| 1 | HMMS, IRX3, IRX5
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| Loss of Iroquois homeobox transcription factors 3 and 5 in osteoblasts disrupts cranial mineralization.
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| Cain CJ, Gaborit N, Lwin W, Barruet E, Ho S, Bonnard C, Hamamy H, Shboul M, Reversade B, Kayserili H, Bruneau BG, Hsiao EC.
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| Bone Rep 5:86-95. doi: 10.1016/j.bonr.2016.02.005. eCollection 2016 Dec.
2016
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| 2 | IRX5
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| Iroquois homeobox transcription factor (Irx5) promotes G1/S-phase transition in vascular smooth muscle cells by CDK2-dependent activation.
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| Liu D, Pattabiraman V, Bacanamwo M, Anderson LM.
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| Am J Physiol Cell Physiol 311(2):C179-89. doi: 10.1152/ajpcell.00293.2015. Epub 2016 May 11.
2016
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| 3 | FTO, IRX5
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| Complete re-sequencing of a 2Mb topological domain encompassing the FTO/IRXB genes identifies a novel obesity-associated region upstream of IRX5.
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| Hunt LE, Noyvert B, Bhaw-Rosun L, Sesay AK, Paternoster L, Nohr EA, Davey Smith G, Tommerup N, Sĝrensen TI, Elgar G.
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| Genome Med 7:126. doi: 10.1186/s13073-015-0250-3.
2015
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| 4 | IRX3, IRX5
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| Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling.
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| Li D, Sakuma R, Vakili NA, Mo R, Puviindran V, Deimling S, Zhang X, Hopyan S, Hui CC.
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| Dev Cell 29(2):233-40. doi: 10.1016/j.devcel.2014.03.001. Epub 2014 Apr 10.
2014
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| 5 | IRX3, IRX5
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| Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology.
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| Gaborit N, Sakuma R, Wylie JN, Kim KH, Zhang SS, Hui CC, Bruneau BG.
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| Development 139(21):4007-19. doi: 10.1242/dev.081703. Epub 2012 Sep 19.
2012
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| 6 | CXCL12, GATA3, IRX5, TRPS1
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| Mutations in IRX5 impair craniofacial development and germ cell migration via SDF1.
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| Bonnard C, Strobl AC, Shboul M, Lee H, Merriman B, Nelson SF, Ababneh OH, Uz E, Güran T, Kayserili H, Hamamy H, Reversade B.
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| Nat Genet 44(6):709-13. doi: 10.1038/ng.2259.
2012
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| 7 | IRX5, KCND2
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| Interaction between transcription factors Iroquois proteins 4 and 5 controls cardiac potassium channel Kv4.2 gene transcription.
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| He W, Jia Y, Takimoto K.
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| Cardiovasc Res 81(1):64-71. Epub 2008 Sep 24.PMID: 18815185 2009
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| 8 | IRX5, VSX1
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| Genetic control of circuit function: Vsx1 and Irx5 transcription factors regulate contrast adaptation in the mouse retina.
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| Kerschensteiner D, Liu H, Cheng CW, Demas J, Cheng SH, Hui CC, Chow RL, Wong RO.
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| J Neurosci 28(10):2342-52.PMID: 1832208 2008
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| 9 | IRX5
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| The iroquois homeobox gene 5 is regulated by 1,25-dihydroxyvitamin D3 in human prostate cancer and regulates apoptosis and the cell cycle in LNCaP prostate cancer cells.
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| Myrthue A, Rademacher BL, Pittsenbarger J, Kutyba-Brooks B, Gantner M, Qian DZ, Beer TM.
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| Clin Cancer Res 14(11):3562-70.PMID: 18519790 2008
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| 10 | TRPS1, IRX5, CYP4Z1, FSIP1, FOXA1, ANKRD30A
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| The gene associated with trichorhinophalangeal syndrome in humans is overexpressed in breast cancer.
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| Radvanyi L, Singh-Sandhu D, Gallichan S, Lovitt C, Pedyczak A, Mallo G, Gish K, Kwok K, Hanna W, Zubovits J, Armes J, Venter D, Hakimi J, Shortreed J, Donovan M, Parrington M, Dunn P, Oomen R, Tartaglia J, Berinstein NL.
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| Proc Natl Acad Sci U S A 102(31):11005-10. Epub 2005 Jul 25. 2005
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| 11 | IRX5
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| The Iroquois homeobox gene, Irx5, is required for retinal cone bipolar cell development.
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| Cheng CW, Chow RL, Lebel M, Sakuma R, Cheung HO, Thanabalasingham V, Zhang X, Bruneau BG, Birch DG, Hui CC, McInnes RR, Cheng SH.
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| Dev Biol 287(1):48-60. Epub 2005 Sep 22.PMID: 16182275 2005
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| 12 | IRX1, IRX2, IRX3, IRX4, IRX5, IRX6
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| Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes.
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| Ogura K, Matsumoto K, Kuroiwa A, Isobe T, Otoguro T, Jurecic V, Baldini A, Matsuda Y, Ogura T.
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| Cytogenet Cell Genet 92(3-4):320-5. 2001
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| 13 | IRX1, IRX3, IRX4, IRX5, IRX6
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| Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast.
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| Lewis MT, Ross S, Strickland PA, Snyder CJ, Daniel CW.
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| Cell Tissue Res 296(3):549-54. 1999
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