Citations for
1IGF1R, IRS1
IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling.
Yoneyama Y, Lanzerstorfer P, Niwa H, Umehara T, Shibano T, Yokoyama S, Chida K, Weghuber J, Hakuno F, Takahashi SI.
Elife 7. pii: e32893. doi: 10.7554/eLife.32893. 2018
2CD36, CUL7, IRS1
Ubiquitinated CD36 sustains insulin-stimulated Akt activation by stabilizing insulin receptor substrate 1 in myotubes.
Sun S, Tan P, Huang X, Zhang W, Kong C, Ren F, Su X.
J Biol Chem 293(7):2383-2394. doi: 10.1074/jbc.M117.811471. Epub 2017 Dec 21. 2018
3IRS1
Single-nucleotide polymorphism of INS, INSR, IRS1, IRS2, PPAR-G and CAPN10 genes in the pathogenesis of polycystic ovary syndrome.
Thangavelu M, Godla UR, Paul Solomon FD, Maddaly R.
J Genet 96(1):87-96. 2017
4IRS1
Down-regulation of Insulin Receptor Substrate 1 during Hyperglycemia Induces Vascular Smooth Muscle Cell Dedifferentiation.
Xi G, Wai C, White MF, Clemmons DR.
J Biol Chem 292(5):2009-2020. doi: 10.1074/jbc.M116.758987. Epub 2016 Dec 21. 2017
5IRS1, LPIN1
LPIN1 promotes epithelial cell transformation and mammary tumourigenesis via enhancing insulin receptor substrate 1 stability.
Kim JY, Kim G, Lim SC, Choi HS.
Carcinogenesis 37(12):1199-1209. Epub 2016 Oct 11. 2016
6IGFBP2, IRS1, iGF1
IRS-1 Functions as a Molecular Scaffold to Coordinate IGF-I/IGFBP-2 Signaling During Osteoblast Differentiation.
Xi G, Shen X, Rosen CJ, Clemmons DR.
J Bone Miner Res 31(6):1300-14. doi: 10.1002/jbmr.2791. Epub 2016 Feb 20. 2016
7IRS1
Insulin Receptor Substrate-1 Activation Mediated p53 Downregulation Protects Against Hypoxic-Ischemia in the Neonatal Brain.
Tu YF, Jiang ST, Chow YH, Huang CC, Ho CJ, Chou YP.
Mol Neurobiol 53(6):3658-3669. doi: 10.1007/s12035-015-9300-5. Epub 2015 Jun 26. 2016
8INSR, IRS1
Fatty acylated caveolin-2 is a substrate of insulin receptor tyrosine kinase for insulin receptor substrate-1-directed signaling activation.
Kwon H, Lee J, Jeong K, Jang D, Pak Y.
Biochim Biophys Acta 1853(5):1022-34. doi: 10.1016/j.bbamcr.2015.02.002. Epub 2015 Feb 7. 2015
9APPL1, INSR, IRS1, IRS2
APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor.
Ryu J, Galan AK, Xin X, Dong F, Abdul-Ghani MA, Zhou L, Wang C, Li C, Holmes BM, Sloane LB, Austad SN, Guo S, Musi N, DeFronzo RA, Deng C, White MF, Liu F, Dong LQ.
Cell Rep 7(4):1227-38. doi: 10.1016/j.celrep.2014.04.006. Epub 2014 May 10. 2014
10DVL2, IRS1, IRS2
Insulin receptor substrate 1/2 (IRS1/2) regulates Wnt/β-catenin signaling through blocking autophagic degradation of dishevelled2.
Geng Y, Ju Y, Ren F, Qiu Y, Tomita Y, Tomoeda M, Kishida M, Wang Y, Jin L, Su F, Wei C, Jia B, Li Y, Chang Z.
J Biol Chem 289(16):11230-41. doi: 10.1074/jbc.M113.544999. Epub 2014 Mar 10. 2014
11IRS1
Expression levels of insulin receptor substrate-1 modulate the osteoblastic differentiation of mesenchymal stem cells and osteosarcoma cells.
Contaldo C, Myers TJ, Zucchini C, Manara MC, Chiodoni C, Colombo MP, Nicoletti G, Lollini PL, Li T, Longobardi L, Scotlandi K, Spagnoli A.
Growth Factors 32(1):41-52. doi: 10.3109/08977194.2013.870168. Epub 2014 Jan 20. 2014
12IRS1, TRIM72, UBE2H
MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling.
Yi JS, Park JS, Ham YM, Nguyen N, Lee NR, Hong J, Kim BW, Lee H, Lee CS, Jeong BC, Song HK, Cho H, Kim YK, Lee JS, Park KS, Shin H, Choi I, Lee SH, Park WJ, Park SY, Choi CS, Lin P, Karunasiri M, Tan T, Duann P, Zhu H, Ma J, Ko YG.
Nat Commun 4:2354. doi: 10.1038/ncomms3354. 2013
13IRS1
Regulation of insulin receptor substrate-1 by mTORC2 (mammalian target of rapamycin complex 2).
Destefano MA, Jacinto E.
Biochem Soc Trans 41(4):896-901. doi: 10.1042/BST20130018. Review. 2013
14IRS1, TNS2
C1-Ten is a protein tyrosine phosphatase of insulin receptor substrate 1 (IRS-1), regulating IRS-1 stability and muscle atrophy.
Koh A, Lee MN, Yang YR, Jeong H, Ghim J, Noh J, Kim J, Ryu D, Park S, Song P, Koo SH, Leslie NR, Berggren PO, Choi JH, Suh PG, Ryu SH.
Mol Cell Biol 33(8):1608-20. doi: 10.1128/MCB.01447-12. Epub 2013 Feb 11. 2013
15IRS1, MEMO1
MEMO1, a new IRS1-interacting protein, induces epithelial-mesenchymal transition in mammary epithelial cells.
Sorokin AV, Chen J.
Oncogene 32(26):3130-8. doi: 10.1038/onc.2012.327. Epub 2012 Jul 23. 2013
16IRS1, KHDRBS1
Sam68 interacts with IRS1.
Quintana-Portillo R, Canfrán-Duque A, Issad T, Sánchez-Margalet V, González-Yanes C.
Biochem Pharmacol 83(1):78-87. Epub 2011 Oct 10. 2012
17IRS1, IRS2
Association of IRS-1 and IRS-2 genes polymorphisms with polycystic ovary syndrome: a meta-analysis.
Ruan Y, Ma J, Xie X.
Endocr J 59(7):601-9. Epub 2012 May 21. 2012
18IRS1, SQSTM1
Sequestosome 1/p62, a scaffolding protein, is a newly identified partner of IRS-1 protein.
Geetha T, Zheng C, Vishwaprakash N, Broderick TL, Babu JR.
J Biol Chem 287(35):29672-8. doi: 10.1074/jbc.M111.322404. Epub 2012 Jul 3. 2012
19CRTC2, FBXW8, IRS1
mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8.
Kim SJ, DeStefano MA, Oh WJ, Wu CC, Vega-Cotto NM, Finlan M, Liu D, Su B, Jacinto E.
Mol Cell 48(6):875-87. doi: 10.1016/j.molcel.2012.09.029. Epub 2012 Nov 8. 2012
20IRS1
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
Kilpeläinen TO, Zillikens MC, Stančákova A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS, Luan J, Vandenput L, Styrkarsdottir U, Zhou Y, Smith AV, Zhao JH, Amin N, Vedantam S, Shin SY, Haritunians T, Fu M, Feitosa MF, Kumari M, Halldorsson BV, Tikkanen E, Mangino M, Hayward C, Song C, Arnold AM, Aulchenko YS, Oostra BA, Campbell H, Cupples LA, Davis KE, Döring A, Eiriksdottir G, Estrada K, Fernández-Real JM, Garcia M, Gieger C, Glazer NL, Guiducci C, Hofman A, Humphries SE, Isomaa B, Jacobs LC, Jula A, Karasik D, Karlsson MK, Khaw KT, Kim LJ, Kivimäki M, Klopp N, Kühnel B, Kuusisto J, Liu Y, Ljunggren O, Lorentzon M, Luben RN, McKnight B, Mellström D, Mitchell BD, Mooser V, Moreno JM, Männistö S, O'Connell JR, Pascoe L, Peltonen L, Peral B, Perola M, Psaty BM, Salomaa V, Savage DB, Semple RK, Skaric-Juric T, Sigurdsson G, Song KS, Spector TD, Syvänen AC, Talmud PJ, Thorleifsson G, Thorsteinsdottir U, Uitterlinden AG, van Duijn CM, Vidal-Puig A, Wild SH, Wright AF, Clegg DJ, Schadt E, Wilson JF, Rudan I, Ripatti S, Borecki IB, Shuldiner AR, Ingelsson E, Jansson JO, Kaplan RC, Gudnason V, Harris TB, Groop L, Kiel DP, Rivadeneira F, Walker M, Barroso I, Vollenweider P, Waeber G, Chambers JC, Kooner JS, Soranzo N, Hirschhorn JN, Stefansson K, Wichmann HE, Ohlsson C, O'Rahilly S, Wareham NJ, Speliotes EK, Fox CS, Laakso M, Loos RJ.
Nat Genet 43(8):753-60. doi: 10.1038/ng.866. 2011
21IRS1, MTOR, RHEB, RPTOR
Raptor and Rheb negatively regulate skeletal myogenesis through suppression of insulin receptor substrate 1 (IRS1).
Ge Y, Yoon MS, Chen J.
J Biol Chem 286(41):35675-82. doi: 10.1074/jbc.M111.262881. Epub 2011 Aug 18. 2011
22IRS1
Association of Gly972Arg polymorphism of IRS1 gene with type 2 diabetes mellitus in lean participants of a national health survey in Mexico: a candidate gene study.
Burguete-Garcia AI, Cruz-Lopez M, Madrid-Marina V, Lopez-Ridaura R, Hernández-Avila M, Cortina B, Gómez RE, Velasco-Mondragón E.
Metabolism 59(1):38-45. Epub 2009 Aug 28.PMID: 19716569 2010
23FTO, HMGA2, HNF1A, IRS1, KCNJ11, KCNQ1, KLF14, PPARG
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, McCulloch LJ, Ferreira T, Grallert H, Amin N, Wu G, Willer CJ, Raychaudhuri S, McCarroll SA, Langenberg C, Hofmann OM, Dupuis J, Qi L, Segrè AV, van Hoek M, Navarro P, Ardlie K, Balkau B, Benediktsson R, Bennett AJ, Blagieva R, Boerwinkle E, Bonnycastle LL, Bengtsson Boström K, Bravenboer B, Bumpstead S, Burtt NP, Charpentier G, Chines PS, Cornelis M, Couper DJ, Crawford G, Doney AS, Elliott KS, Elliott AL, Erdos MR, Fox CS, Franklin CS, Ganser M, Gieger C, Grarup N, Green T, Griffin S, Groves CJ, Guiducci C, Hadjadj S, Hassanali N, Herder C, Isomaa B, Jackson AU, Johnson PR, Jørgensen T, Kao WH, Klopp N, Kong A, Kraft P, Kuusisto J, Lauritzen T, Li M, Lieverse A, Lindgren CM, Lyssenko V, Marre M, Meitinger T, Midthjell K, Morken MA, Narisu N, Nilsson P, Owen KR, Payne F, Perry JR, Petersen AK, Platou C, Proença C, Prokopenko I, Rathmann W, Rayner NW, Robertson NR, Rocheleau G, Roden M, Sampson MJ, Saxena R, Shields BM, Shrader P, Sigurdsson G, Sparsø T, Strassburger K, Stringham HM, Sun Q, Swift AJ, Thorand B, Tichet J, Tuomi T, van Dam RM, van Haeften TW, van Herpt T, van Vliet-Ostaptchouk JV, Walters GB, Weedon MN, Wijmenga C, Witteman J, Bergman RN, Cauchi S, Collins FS, Gloyn AL, Gyllensten U, Hansen T, Hide WA, Hitman GA, Hofman A, Hunter DJ, Hveem K, Laakso M, Mohlke KL, Morris AD, Palmer CN, Pramstaller PP, Rudan I, Sijbrands E, Stein LD, Tuomilehto J, Uitterlinden A, Walker M, Wareham NJ, Watanabe RM, Abecasis GR, Boehm BO, Campbell H, Daly MJ, Hattersley AT, Hu FB, Meigs JB, Pankow JS, Pedersen O, Wichmann HE, Barroso I, Florez JC, Frayling TM, Groop L, Sladek R, Thorsteinsdottir U, Wilson JF, Illig T, Froguel P, van Duijn CM, Stefansson K, Altshuler D, Boehnke M, McCarthy MI; MAGIC investigators; GIANT Consortium.
Nat Genet 42(7):579-89.PMID: 20581827 2010
24EIF2AK2, IRS1, IRS2
The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells.
Yang X, Nath A, Opperman MJ, Chan C.
Mol Biol Cell 21(19):3449-58. doi: 10.1091/mbc.E10-06-0481. Epub 2010 Aug 4. 2010
25FOXF2, IRS1
Overexpression of Foxf2 in adipose tissue is associated with lower levels of IRS1 and decreased glucose uptake in vivo.
Westergren R, Nilsson D, Heglind M, Arani Z, Grände M, Cederberg A, Ahrén B, Enerbäck S.
Am J Physiol Endocrinol Metab 298(3):E548-54. doi: 10.1152/ajpendo.00395.2009. Epub 2009 Dec 15. 2010
26IRS1
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.
Rung J, Cauchi S, Albrechtsen A, Shen L, Rocheleau G, Cavalcanti-Proença C, Bacot F, Balkau B, Belisle A, Borch-Johnsen K, Charpentier G, Dina C, Durand E, Elliott P, Hadjadj S, Järvelin MR, Laitinen J, Lauritzen T, Marre M, Mazur A, Meyre D, Montpetit A, Pisinger C, Posner B, Poulsen P, Pouta A, Prentki M, Ribel-Madsen R, Ruokonen A, Sandbaek A, Serre D, Tichet J, Vaxillaire M, Wojtaszewski JF, Vaag A, Hansen T, Polychronakos C, Pedersen O, Froguel P, Sladek R.
Nat Genet 41(10):1110-5. Epub 2009 Sep 6. Erratum in: Nat Genet. 2009 Oct;41(10):1156. PMID: 19734900 2009
27IRS1, IRS2
Increased expression of both insulin receptor substrates 1 and 2 confers increased sensitivity to IGF-1 stimulated cell migration.
de Blaquière GE, May FE, Westley BR.
Endocr Relat Cancer 16(2):635-47. Epub 2009 Mar 4.PMID: 19261680 2009
28CUL7, IRS1, SKP1
The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation.
Xu X, Sarikas A, Dias-Santagata DC, Dolios G, Lafontant PJ, Tsai SC, Zhu W, Nakajima H, Nakajima HO, Field LJ, Wang R, Pan ZQ.
Mol Cell 30(4):403-14.PMID: 18498745 2008
29IRS1
Human, but not rat, IRS1 targets to the plasma membrane in both human and rat adipocytes.
Stenkula KG, Thorn H, Franck N, Hallin E, Sauma L, Nystrom FH, StrŒlfors P.
Biochem Biophys Res Commun 363(3):840-5. Epub 2007 Sep 24. 2007
30IRS1
Polycystic ovary syndrome is associated with genetic polymorphism in the insulin signaling gene IRS-1 but not ENPP1 in a Japanese population.
Baba T, Endo T, Sata F, Honnma H, Kitajima Y, Hayashi T, Manase K, Kanaya M, Yamada H, Minakami H, Kishi R, Saito T.
Life Sci 81(10):850-4. Epub 2007 Aug 7.PMID: 17719609 2007
31IRS1, IRS2
Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2.
Dearth RK, Cui X, Kim HJ, Kuiatse I, Lawrence NA, Zhang X, Divisova J, Britton OL, Mohsin S, Allred DC, Hadsell DL, Lee AV.
Mol Cell Biol 26(24):9302-14. Epub 2006 Oct 9. 2006
32IRS1, IRS2
Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis.
Ma Z, Gibson SL, Byrne MA, Zhang J, White MF, Shaw LM.
Mol Cell Biol 26(24):9338-51. Epub 2006 Oct 9. 2006
33ADIPOQ, IRS1, PPARG
Common polymorphisms in the PPARgamma2 and IRS-1 genes and their interaction influence serum adiponectin concentration in young Finnish men.
Mousavinasab F, Tahtinen T, Jokelainen J, Koskela P, Vanhala M, Oikarinen J, Keinanen-Kiukaanniemi S, Laakso M.
Mol Genet Metab 84(4):344-8. Epub 2005 Jan 25. 2005
34IRS1
A functional variant of IRS1 is associated with type 1 diabetes in families from the US and UK.
Morrison VA, Onengut-Gumuscu S, Concannon P.
Mol Genet Metab 81(4):291-4. 2004
35MAPK8, XBP1, IRS1
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.
Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Gorgun C, Glimcher LH, Hotamisligil GS.
Science 306(5695):457-61. 2004
36IRS1, IRS2, IRS3L, IRS4
Differential roles of insulin receptor substrates in brown adipocyte differentiation.
Tseng YH, Kriauciunas KM, Kokkotou E, Kahn CR.
Mol Cell Biol 24(5):1918-29.PMID: 14966273 2004
37IRS1, IRS2, IRS4, NISCH
Insulin receptor substrate 4 associates with the protein IRAS.
Sano H, Liu SC, Lane WS, Piletz JE, Lienhard GE.
J Biol Chem 277(22):19439-47. 2002
38IRS1, IRS2
Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome.
Ehrmann DA, Tang X, Yoshiuchi I, Cox NJ, Bell GI.
J Clin Endocrinol Metab 87(9):4297-300. 2002
39IRS1, IRS2
Increased insulin resistance in obese children who have both 972 IRS-1 and 1057 IRS-2 polymorphisms.
Le Fur S, Le Stunff C, Bougneres P.
Diabetes 51 Suppl 3:S304-7. 2002
40IRS1
A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.
Ozes ON, Akca H, Mayo LD, Gustin JA, Maehama T, Dixon JE, Donner DB.
Proc Natl Acad Sci U S A 98(8):4640-5. 2001
41IRS1, PIK3R1
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase.
Terauchi Y, et al.
Nat Genet 21(2):230-5. 1999
42IRS1, IRS3L
Different subcellular distribution and regulation of expression of insulin receptor substrate (IRS)-3 from those of IRS-1 and IRS-2.
Anai M, et al.
J Biol Chem 273 : 29686-29692. 1998
43IRS1
Insulin receptor substrate-1 gene variants in lipoatrophic diabetes mellitus and non-insulin-dependent diabetes mellitus : a study of South African black and white subjects.
Panz VR, Raal FJ, O'Rahilly S, Kedda MA, Joffe BI.
Hum Genet 101(1):118-9. 1997
44IRS1, NIDDM3
Deletion of gly723 in the insulin receptor substrate-1 of a patient with noninsulin-dependent diabetes mellitus.
Esposito DL, et al.
Hum Mutat 7 : 364-366. 1996
45ADRB3, GYS2, IRS1
UKPDS 19 : heterogeneity in NIDDM : separate contributions of IRS-1 and beta3-adrenergic-receptor mutations to insulin resistance and obesity respectively with no evidence for glycogene synthase gene mutations.
Zhang Y, et al.
Diabetologia 39 : 1505-1511. 1996
46IRS1, NIDDM3
Insulin receptor substrate-1 gene mutations in NIDDM; implications for the study of polygenic disease.
Hitman GA, et al.
Diabetologia 38 : 481-486. 1995
47NIDDM3, IRS1
Insulin resistance : interactions between obesity and a common variant of insulin receptor substrate-1.
Clausen JO, et al.
Lancet 346 : 397-402. 1995
48IRS1
PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities.
Wolf G, Trüb T, Ottinger E, Groninga L, Lynch A, White MF, Miyazaki M, Lee J, Shoelson SE.
J Biol Chem 270(46):27407-10.PMID: 7499194 1995
49IRS1
The human insulin receptor substrate-1 gene (IRS1) is localized on 2q36.
Nishiyama M, et al.
Genomics 20 : 139-141. 1994
50IRS1, NIDDM3
Insulin receptor substrate (IRS-1) gene polymorphisms in French NIDDM families.
Hager J, et al.
Lancet 342 : 1430. 1993
51IRS1
Human skeletal muscle insulin receptor substrate-1.
Araki E, et al.
Diabetes 42 : 1041-1054. 1993
52IRS1, NIDDM3
Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus.
Almind K, et al.
Lancet 342 : 828-832. 1993
53IRS1, PIK3R1
Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation.
Backer JM, et al.
EMBO J 11(9):3469-79. 1992