| 1 | ITGB4, S1PR2, S1PR3
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| Interaction of integrin β4 with S1P receptors in S1P- and HGF-induced endothelial barrier enhancement.
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| Ni X, Epshtein Y, Chen W, Zhou T, Xie L, Garcia JG, Jacobson JR.
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| J Cell Biochem 115(6):1187-95.
2014
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| 2 | ITGB4, SRC
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| The role of c-Src in integrin (alpha6beta4) dependent translational control.
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| Soung YH, Korneeva N, Kim TH, Chung J.
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| BMC Cell Biol 14(1):49. [Epub ahead of print]
2013
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| 3 | ITGB4
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| Endothelial β4 integrin is predominantly expressed in arterioles, where it promotes vascular remodeling in the hypoxic brain.
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| Welser-Alves JV, Boroujerdi A, Tigges U, Wrabetz L, Feltri ML, Milner R.
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| Arterioscler Thromb Vasc Biol 33(5):943-53. doi: 10.1161/ATVBAHA.112.300566. Epub 2013 Mar 7.
2013
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| 4 | ITGB4, SPARC
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| Integrin β4 regulates SPARC protein to promote invasion.
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| Gerson KD, Shearstone JR, Maddula VS, Seligmann BE, Mercurio AM.
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| J Biol Chem 287(13):9835-44. doi: 10.1074/jbc.M111.317727. Epub 2012 Feb 3.
2012
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| 5 | ITGB4
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| The calcium/calcineurin pathway promotes hemidesmosome stability through inhibition of β4 integrin phosphorylation.
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| Kashyap T, Rabinovitz I.
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| J Biol Chem 287(39):32440-9. Epub 2012 Aug 3.
2012
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| 6 | ITGB4
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| α6β4 integrin, a master regulator of expression of integrins in human keratinocytes.
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| Kligys KR, Wu Y, Hopkinson SB, Kaur S, Platanias LC, Jones JC.
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| J Biol Chem 287(22):17975-84. doi: 10.1074/jbc.M111.310458. Epub 2012 Apr 6.
2012
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| 7 | ITGB4
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| Integrin α6β4 cooperates with LPA signaling to stimulate Rac through AKAP-Lbc-mediated RhoA activation.
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| O'Connor KL, Chen M, Towers LN.
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| Am J Physiol Cell Physiol 302(3):C605-14. doi: 10.1152/ajpcell.00095.2011. Epub 2011 Nov 2.
2012
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| 8 | ITGB4, MMP9
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| MMP9 cleavage of the β4 integrin ectodomain leads to recurrent epithelial erosions in mice.
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| Pal-Ghosh S, Blanco T, Tadvalkar G, Pajoohesh-Ganji A, Parthasarathy A, Zieske JD, Stepp MA.
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| J Cell Sci 124(Pt 15):2666-75. doi: 10.1242/jcs.085480. Epub 2011 Jul 12.
2011
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| 9 | ARRDC3, ITGB4
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| ARRDC3 suppresses breast cancer progression by negatively regulating integrin beta4.
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| Draheim KM, Chen HB, Tao Q, Moore N, Roche M, Lyle S.
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| Oncogene 29(36):5032-47. Epub 2010 Jul 5. 2010
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| 10 | ITGB4
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| EGF-induced MAPK signaling inhibits hemidesmosome formation through phosphorylation of the integrin {beta}4.
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| Frijns E, Sachs N, Kreft M, Wilhelmsen K, Sonnenberg A.
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| J Biol Chem 285(48):37650-62. doi: 10.1074/jbc.M110.138818. Epub 2010 Sep 24.
2010
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| 11 | ITGB4
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| Modulation of vascular endothelial cell senescence by integrin β4.
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| Sun C, Liu X, Qi L, Xu J, Zhao J, Zhang Y, Zhang S, Miao J.
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| J Cell Physiol 225(3):673-81. doi: 10.1002/jcp.22262.
2010
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| 12 | ITGB4
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| Integrin alpha6Bbeta4 inhibits colon cancer cell proliferation and c-Myc activity.
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| Dydensborg AB, Teller IC, Groulx JF, Basora N, Paré F, Herring E, Gauthier R, Jean D, Beaulieu JF.
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| BMC Cancer 9:223. doi: 10.1186/1471-2407-9-223.
2009
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| 13 | ITGB4
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| Integrin beta-4 signaling plays a key role in mouse embryogenesis.
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| Roberts JE, Nikolopoulos SN, Oktem O, Giancotti F, Oktay K.
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| Reprod Sci 16(3):286-93. doi: 10.1177/1933719108325506. Epub 2008 Dec 15.
2009
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| 14 | EBJPAB, ITGB4
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| Deletion of the first pair of fibronectin type III repeats of the integrin beta-4 gene is associated with epidermolysis bullosa, pyloric atresia and aplasia cutis congenita in the original Carmi syndrome patients.
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| Birnbaum RY, Landau D, Elbedour K, Ofir R, Birk OS, Carmi R.
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| Am J Med Genet A 146A(8):1063-6. No abstract available. 2008
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| 15 | COL17A1, EBJ1A, EBJ1B, EBJ1C, EBJ2A, EBJ2B, EBJ2C, EBJ2D, EBJ2E, EBJPAA, EBS1, EBSMD, ITGA6, ITGB4, LAMA3, LAMB3, LAMC2, PLEC
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| Epidermolysis bullosa. I. Molecular genetics of the junctional and hemidesmosomal variants.
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| Varki R, Sadowski S, Pfendner E, Uitto J.
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| J Med Genet 43(8):641-52. Epub 2006 Feb 10. 2006
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| 16 | AGPAT6, AGTPBP1, AJUBA, BATF2, BEND2, CCDC107, CELF2, CSTF2, ECM1, EFEMP1, FAM127A, ITGB4, KIF17, LTBP4, NELF, NETS, NPHP1, PCDRS, PEG3, PELI2, PTPRN, PTPRN2, RAD54L2, RBFOX1, RBFOX2, RBPMS, RHOXF1, SCAMP1, SPINK5, TAF9, THAP1, TTC19, UBE2E3, UCHL3, WDYHV1, ZFPM2, ZNF488
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| A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
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| Lim J, Hao T, Shaw C, Patel AJ, Szabo G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabasi AL, Vidal M, Zoghbi HY.
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| Cell 125(4):801-14. 2006
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| 17 | LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMC1, LAMC2, LAMC3, ITGA3, ITGA6, ITGB1, ITGB4
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| Retinal pigment epithelial cells synthesize laminins, including laminin 5, and adhere to them through alpha3- and alpha6-containing integrins.
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| Aisenbrey S, Zhang M, Bacher D, Yee J, Brunken WJ, Hunter DD.
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| Invest Ophthalmol Vis Sci 47(12):5537-44. 2006
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| 18 | LAMC2, LAMA5, ITGB4, ITGA6
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| Laminin 5 regulates polycystic kidney cell proliferation and cyst formation.
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| Joly D, Berissi S, Bertrand A, Strehl L, Patey N, Knebelmann B.
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| J Biol Chem 281(39):29181-9. Epub 2006 Jul 26. 2006
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| 19 | ITGB4, RAC1
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| beta4 integrin and epidermal growth factor coordinately regulate electric field-mediated directional migration via Rac1.
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| Pullar CE, Baier BS, Kariya Y, Russell AJ, Horst BA, Marinkovich MP, Isseroff RR.
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| Mol Biol Cell 17(11):4925-35. Epub 2006 Aug 16. 2006
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| 20 | ITGA6, ITGB4, PTHLH
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| PTH-related protein upregulates integrin alpha6beta4 expression and activates Akt in breast cancer cells.
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| Shen X, Falzon M.
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| Exp Cell Res 312(19):3822-34. Epub 2006 Aug 17. 2006
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| 21 | ITGB4
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| Targeted deletion of the integrin beta4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-kappaB, causing defects in epidermal growth and migration.
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| Nikolopoulos SN, Blaikie P, Yoshioka T, Guo W, Puri C, Tacchetti C, Giancotti FG.
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| Mol Cell Biol 25(14):6090-102. Erratum in: Mol Cell Biol. 2005 Sep;25(17):7926. 2005
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| 22 | ITGB4
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| Deletion of a cytoplasmic domain of integrin beta4 causes epidermolysis bullosa simplex.
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| Jonkman MF, Pas HH, Nijenhuis M, Kloosterhuis G, Steege G.
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| J Invest Dermatol 119(6):1275-81. 2002
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| 23 | EBJPAB, ITGB4
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| Splicing modulation of integrin beta4 pre-mRNA carrying a branch point mutation underlies epidermolysis bullosa with pyloric atresia undergoing spontaneous amelioration with ageing.
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| Chavanas S, Gache Y, Vailly J, Kanitakis J, Pulkkinen L, Uitto J, Ortonne J, Meneguzzi G.
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| Hum Mol Genet 8(11):2097-105 1999
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| 24 | ATF4B, ATF4C, D17S1534, D17S802, D17S929, D17S939, EBJPAB, GRB2, HNA, ITGB4, LGALS3BP, NPTX1, SRSF2, ST6GALNAC2
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| A sequence-ready BAC/PAC contig and partial transcript map of approximately 1.5 Mb in human chromosome 17q25 comprising multiple disease genes.
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| Kuhlenbaumer G, Schirmacher A, Meuleman J, Tissir F, Del-Favero J, Stogbauer F, Young P, Ringelstein B, Van Broeckhoven C, Timmerman V.
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| Genomics 62(2):242-50. 1999
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| 25 | ITGB4, ITGB1
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| Expression of beta1 and beta4 integrins in normal arachnoid membrane and meningiomas.
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| Beschet I, Brunon J, Scoazec JY, Mosnier JF.
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| Cancer 86(12):2649-58. 1999
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| 26 | EBJPAB, ITGB4
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| Novel ITGB4 mutations in lethal and nonlethal variants of epidermolysis bullosa with pyloric atresia : missense versus nonsense.
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| Pulkkinen L, Rouan F, Bruckner-Tuderman L, Wallerstein R, Garzon M, Brown T, Smith L, Carter W, Uitto J.
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| Am J Hum Genet 63(5):1376-87 1998
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| 27 | EBJPAB, ITGB4
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| Pyloric atresia-junctional epidermolysis bullosa syndrome : mutations in the integrin beta4 gene (ITGB4) in two unrelated patients with mild disease.
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| Mellerio JE, Pulkkinen L, McMillan JR, Lake BD, Horn HM, Tidman MJ, Harper JI, McGrath JA, Uitto J, Eady RA.
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| Br J Dermatol 139(5):862-71 1998
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| 28 | ITGB4
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| Cloning and characterization of the human beta4-integrin gene promoter and enhancers.
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| Takaoka AS, Yamada T, Gotoh M, Kanai Y, Imai K, Hirohashi S.
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| J Biol Chem 273(50):33848-55 1998
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| 29 | EBJPAB, ITGB4
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| Genomic organization of the human integrin beta4 gene.
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| Iacovacci S, Gagnoux-Palacios L, Zambruno G, Meneguzzi G, D'Alessio M.
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| Mamm Genome 8(6):448-50. No abstract available. 1997
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| 30 | EBJPAB, ITGB4
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| Novel ITGB4 mutations in a patient with junctional epidermolysis bullosa-pyloric atresia syndrome and altered basement membrane zone immunofluorescence for the alpha6beta4 integrin.
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| Takizawa Y, Shimizu H, Nishikawa T, Hatta N, Pulkkinen L, Uitto J.
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| J Invest Dermatol 108(6):943-6. 1997
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| 31 | EBJPAB, ITGB4
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| Integrin beta 4 mutations associated with junctional epidermolysis bullosa with pyloric atresia.
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| Vidal F, Aberdam D, Miquel C, Christiano AM, Pulkkinen L, Uitto J, Ortonne JP, Meneguzzi G.
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| Nat Genet 10(2):229-34. 1995
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| 32 | ITGA6, ITGB4
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| Molecular cloning of the human alpha 6 integrin subunit. Alternative splicing of alpha 6 mRNA and chromosomal localization of the alpha 6 and beta 4 genes.
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| Hogervorst F, Kuikman I, van Kessel AG, Sonnenberg A.
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| Eur J Biochem 199(2):425-33. 1991
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| 33 | ITGA6, ITGB4
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| Localization of the human alpha-6 and beta-4 integrin genes on chromosome 2 and 17, respectively.
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| Hogervorst F, et al.
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| (HGM11) Cytogenet Cell Genet 58 : 1869. 1991
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| 34 | ITGB4
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| Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 kd cytoplasmic domain.
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| Hogervorst F, Kuikman I, von dem Borne AE, Sonnenberg A.
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| EMBO J 9(3):765-70. 1990
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| 35 | ITGB4
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| Amino acid sequence of a novel integrin beta-4 subunit and primary expression of the mRNA in epithelial cells.
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| Suzuki S, Naitoh Y.
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| EMBO J 9(3):757-63. 1990
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| 36 | ITGA6, ITGB4
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| A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors.
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| Kajiji S, Tamura RN, Quaranta V.
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| EMBO J 8(3):673-80. 1989
|