| 1 | ITSN1, WIPF1
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| WIP/ITSN1 complex is involved in cellular vesicle trafficking and formation of filopodia-like protrusions.
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| Gryaznova T, Gubar O, Burdyniuk M, Kropyvko S, Rynditch A.
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| Gene 674:49-56. doi: 10.1016/j.gene.2018.06.078. Epub 2018 Jun 27.
2018
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| 2 | ITCH, ITSN1
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| Ubiquitin-ligase AIP4 controls differential ubiquitination and stability of isoforms of the scaffold protein ITSN1.
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| Dergai O, Dergai M, Rynditch A.
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| FEBS Lett 592(13):2259-2267. doi: 10.1002/1873-3468.13118. Epub 2018 Jun 16.
2018
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| 3 | CDC42, ITSN1, ITSN2
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| Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment.
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| Ashraf S, Kudo H, Rao J, Kikuchi A, Widmeier E, Lawson JA, Tan W, Hermle T, Warejko JK, Shril S, Airik M, Jobst-Schwan T, Lovric S, Braun DA, Gee HY, Schapiro D, Majmundar AJ, Sadowski CE, Pabst WL, Daga A, van der Ven AT, Schmidt JM, Low BC, Gupta AB, Tripathi BK, Wong J, Campbell K, Metcalfe K, Schanze D, Niihori T, Kaito H, Nozu K, Tsukaguchi H, Tanaka R, Hamahira K, Kobayashi Y, Takizawa T, Funayama R, Nakayama K, Aoki Y, Kumagai N, Iijima K, Fehrenbach H, Kari JA, El Desoky S, Jalalah S, Bogdanovic R, Stajić N, Zappel H, Rakhmetova A, Wassmer SR, Jungraithmayr T, Strehlau J, Kumar AS, Bagga A, Soliman NA, Mane SM, Kaufman L, Lowy DR, Jairajpuri MA, Lifton RP, Pei Y, Zenker M, Kure S, Hildebrandt F.
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| Nat Commun 9(1):1960. doi: 10.1038/s41467-018-04193-w.
2018
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| 4 | ITSN1, RELN
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| Intersectin 1 is a component of the Reelin pathway to regulate neuronal migration and synaptic plasticity in the hippocampus.
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| Jakob B, Kochlamazashvili G, Jäpel M, Gauhar A, Bock HH, Maritzen T, Haucke V.
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| Proc Natl Acad Sci U S A 114(21):5533-5538. doi: 10.1073/pnas.1704447114. Epub 2017 May 8.
2017
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| 5 | ITSN1, ITSN2, WIPF3
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| Mammalian verprolin CR16 acts as a modulator of ITSN scaffold proteins association with actin.
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| Kropyvko S, Gryaznova T, Morderer D, Rynditch A.
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| Biochem Biophys Res Commun 484(4):813-819. doi: 10.1016/j.bbrc.2017.01.177. Epub 2017 Feb 1.
2017
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| 6 | ITSN1, ITSN2, WIPF1
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| Intersectin adaptor proteins are associated with actin-regulating protein WIP in invadopodia.
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| Gryaznova T, Kropyvko S, Burdyniuk M, Gubar O, Kryklyva V, Tsyba L, Rynditch A.
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| Cell Signal 27(7):1499-508. doi: 10.1016/j.cellsig.2015.03.006. Epub 2015 Mar 19.
2015
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| 7 | ITSN1
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| Intersectin1-S, a multidomain adapter protein, is essential for malignant glioma proliferation.
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| Gu F, Zhang H, Qin F, Liu X, Li W, Fu L, Ying G, Li B, Zhang M, Ma Y.
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| Glia 63(9):1595-605. doi: 10.1002/glia.22830. Epub 2015 Apr 2.
2015
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| 8 | ITSN1, ITSN2
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| Intersectin adaptor proteins are associated with actin-regulating protein WIP in invadopodia.
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| Gryaznova T, Kropyvko S, Burdyniuk M, Gubar O, Kryklyva V, Tsyba L, Rynditch A.
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| Cell Signal 27(7):1499-508. doi: 10.1016/j.cellsig.2015.03.006. Epub 2015 Mar 19.
2015
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| 9 | CDC42, ITSN1, NCK1, WASL
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| Cdc42 and the Rho GEF intersectin-1 collaborate with Nck to promote N-WASP-dependent actin polymerisation.
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| Humphries AC, Donnelly SK, Way M.
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| J Cell Sci 127(Pt 3):673-85. doi: 10.1242/jcs.141366. Epub 2013 Nov 27.
2014
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| 10 | CDC42, ITSN1
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| Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility.
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| Friesland A, Zhao Y, Chen YH, Wang L, Zhou H, Lu Q.
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| Proc Natl Acad Sci U S A 110(4):1261-6. doi: 10.1073/pnas.1116051110. Epub 2013 Jan 2.
2013
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| 11 | ITSN1, ITSN2
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| Adaptor proteins intersectin 1 and 2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins.
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| Novokhatska O, Dergai M, Tsyba L, Skrypkina I, Filonenko V, Moreau J, Rynditch A.
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| PLoS One 8(7):e70546. doi: 10.1371/journal.pone.0070546. Print 2013.
2013
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| 12 | ITSN1, ITSN2
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| Crystal structure of human Intersectin-2L C2 domain.
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| Zhang W, Shen Y, Xiong G, Guo Y, Deng L, Li B, Yang J, Qi C.
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| Biochem Biophys Res Commun 431(1):76-80. doi: 10.1016/j.bbrc.2012.12.087. Epub 2012 Dec 27.
2013
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| 13 | ITSN1, ITSN2
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| Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.
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| Wong KA, Wilson J, Russo A, Wang L, Okur MN, Wang X, Martin NP, Scappini E, Carnegie GK, O'Bryan JP.
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| PLoS One 7(4):e36023. doi: 10.1371/journal.pone.0036023. Epub 2012 Apr 27.
2012
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| 14 | ITSN1
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| Intersectin 1 is required for neuroblastoma tumorigenesis.
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| Russo A, O'Bryan JP.
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| Oncogene 31(46):4828-34. doi: 10.1038/onc.2011.643. Epub 2012 Jan 23.
2012
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| 15 | ARHGAP31, ITSN1
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| Cdc42 GTPase-activating protein (CdGAP) interacts with the SH3D domain of Intersectin through a novel basic-rich motif.
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| Primeau M, Ben Djoudi Ouadda A, Lamarche-Vane N.
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| FEBS Lett 585(6):847-53. Epub 2011 Feb 22.
2011
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| 16 | ITSN1
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| Identification and characterization of a novel mammalian isoform of the endocytic adaptor ITSN1.
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| Dergai M, Skrypkina I, Dergai O, Tsyba L, Novokhatska O, Filonenko V, Drobot L, Rynditch A.
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| Gene 485(2):120-9. doi: 10.1016/j.gene.2011.06.021. Epub 2011 Jun 25.
2011
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| 17 | DEL21QD, ITSN1
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| Detailed molecular and clinical characterization of three patients with 21q deletions.
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| Lindstrand A, Malmgren H, Sahlén S, Schoumans J, Nordgren A, Ergander U, Holm E, Anderlid BM, Blennow E.
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| Clin Genet 77(2):145-54. Epub 2009 Oct 23. 2010
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| 18 | ITSN1, REPS1, SGIP1
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| Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits.
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| Dergai O, Novokhatska O, Dergai M, Skrypkina I, Tsyba L, Moreau J, Rynditch A.
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| Biochem Biophys Res Commun 402(2):408-13. Epub 2010 Oct 12.
2010
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| 19 | ITSN1
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| Structural diversity and differential expression of novel human intersectin 1 isoforms.
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| Kropyvko S, Gerasymchuk D, Skrypkina I, Dergai M, Dergai O, Nikolaienko O, Rynditch A, Tsyba L.
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| Mol Biol Rep 37(6):2789-96. Epub 2009 Sep 24.
2010
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| 20 | ITSN1
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| Characterisation of the nucleotide exchange factor ITSN1L: evidence for a kinetic discrimination of GEF-stimulated nucleotide release from Cdc42.
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| Kintscher C, Groemping Y.
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| J Mol Biol 387(2):270-83. Epub 2009 Feb 3.
2009
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| 21 | ITSN1
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| Intersectin regulates dendritic spine development and somatodendritic endocytosis but not synaptic vesicle recycling in hippocampal neurons.
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| Thomas S, Ritter B, Verbich D, Sanson C, Bourbonnière L, McKinney RA, McPherson PS.
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| J Biol Chem 284(18):12410-9. Epub 2009 Mar 3.
2009
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| 22 | INPPL1, ITSN1
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| SHIP2 associates with intersectin and recruits it to the plasma membrane in response to EGF.
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| Xie J, Vandenbroere I, Pirson I.
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| FEBS Lett 582(20):3011-7. Epub 2008 Aug 8.
2008
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| 23 | ITSN1
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| Alternative splicing affecting the SH3A domain controls the binding properties of intersectin 1 in neurons.
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| Tsyba L, Gryaznova T, Dergai O, Dergai M, Skrypkina I, Kropyvko S, Boldyryev O, Nikolaienko O, Novokhatska O, Rynditch A.
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| Biochem Biophys Res Commun 372(4):929-34. Epub 2008 Jun 6.
2008
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| 24 | EPS15, ITSN1
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| ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1.
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| Wang W, Bouhours M, Gracheva EO, Liao EH, Xu K, Sengar AS, Xin X, Roder J, Boone C, Richmond JE, Zhen M, Egan SE.
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| Traffic 9(5):742-54. Epub 2008 Feb 20.
2008
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| 25 | ITSN1
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| ntersectin-1s regulates the mitochondrial apoptotic pathway in endothelial cells.
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| Predescu SA, Predescu DN, Knezevic I, Klein IK, Malik AB.
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| J Biol Chem 282(23):17166-78. Epub 2007 Apr 3.
2007
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| 26 | ITSN1
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| Intersectin-1L nucleotide exchange factor regulates secretory granule exocytosis by activating Cdc42.
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| Malacombe M, Ceridono M, Calco V, Chasserot-Golaz S, McPherson PS, Bader MF, Gasman S.
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| EMBO J 25(15):3494-503. Epub 2006 Jul 27. 2006
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| 27 | ITSN1
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| Alternative splicing of mammalian Intersectin 1: domain associations and tissue specificities.
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| Tsyba L, Skrypkina I, Rynditch A, Nikolaienko O, Ferenets G, Fortna A, Gardiner K.
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| Genomics 84(1):106-13. 2004
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| 28 | ITSN1, ITSN2
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| The human intersectin genes and their spliced variants are differentially expressed.
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| Pucharcos C, Casas C, Nadal M, Estivill X, de la Luna S.
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| Biochim Biophys Acta 1521(1-3):1-11. 2001
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| 29 | ITSN1, ITSN2
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| Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis.
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| Pucharcos C, Estivill X, de la Luna S.
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| FEBS Lett 478(1-2):43-51. 2000
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| 30 | ITSN1
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| Alu-splice cloning of human Intersectin (ITSN), a putative multivalent binding protein expressed in proliferating and differentiating neurons and overexpressed in Down syndrome.
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| Pucharcos C, et al.
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| Eur J Hum Genet 7(6):704-12 1999
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| 31 | CLIC3, GNB4, ITSN1
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| Isolation and characterization ofthree human chromosome 21 (HC21) genes.
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| Guipponi M, Mittaz L, guidi S, Chen H, Barras C, Sail-Duriaux G, Schebesta A, Rossier C, Neerman-Arbez M, Blouin JL, Scott HS, Antonarakis SE.
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| Cytogenet Cell Genet 86:16 1999
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| 32 | LYP, ITSN1
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| A new candidate region for the positional cloning of the XLP gene.
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| Bolino A, Yin L, Seri M, Cusano R, Cinti R, Coffey A, Brooksbank R, Howell G, Bentley D, Davis JR, Lanyi A, Huang D, Stark M, Creaven M, Bjorkhaug L, Heitzmann F, Lamartine J, Gaudi S, Sylla BS, Lenoir GM, Castagnola E, Giacchino R, Porta G, Franco B, Zollo M, Sumegi J, Romeo G.
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| Eur J Hum Genet 6 : 509-517. 1998
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| 33 | ITSN1
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| Two isoforms of a human intersectin (ITSN) protein are produced by brain-specific alternative splicing in a stop codon.
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| Guipponi M, et al.
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| Genomics 53 : 369-376. 1998
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| 34 | ITSN1
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| Genomic structure, sequence, and refined mapping of the human intersectin gene (ITSN), which encompasses 250 kb on chromosome 21q22.1->q22.2.
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| Guipponi M, et al.
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| Cytogenet Cell Genet 83 : 218-220 1998
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| 35 | ITSN1
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| Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains.
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| Yamabhai M, Hoffman NG, Hardison NL, McPherson PS, Castagnoli L, Cesareni G, Kay BK.
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| J Biol Chem 273(47):31401-7. 1998
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| 36 | MORC3, RRP1B, ITSN1
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| Mapping of a novel SH3 domain protein and two proteins of unknown function to human chromosome 21.
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| Katsanis N, Beck JA, Fisher EM.
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| Hum Genet 100(3-4):477-80. 1997
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| 37 | ITSN1
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| The SH3D1A gene maps to human chromosome 21q22.1-->q22.2.
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| Chen H, Antonarakis SE.
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| Cytogenet Cell Genet 78(3-4):213-5. 1997
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| 38 | ITSN1
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| Cloning of ligand targets : systematic isolation of SH3 domain-containing proteins.
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| Sparks AB, et al.
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| Nat Biotechnol 14 : 741-744. 1996
|