| 1 | CXCR4, ISL1, LHX3, STAM
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| Identification of STAM1 as a novel effector of ventral projection of spinal motor neurons.
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| Nam H, Lee S.
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| Development 143(13):2334-43. doi: 10.1242/dev.135848. Epub 2016 May 9.
2016
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| 2 | ISL1, MAFA, NRDC
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| Nardilysin Is Required for Maintaining Pancreatic β-Cell Function
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| Nishi K, Sato Y, Ohno M, Hiraoka Y, Saijo S, Sakamoto J, Chen PM, Morita Y, Matsuda S, Iwasaki K, Sugizaki K, Harada N, Mukumoto Y, Kiyonari H, Furuyama K, Kawaguchi Y, Uemoto S, Kita T, Inagaki N, Kimura T, Nishi E.
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| Diabetes. Oct;65(10):3015-27. doi: 10.2337/db16-0178. Epub 2016 Jul 6. 2016
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| 3 | BARX1, ISL1, PITX1, PITX2, SIX2
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| Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1.
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| Jayewickreme CD, Shivdasani RA.
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| Dev Biol 405(1):21-32. doi: 10.1016/j.ydbio.2015.05.024. Epub 2015 Jun 6.
2015
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| 4 | CDH6, iSL1
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| Cadherin-6B is required for the generation of Islet-1-expressing dorsal interneurons.
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| Park KS, Gumbiner BM.
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| Biochem Biophys Res Commun 459(3):504-8. doi: 10.1016/j.bbrc.2015.02.136.
2015
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| 5 | ISL1, LDB1, SSBP3
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| SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic β-Cell Target Genes.
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| Galloway JR, Bethea M, Liu Y, Underwood R, Mobley JA, Hunter CS.
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| Mol Endocrinol 29(12):1774-86. doi: 10.1210/me.2015-1165. Epub 2015 Oct 23.
2015
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| 6 | ISL1, LDB1
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| The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors.
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| Caputo L, Witzel HR, Kolovos P, Cheedipudi S, Looso M, Mylona A, van IJcken WF, Laugwitz KL, Evans SM, Braun T, Soler E, Grosveld F, Dobreva G.
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| Cell Stem Cell 17(3):287-99. doi: 10.1016/j.stem.2015.08.007. Epub 2015 Aug 27.
2015
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| 7 | GATA3, ISL1
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| LIM homeodomain transcription factor Isl1 directs normal pyloric development by targeting Gata3.
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| Li Y, Pan J, Wei C, Chen J, Liu Y, Liu J, Zhang X, Evans SM, Cui Y, Cui S.
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| BMC Biol 12:25. doi: 10.1186/1741-7007-12-25.
2014
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| 8 | ISL1
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| The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse.
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| Ehrman LA, Mu X, Waclaw RR, Yoshida Y, Vorhees CV, Klein WH, Campbell K.
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| Proc Natl Acad Sci U S A 110(42):E4026-35. doi: 10.1073/pnas.1308275110. Epub 2013 Sep 30.
2013
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| 9 | ISL1, LDB1
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| Islet α-, β-, and δ-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor.
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| Hunter CS, Dixit S, Cohen T, Ediger B, Wilcox C, Ferreira M, Westphal H, Stein R, May CL.
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| Diabetes 62(3):875-86. doi: 10.2337/db12-0952. Epub 2012 Nov 27.
2013
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| 10 | ISL1, LHX3
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| A distal modular enhancer complex acts to control pituitary- and nervous system-specific expression of the LHX3 regulatory gene.
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| Mullen RD, Park S, Rhodes SJ.
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| Mol Endocrinol 26(2):308-19. Epub 2011 Dec 22.
2012
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| 11 | ISL1, LHX3
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| Fusion protein Isl1-Lhx3 specifies motor neuron fate by inducing motor neuron genes and concomitantly suppressing the interneuron programs.
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| Lee S, Cuvillier JM, Lee B, Shen R, Lee JW, Lee SK.
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| Proc Natl Acad Sci U S A 109(9):3383-8. Epub 2012 Feb 16.
2012
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| 12 | FGF10, ISL1
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| ISL1 directly regulates FGF10 transcription during human cardiac outflow formation.
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| Golzio C, Havis E, Daubas P, Nuel G, Babarit C, Munnich A, Vekemans M, Zaffran S, Lyonnet S, Etchevers HC.
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| PLoS One 7(1):e30677. doi: 10.1371/journal.pone.0030677. Epub 2012 Jan 27.
2012
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| 13 | AJUBA, ISL1
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| The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity.
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| Witzel HR, Jungblut B, Choe CP, Crump JG, Braun T, Dobreva G.
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| Dev Cell 23(1):58-70. doi: 10.1016/j.devcel.2012.06.005.
2012
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| 14 | FBXO25, HAND1, ISL1, NKX2-5
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| A novel Fbxo25 acts as an E3 ligase for destructing cardiac specific transcription factors.
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| Jang JW, Lee WY, Lee JH, Moon SH, Kim CH, Chung HM.
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| Biochem Biophys Res Commun 410(2):183-8. Epub 2011 May 7.
2011
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| 15 | ISL1
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| Islet1-mediated activation of the β-catenin pathway is necessary for hindlimb initiation in mice.
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| Kawakami Y, Marti M, Kawakami H, Itou J, Quach T, Johnson A, Sahara S, O'Leary DD, Nakagawa Y, Lewandoski M, Pfaff S, Evans SM, Izpisua Belmonte JC.
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| Development 138(20):4465-73.
2011
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| 16 | ISL1, NEUROD4, POU4F1
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| Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation.
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| Dykes IM, Tempest L, Lee SI, Turner EE.
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| J Neurosci 31(27):9789-99.
2011
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| 17 | ISL1
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| Isl1 is required for multiple aspects of motor neuron development.
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| Liang X, Song MR, Xu Z, Lanuza GM, Liu Y, Zhuang T, Chen Y, Pfaff SL, Evans SM, Sun Y.
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| Mol Cell Neurosci 47(3):215-22. Epub 2011 May 4.
2011
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| 18 | ISL1
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| Common variation in ISL1 confers genetic susceptibility for human congenital heart disease.
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| Stevens KN, Hakonarson H, Kim CE, Doevendans PA, Koeleman BP, Mital S, Raue J, Glessner JT, Coles JG, Moreno V, Granger A, Gruber SB, Gruber PJ.
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| PLoS One 5(5):e10855.
2010
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| 19 | ISL1
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| Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages.
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| Bu L, Jiang X, Martin-Puig S, Caron L, Zhu S, Shao Y, Roberts DJ, Huang PL, Domian IJ, Chien KR.
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| Nature 460(7251):113-7.
2009
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| 20 | ISL1, NEUROD1
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| The LIM-homeodomain protein ISL1 activates insulin gene promoter directly through synergy with BETA2.
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| Zhang H, Wang WP, Guo T, Yang JC, Chen P, Ma KT, Guan YF, Zhou CY.
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| J Mol Biol 392(3):566-77. Epub 2009 Jul 17.
2009
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| 21 | ISL1
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| A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs.
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| Sun Y, Dykes IM, Liang X, Eng SR, Evans SM, Turner EE.
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| Nat Neurosci. 11(11):1246. 2008
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| 22 | ISL1
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| The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons.
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| Elshatory Y, Gan L.
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| J Neurosci 28(13):3291-7.PMID: 18367596 2008
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| 23 | ISL1, POU4F2
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| ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells.
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| Pan L, Deng M, Xie X, Gan L.
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| Development 135(11):1981-90. Epub 2008 Apr 23.PMID: 18434421 2008
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| 24 | CTNNB1,ISL1
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| Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis.
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| Lin L, Cui L, Zhou W, Dufort D, Zhang X, Cai CL, Bu L, Yang L, Martin J, Kemler R, Rosenfeld MG, Chen J, Evans SM.
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| Proc Natl Acad Sci U S A 104(22):9313-8. Epub 2007 May 22. 2007
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| 25 | NEUROD1, ISL1
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| ISL1 physically interacts with BETA2 to promote insulin gene transcriptional synergy in non-beta cells.
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| Peng SY, Wang WP, Meng J, Li T, Zhang H, Li YM, Chen P, Ma KT, Zhou CY.
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| Biochim Biophys Acta 1731(3):154-9. Epub 2005 Nov 2. 2005
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| 26 | ISL-1, ISL1, ISLET1
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| Role of islet1 in the patterning of murine dentition
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| Mitsiadis, T. A.; Angeli, I.; James, C.; Lendahl, U.; Sharpe, P. T.
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| Development 130: 4451-4460 2003
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| 27 | ISL1, LDB1, RNF12
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| Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors.
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| Ostendorff HP, Peirano RI, Peters MA, Schluter A, Bossenz M, Scheffner M, Bach I.
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| Nature 416(6876):99-103. 2002
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| 28 | ISL1
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| Positional candidate gene analysis of Lim domain homeobox gene (Isl-1) on chromosome 5q11-q13 in a French morbidly obese population suggests indication for association with type 2 diabetes.
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| Barat-Houari M, Clement K, Vatin V, Dina C, Bonhomme G, Vasseur F, Guy-Grand B, Froguel P.
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| Diabetes 51(5):1640-3. 2002
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| 29 | ISL1
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| Nonsense mutation of islet-1 gene (Q310X) found in a type 2 diabetic patient with a strong family history.
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| Shimomura H, Sanke T, Hanabusa T, Tsunoda K, Furuta H, Nanjo K.
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| Diabetes 49(9):1597-600. 2000
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| 30 | ISL1
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| Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron–dependent step in interneuron differentiation
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| Pfaff, S.L., Mendelsohn, M., Stewart, C.L., Edlund, T. & Jessell, T.M. Requirement for
LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron–dependent
step in interneuron differentiation
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| Cell 84, 309–320 1996
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| 31 | ISL1
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| Isolation of the human LIM/homeodomain gene islet-1 and identification of a simple sequence repeat 1.
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| Tanizawa Y, et al.
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| Diabetes 43 : 935-941. 1994
|