Citations for
1ISG15, USP18
Structural basis of the specificity of USP18 toward ISG15.
Basters A, Geurink PP, Röcker A, Witting KF, Tadayon R, Hess S, Semrau MS, Storici P, Ovaa H, Knobeloch KP, Fritz G.
Nat Struct Mol Biol 24(3):270-278. doi: 10.1038/nsmb.3371. Epub 2017 Feb 6. 2017
2ISG15, UBD
Newly translated proteins are substrates for ubiquitin, ISG15, and FAT10.
Spinnenhirn V, Bitzer A, Aichem A, Groettrup M.
FEBS Lett 591(1):186-195. doi: 10.1002/1873-3468.12512. Epub 2016 Dec 20. 2017
3IMD38, ISG15
Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation.
Zhang X, Bogunovic D, Payelle-Brogard B, Francois-Newton V, Speer SD, Yuan C, Volpi S, Li Z, Sanal O, Mansouri D, Tezcan I, Rice GI, Chen C, Mansouri N, Mahdaviani SA, Itan Y, Boisson B, Okada S, Zeng L, Wang X, Jiang H, Liu W, Han T, Liu D, Ma T, Wang B, Liu M, Liu JY, Wang QK, Yalnizoglu D, Radoshevich L, Uzé G, Gros P, Rozenberg F, Zhang SY, Jouanguy E, Bustamante J, García-Sastre A, Abel L, Lebon P, Notarangelo LD, Crow YJ, Boisson-Dupuis S, Casanova JL, Pellegrini S.
Nature 517(7532):89-93. doi: 10.1038/nature13801. Epub 2014 Oct 12. 2015
4ISG15
ISG15 counteracts Listeria monocytogenes infection.
Radoshevich L, Impens F, Ribet D, Quereda JJ, Nam Tham T, Nahori MA, Bierne H, Dussurget O, Pizarro-Cerdá J, Knobeloch KP, Cossart P.
Elife 4. doi: 10.7554/eLife.06848. 2015
5ISG15
Identification and characterization of a novel ISG15-ubiquitin mixed chain and its role in regulating protein homeostasis.
Fan JB, Arimoto K, Motamedchaboki K, Yan M, Wolf DA, Zhang DE.
Sci Rep 5:12704. doi: 10.1038/srep12704. 2015
6ISG15
ISG15 is a critical microenvironmental factor for pancreatic cancer stem cells.
Sainz B Jr, Martín B, Tatari M, Heeschen C, Guerra S.
Cancer Res 74(24):7309-20. doi: 10.1158/0008-5472.CAN-14-1354. Epub 2014 Nov 3. 2014
7ISG15
ISG15 functions as an interferon-mediated antiviral effector early in the murine norovirus life cycle.
Rodriguez MR, Monte K, Thackray LB, Lenschow DJ.
J Virol 88(16):9277-86. doi: 10.1128/JVI.01422-14. Epub 2014 Jun 4. 2014
8ISG15, TP53
Isg15 controls p53 stability and functions.
Huang YF, Wee S, Gunaratne J, Lane DP, Bulavin DV.
Cell Cycle 13(14):2200-10. doi: 10.4161/cc.29209. Epub 2014 May 20. 2014
9ISG15
ISG15 regulates peritoneal macrophages functionality against viral infection.
Yángüez E, García-Culebras A, Frau A, Llompart C, Knobeloch KP, Gutierrez-Erlandsson S, García-Sastre A, Esteban M, Nieto A, Guerra S.
PLoS Pathog 9(10):e1003632. doi: 10.1371/journal.ppat.1003632. Epub 2013 Oct 10. Erratum in: PLoS Pathog. 2013 Oct;9(10). doi: 10.1371/annot 2013
10EIF2AK2, ISG15
Activation of double-stranded RNA-activated protein kinase (PKR) by interferon-stimulated gene 15 (ISG15) modification down-regulates protein translation.
Okumura F, Okumura AJ, Uematsu K, Hatakeyama S, Zhang DE, Kamura T.
J Biol Chem 288(4):2839-47. doi: 10.1074/jbc.M112.401851. Epub 2012 Dec 10. 2013
11IFNA1, ISG15
ISG15 inhibits IFN-α-resistant liver cancer cell growth.
Wan XX, Chen HC, Khan MA, Xu AH, Yang FL, Zhang YY, Zhang DZ.
Biomed Res Int 2013:570909. doi: 10.1155/2013/570909. Epub 2013 Aug 20. 2013
12CCND1, ISG15, USP18
Evidence for the ubiquitin protease UBP43 as an antineoplastic target.
Guo Y, Chinyengetere F, Dolinko AV, Lopez-Aguiar A, Lu Y, Galimberti F, Ma T, Feng Q, Sekula D, Freemantle SJ, Andrew AS, Memoli V, Dmitrovsky E.
Mol Cancer Ther 11(9):1968-77. doi: 10.1158/1535-7163.MCT-12-0248. Epub 2012 Jul 2. 2012
13ISG15, USP18
High yield expression of catalytically active USP18 (UBP43) using a Trigger Factor fusion system.
Basters A, Ketscher L, Deuerling E, Arkona C, Rademann J, Knobeloch KP, Fritz G.
BMC Biotechnol 12:56. doi: 10.1186/1472-6750-12-56. 2012
14ISG15, SULF2
SULF2 methylation is prognostic for lung cancer survival and increases sensitivity to topoisomerase-I inhibitors via induction of ISG15.
Tessema M, Yingling CM, Thomas CL, Klinge DM, Bernauer AM, Liu Y, Dacic S, Siegfried JM, Dahlberg SE, Schiller JH, Belinsky SA.
Oncogene 31(37):4107-16. doi: 10.1038/onc.2011.577. Epub 2011 Dec 12. 2012
15IMD38, ISG15
Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency.
Bogunovic D, Byun M, Durfee LA, Abhyankar A, Sanal O, Mansouri D, Salem S, Radovanovic I, Grant AV, Adimi P, Mansouri N, Okada S, Bryant VL, Kong XF, Kreins A, Velez MM, Boisson B, Khalilzadeh S, Ozcelik U, Darazam IA, Schoggins JW, Rice CM, Al-Muhsen S, Behr M, Vogt G, Puel A, Bustamante J, Gros P, Huibregtse JM, Abel L, Boisson-Dupuis S, Casanova JL.
Science 337(6102):1684-8. Epub 2012 Aug 2. 2012
16ISG15, USP21
Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21.
Ye Y, Akutsu M, Reyes-Turcu F, Enchev RI, Wilkinson KD, Komander D.
EMBO Rep 12(4):350-7. Epub 2011 Mar 11. 2011
17ISG15
Interferon-stimulated gene 15 and the protein ISGylation system.
Zhang D, Zhang DE.
J Interferon Cytokine Res 31(1):119-30. doi: 10.1089/jir.2010.0110. Epub 2010 Dec 29. Review. 2011
18HERC5, IRF3, ISG15
Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification.
Shi HX, Yang K, Liu X, Liu XY, Wei B, Shan YF, Zhu LH, Wang C.
Mol Cell Biol 30(10):2424-36. Epub 2010 Mar 22.PMID: 20308324 2010
19ISG15
ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway.
Jeon YJ, Choi JS, Lee JY, Yu KR, Kim SM, Ka SH, Oh KH, Kim KI, Zhang DE, Bang OS, Chung CH.
EMBO Rep 10(4):374-80. Epub 2009 Mar 6. 2009
20ISG15,UBR1
Negative regulation of ISG15 E3 ligase EFP through its autoISGylation.
Zou W, Wang J, Zhang DE.
Biochem Biophys Res Commun 354(1):321-7. Epub 2007 Jan 8. 2007
21EIF4E2,ISG15
ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP.
Okumura F, Zou W, Zhang DE.
Genes Dev 21(3):255-60. 2007
22ISG15, USP18
Ubp43 gene expression is required for normal Isg15 expression and fetal development.
Rempel LA, Austin KJ, Ritchie KJ, Yan M, Shen M, Zhang DE, Henkes LE, Hansen TR.
Reprod Biol Endocrinol 5:13. 2007
23EIF4E2, ISG15
ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP.
Okumura F, Zou W, Zhang DE.
Genes Dev 21(3):255-60. 2007
24ISG15,PPP2CB
Negative regulation of protein phosphatase 2Cbeta by ISG15 conjugation.
Takeuchi T, Kobayashi T, Tamura S, Yokosawa H.
FEBS Lett 580(18):4521-6. Epub 2006 Jul 20. 2006
25ISG15
The interferon regulated ubiquitin-like protein, ISG15, in tumorigenesis: friend or foe?
Andersen JB, Hassel BA.
Cytokine Growth Factor Rev 17(6):411-21. Epub 2006 Nov 13. Review. 2006
26ISG15
ISG15 enhances the innate antiviral response by inhibition of IRF-3 degradation.
Lu G, Reinert JT, Pitha-Rowe I, Okumura A, Kellum M, Knobeloch KP, Hassel B, Pitha PM.
Cell Mol Biol (Noisy-le-grand) 52(1):29-41. 2006
27ISG15, USP18
UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity.
Malakhova OA, Kim KI, Luo JK, Zou W, Kumar KG, Fuchs SY, Shuai K, Zhang DE.
EMBO J 25(11):2358-67. Epub 2006 May 18. 2006
28ISG15
ISG15, an interferon-stimulated ubiquitin-like protein, is not essential for STAT1 signaling and responses against vesicular stomatitis and lymphocytic choriomeningitis virus.
Osiak A, Utermohlen O, Niendorf S, Horak I, Knobeloch KP.
Mol Cell Biol 25(15):6338-45. 2005
29ISG15,UBE2N
ISG15 modification of Ubc13 suppresses its ubiquitin-conjugating activity.
Takeuchi T, Yokosawa H.
Biochem Biophys Res Commun 336(1):9-13. 2005
30ISG15, UBE2L6
Down-regulation of UCRP and UBE2L6 in BRCA2 knocked-down human breast cells.
Tripathi MK, Chaudhuri G.
Biochem Biophys Res Commun 328(1):43-8. 2005
31ISG15, USP18
Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection.
Ritchie KJ, Hahn CS, Kim KI, Yan M, Rosario D, Li L, de la Torre JC, Zhang DE.
Nat Med 10(12):1374-8. Epub 2004 Dec. 2004
32UBA7, ISG15
Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia.
Pitha-Rowe I, Hassel BA, Dmitrovsky E.
J Biol Chem 279(18):18178-87. Epub 2004 Feb 18. 2004
33ISG15
ISG15, not just another ubiquitin-like protein.
Kim KI, Zhang DE.
Biochem Biophys Res Commun 307(3):431-4. Review. 2003
34ISG15
UBP43 (USP18) specifically removes ISG15 from conjugated proteins.
Malakhov MP, Malakhova OA, Kim KI, Ritchie KJ, Zhang DE.
J Biol Chem 277(12):9976-81. Epub 2002 Jan 11. 2002
35ISG15, IKBKG
Novel NEMO/IkappaB kinase and NF-kappa B target genes at the pre-B to immature B cell transition.
Li J, Peet GW, Balzarano D, Li X, Massa P, Barton RW, Marcu KB.
J Biol Chem 276(21):18579-90. 2001
36ISG15, IFI16
Chromosomal localization of two human genes inducible by interferons, double-stranded RNA, and viruses.
Clauss IM, et al.
Cytogenet Cell Genet 53 : 166-168. 1990
37ISG15
Molecular characterization of the interferon-induced 15-kDa protein. Molecular cloning and nucleotide and amino acid sequence.
Blomstrom DC, Fahey D, Kutny R, Korant BD, Knight E Jr.
J Biol Chem 261(19):8811-6. 1986