1 | ADAM7, CANX, HSPA5, ITM2B
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| Identification of heat shock protein 5, calnexin and integral membrane protein 2B as Adam7-interacting membrane proteins in mouse sperm.
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| Han C, Park I, Lee B, Jin S, Choi H, Kwon JT, Kwon YI, Kim do H, Park ZY, Cho C.
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| J Cell Physiol 226(5):1186-95. doi: 10.1002/jcp.22444.
2011
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2 | ITM2B
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| BRI2 protein regulates β-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE).
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| Kilger E, Buehler A, Woelfing H, Kumar S, Kaeser SA, Nagarathinam A, Walter J, Jucker M, Coomaraswamy J.
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| J Biol Chem 286(43):37446-57. Epub 2011 Aug 26.
2011
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3 | FBD, ITM2B
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| Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis.
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| Tamayev R, Giliberto L, Li W, d'Abramo C, Arancio O, Vidal R, D'Adamio L.
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| J Neurosci 30(44):14915-24.
2010
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4 | ITM2B
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| Bri2-23 is a potential cerebrospinal fluid biomarker in multiple sclerosis.
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| Harris VK, Diamanduros A, Good P, Zakin E, Chalivendra V, Sadiq SA.
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| Neurobiol Dis 40(1):331-9. Epub 2010 Jun 19.
2010
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5 | ITM2B
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| The extracellular domain of Bri2 (ITM2B) binds the ABri peptide (1-23) and amyloid beta-peptide (Abeta1-40): Implications for Bri2 effects on processing of amyloid precursor protein and Abeta aggregation.
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| Peng S, Fitzen M, Jörnvall H, Johansson J.
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| Biochem Biophys Res Commun 393(3):356-61. Epub 2009 Dec 28.
2010
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6 | ITM2B
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| BRI2 homodimerizes with the involvement of intermolecular disulfide bonds.
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| Tsachaki M, Ghiso J, Rostagno A, Efthimiopoulos S.
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| Neurobiol Aging 31(1):88-98. Epub 2008 Apr 28.
2010
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7 | ITM2B, ITM2C
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| BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2.
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| Matsuda S, Matsuda Y, D'Adamio L.
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| J Biol Chem 284(23):15815-25. Epub 2009 Apr 14.
2009
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8 | ITM2B, SPPL2A
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| Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b.
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| Martin L, Fluhrer R, Reiss K, Kremmer E, Saftig P, Haass C.
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| J Biol Chem 283(3):1644-52. Epub 2007 Oct 25. 2008
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9 | FBD, ITM2B
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| Expression of BRI2 mRNA and protein in normal human brain and familial British dementia: its relevance to the pathogenesis of disease.
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| Lashley T, Revesz T, Plant G, Bandopadhyay R, Lees AJ, Frangione B, Wood NW, de Silva R, Ghiso J, Rostagno A, Holton JL.
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| Neuropathol Appl Neurobiol 34(5):492-505. Epub 2008 Feb 13.
2008
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10 | ITM2B
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| Expression and regulation of type II integral membrane protein family members in mouse male reproductive tissues.
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| Rengaraj D, Gao F, Liang XH, Yang ZM.
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| Endocrine 31(2):193-201.
2007
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11 | FBD, FDD, ITM2B
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| Genetic alterations of the BRI2 gene: familial British and Danish dementias.
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| Ghiso J, Rostagno A, Tomidokoro Y, Lashley T, Bojsen-M¿ller M, Braendgaard H, Plant G, Holton J, Lal R, Revesz T, Frangione B.
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| Brain Pathol 16(1):71-9. 2006
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12 | FBD,FDD,ITM2B
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| Chromosome 13 dementias.
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| Rostagno A, Tomidokoro Y, Lashley T, Ng D, Plant G, Holton J, Frangione B, Revesz T, Ghiso J.
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| Cell Mol Life Sci 62(16):1814-25. Review. 2005
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13 | ITM2B, FBD
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| Expression of BRI, the normal precursor of the amyloid protein of familial British dementia, in human brain.
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| Akiyama H, Kondo H, Arai T, Ikeda K, Kato M, Iseki E, Schwab C, McGeer PL.
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| Acta Neuropathol (Berl) 107(1):53-8. Epub 2003 Oct 29. 2004
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14 | TSG13A, TSG13B, TSG13D, ITM2B, RCBTB2, FNDC3A
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| Extensive analysis of the 13q14 region in human prostate tumors: DNA analysis and quantitative expression of genes lying in the interval of deletion.
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| Latil A, Chene L, Mangin P, Fournier G, Berthon P, Cussenot O.
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| Prostate 57(1):39-50. 2003
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15 | ITM2B, BRI3, ITM2C
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| Sequence, genomic structure and tissue expression of Human BRI3, a member of the BRI gene family.
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| Vidal R, Calero M, Revesz T, Plant G, Ghiso J, Frangione B.
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| Gene 266(1-2):95-102. 2001
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16 | ITM2B, FDD
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| A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred.
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| Vidal R, Revesz T, Rostagno A, Kim E, Holton JL, Bek T, Bojsen-Moller M, Braendgaard H, Plant G, Ghiso J, Frangione B.
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| Proc Natl Acad Sci U S A 97(9):4920-5. 2000
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17 | ITM2B, FBD
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| A stop-codon mutation in the BRI gene associated with familial British dementia.
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| Vidal R, et al.
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| Nature 399(6738):776-81. 1999
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18 | ITM2B
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| cDNA sequence analysis, chromosomal assignment and expression pattern of the gene coding for integral membrane protein 2B.
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| Pittois K, et al.
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| Gene 217 : 141-149. 1998
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