Citations for
1CDC42, ITSN1, ITSN2
Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment.
Ashraf S, Kudo H, Rao J, Kikuchi A, Widmeier E, Lawson JA, Tan W, Hermle T, Warejko JK, Shril S, Airik M, Jobst-Schwan T, Lovric S, Braun DA, Gee HY, Schapiro D, Majmundar AJ, Sadowski CE, Pabst WL, Daga A, van der Ven AT, Schmidt JM, Low BC, Gupta AB, Tripathi BK, Wong J, Campbell K, Metcalfe K, Schanze D, Niihori T, Kaito H, Nozu K, Tsukaguchi H, Tanaka R, Hamahira K, Kobayashi Y, Takizawa T, Funayama R, Nakayama K, Aoki Y, Kumagai N, Iijima K, Fehrenbach H, Kari JA, El Desoky S, Jalalah S, Bogdanovic R, Stajić N, Zappel H, Rakhmetova A, Wassmer SR, Jungraithmayr T, Strehlau J, Kumar AS, Bagga A, Soliman NA, Mane SM, Kaufman L, Lowy DR, Jairajpuri MA, Lifton RP, Pei Y, Zenker M, Kure S, Hildebrandt F.
Nat Commun 9(1):1960. doi: 10.1038/s41467-018-04193-w. 2018
2ITSN1, ITSN2, WIPF3
Mammalian verprolin CR16 acts as a modulator of ITSN scaffold proteins association with actin.
Kropyvko S, Gryaznova T, Morderer D, Rynditch A.
Biochem Biophys Res Commun 484(4):813-819. doi: 10.1016/j.bbrc.2017.01.177. Epub 2017 Feb 1. 2017
3ITSN1, ITSN2, WIPF1
Intersectin adaptor proteins are associated with actin-regulating protein WIP in invadopodia.
Gryaznova T, Kropyvko S, Burdyniuk M, Gubar O, Kryklyva V, Tsyba L, Rynditch A.
Cell Signal 27(7):1499-508. doi: 10.1016/j.cellsig.2015.03.006. Epub 2015 Mar 19. 2015
4ITSN1, ITSN2
Intersectin adaptor proteins are associated with actin-regulating protein WIP in invadopodia.
Gryaznova T, Kropyvko S, Burdyniuk M, Gubar O, Kryklyva V, Tsyba L, Rynditch A.
Cell Signal 27(7):1499-508. doi: 10.1016/j.cellsig.2015.03.006. Epub 2015 Mar 19. 2015
5ITSN1, ITSN2
Adaptor proteins intersectin 1 and 2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins.
Novokhatska O, Dergai M, Tsyba L, Skrypkina I, Filonenko V, Moreau J, Rynditch A.
PLoS One 8(7):e70546. doi: 10.1371/journal.pone.0070546. Print 2013. 2013
6ITSN1, ITSN2
Crystal structure of human Intersectin-2L C2 domain.
Zhang W, Shen Y, Xiong G, Guo Y, Deng L, Li B, Yang J, Qi C.
Biochem Biophys Res Commun 431(1):76-80. doi: 10.1016/j.bbrc.2012.12.087. Epub 2012 Dec 27. 2013
7ING1, ITSN2
The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway.
Rajarajacholan UK, Thalappilly S, Riabowol K.
PLoS Biol 11(3):e1001502. doi: 10.1371/journal.pbio.1001502. Epub 2013 Mar 5. 2013
8ITSN1, ITSN2
Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.
Wong KA, Wilson J, Russo A, Wang L, Okur MN, Wang X, Martin NP, Scappini E, Carnegie GK, O'Bryan JP.
PLoS One 7(4):e36023. doi: 10.1371/journal.pone.0036023. Epub 2012 Apr 27. 2012
9EPS8, ITSN2
Human intersectin 2 (ITSN2) binds to Eps8 protein and enhances its degradation.
Ding X, Yang Z, Zhou F, Hu X, Zhou C, Luo C, He Z, Liu Q, Li H, Yan F, Wang F, Xiang S, Zhang J.
BMB Rep 45(3):183-8. doi: 10.5483/BMBRep.2012.45.3.183. 2012
10ITSN2
Intersectin-2L regulates caveola endocytosis secondary to Cdc42-mediated actin polymerization.
Klein IK, Predescu DN, Sharma T, Knezevic I, Malik AB, Predescu S.
J Biol Chem 284(38):25953-61. doi: 10.1074/jbc.M109.035071. Epub 2009 Jul 21 2009
11ITSN2
Expression analysis of human intersectin 2 gene (ITSN2) minor splice variants showing differential expression in normal human brain.
Seifert M, Ampofo C, Mehraein Y, Reichrath J, Welter C.
Oncol Rep 17(5):1207-11. 2007
12CDC42, ITSN2, WAS
The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis.
McGavin MK, Badour K, Hardy LA, Kubiseski TJ, Zhang J, Siminovitch KA.
J Exp Med 194(12):1777-87. 2001
13ITSN1, ITSN2
The human intersectin genes and their spliced variants are differentially expressed.
Pucharcos C, Casas C, Nadal M, Estivill X, de la Luna S.
Biochim Biophys Acta 1521(1-3):1-11. 2001
14ITSN1, ITSN2
Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis.
Pucharcos C, Estivill X, de la Luna S.
FEBS Lett 478(1-2):43-51. 2000