Citations for
1CXCR4, ISL1, LHX3, STAM
Identification of STAM1 as a novel effector of ventral projection of spinal motor neurons.
Nam H, Lee S.
Development 143(13):2334-43. doi: 10.1242/dev.135848. Epub 2016 May 9. 2016
2ISL1, MAFA, NRDC
Nardilysin Is Required for Maintaining Pancreatic β-Cell Function
Nishi K, Sato Y, Ohno M, Hiraoka Y, Saijo S, Sakamoto J, Chen PM, Morita Y, Matsuda S, Iwasaki K, Sugizaki K, Harada N, Mukumoto Y, Kiyonari H, Furuyama K, Kawaguchi Y, Uemoto S, Kita T, Inagaki N, Kimura T, Nishi E.
Diabetes. Oct;65(10):3015-27. doi: 10.2337/db16-0178. Epub 2016 Jul 6. 2016
3BARX1, ISL1, PITX1, PITX2, SIX2
Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1.
Jayewickreme CD, Shivdasani RA.
Dev Biol 405(1):21-32. doi: 10.1016/j.ydbio.2015.05.024. Epub 2015 Jun 6. 2015
4CDH6, iSL1
Cadherin-6B is required for the generation of Islet-1-expressing dorsal interneurons.
Park KS, Gumbiner BM.
Biochem Biophys Res Commun 459(3):504-8. doi: 10.1016/j.bbrc.2015.02.136. 2015
5ISL1, LDB1, SSBP3
SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic β-Cell Target Genes.
Galloway JR, Bethea M, Liu Y, Underwood R, Mobley JA, Hunter CS.
Mol Endocrinol 29(12):1774-86. doi: 10.1210/me.2015-1165. Epub 2015 Oct 23. 2015
6ISL1, LDB1
The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors.
Caputo L, Witzel HR, Kolovos P, Cheedipudi S, Looso M, Mylona A, van IJcken WF, Laugwitz KL, Evans SM, Braun T, Soler E, Grosveld F, Dobreva G.
Cell Stem Cell 17(3):287-99. doi: 10.1016/j.stem.2015.08.007. Epub 2015 Aug 27. 2015
7GATA3, ISL1
LIM homeodomain transcription factor Isl1 directs normal pyloric development by targeting Gata3.
Li Y, Pan J, Wei C, Chen J, Liu Y, Liu J, Zhang X, Evans SM, Cui Y, Cui S.
BMC Biol 12:25. doi: 10.1186/1741-7007-12-25. 2014
8ISL1
The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse.
Ehrman LA, Mu X, Waclaw RR, Yoshida Y, Vorhees CV, Klein WH, Campbell K.
Proc Natl Acad Sci U S A 110(42):E4026-35. doi: 10.1073/pnas.1308275110. Epub 2013 Sep 30. 2013
9ISL1, LDB1
Islet α-, β-, and δ-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor.
Hunter CS, Dixit S, Cohen T, Ediger B, Wilcox C, Ferreira M, Westphal H, Stein R, May CL.
Diabetes 62(3):875-86. doi: 10.2337/db12-0952. Epub 2012 Nov 27. 2013
10ISL1, LHX3
A distal modular enhancer complex acts to control pituitary- and nervous system-specific expression of the LHX3 regulatory gene.
Mullen RD, Park S, Rhodes SJ.
Mol Endocrinol 26(2):308-19. Epub 2011 Dec 22. 2012
11ISL1, LHX3
Fusion protein Isl1-Lhx3 specifies motor neuron fate by inducing motor neuron genes and concomitantly suppressing the interneuron programs.
Lee S, Cuvillier JM, Lee B, Shen R, Lee JW, Lee SK.
Proc Natl Acad Sci U S A 109(9):3383-8. Epub 2012 Feb 16. 2012
12FGF10, ISL1
ISL1 directly regulates FGF10 transcription during human cardiac outflow formation.
Golzio C, Havis E, Daubas P, Nuel G, Babarit C, Munnich A, Vekemans M, Zaffran S, Lyonnet S, Etchevers HC.
PLoS One 7(1):e30677. doi: 10.1371/journal.pone.0030677. Epub 2012 Jan 27. 2012
13AJUBA, ISL1
The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity.
Witzel HR, Jungblut B, Choe CP, Crump JG, Braun T, Dobreva G.
Dev Cell 23(1):58-70. doi: 10.1016/j.devcel.2012.06.005. 2012
14FBXO25, HAND1, ISL1, NKX2-5
A novel Fbxo25 acts as an E3 ligase for destructing cardiac specific transcription factors.
Jang JW, Lee WY, Lee JH, Moon SH, Kim CH, Chung HM.
Biochem Biophys Res Commun 410(2):183-8. Epub 2011 May 7. 2011
15ISL1
Islet1-mediated activation of the β-catenin pathway is necessary for hindlimb initiation in mice.
Kawakami Y, Marti M, Kawakami H, Itou J, Quach T, Johnson A, Sahara S, O'Leary DD, Nakagawa Y, Lewandoski M, Pfaff S, Evans SM, Izpisua Belmonte JC.
Development 138(20):4465-73. 2011
16ISL1, NEUROD4, POU4F1
Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation.
Dykes IM, Tempest L, Lee SI, Turner EE.
J Neurosci 31(27):9789-99. 2011
17ISL1
Isl1 is required for multiple aspects of motor neuron development.
Liang X, Song MR, Xu Z, Lanuza GM, Liu Y, Zhuang T, Chen Y, Pfaff SL, Evans SM, Sun Y.
Mol Cell Neurosci 47(3):215-22. Epub 2011 May 4. 2011
18ISL1
Common variation in ISL1 confers genetic susceptibility for human congenital heart disease.
Stevens KN, Hakonarson H, Kim CE, Doevendans PA, Koeleman BP, Mital S, Raue J, Glessner JT, Coles JG, Moreno V, Granger A, Gruber SB, Gruber PJ.
PLoS One 5(5):e10855. 2010
19ISL1
Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages.
Bu L, Jiang X, Martin-Puig S, Caron L, Zhu S, Shao Y, Roberts DJ, Huang PL, Domian IJ, Chien KR.
Nature 460(7251):113-7. 2009
20ISL1, NEUROD1
The LIM-homeodomain protein ISL1 activates insulin gene promoter directly through synergy with BETA2.
Zhang H, Wang WP, Guo T, Yang JC, Chen P, Ma KT, Guan YF, Zhou CY.
J Mol Biol 392(3):566-77. Epub 2009 Jul 17. 2009
21ISL1
A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs.
Sun Y, Dykes IM, Liang X, Eng SR, Evans SM, Turner EE.
Nat Neurosci. 11(11):1246. 2008
22ISL1
The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons.
Elshatory Y, Gan L.
J Neurosci 28(13):3291-7.PMID: 18367596 2008
23ISL1, POU4F2
ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells.
Pan L, Deng M, Xie X, Gan L.
Development 135(11):1981-90. Epub 2008 Apr 23.PMID: 18434421 2008
24CTNNB1,ISL1
Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis.
Lin L, Cui L, Zhou W, Dufort D, Zhang X, Cai CL, Bu L, Yang L, Martin J, Kemler R, Rosenfeld MG, Chen J, Evans SM.
Proc Natl Acad Sci U S A 104(22):9313-8. Epub 2007 May 22. 2007
25NEUROD1, ISL1
ISL1 physically interacts with BETA2 to promote insulin gene transcriptional synergy in non-beta cells.
Peng SY, Wang WP, Meng J, Li T, Zhang H, Li YM, Chen P, Ma KT, Zhou CY.
Biochim Biophys Acta 1731(3):154-9. Epub 2005 Nov 2. 2005
26ISL-1, ISL1, ISLET1
Role of islet1 in the patterning of murine dentition
Mitsiadis, T. A.; Angeli, I.; James, C.; Lendahl, U.; Sharpe, P. T.
Development 130: 4451-4460 2003
27ISL1, LDB1, RNF12
Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors.
Ostendorff HP, Peirano RI, Peters MA, Schluter A, Bossenz M, Scheffner M, Bach I.
Nature 416(6876):99-103. 2002
28ISL1
Positional candidate gene analysis of Lim domain homeobox gene (Isl-1) on chromosome 5q11-q13 in a French morbidly obese population suggests indication for association with type 2 diabetes.
Barat-Houari M, Clement K, Vatin V, Dina C, Bonhomme G, Vasseur F, Guy-Grand B, Froguel P.
Diabetes 51(5):1640-3. 2002
29ISL1
Nonsense mutation of islet-1 gene (Q310X) found in a type 2 diabetic patient with a strong family history.
Shimomura H, Sanke T, Hanabusa T, Tsunoda K, Furuta H, Nanjo K.
Diabetes 49(9):1597-600. 2000
30ISL1
Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron–dependent step in interneuron differentiation
Pfaff, S.L., Mendelsohn, M., Stewart, C.L., Edlund, T. & Jessell, T.M. Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron–dependent step in interneuron differentiation
Cell 84, 309–320 1996
31ISL1
Isolation of the human LIM/homeodomain gene islet-1 and identification of a simple sequence repeat 1.
Tanizawa Y, et al.
Diabetes 43 : 935-941. 1994