Citations for
1CLK2, HIPK1, JUN, PAGE4
PAGE4 and Conformational Switching: Insights from Molecular Dynamics Simulations and Implications for Prostate Cancer.
Lin X, Roy S, Jolly MK, Bocci F, Schafer NP, Tsai MY, Chen Y, He Y, Grishaev A, Weninger K, Orban J, Kulkarni P, Rangarajan G, Levine H, Onuchic JN.
J Mol Biol 430(16):2422-2438. doi: 10.1016/j.jmb.2018.05.011. Epub 2018 Jun 5. 2018
2CYP11A1, FDX1, JUN
Transcription factors SF1 and cJUN cooperate to activate the Fdx1 promoter in MA-10 Leydig cells.
Roumaud P, Rwigemera A, Martin LJ.
J Steroid Biochem Mol Biol 171:121-132. doi: 10.1016/j.jsbmb.2017.03.003. Epub 2017 Mar 6. 2017
3BATF, JUN, JUNB
Inhibition of BATF/JUN transcriptional activity protects against osteoarthritic cartilage destruction.
Rhee J, Park SH, Kim SK, Kim JH, Ha CW, Chun CH, Chun JS.
Ann Rheum Dis 76(2):427-434. doi: 10.1136/annrheumdis-2015-208953. Epub 2016 May 4. 2017
4CLK2, HIPK1, JUN, PAGE4
Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity.
Kulkarni P, Jolly MK, Jia D, Mooney SM, Bhargava A, Kagohara LT, Chen Y, Hao P, He Y, Veltri RW, Grishaev A, Weninger K, Levine H, Orban J.
Proc Natl Acad Sci U S A 114(13):E2644-E2653. doi: 10.1073/pnas.1700082114. Epub 2017 Mar 13. 2017
5JUN, KLF15
c-Jun regulates adipocyte differentiation via the KLF15-mediated mode.
Lee da S, Choi H, Han BS, Kim WK, Lee SC, Oh KJ, Bae KH.
Biochem Biophys Res Commun 469(3):552-8. doi: 10.1016/j.bbrc.2015.12.035. Epub 2015 Dec 13. 2016
6JUN, RBPMS
The RNA-binding protein RBPMS1 represses AP-1 signaling and regulates breast cancer cell proliferation and migration.
Fu J, Cheng L, Wang Y, Yuan P, Xu X, Ding L, Zhang H, Jiang K, Song H, Chen Z, Ye Q.
Biochim Biophys Acta 1853(1):1-13. doi: 10.1016/j.bbamcr.2014.09.022. 2015
7APPL1, DVL2, JUN
APPL1 endocytic adaptor as a fine tuner of Dvl2-induced transcription.
Banach-Orlowska M, Szymanska E, Miaczynska M.
FEBS Lett 589(4):532-9. doi: 10.1016/j.febslet.2015.01.022. Epub 2015 Jan 23. 2015
8COPS6, JUN, MAP3K1
CSN6 positively regulates c-Jun in a MEKK1-dependent manner.
Shin J, Phan L, Chen J, Lu Z, Lee MH.
Cell Cycle 14(19):3079-87. doi: 10.1080/15384101.2015.1078030. Epub 2015 Aug 3. 2015
9JUN, KRIT1
KRIT1 loss of function causes a ROS-dependent upregulation of c-Jun.
Goitre L, De Luca E, Braggion S, Trapani E, Guglielmotto M, Biasi F, Forni M, Moglia A, Trabalzini L, Retta SF.
Free Radic Biol Med 68:134-47. doi: 10.1016/j.freeradbiomed.2013.11.020. Epub 2013 Nov 28. 2014
10JUN, PAK3
p21-activated kinase 3 (PAK3) is an AP-1 regulated gene contributing to actin organisation and migration of transformed fibroblasts.
Holderness Parker N, Donninger H, Birrer MJ, Leaner VD.
PLoS One 8(6):e66892. doi: 10.1371/journal.pone.0066892. Print 2013. 2013
11AFF2, FOS, JUN
Loss of FMR2 further emphasizes the link between deregulation of immediate early response genes FOS and JUN and intellectual disability.
Melko M, Nguyen LS, Shaw M, Jolly L, Bardoni B, Gecz J.
Hum Mol Genet 22(15):2984-91. doi: 10.1093/hmg/ddt155. Epub 2013 Apr 5. 2013
12IPO13, JUN, KRT17
Increased importin 13 activity is associated with the pathogenesis of pterygium. PMID:
Xu K, Tao T, Jie J, Lu X, Li X, Mehmood MA, He H, Liu Z, Xiao X, Yang J, Ma JX, Li W, Zhou Y, Liu Z.
Mol Vis. 2013;19:604-13. Epub 2013 Mar 20. 2013
13JUN
Neuronal c-Jun is required for successful axonal regeneration, but the effects of phosphorylation of its N-terminus are moderate.
Ruff CA, Staak N, Patodia S, Kaswich M, Rocha-Ferreira E, Da Costa C, Brecht S, Makwana M, Fontana X, Hristova M, Rumajogee P, Galiano M, Bohatschek M, Herdegen T, Behrens A, Raivich G.
J Neurochem. 121(4):607-18. 2012
14JUN
Rack1 protects N-terminal phosphorylated c-Jun from Fbw7-mediated degradation.
Zhang J, Zhu F, Li X, Dong Z, Xu Y, Peng C, Li S, Cho YY, Yao K, Zykova TA, Bode AM, Dong Z.
Oncogene. 31(14):1835-44. 2012
15CCND1, JUN, PAX2
PAX2 protein induces expression of cyclin D1 through activating AP-1 protein and promotes proliferation of colon cancer cells.
Zhang HS, Yan B, Li XB, Fan L, Zhang YF, Wu GH, Li M, Fang J.
J Biol Chem 287(53):44164-72. doi: 10.1074/jbc.M112.401521. Epub 2012 Nov 7. 2012
16FOSB, JUN, SERPINB2
Regulation of the human plasminogen activator inhibitor type 2 gene: cooperation of an upstream silencer and transactivator.
Stringer B, Udofa EA, Antalis TM.
J Biol Chem 287(13):10579-89. doi: 10.1074/jbc.M111.318758. Epub 2012 Feb 9. 2012
17DYRK2, JUN, MYC
DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells.
Taira N, Mimoto R, Kurata M, Yamaguchi T, Kitagawa M, Miki Y, Yoshida K.
J Clin Invest 122(3):859-72. doi: 10.1172/JCI60818. Epub 2012 Feb 6. 2012
18AATF, JUN
Nucleolar AATF regulates c-Jun-mediated apoptosis.
Ferraris SE, Isoniemi K, Torvaldson E, Anckar J, Westermarck J, Eriksson JE.
Mol Biol Cell 23(21):4323-32. doi: 10.1091/mbc.E12-05-0419. Epub 2012 Aug 29. 2012
19JUN, STRAP
STRAP regulates c-Jun ubiquitin-mediated proteolysis and cellular proliferation.
Reiner J, Ye F, Kashikar ND, Datta PK.
Biochem Biophys Res Commun 407(2):372-7. Epub 2011 Mar 21. 2011
20JUN
Transcription factor AP1 potentiates chromatin accessibility and glucocorticoid receptor binding.
Biddie SC, John S, Sabo PJ, Thurman RE, Johnson TA, Schiltz RL, Miranda TB, Sung MH, Trump S, Lightman SL, Vinson C, Stamatoyannopoulos JA, Hager GL.
Mol Cell 43(1):145-55. 2011
21JUN
Stat6 and c-Jun mediate Th2 cell-specific IL-24 gene expression.
Sahoo A, Lee CG, Jash A, Son JS, Kim G, Kwon HK, So JS, Im SH.
J Immunol. 186(7):4098-109. 2011
22JUN
c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex.
Aguilera C, Nakagawa K, Sancho R, Chakraborty A, Hendrich B, Behrens A.
Nature. 469(7329):231-5 2011
23JUN
Bidirectional autoregulatory mechanism of metastasis-associated protein 1-alternative reading frame pathway in oncogenesis.
Li DQ, Pakala SB, Reddy SD, Ohshiro K, Zhang JX, Wang L, Zhang Y, Moreno de Alborán I, Pillai MR, Eswaran J, Kumar R.
Proc Natl Acad Sci U S A. 108(21):8791-6. 2011
24FOS, JUN
Thermodynamic analysis of Jun-Fos coiled coil peptide antagonists.
Worrall JA, Mason JM.
FEBS J 278(4):663-72. doi: 10.1111/j.1742-4658.2010.07988.x. Epub 2010 Dec 31. 2011
25IL24, JUN, STAT6
Stat6 and c-Jun mediate Th2 cell-specific IL-24 gene expression.
Sahoo A, Lee CG, Jash A, Son JS, Kim G, Kwon HK, So JS, Im SH.
J Immunol 186(7):4098-109. doi: 10.4049/jimmunol.1002620. Epub 2011 Feb 25. 2011
26FOSL1, JUN
Heterodimerization with Fra-1 cooperates with the ERK pathway to stabilize c-Jun in response to the RAS oncoprotein.
Talotta F, Mega T, Bossis G, Casalino L, Basbous J, Jariel-Encontre I, Piechaczyk M, Verde P.
Oncogene 29(33):4732-40. Epub 2010 Jun 14.PMID: 20543861 2010
27JUN
AP1 factor inactivation in the suprabasal epidermis causes increased epidermal hyperproliferation and hyperkeratosis but reduced carcinogen-dependent tumor formation.
Rorke EA, Adhikary G, Jans R, Crish JF, Eckert RL.
Oncogene 29(44):5873-82. Epub 2010 Sep 6. 2010
28JUN, NFE2L2
C-Myc is a Nrf2-interacting protein that negatively regulates phase II genes through their electrophile responsive elements.
Levy S, Forman HJ.
IUBMB Life. 62(3):237-46. 2010
29JUN
Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation.
Davies CC, Chakraborty A, Cipriani F, Haigh K, Haigh JJ, Behrens A.
Nat Cell Biol. 12(10):963-72. 2010
30JUN
p21(Cip1) up-regulated during histone deacetylase inhibitor-induced CD4(+) T-cell anergy selectively associates with mitogen-activated protein kinases.
Selma Dagtas A, Gilbert KM.
Immunology. 129(4):589-99. 2010
31JUN, JUND
Jun and JunD-dependent functions in cell proliferation and stress response.
Meixner A, Karreth F, Kenner L, Penninger JM, Wagner EF.
Cell Death Differ 17(9):1409-19. doi: 10.1038/cdd.2010.22. Epub 2010 Mar 19. 2010
32ITGA6, JUN, TAF4B
TAF4b and Jun/activating protein-1 collaborate to regulate the expression of integrin alpha6 and cancer cell migration properties.
Kalogeropoulou M, Voulgari A, Kostourou V, Sandaltzopoulos R, Dikstein R, Davidson I, Tora L, Pintzas A.
Mol Cancer Res 8(4):554-68. doi: 10.1158/1541-7786.MCR-09-0159. Epub 2010 Mar 30. 2010
33IL10, JUN
c-jun controls the ability of IL-12 to induce IL-10 production from human memory CD4+ T cells.
Garcia CA, Wang H, Benakanakere MR, Barrett E, Kinane DF, Martin M.
J Immunol 183(7):4475-82. Epub 2009 Sep 4.PMID: 19734233 2009
34GATA2, JUN, PTPN11
Increased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutants.
Yang Z, Kondo T, Voorhorst CS, Nabinger SC, Ndong L, Yin F, Chan EM, Yu M, Würstlin O, Kratz CP, Niemeyer CM, Flotho C, Hashino E, Chan RJ.
Mol Cell Biol 29(16):4376-93. Epub 2009 Jun 15.PMID: 19528235 2009
35JUN
A selective small-molecule inhibitor of c-Jun N-terminal kinase 1.
Yao K, Cho YY, Bode AM, Vummenthala A, Park JG, Liu K, Pang YP, Dong Z.
FEBS Lett. 583(13):2208-12. 2009
36JUN, MAZ, MMP1
Transcriptional synergy mediated by SAF-1 and AP-1: critical role of N-terminal polyalanine and two zinc finger domains of SAF-1.
Kumar D, Ray A, Ray BK.
J Biol Chem. 284(3):1853-62. 2009
37JUN, XRCC5, XRCC6
Purification and identification of positive regulators binding to a novel element in the c-Jun promoter.
Jiang D, Zhou Y, Moxley RA, Jarrett HW.
Biochemistry 47(35):9318-34. Epub 2008 Aug 9. 2008
38JUN
Evidence that the bZIP domains of the Jun transcription factor bind to DNA as monomers prior to folding and homodimerization.
Seldeen KL, McDonald CB, Deegan BJ, Farooq A.
Arch Biochem Biophys 480(2):75-84. Epub 2008 Oct 12.PMID: 18940179 2008
39FOS, JUN
Thermodynamic analysis of the heterodimerization of leucine zippers of Jun and Fos transcription factors.
Seldeen KL, McDonald CB, Deegan BJ, Farooq A.
Biochem Biophys Res Commun 375(4):634-8. Epub 2008 Aug 24.PMID: 18725194 2008
40CDCA4, JUN
Transcriptional co-factor CDCA4 participates in the regulation of JUN oncogene expression.
Tategu M, Nakagawa H, Hayashi R, Yoshida K.
Biochimie 90(10):1515-22. Epub 2008 Jun 3.PMID: 18572021 2008
41AP3B1, JUN
AP-1 and AP-3 mediate sorting of melanosomal and lysosomal membrane proteins into distinct post-Golgi trafficking pathways.
Chapuy B, Tikkanen R, Mühlhausen C, Wenzel D, von Figura K, Höning S.
Traffic 9(7):1157-72. Epub 2008 Apr 9.PMID: 18410487 2008
42JUN, SIRT1
Inhibition of transcriptional activity of c-JUN by SIRT1.
Gao Z, Ye J.
Biochem Biophys Res Commun. 376(4):793-6. 2008
43JUN
Calcineurin-mediated dephosphorylation of c-Jun Ser-243 is required for c-Jun protein stability and cell transformation.
Huang CC, Wang JM, Kikkawa U, Mukai H, Shen MR, Morita I, Chen BK, Chang WC.
Oncogene. 27(17):2422-9. 2008
44JUN
Stromally expressed c-Jun regulates proliferation of prostate epithelial cells.
Li W, Wu CL, Febbo PG, Olumi AF.
Am J Pathol 171(4):1189-98. Epub 2007 Aug 16.PMID: 1770289 2007
45JUN
Critical role of c-Jun overexpression in liver metastasis of human breast cancer xenograft model.
Zhang Y, Pu X, Shi M, Chen L, Song Y, Qian L, Yuan G, Zhang H, Yu M, Hu M, Shen B, Guo N.
BMC Cancer 7:145.PMID: 17672916 2007
46JUN
The F-box protein Fbl10 is a novel transcriptional repressor of c-Jun.
Koyama-Nasu R, David G, Tanese N.
Nat Cell Biol. 9(9):1074-80. 2007
47JUN
Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth.
Wu K, Liu M, Li A, Donninger H, Rao M, Jiao X, Lisanti MP, Cvekl A, Birrer M, Pestell RG.
Mol Cell Biol. 18(3):755-67. 2007
48GAK, JUN
Canonical interaction of cyclin G associated kinase with adaptor protein 1 regulates lysosomal enzyme sorting.
Kametaka S, Moriyama K, Burgos PV, Eisenberg E, Greene LE, Mattera R, Bonifacino JS.
Mol Biol Cell 18(8):2991-3001. Epub 2007 May 30. 2007
49JUN, MAPK8
Neuroprotection by histone deacetylase-related protein.
Morrison BE, Majdzadeh N, Zhang X, Lyles A, Bassel-Duby R, Olson EN, D'Mello SR.
Mol Cell Biol. 26(9):3550-64. 2006
50JUN
COOH-terminal Src kinase-mediated c-Jun phosphorylation promotes c-Jun degradation and inhibits cell transformation.
Zhu F, Choi BY, Ma WY, Zhao Z, Zhang Y, Cho YY, Choi HS, Imamoto A, Bode AM, Dong Z.
Cancer Res. 66(11):5729-36. 2006
51JUN, TAF4B
Cell-type-selective induction of c-jun by TAF4b directs ovarian-specific transcription networks.
Geles KG, Freiman RN, Liu WL, Zheng S, Voronina E, Tjian R.
Proc Natl Acad Sci U S A 103(8):2594-9. Epub 2006 Feb 10. 2006
52TCF4, JUN
Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development.
Nateri AS, Spencer-Dene B, Behrens A.
Nature 437(7056):281-5. Epub 2005 Jul 10. 2005
53RP1, MAPK8, MAPK9, MAPK10, MAP2K4 , MAP2, JUN
Distinct gene expression profiles and reduced JNK signaling in retinitis pigmentosa caused by RP1 mutations.
Liu J, Huang Q, Higdon J, Liu W, Xie T, Yamashita T, Cheon K, Cheng C, Zuo J.
Hum Mol Genet 14(19):2945-58. Epub 2005 Aug 26. 2005
54SENP1, EP300, JUN
Differential regulation of c-Jun-dependent transcription by SUMO-specific proteases.
Cheng J, Perkins ND, Yeh ET.
J Biol Chem 280(15):14492-8. Epub 2005 Feb 8. 2005
55JUN
Jun proteins modulate the ovary-specific promoter of aromatase gene in ovarian granulosa cells via a cAMP-responsive element.
Ghosh S, Wu Y, Li R, Hu Y.
Oncogene. 24(13):2236-46. 2005
56JUN
The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase.
Wei W, Jin J, Schlisio S, Harper JW, Kaelin WG Jr.
Cancer Cell. 8(1):25-33. 2005
57JUN
The promyelocytic leukemia protein PML regulates c-Jun function in response to DNA damage.
Salomoni P, Bernardi R, Bergmann S, Changou A, Tuttle S, Pandolfi PP.
Blood. 105(9):3686-90. 2005
58JUN
DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell proliferation.
Mialon A, Sankinen M, Söderström H, Junttila TT, Holmström T, Koivusalo R, Papageorgiou AC, Johnson RS, Hietanen S, Elenius K, Westermarck J.
Mol Cell Biol. 25(12):5040-51. 2005
59JUN
Cerebral c-jun expression mapping in sudden infant death syndrome.
Rickert CH, Zahiragic L, Nolte KW, Bajanowski T, Brinkmann B, Paulus W.
Acta Neuropathol (Berl) 107(2):119-26. Epub 2003 Nov 6. 2004
60ETV4, JUN, SPP1, CTNNB1
Ets gene PEA3 cooperates with beta-catenin-Lef-1 and c-Jun in regulation of osteopontin transcription.
El-Tanani M, Platt-Higgins A, Rudland PS, Campbell FC.
J Biol Chem 279(20):20794-806. Epub 2004 Feb 27. 2004
61TAF1, JUN
The basic leucine zipper domain of c-Jun functions in transcriptional activation through interaction with the N terminus of human TATA-binding protein-associated factor-1 (human TAF(II)250).
Lively TN, Nguyen TN, Galasinski SK, Goodrich JA.
J Biol Chem 279(25):26257-65. Epub 2004 Apr 15. 2004
62JUN, TRIM45, ELK1
TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional activities of ElK-1 and AP-1.
Wang Y, Li Y, Qi X, Yuan W, Ai J, Zhu C, Cao L, Yang H, Liu F, Wu X, Liu M.
Biochem Biophys Res Commun 323(1):9-16. 2004
63VRK1, JUN
c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK).
Sevilla A, Santos CR, Barcia R, Vega FM, Lazo PA.
Oncogene 23(55):8950-8. 2004
64JUN, JUNB
Heterodimer formation between c-Jun and Jun B proteins mediated by Epstein-Barr virus encoded latent membrane protein 1.
Song X, Tao YG, Deng XY, Jin X, Tan YN, Tang M, Wu Q, Lee LM, Cao Y.
Cell Signal. 16(10):1153-62. 2004
65JUN
COBRA1 inhibits AP-1 transcriptional activity in transfected cells.
Zhong H, Zhu J, Zhang H, Ding L, Sun Y, Huang C, Ye Q.
Biochem Biophys Res Commun. 325(2):568-73. 2004
66JUN, RFWD2
Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity.
Bianchi E, Denti S, Catena R, Rossetti G, Polo S, Gasparian S, Putignano S, Rogge L, Pardi R.
J Biol Chem 278(22):19682-90. Epub 2003 Mar 03. 2003
67JUN, TAF7
TAF7 (TAFII55) plays a role in the transcription activation by c-Jun.
Munz C, Psichari E, Mandilis D, Lavigne AC, Spiliotaki M, Oehler T, Davidson I, Tora L, Angel P, Pintzas A.
J Biol Chem 278(24):21510-6. Epub 2003 Apr 03. 2003
68JUN
Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53.
Eferl R, Ricci R, Kenner L, Zenz R, David JP, Rath M, Wagner EF.
Cell. 112(2):181-92. 2003
69JUN
JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun.
Weiss C, Schneider S, Wagner EF, Zhang X, Seto E, Bohmann D.
EMBO J. 22(14):3686-95. 2003
70JUN
Receptor-interacting protein 140 binds c-Jun and inhibits estradiol-induced activator protein-1 activity by reversing glucocorticoid receptor-interacting protein 1 effect.
Teyssier C, Belguise K, Galtier F, Cavailles V, Chalbos D.
Mol Endocrinol. 17(2):287-99. 2003
71JUN
Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK.
Sundarrajan M, Boyle DL, Chabaud-Riou M, Hammaker D, Firestein GS.
Arthritis Rheum. 48(9):2450-60. 2003
72JUN
Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome.
Uhle S, Medalia O, Waldron R, Dumdey R, Henklein P, Bech-Otschir D, Huang X, Berse M, Sperling J, Schade R, Dubiel W.
EMBO J. 22(6):1302-12. 2003
73BRCA1, JUN, JUNB
JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction.
Hu YF, Li R.
Genes Dev 16(12):1509-17. 2002
74JUN, JUNB
Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.
Mathas S, Hinz M, Anagnostopoulos I, Krappmann D, Lietz A, Jundt F, Bommert K, Mechta-Grigoriou F, Stein H, Dorken B, Scheidereit C.
EMBO J 21(15):4104-13. 2002
75JUN, JUNB
JunB can substitute for Jun in mouse development and cell proliferation.
Passegue E, Jochum W, Behrens A, Ricci R, Wagner EF.
Nat Genet 30(2):158-66. 2002
76CDKN1B, COPS5, JUN
Jab1 co-activation of c-Jun is abrogated by the serine 10-phosphorylated form of p27Kip1.
Chopra S, Fernandez De Mattos S, Lam EW, Mann DJ.
J Biol Chem 277(36):32413-6. 2002
77CREB1, MAPK8, SKI, JUN, SMAD2
c-Jun associates with the oncoprotein Ski and suppresses Smad2 transcriptional activity.
Pessah M, Marais J, Prunier C, Ferrand N, Lallemand F, Mauviel A, Atfi A.
J Biol Chem 277(32):29094-100. 2002
78JUN, RBM39
Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors.
Jung DJ, Na SY, Na DS, Lee JW.
J Biol Chem 277(2):1229-34. Epub 2001 Nov 09. 2002
79BCL6, JUN, JUNB, PRDM1
Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene.
Vasanwala FH, Kusam S, Toney LM, Dent AL.
J Immunol 169(4):1922-9. 2002
80JUN, MAPK8
Protein kinase D complexes with C-Jun N-terminal kinase via activation loop phosphorylation and phosphorylates the C-Jun N-terminus.
Hurd C, Waldron RT, Rozengurt E.
Oncogene. 21(14):2154-60 2002
81HIF1A, JUN
c-Jun and hypoxia-inducible factor 1 functionally cooperate in hypoxia-induced gene transcription.
Alfranca A, Gutiérrez MD, Vara A, Aragonés J, Vidal F, Landázuri MO.
Mol Cell Biol. 22(1):12-22. 2002
82JUN
The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription.
Westermarck J, Weiss C, Saffrich R, Kast J, Musti AM, Wessely M, Ansorge W, Séraphin B, Wilm M, Valdez BC, Bohmann D.
EMBO J. 21(3):451-60. 2002
83JUN
Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1.
Nakahira M, Ahn HJ, Park WR, Gao P, Tomura M, Park CS, Hamaoka T, Ohta T, Kurimoto M, Fujiwara H.
J Immunol. 168(3):1146-53. 2002
84JUN
An alternative model of H ferritin promoter transactivation by c-Jun.
Faniello MC, Chirico G, Quaresima B, Cuda G, Allevato G, Bevilacqua MA, Baudi F, Colantuoni V, Cimino F, Venuta S, Avvedimento VE, Costanzo F.
Biochem J. 363(Pt 1):53-8. 2002
85JUN
Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation.
D'Alonzo RC, Selvamurugan N, Karsenty G, Partridge NC.
J Biol Chem. 277(1):816-22. 2002
86JUN
Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity.
Schmidt D, Müller S.
Proc Natl Acad Sci U S A. 99(5):2872-7. 2002
87JUN
Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1.
Sun Y, Wilson MP, Majerus PW.
J Biol Chem. 277(48):45759-64. 2002
88JUN, SMARCD1
Identification of SWI.SNF complex subunit BAF60a as a determinant of the transactivation potential of Fos/Jun dimers.
Ito T, Yamauchi M, Nishina M, Yamamichi N, Mizutani T, Ui M, Murakami M, Iba H.
J Biol Chem 276(4):2852-7. 2001
89JUN, JUNB
Characterization of the physical interaction between estrogen receptor alpha and JUN proteins.
Teyssier C, Belguise K, Galtier F, Chalbos D.
J Biol Chem. 276(39):36361-9. 2001
90JUN
Functional interaction of Jun and homeodomain proteins.
Schaefer LK, Wang S, Schaefer TS.
J Biol Chem. 276(46):43074-82. 2001
91JUN
Vav-Rac1-mediated activation of the c-Jun N-terminal kinase/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoter.
Kaminuma O, Deckert M, Elly C, Liu YC, Altman A.
Mol Cell Biol. 21(9):3126-36. 2001
92JUN
c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity.
Pessah M, Prunier C, Marais J, Ferrand N, Mazars A, Lallemand F, Gauthier JM, Atfi A.
Proc Natl Acad Sci U S A. 98(11):6198-203. 2001
93JUN
c-Jun binds the N terminus of human TAF(II)250 to derepress RNA polymerase II transcription in vitro.
Lively TN, Ferguson HA, Galasinski SK, Seto AG, Goodrich JA.
J Biol Chem. 276(27):25582-8. 2001
94JUN
AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element.
Hess J, Porte D, Munz C, Angel P.
J Biol Chem. 276(23):20029-38. 2001
95JUN
Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1.
Wulf GM, Ryo A, Wulf GG, Lee SW, Niu T, Petkova V, Lu KP.
EMBO J. 20(13):3459-72. 2001
96CCND1, JUN, JUNB
Cell cycle-dependent variations in c-Jun and JunB phosphorylation: a role in the control of cyclin D1 expression.
Bakiri L, Lallemand D, Bossy-Wetzel E, Yaniv M.
EMBO J 19(9):2056-68. 2000
97JUN
Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2.
Lee SK, Na SY, Jung SY, Choi JE, Jhun BH, Cheong J, Meltzer PS, Lee YC, Lee JW.
Mol Endocrinol. 14(6):915-25. 2000
98JUN
A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK.
Barilá D, Mangano R, Gonfloni S, Kretzschmar J, Moro M, Bohmann D, Superti-Furga G.
EMBO J. 19(2):273-81. 2000
99JUN
c-Jun and p53 activity is modulated by SUMO-1 modification.
Muller S, Berger M, Lehembre F, Seeler JS, Haupt Y, Dejean A.
J Biol Chem. 275(18):13321-9. 2000
100JUN
Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor.
Lee SK, Kim JH, Lee YC, Cheong J, Lee JW.
J Biol Chem. 275(17):12470-4. 2000
101ALB, CAD, CCNA2, CDC25A, CDK1, CEBPA, COL1A1, COL1A2, COL3A1, COL6A3, DHFR, DMTF1, GADD45A, JUN, LDHA, MXI1, MYC, ODC1, RCC1, SERPINE1, TERT, TK1, TK2, TP53
c-Myc target genes involved in cell growth, apoptosis, and metabolism.
Dang CV.
Mol Cell Biol 19(1):1-11. Review. No abstract available 1999
102JUN, RB1
Recruitment of the retinoblastoma protein to c-Jun enhances transcription activity mediated through the AP-1 binding site.
Nishitani J, Nishinaka T, Cheng CH, Rong W, Yokoyama KK, Chiu R.
J Biol Chem. 274(9):5454-61. 1999
103DDIT3, JUN
CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins.
Ubeda M, Vallejo M, Habener JF.
Mol Cell Biol. 19(11):7589-99. 1999
104JUN
ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-kappaB.
Yang X, Chen Y, Gabuzda D.
J Biol Chem. 274(39):27981-8. 1999
105JUN
Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation.
Na SY, Choi JE, Kim HJ, Jhun BH, Lee YC, Lee JW.
J Biol Chem. 274(40):28491-6. 1999
106JUN
Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation.
Behrens A, Sibilia M, Wagner EF.
Nat Genet. 21(3):326-9. 1999
107JUN
A two-hit mechanism for vitamin D3-mediated transcriptional repression of the granulocyte-macrophage colony-stimulating factor gene: vitamin D receptor competes for DNA binding with NFAT1 and stabilizes c-Jun.
Towers TL, Staeva TP, Freedman LP.
Mol Cell Biol. 19(6):4191-9. 1999
108JUN, STAT3
Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation.
Zhang X, Wrzeszczynska MH, Horvath CM, Darnell JE Jr.
Mol Cell Biol. 19(10):7138-46. 1999
109JUN
SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1.
Rao S, Matsumura A, Yoon J, Simon MC.
J Biol Chem. 274(16):11115-24. 1999
110JUN
Function of steroidogenic factor 1 domains in nuclear localization, transactivation, and interaction with transcription factor TFIIB and c-Jun.
Li LA, Chiang EF, Chen JC, Hsu NC, Chen YJ, Chung BC.
Mol Endocrinol. 13(9):1588-98. 1999
111JUN
Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits.
Lee SK, Kim HJ, Na SY, Kim TS, Choi HS, Im SY, Lee JW.
J Biol Chem. 273(27):16651-4. 1998
112JUN, NFE2L1, NFE2L2
Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes.
Venugopal R, Jaiswal AK.
Oncogene. 17(24):3145-56. 1998
113JUN
Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains.
Carrère S, Verger A, Flourens A, Stehelin D, Duterque-Coquillaud M.
Oncogene. 16(25):3261-8. 1998
114JUN
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription.
Zhang Y, Feng XH, Derynck R.
Nature. 394(6696):909-13. 1998
115JUN
Rb binds c-Jun and activates transcription.
Nead MA, Baglia LA, Antinore MJ, Ludlow JW, McCance DJ.
EMBO J. 17(8):2342-52. 1998
116JUN
Bone-specific expression of the alpha chain of the nascent polypeptide-associated complex, a coactivator potentiating c-Jun-mediated transcription.
Moreau A, Yotov WV, Glorieux FH, St-Arnaud R.
Mol Cell Biol. 18(3):1312-21. 1998
117JUN
The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner.
Basuyaux JP, Ferreira E, Stéhelin D, Butticè G.
J Biol Chem. 272(42):26188-95. 1997
118COPS5, JUN
A new group of conserved coactivators that increase the specificity of AP-1 transcription factors.
Claret FX, Hibi M, Dhut S, Toda T, Karin M.
Nature 383(6599):453-7. 1996
119JUN
Synergistic transcriptional activation of the tissue inhibitor of metalloproteinases-1 promoter via functional interaction of AP-1 and Ets-1 transcription factors.
Logan SK, Garabedian MJ, Campbell CE, Werb Z.
J Biol Chem. 271(2):774-82. 1996
120JUN
Interaction of the Ubc9 human homologue with c-Jun and with the glucocorticoid receptor.
Göttlicher M, Heck S, Doucas V, Wade E, Kullmann M, Cato AC, Evans RM, Herrlich P.
Steroids. 61(4):257-62. 1996
121JUN
The c-Jun delta-domain inhibits neuroendocrine promoter activity in a DNA sequence- and pituitary-specific manner.
Farrow KN, Manning N, Schaufele F, Gutierrez-Hartmann A.
J Biol Chem. 271(29):17139-46. 1996
122JUN
Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF.
Martin ML, Lieberman PM, Curran T.
Mol Cell Biol. 16(5):2110-8. 1996
123JUN
In vitro association between the Jun protein family and the general transcription factors, TBP and TFIIB.
Franklin CC, McCulloch AV, Kraft AS.
Biochem J. 305 ( Pt 3):967-74. 1995
124JUN
The leucine zipper of c-Jun binds to ribosomal protein L18a: a role in Jun protein regulation?
Gramatikoff K, Schaffner W, Georgiev O.
Biol Chem Hoppe Seyler. 376(5):321-5. 1995
125JUN
Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun.
Kerppola TK, Curran T.
Oncogene. 9(3):675-84. 1994
126CREB5, JUN
Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1.
Nomura N, Zu YL, Maekawa T, Tabata S, Akiyama T, Ishii S.
J Biol Chem 268(6):4259-66. 1993
127JUN
c-jun is essential for normal mouse development and hepatogenesis.
Hilberg F, Aguzzi A, Howells N, Wagner EF.
Nature. 365(6442):179-81. 1993
128JUN
Modification of DNA topoisomerase II activity via direct interactions with the cyclic adenosine-3',5'-monophosphate response element-binding protein and related transcription factors.
Kroll DJ, Sullivan DM, Gutierrez-Hartmann A, Hoeffler JP.
Mol Endocrinol. 7(3):305-18. 1993
129JUN, FOS
An altered repertoire of fos/jun (AP-1) at the onset of replicative senescence.
Irving J, et al.
Exp Cell Res 202 : 161-166. 1992
130JUN, TPM1
Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun.
Chevray PM, Nathans D.
Proc Natl Acad Sci U S A 89(13):5789-93. 1992
131JUN
Functional antagonism between c-Jun and MyoD proteins: a direct physical association.
Bengal E, Ransone L, Scharfmann R, Dwarki VJ, Tapscott SJ, Weintraub H, Verma IM.
Cell. 68(3):507-19. 1992
132JUN
Phosphorylation of c-jun mediated by MAP kinases.
Pulverer BJ, Kyriakis JM, Avruch J, Nikolakaki E, Woodgett JR.
Nature. 353(6345):670-4. 1991
133JUN
Heterodimer formation between CREB and JUN proteins.
Benbrook DM, Jones NC.
Oncogene. 5(3):295-302. 1990
134JUN
Structure and chromosomal localization of the functional intronless human JUN protooncogene.
Hattori K, Angel P, Le Beau MM, Karin M.
Proc Natl Acad Sci U S A 85 : 9148-9152. 1988
135JUN
Localization of the human JUN protooncogene to chromosome region 1p31-32.
Haluska FG, et al.
Proc Natl Acad Sci U S A 85 : 2215-2218. 1988