Citations for
1ITCH, ITSN1
Ubiquitin-ligase AIP4 controls differential ubiquitination and stability of isoforms of the scaffold protein ITSN1.
Dergai O, Dergai M, Rynditch A.
FEBS Lett 592(13):2259-2267. doi: 10.1002/1873-3468.13118. Epub 2018 Jun 16. 2018
2ITCH, PPIA
CypA Regulates AIP4-Mediated M1 Ubiquitination of Influenza A Virus.
Mahesutihan M, Zheng W, Cui L, Li Y, Jiao P, Yang W, Liu W, Li J, Fan W, Yang L, Liu W, Sun L.
Virol Sin 33(5):440-448. doi: 10.1007/s12250-018-0058-6. Epub 2018 Oct 16. 2018
3ITCH, TAZ, YAP1, YOD1
Deubiquitinase YOD1: The Potent Activator of YAP in Hepatomegaly and Liver Cancer.
Kim Y, Jho EH.
BMB Rep MB Rep. 2017 May 15. pii: 3845. [Epub ahead of print] 2017
4ITCH, TAZ, YAP1, YOD1
Deubiquitinase YOD1 potentiates YAP/TAZ activities through enhancing ITCH stability.
Kim Y, Kim W, Song Y, Kim JR, Cho K, Moon H, Ro SW, Seo E, Ryu YM, Myung SJ, Jho EH.
Proc Natl Acad Sci U S A 114(18):4691-4696. doi: 10.1073/pnas.1620306114. Epub 2017 Apr 17. 2017
5ITCH, MAVS, TAX1BP1
TAX1BP1 Restrains Virus-Induced Apoptosis by Facilitating Itch-Mediated Degradation of the Mitochondrial Adaptor MAVS.
Choi YB, Shembade N, Parvatiyar K, Balachandran S, Harhaj EW.
Mol Cell Biol 37(1). pii: e00422-16. Print 2017 Jan 1. 2016
6ITCH, SMAD7
Itch E3 ubiquitin ligase positively regulates TGF-β signaling to EMT via Smad7 ubiquitination.
Park SH, Jung EH, Kim GY, Kim BC, Lim JH, Woo CH.
Mol Cells 38(1):20-5. doi: 10.14348/molcells.2015.2120. Epub 2014 Dec 16. 2015
7ITCH, NDFIP1, UBE2L3
Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7.
Kathania M, Zeng M, Yadav VN, Moghaddam SJ, Yang B, Venuprasad K.
J Immunol 194(5):2160-7. doi: 10.4049/jimmunol.1402742. Epub 2015 Jan 28. 2015
8ITCH, PDYN
Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord.
Kardon AP, Polgár E, Hachisuka J, Snyder LM, Cameron D, Savage S, Cai X, Karnup S, Fan CR, Hemenway GM, Bernard CS, Schwartz ES, Nagase H, Schwarzer C, Watanabe M, Furuta T, Kaneko T, Koerber HR, Todd AJ, Ross SE.
Neuron 82(3):573-86. doi: 10.1016/j.neuron.2014.02.046. Epub 2014 Apr 10. 2014
9ITCH, POU5F1
Itch, an E3 ligase of Oct4, is required for embryonic stem cell self-renewal and pluripotency induction.
Liao B, Zhong X, Xu H, Xiao F, Fang Z, Gu J, Chen Y, Zhao Y, Jin Y.
J Cell Physiol 228(7):1443-51. doi: 10.1002/jcp.24297. 2013
10GBA, ITCH
ITCH regulates degradation of mutant glucocerebrosidase: implications to Gaucher disease.
Maor G, Filocamo M, Horowitz M.
Hum Mol Genet 22(7):1316-27. doi: 10.1093/hmg/dds535. Epub 2012 Dec 18. 2013
11AMOT, ITCH, YAP1
Amot130 adapts atrophin-1 interacting protein 4 to inhibit yes-associated protein signaling and cell growth.
Adler JJ, Heller BL, Bringman LR, Ranahan WP, Cocklin RR, Goebl MG, Oh M, Lim HS, Ingham RJ, Wells CD.
J Biol Chem 288(21):15181-93. doi: 10.1074/jbc.M112.446534. Epub 2013 Apr 5. 2013
12ITCH, TRAF6
Ubiquitin E3 ligase Itch negatively regulates osteoclast formation by promoting deubiquitination of tumor necrosis factor (TNF) receptor-associated factor 6.
Zhang H, Wu C, Matesic LE, Li X, Wang Z, Boyce BF, Xing L.
J Biol Chem 288(31):22359-68. doi: 10.1074/jbc.M112.442459. Epub 2013 Jun 19. 2013
13AMOT, ITCH, LATS1, LATS2, YAP1
Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases.
Adler JJ, Johnson DE, Heller BL, Bringman LR, Ranahan WP, Conwell MD, Sun Y, Hudmon A, Wells CD.
Proc Natl Acad Sci U S A 110(43):17368-73. doi: 10.1073/pnas.1308236110. Epub 2013 Oct 7. 2013
14BIRC2, ITCH, NOD2
A discrete ubiquitin-mediated network regulates the strength of NOD2 signaling.
Tigno-Aranjuez JT, Bai X, Abbott DW.
Mol Cell Biol 33(1):146-58. doi: 10.1128/MCB.01049-12. Epub 2012 Oct 29. 2013
15DVL1, ITCH
The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein.
Wei W, Li M, Wang J, Nie F, Li L.
Mol Cell Biol 32(19):3903-12. doi: 10.1128/MCB.00251-12. Epub 2012 Jul 23. 2012
16APBB1, ITCH, NOTCH1
Dual regulation of notch1 signaling pathway by adaptor protein fe65.
Kim MY, Mo JS, Ann EJ, Yoon JH, Park HS.
J Biol Chem 287(7):4690-701. doi: 10.1074/jbc.M111.289637. Epub 2011 Dec 23. 2012
17AMOT, ITCH, NEDD4, NEDD4L
The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation.
Wang C, An J, Zhang P, Xu C, Gao K, Wu D, Wang D, Yu H, Liu JO, Yu L.
Biochem J 444(2):279-89. doi: 10.1042/BJ20111983. 2012
18ITCH, STAM
Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling.
Malik R, Soh UJ, Trejo J, Marchese A.
J Biol Chem 287(12):9013-27. doi: 10.1074/jbc.M111.336792. Epub 2012 Jan 24. 2012
19ITCH, LITAF
SIMPLE/LITAF expression induces the translocation of the ubiquitin ligase itch towards the lysosomal compartments.
Eaton HE, Desrochers G, Drory SB, Metcalf J, Angers A, Brunetti CR.
PLoS One 6(2):e16873. 2011
20ITCH, LAPTM5
HECT-type ubiquitin ligase ITCH targets lysosomal-associated protein multispanning transmembrane 5 (LAPTM5) and prevents LAPTM5-mediated cell death.
Ishihara T, Inoue J, Kozaki K, Imoto I, Inazawa J.
J Biol Chem 286(51):44086-94. doi: 10.1074/jbc.M111.251694. Epub 2011 Oct 18. 2011
21ITCH, TXNIP
The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation.
Zhang P, Wang C, Gao K, Wang D, Mao J, An J, Xu C, Wu D, Yu H, Liu JO, Yu L.
J Biol Chem 285(12):8869-79. Epub 2010 Jan 12.PMID: 20068034 2010
22ITCH, ITCHD
Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease.
Lohr NJ, Molleston JP, Strauss KA, Torres-Martinez W, Sherman EA, Squires RH, Rider NL, Chikwava KR, Cummings OW, Morton DH, Puffenberger EG.
Am J Hum Genet 86(3):447-53. Epub 2010 Feb 18.PMID: 20170897 2010
23BMPR2, ITCH
Identification of a lysosomal pathway regulating degradation of the bone morphogenetic protein receptor type II.
Durrington HJ, Upton PD, Hoer S, Boname J, Dunmore BJ, Yang J, Crilley TK, Butler LM, Blackbourn DJ, Nash GB, Lehner PJ, Morrell NW.
J Biol Chem 285(48):37641-9. Epub 2010 Sep 24. 2010
24HGS, ITCH, STAM, USP8
The deubiquitinating enzyme USP8 promotes trafficking and degradation of the chemokine receptor 4 at the sorting endosome.
Berlin I, Higginbotham KM, Dise RS, Sierra MI, Nash PD.
J Biol Chem 285(48):37895-908. Epub 2010 Sep 27. 2010
25ITCH, RIPK1, RNF11, TAX1BP1, TNFAIP3
The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling.
Shembade N, Parvatiyar K, Harhaj NS, Harhaj EW.
EMBO J 28(5):513-22. Epub 2009 Jan 8. 2009
26ITCH, SPART, WWP1
Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5.
Edwards TL, Clowes VE, Tsang HT, Connell JW, Sanderson CM, Luzio JP, Reid E.
Biochem J 423(1):31-9. Erratum in: Biochem J. 2009 Nov 1;423(3):442. PMID: 19580544 2009
27ITCH, SPART, WWP1
Identification of novel spartin-interactors shows spartin is a multifunctional protein.
Milewska M, McRedmond J, Byrne PC.
J Neurochem 111(4):1022-30. Epub 2009 Sep 16.PMID: 19765186 2009
28ITCH, MAVS, PCBP2
PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4.
You F, Sun H, Zhou X, Sun W, Liang S, Zhai Z, Jiang Z.
Nat Immunol 10(12):1300-8. Epub 2009 Nov 1.PMID: 19881509 2009
29ITCH, NOD2, RIPK2
ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways.
Tao M, Scacheri PC, Marinis JM, Harhaj EW, Matesic LE, Abbott DW.
Curr Biol 19(15):1255-63. Epub 2009 Jul 9.PMID: 19592251 2009
30CXCR4, ITCH
The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction.
Bhandari D, Robia SL, Marchese A.
Mol Biol Cell 20(5):1324-39. Epub 2008 Dec 30.PMID: 19116316 2009
31ITCH
Caspase cleavage of Itch in chronic lymphocytic leukemia cells.
Rossi M, Inoue S, Walewska R, Knight RA, Dyer MJ, Cohen GM, Melino G.
Biochem Biophys Res Commun 379(3):659-64. Epub 2008 Dec 13.PMID: 19073138 2009
32ITCH
Itch: a HECT-type E3 ligase regulating immunity, skin and cancer.
Melino G, Gallagher E, Aqeilan RI, Knight R, Peschiaroli A, Rossi M, Scialpi F, Malatesta M, Zocchi L, Browne G, Ciechanover A, Bernassola F.
Cell Death Differ 15(7):1103-12. Review. 2008
33ITCH, UBE2L3
Modelling and molecular dynamics of the interaction between the E3 ubiquitin ligase Itch and the E2 UbcH7.
Raimondo D, Giorgetti A, Bernassola F, Melino G, Tramontano A.
Biochem Pharmacol 76(11):1620-7. Epub 2008 Aug 31. 2008
34ITCH,N4BP1
The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch.
Oberst A, Malatesta M, Aqeilan RI, Rossi M, Salomoni P, Murillas R, Sharma P, Kuehn MR, Oren M, Croce CM, Bernassola F, Melino G.
Proc Natl Acad Sci U S A 104(27):11280-5. Epub 2007 Jun 25. 2007
35ARRB2, ITCH
Arrestin-2 Interacts with the Ubiquitin-Protein Isopeptide Ligase Atrophin-interacting Protein 4 and Mediates Endosomal Sorting of the Chemokine Receptor CXCR4.
Bhandari D, Trejo J, Benovic JL, Marchese A.
J Biol Chem 282(51):36971-9. Epub 2007 Oct 18. 2007
36GLI1, ITCH, NUMB
Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination.
Di Marcotullio L, Ferretti E, Greco A, De Smaele E, Po A, Sico MA, Alimandi M, Giannini G, Maroder M, Screpanti I, Gulino A.
Nat Cell Biol 8(12):1415-23. Epub 2006 Nov 19. 2006
37ITCH, USP9X
The ubiquitin ligase itch is auto-ubiquitylated in vivo and in vitro but is protected from degradation by interacting with the deubiquitylating enzyme FAM/USP9X.
Mouchantaf R, Azakir BA, McPherson PS, Millard SM, Wood SA, Angers A.
J Biol Chem 281(50):38738-47. Epub 2006 Oct 12. 2006
38DTX1, DTX3, ITCH
Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains.
Chastagner P, Israël A, Brou C.
EMBO Rep 7(11):1147-53. Epub 2006 Oct 6.PMID: 17028573 2006
39ITCH
AIP4 restricts transforming growth factor-beta signaling through a ubiquitination-independent mechanism.
Lallemand F, Seo SR, Ferrand N, Pessah M, L'Hoste S, Rawadi G, Roman-Roman S, Camonis J, Atfi A.
J Biol Chem 280(30):27645-53. Epub 2005 Jun 8. 2005
40ITCH
Human ITCH is a coregulator of the hematopoietic transcription factor NF-E2.
Chen X, Wen S, Fukuda MN, Gavva NR, Hsu D, Akama TO, Yang-Feng T, Shen CK.
Genomics 73(2):238-41. 2001
41ITCH
Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase.
Qiu L, Joazeiro C, Fang N, Wang HY, Elly C, Altman Y, Fang D, Hunter T, Liu YC.
J Biol Chem 275(46):35734-7. 2000