Citations for
1IRF8, ZMIZ1
The latitude-dependent autoimmune disease risk genes ZMIZ1 and IRF8 regulate mononuclear phagocytic cell differentiation in response to vitamin D.
Parnell GP, Schibeci SD, Fewings NL, Afrasiabi A, Law SPL, Samaranayake S, Kh'ng JH, Fong YH, Brown DA, Liddle C, Stewart GJ, Booth DR.
Hum Mol Genet 28(2):269-278. doi: 10.1093/hmg/ddy324. 2019
2IRF8, NAIP, NLRC4
IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.
Karki R, Lee E, Place D, Samir P, Mavuluri J, Sharma BR, Balakrishnan A, Malireddi RKS, Geiger R, Zhu Q, Neale G, Kanneganti TD.
Cell 173(4):920-933.e13. doi: 10.1016/j.cell.2018.02.055. Epub 2018 Mar 22. 2018
3IFIT1, IRF8
Interferon Regulatory Factor 8 (IRF8) Impairs Induction of Interferon Induced with Tetratricopeptide Repeat Motif (IFIT) Gene Family Members.
White CL, Kessler PM, Dickerman BK, Ozato K, Sen GC.
J Biol Chem 291(26):13535-45. doi: 10.1074/jbc.M115.705467. 2016
4IRF5, IRF8, TLR9
IRF5 and IRF8 modulate the CAL-1 human plasmacytoid dendritic cell line response following TLR9 ligation.
Steinhagen F, Rodriguez LG, Tross D, Tewary P, Bode C, Klinman DM.
Eur J Immunol 46(3):647-55. doi: 10.1002/eji.201545911. Epub 2015 Dec 17. 2016
5BCL6, BCOR, IRF8
Interferon regulatory factor 8 (IRF8) interacts with the B cell lymphoma 6 (BCL6) corepressor BCOR.
Yoon J, Feng X, Kim YS, Shin DM, Hatzi K, Wang H, Morse HC 3rd.
J Biol Chem 289(49):34250-7. doi: 10.1074/jbc.M114.571182. Epub 2014 Oct 20. 2014
6IRF8, SLC15A4
Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus.
Baccala R, Gonzalez-Quintial R, Blasius AL, Rimann I, Ozato K, Kono DH, Beutler B, Theofilopoulos AN.
Proc Natl Acad Sci U S A 110(8):2940-5. doi: 10.1073/pnas.1222798110. Epub 2013 Feb 4. 2013
7IRF8, TNFSF13
A capture-sequencing strategy identifies IRF8, EBF1, and APRIL as novel IGH fusion partners in B-cell lymphoma.
Bouamar H, Abbas S, Lin AP, Wang L, Jiang D, Holder KN, Kinney MC, Hunicke-Smith S, Aguiar RC.
Blood 122(5):726-33. doi: 10.1182/blood-2013-04-495804. Epub 2013 Jun 17. 2013
8IKZF3, IRF8, TMEM39A, ZPBP2
Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as Susceptibility Loci for Systemic Lupus Erythematosus in a Large-Scale Multiracial Replication Study.
Lessard CJ, Adrianto I, Ice JA, Wiley GB, Kelly JA, Glenn SB, Adler AJ, Li H, Rasmussen A, Williams AH, Ziegler J, Comeau ME, Marion M, Wakeland BE, Liang C, Ramos PS, Grundahl KM, Gallant CJ; Marta E.
Am J Hum Genet 90(4):648-60. Epub 2012 Mar 29. 2012
9ETV6, HDAC3, IRF8, PDGFRB, PTPN13
The leukemia-associated fusion protein Tel-platelet-derived growth factor receptor β (Tel-PdgfRβ) inhibits transcriptional repression of PTPN13 gene by interferon consensus sequence binding protein (Icsbp).
Huang W, Hu L, Bei L, Hjort E, Eklund EA.
J Biol Chem 287(11):8110-25. doi: 10.1074/jbc.M111.294884. Epub 2012 Jan 18. 2012
10IRF3, IRF8
IRF8 and IRF3 cooperatively regulate rapid interferon-β induction in human blood monocytes.
Li P, Wong JJ, Sum C, Sin WX, Ng KQ, Koh MB, Chin KC.
Blood 117(10):2847-54. Epub 2011 Jan 12. 2011
11ASAH1, IRF8
IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia.
Hu X, Yang D, Zimmerman M, Liu F, Yang J, Kannan S, Burchert A, Szulc Z, Bielawska A, Ozato K, Bhalla K, Liu K.
Cancer Res 71(8):2882-91. Epub 2011 Apr 12. 2011
12CST3, IRF8
IL-10 controls cystatin C synthesis and blood concentration in response to inflammation through regulation of IFN regulatory factor 8 expression.
Xu Y, Schnorrer P, Proietto A, Kowalski G, Febbraio MA, Acha-Orbea H, Dickins RA, Villadangos JA.
J Immunol 186(6):3666-73. Epub 2011 Feb 7. 2011
13IRF4, IRF5, IRF8, PRDM1
Critical role of IRF-5 in regulation of B-cell differentiation.
Lien C, Fang CM, Huso D, Livak F, Lu R, Pitha PM.
Proc Natl Acad Sci U S A 107(10):4664-8. Epub 2010 Feb 22. 2010
14FANCF, IRF8
The interferon consensus sequence binding protein (ICSBP/IRF8) activates transcription of the FANCF gene during myeloid differentiation.
Saberwal G, Horvath E, Hu L, Zhu C, Hjort E, Eklund EA.
J Biol Chem 284(48):33242-54. Epub 2009 Oct 2.PMID: 19801548 2009
15IRF8
Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis.
Zhao B, Takami M, Yamada A, Wang X, Koga T, Hu X, Tamura T, Ozato K, Choi Y, Ivashkiv LB, Takayanagi H, Kamijo R.
Nat Med 15(9):1066-71. Epub 2009 Aug 30.PMID: 19718038 2009
16IRF8
IRF8 regulates myeloid and B lymphoid lineage diversification.
Wang H, Morse HC 3rd.
Immunol Res 43(1-3):109-17. Review.PMID: 1880693 2009
17CD6, IRF8
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S; International MS Genetics Consortium, Baranzini SE, McCauley JL, Pericak-Vance MA, Haines JL, Gibson RA, Naeglin Y, Uitdehaag B, Matthews PM, Kappos L, Polman C, McArdle WL, Strachan DP, Evans D, Cross AH, Daly MJ, Compston A, Sawcer SJ, Weiner HL, Hauser SL, Hafler DA, Oksenberg JR.
Nat Genet 41(7):776-82. doi: 10.1038/ng.401. Epub 2009 Jun 14. 2009
18IRF8, PTPN13
The interferon consensus sequence-binding protein (ICSBP/IRF8) represses PTPN13 gene transcription in differentiating myeloid cells.
Huang W, Zhu C, Wang H, Horvath E, Eklund EA.
J Biol Chem 283(12):7921-35. Epub 2008 Jan 14.PMID: 18195016 2008
19IRF8, MEIS1, MEIS3
Acceleration of chronic myeloproliferation by enforced expression of Meis1 or Meis3 in Icsbp-deficient bone marrow cells.
Hara T, Schwieger M, Kazama R, Okamoto S, Minehata K, Ziegler M, Löhler J, Stocking C.
Oncogene 27(27):3865-9. Epub 2008 Jan 28. 2008
20IRF8, AIRE, CHRNA1
An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus.
Giraud M, Taubert R, Vandiedonck C, Ke X, Levi-Strauss M, Pagani F, Baralle FE, Eymard B, Tranchant C, Gajdos P, Vincent A, Willcox N, Beeson D, Kyewski B, Garchon HJ.
Nature 448(7156):934-7. Epub 2007 Aug 8. 2007
21IRF8
Synergistic activation of interleukin-12 p35 gene transcription by interferon regulatory factor-1 and interferon consensus sequence-binding protein.
Liu J, Guan X, Tamura T, Ozato K, Ma X.
J Biol Chem 279(53):55609-17. Epub 2004 Oct 15. 2004
22IRF4, IRF8
Differential expression and distinct functions of IFN regulatory factor 4 and IFN consensus sequence binding protein in macrophages.
Marecki S, Atchison ML, Fenton MJ.
J Immunol 163(5):2713-22.PMID: 10453013 1999
23IRF8
Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene.
Holtschke T, Lohler J, Kanno Y, Fehr T, Giese N, Rosenbauer F, Lou J,Knobeloch KP, Gabriele L, Waring JF, Bachmann MF, Zinkernagel RM, Morse HC 3rd,Ozato K, Horak I.
Cell 87(2):307-17. 1996
24IRF8
Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors.
Sharf R, Azriel A, Lejbkowicz F, Winograd SS, Ehrlich R, Levi BZ.
J Biol Chem 270(22):13063-9.PMID: 7768900 1995
25IRF8
Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes.
Weisz A, Marx P, Sharf R, Appella E, Driggers PH, Ozato K, Levi BZ.
J Biol Chem 267(35):25589-96. 1992