Citations for
1GT2, GT3, ITGA2B, ITGB3
ITGA2B and ITGB3 gene mutations associated with Glanzmann thrombasthenia.
Nurden AT, Pillois X.
Platelets 29(1):98-101. doi: 10.1080/09537104.2017.1371291. Epub 2017 Nov 10. Review. No abstract available. 2018
2FLNA, ITGA2B, ITGB3
Gain-of-Function Mutation in Filamin A Potentiates Platelet Integrin αIIbβ3 Activation.
Berrou E, Adam F, Lebret M, Planche V, Fergelot P, Issertial O, Coupry I, Bordet JC, Nurden P, Bonneau D, Colin E, Goizet C, Rosa JP, Bryckaert M.
Arterioscler Thromb Vasc Biol 37(6):1087-1097. doi: 10.1161/ATVBAHA.117.309337. Epub 2017 Apr 20. 2017
3ITGA2B
Platelet GPIIb supports initial pulmonary retention but inhibits subsequent proliferation of melanoma cells during hematogenic metastasis.
Echtler K, Konrad I, Lorenz M, Schneider S, Hofmaier S, Plenagl F, Stark K, Czermak T, Tirniceriu A, Eichhorn M, Walch A, Enders G, Massberg S, Schulz C.
PLoS One 12(3):e0172788. doi: 10.1371/journal.pone.0172788. eCollection 2017. 2017
4ITGA2B, TLN1, WDR1
Wdr1-Dependent Actin Reorganization in Platelet Activation.
Dasgupta SK, Le A, Da Q, Cruz M, Rumbaut RE, Thiagarajan P.
PLoS One 11(9):e0162897. doi: 10.1371/journal.pone.0162897. eCollection 2016. 2016
5ITGA2B, ITGB3
Identification of ITGA2B and ITGB3 Single-Nucleotide Polymorphisms and Their Influences on the Platelet Function.
Xiang Q, Ji SD, Zhang Z, Zhao X, Cui YM.
Biomed Res Int 2016:5675084. Epub 2016 Nov 14. 2016
6ITGA2B, ITGB3
Implications of the differing roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin function.
Lu Z, Mathew S, Chen J, Hadziselimovic A, Palamuttam R, Hudson BG, Fässler R, Pozzi A, Sanders CR, Zent R.
Elife 5. pii: e18633. doi: 10.7554/eLife.18633. 2016
7ITGA2B, ITGB3
The Platelet Integrin αIIbβ3 Differentially Interacts with Fibrin Versus Fibrinogen.
Litvinov RI, Farrell DH, Weisel JW, Bennett JS.
J Biol Chem 291(15):7858-67. doi: 10.1074/jbc.M115.706861. Epub 2016 Feb 10. 2016
8GIT1, ITGA2B, ITGA8, SHC1
ITGA2B and ITGA8 are predictive of prognosis in clear cell renal cell carcinoma patients.
Lu X, Wan F, Zhang H, Shi G, Ye D.
Tumour Biol 37(1):253-62. doi: 10.1007/s13277-015-3792-5. Epub 2015 Jul 22. 2016
9FYB1, ITGA2B, ITGB3, SKAP1
ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding.
Kasirer-Friede A, Kang J, Kahner B, Ye F, Ginsberg MH, Shattil SJ.
Blood 123(20):3156-65. doi: 10.1182/blood-2013-08-520627. Epub 2014 Feb 12. 2014
10ITGA2B, ITGB3
The interaction of integrin αIIbβ3 with fibrin occurs through multiple binding sites in the αIIb β-propeller domain.
Podolnikova NP, Yakovlev S, Yakubenko VP, Wang X, Gorkun OV, Ugarova TP.
J Biol Chem 289(4):2371-83. doi: 10.1074/jbc.M113.518126. Epub 2013 Dec 12. 2014
11ITGA2B, ITGB3
Serine/threonine phosphatases regulate platelet αIIbβ3 integrin receptor outside-in signaling mechanisms and clot retraction.
Moscardó A, Santos MT, Latorre A, Madrid I, Vallés J.
Life Sci 93(20):707-13. doi: 10.1016/j.lfs.2013.09.020. Epub 2013 Oct 1. 2013
12ITGA2B, ITGB3
Activation induced morphological changes and integrin αIIbβ3 activity of living platelets.
Posch S, Neundlinger I, Leitner M, Siostrzonek P, Panzer S, Hinterdorfer P, Ebner A.
Methods 60(2):179-85. doi: 10.1016/j.ymeth.2013.03.034. Epub 2013 Apr 6. 2013
13ITGA2B, ITGB3
Autocrine amplification of integrin αIIbβ3 activation and platelet adhesive responses by deoxyribose-1-phosphate.
Vara DS, Campanella M, Canobbio I, Dunn WB, Pizzorno G, Hirano M, Pula G.
Thromb Haemost 109(6):1108-19. doi: 10.1160/TH12-10-0751. Epub 2013 Mar 14. 2013
14ITGA2B, ITGB3, PTK2B
The proline-rich tyrosine kinase Pyk2 regulates platelet integrin αIIbβ3 outside-in signaling.
Cipolla L, Consonni A, Guidetti G, Canobbio I, Okigaki M, Falasca M, Ciraolo E, Hirsch E, Balduini C, Torti M.
J Thromb Haemost 11(2):345-56. doi: 10.1111/jth.12099. 2013
15ITGA2B, KDM6B, MPL
Itga2b regulation at the onset of definitive hematopoiesis and commitment to differentiation.
Dumon S, Walton DS, Volpe G, Wilson N, Dassé E, Del Pozzo W, Landry JR, Turner B, O'Neill LP, Göttgens B, Frampton J.
PLoS One 7(8):e43300. doi: 10.1371/journal.pone.0043300. Epub 2012 Aug 28. 2012
16ITGA2B, ITGB3
Clinical disability progression and platelet GP IIb/IIIa values in patients with atopic myelitis.
Ainiding G, Yamashita K, Torii T, Furuta K, Isobe N, Matsushita T, Masaki K, Matsumoto S, Kira J.
J Neuroimmunol 246(1-2):108-12. doi: 10.1016/j.jneuroim.2012.03.009. Epub 2012 Apr 5. 2012
17ITGA2B, ITGB3
Heterozygous ITGA2B R995W mutation inducing constitutive activation of the αIIbβ3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia.
Kunishima S, Kashiwagi H, Otsu M, Takayama N, Eto K, Onodera M, Miyajima Y, Takamatsu Y, Suzumiya J, Matsubara K, Tomiyama Y, Saito H.
Blood 117(20):5479-84. doi: 10.1182/blood-2010-12-323691. Epub 2011 Mar 31. 2011
18ITGA2B, ITGB3
CD41 is developmentally regulated and differentially expressed on mouse hematopoietic stem cells.
Robin C, Ottersbach K, Boisset JC, Oziemlak A, Dzierzak E.
Blood 117(19):5088-91. doi: 10.1182/blood-2011-01-329516. Epub 2011 Mar 17. 2011
19ITGA2B, ITGB3
Predictive value of platelet activation for the rate of cognitive decline in Alzheimer's disease patients.
Stellos K, Panagiota V, Kögel A, Leyhe T, Gawaz M, Laske C.
J Cereb Blood Flow Metab 30(11):1817-20. Epub 2010 Aug 18.PMID: 20717123 2010
20ITGA2B, ITGB3
Dynamic regulation of fibrinogen: integrin αIIbβ3 binding.
Hantgan RR, Stahle MC, Lord ST.
Biochemistry 49(43):9217-25. doi: 10.1021/bi1009858. 2010
21ITGA2B, ITGB3
A unique interaction between alphaIIb and beta3 in the head region is essential for outside-in signaling-related functions of alphaIIbbeta3 integrin.
Hauschner H, Landau M, Seligsohn U, Rosenberg N.
Blood 115(22):4542-50. doi: 10.1182/blood-2009-10-251066. Epub 2010 Mar 22. 2010
22ITGA2B, ITGB3
Structure of an integrin alphaIIb beta3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation.
Yang J, Ma YQ, Page RC, Misra S, Plow EF, Qin J.
Proc Natl Acad Sci U S A 106(42):17729-34. doi: 10.1073/pnas.0909589106. Epub 2009 Oct 1. 2009
23ITGA2B, ITGB3
Evidence that integrin alpha IIb beta 3-dependent interaction of mast cells with fibrinogen exacerbates chronic inflammation.
Oki T, Eto K, Izawa K, Yamanishi Y, Inagaki N, Frampton J, Kitamura T, Kitaura J.
J Biol Chem 284(45):31463-72. doi: 10.1074/jbc.M109.030213. Epub 2009 Sep 15. 2009
24ITGA2B, ITGB3
Factor H binds to platelet integrin alphaIIbbeta3.
Mnjoyan Z, Li J, Afshar-Kharghan V.
Platelets 19(7):512-9. doi: 10.1080/09537100802238494. 2008
25ITGA2B, ITGB3, MMP2
MMP-2 regulates human platelet activation by interacting with integrin alphaIIbbeta3.
Choi WS, Jeon OH, Kim HH, Kim DS.
J Thromb Haemost 6(3):517-23. Epub 2007 Dec 12. 2008
26ITGA2B, ITGB3
Platelet integrin alpha(IIb)beta(3): activation mechanisms.
Ma YQ, Qin J, Plow EF.
J Thromb Haemost 5(7):1345-52. Review. 2007
27GATA1, FLI1, ITGA2B, GP9
Ets-dependent regulation of target gene expression during megakaryopoiesis.
Jackers P, Szalai G, Moussa O, Watson DK.
J Biol Chem 279(50):52183-90. Epub 2004 Oct 5. Erratum in: J Biol Chem. 2005 Jul 1;280(26):25304. 2004
28ITGA2B
Identification of distal regulatory regions in the human alpha IIb gene locus necessary for consistent, high-level megakaryocyte expression.
Thornton MA, Zhang C, Kowalska MA, Poncz M.
Blood 100(10):3588-96. Epub 2002 Jul 25. 2002
29GT2,ITGA2B
A novel (288delC) mutation in exon 2 of GPIIb associated with type I Glanzmann's thrombasthenia.
Tao J, Arias-Salgado EG, Gonzalez-Manchon C, Diaz-Cremades J, Ayuso MS, Parrilla R.
Br J Haematol 111(1):96-103. 2000
30ITGA2B
A mutation in the alpha subunit of the platelet integrin alphaIIbbeta3 identifies a novel region important for ligand binding.
Tozer EC, et al.
Blood 93(3):918-24. 1999
31GT2,GT3,ITGA2B,ITGB3
Molecular genetic analysis of a compound heterozygote for the glycoprotein (GP) IIb gene associated with Glanzmann's thrombasthenia: disruption of the 674-687 disulfide bridge in GPIIb prevents surface exposure of GPIIb-IIIa complexes.
Gonzalez-Manchon C, et al.
Blood 93(3):866-75. 1999
32ITGA2B, GT2
Glycoprotein IIb Leu214Pro mutation produces glanzmann thrombasthenia with both quantitative and qualitative abnormalities in GPIIb/IIIa.
Grimaldi CM, Chen F, Wu C, Weiss HJ, Coller BS, French DL.
Blood 91(5):1562-71. 1998
33ITGA2B
Novel point mutations in the alphaIIb subunit (Phe289-Ser, Glu324-Lys and Gln747-Pro) causing thrombasthenic phenotypes in four Japanese patients.
Ambo H, et al.
Br J Haematol 102 : 829-840. 1998
34GT2,ITGA2B
Glanzmann thrombasthenia in two Iraqi-Jewish siblings is caused by a novel splice junction mutation in the glycoprotein IIb.
Yatuv R, Rosenberg N, Dardik R, Brenner B, Seligsohn U.
Blood Coagul Fibrinolysis 9 : 285-288. 1998
35GT2,ITGA2B
A two-amino acid insertion in the Cys146- Cys167 loop of the alphaIIb subunit is associated with a variant of Glanzmann thrombasthenia. Critical role of Asp163 in ligand binding.
Honda S, Tomiyama Y, Shiraga M, Tadokoro S, Takamatsu J, Saito H, Kurata Y, Matsuzawa Y.
J Clin Invest 102(6):1183-92. 1998
36ITGA2B
A frameshift mutation at Gly975 in the transmembrane domain of GPIIb prevents GPIIb-IIIa expression--analysis of two novel mutations in a kindred with type I glanzmann thrombasthenia.
Scott JP 3rd, Scott JP 2nd, Chao YL, Newman PJ, Ward CM.
Thromb Haemost 80 : 546-550. 1998
37GT2,ITGA2B
A Gln747-->Pro substitution in the IIb subunit is responsible for a moderate IIbbeta3 deficiency in Glanzmann thrombasthenia.
Takokoro S, et al.
Blood 92 : 2750-2758. 1998
38GT2,GT3,ITGA2B,ITGB3
Truncation of glycoprotein (GP) IIIa (616-762) prevents complex formation with GPIIb : novel mutation in exon 11 of GPIIIa associated with thrombasthenia.
Ferrer M, et al.
Blood 92 : 4712-4720. 1998
39ITGA2B, GT2
A cys374Tyr homozygous mutation of platelet glycoprotein IIIa (beta3) in a Chinese patient with Glanzmann's thrombasthenia.
Grimaldi CM, et al.
Blood 88 : 1666-1675. 1996
40ITGA2B
A nonsense mutation in the GPIIb heavy chain (Ser 870-stop) impairs platelet GPIIb-IIIa expression.
Vinciguerra C, et al.
Br J Haematol 95 : 399-407. 1996
41ITGA2B
The molecular genetic basis of Glanzmann's thrombasthenia in a Gypsy population in France : identification of a new mutation on the alphaIIb gene.
Schlegel N, et al.
Blood 86 : 977-982. 1995
42D17S183, D17S1183, D17S1184, SLC4A1, ITGA2B
A physical map encompassing GP2B,EPB3,D17S183,D17S78,D17S1183, and D17S1184.
Miki Y, et al.
Genomics 25 : 295-299. 1995
43ITGA2B
Glanzmann's thrombasthenia associated with deletion-insertion and alternative splicing in the glycoprotein IIb gene.
Peretz H, et al.
Blood 85 : 414-420. 1995
44ITGA2B
Glanzmann thrombasthenia resulting from a single amino acid substitution between the second and third calcium-binding domains of GPIIb.
Wilcox DA, et al.
J Clin Invest 95 : 1553-1560. 1995
45ITGA2B
Abnormal processing of the glycoprotein IIb transcript due to a nonsense mutation in exon 17 associated with Glanzmann's thrombasthenia.
Tomiyama Y, et al.
Thromb Haemost 73 : 756-762. 1995
46ITGA2B, GT2, GT3
Glanzmann thrombasthenia secondary to a Gly273-Asp mutation adjacent to the first calcium-binding domain of platelet glycoprotein IIb.
Poncz M, et al.
J Clin Invest 93 : 172-179. 1994
47ITGA2B, GT2, GT3
An exon 28 mutation resulting in alternative splicing of the glycoprotein IIb transcript and Glanzmann's thrombasthenia.
Iwamoto S, et al.
Blood 83 : 1017-1023. 1994
48ITGA2B, GT2, GT3
Identification of a nonsense mutation at amino acid 584-arginine of platelet glycoprotein IIb in patients with type I Glanzmann thrombasthenia.
Gu JM, et al.
Br J Haematol 43 : 442-449. 1993
49ITGA2B, GT2, GT3
Molecular basis for Glanzmann's thrombasthenia (GT) in a compound heterozygote with glycoprotein IIb gene : a proposal for the classification of GT based on the biosynthetic pathway of glycoprotein IIb-IIIa complex.
Kato A, et al.
Blood 79 : 3212-3218. 1992
50ITGA2B, ITGB3, GT2, GT3
The molecular genetic basis of Glanzmann thrombasthenia in the Iraqi-Jewish and Arab populations in Israel.
Newman PJ, et al.
Proc Natl Acad Sci U S A 88 : 3160-3164. 1991
51ITGA2B, GT2, GT3
A deletion in the gene for glycoprotein IIb associated with Glanzmann's thrombasthenia.
Burk CD, et al.
J Clin Invest 87 : 270-276. 1991
52ITGA2B
Polymorphism of human platelet membrane glycoprotein IIb associated with the Bak-a/Bak-b alloantigen system.
Lyman S, et al.
Blood 75 : 2343-2348. 1990
53ITGA2B
Precise localization of the gene for platelet membrane glycoprotein IIb to 17q21.32 using structural rearrangements of chromosome 17.
Luo XY, et al.
(HGM10) Cytogenet Cell Genet 51 : 1036. 1989
54GT2,GT3,ITGA2B,ITGB3
Glanzmann's thrombasthenia.
Caen JP.
Baillire Clin Haematol 2 : 609-625. 1989
55ITGA2B
Assignment of human platelet GP2B (GPIIb) gene to chromosome 17, region q21.1-q21.3.
Cong NV, Uzan G, Gross MS, Jegou-Foubert C, Frachet P, Boucheix C, Marguerie G, Frezal J.
Hum Genet 80 : 389-392. 1988
56ITGA2B, ITGB3
Physical linkage of the genes for platelet membrane glycoproteins IIb and IIIa.
Bray PF, Barsh G, Rosa JP, Luo XY, Magenis E, Shuman MA.
Proc Natl Acad Sci U S A 85 : 8683-8687. 1988
57ITGA2B, ITGB3, ITGAV, ITGA5, ITGB1
Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa.
Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS, et al.
J Clin Invest 81(6):1993-8. 1988
58ITGA2B
Assignment of a gene coding for human platelet GPIIb (GP2B) to 17q21.1-q21.3 by in situ hybridization.
Uzan G, et al.
(HGM9) Cytogenet Cell Genet 46 : 707. 1987
59ITGA2B
Platelet glycoprotein IIb.
Bray PF, et al.
J Clin Invest 80 : 1812-1817. 1987