9
STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation.
Liu X, Vorontchikhina M, Wang YL, Faiola F, Martinez E.
Mol Cell Biol 28(1):108-21. Epub 2007 Oct 29.PMID: 17967894 2008
30KAT2A, TRRAP
TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription.
Kenneth NS, Ramsbottom BA, Gomez-Roman N, Marshall L, Cole PA, White RJ.
Proc Natl Acad Sci U S A 104(38):14917-22. Epub 2007 Sep 11. 2007
31KAT2A, KAT2B, SUPT3H, SUPT7L, TADA1, TAF9
Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.
Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG.
Mol Cell Biol 21(20):6782-95.PMID: 11564863 2001
32GCN5, KAT2A
Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development.
Xu, W.; Edmondson, D. G.; Evrard, Y. A.; Wakamiya, M.; Behringer, R. R.; Roth, S. Y.
Nature Genet 26: 229-232 2000
33HDAC1, HDAC2, HDAC3, KAT2A, KAT2B
Identification and mapping of human histone acetylation modifier gene homologues.
Randhawa GS, et al.
Genomics 51 : 262-269. 1998
34GCN5, KAT2A, KAT2B
Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates.
Xu W, Edmondson DG, Roth SY.
Mol Cell Biol 18(10):5659-69. 1998
35GCN5, KAT2A, TADA2L
The human transcriptional adaptor genes TADA2L and GCN5L2 colocalize to chromosome 17q12-q21 and display a similar tissue expression pattern.
Carter, K. C.; Wang, L.; Shell, B. K.; Zamir, I.; Berger, S. L.; Moore, P. A.
Genomics 40: 497-500 1997
36GCN5, KAT2A, TADA2L
Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5.
Candau, R.; Moore, P. A.; Wang, L.; Barlev, N.; Ying, C. Y.; Rosen, C. A.; Berger, S. L.
Molec. Cell. Biol. 16: 593-602 1996
37ACLY, BRCA1, CNP, KAT2A, NBR1, PSME3, PYY, RAB5C
A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21.
Albertsen HM, et al.
Nat Genet 7 : 472-479. 1994
38KAT2A, KAT2B
Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription.
Georgakopoulos T, et al.
EMBO J 11 : 4145-4152. 1992