| 1 | IRF3, IRF5, IRF7
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| DNA-binding landscape of IRF3, IRF5 and IRF7 dimers: implications for dimer-specific gene regulation.
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| Andrilenas KK, Ramlall V, Kurland J, Leung B, Harbaugh AG, Siggers T.
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| Nucleic Acids Res ucleic Acids Res. 2018 Jan 18. doi: 10.1093/nar/gky002. [Epub ahead of print]
2018
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| 2 | IKBKB, IRAK4, IRF5, MAP3K7
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| IRAK4 kinase activity controls Toll-like receptor-induced inflammation through the transcription factor IRF5 in primary human monocytes.
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| Cushing L, Winkler A, Jelinsky SA, Lee K, Korver W, Hawtin R, Rao VR, Fleming M, Lin LL.
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| J Biol Chem 292(45):18689-18698. doi: 10.1074/jbc.M117.796912. Epub 2017 Sep 18.
2017
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| 3 | IRF5, VCAM1
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| IRF-5 accelerates leukocyte adhesion to endothelial cells in ischemia-reperfusion injury through regulating the transcription of VCAM-1.
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| Cai H, Yao Z, Li W.
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| Biochem Biophys Res Commun 492(2):192-198. doi: 10.1016/j.bbrc.2017.08.044. Epub 2017 Aug 14.
2017
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| 4 | IRF5
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| A critical role for IRF5 in regulating allergic airway inflammation.
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| Byrne AJ, Weiss M, Mathie SA, Walker SA, Eames HL, Saliba D, Lloyd CM, Udalova IA.
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| Mucosal Immunol 10(3):716-726. doi: 10.1038/mi.2016.92. Epub 2016 Oct 19.
2017
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| 5 | IRF5, SP1
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| Expression of interferon regulatory factor 5 is regulated by the Sp1 transcription factor.
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| Shu J, Wang XH, Zhou LB, Jiang CM, Yang WX, Jin R, Wang LL, Zhou GP.
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| Mol Med Rep 14(3):2815-22. doi: 10.3892/mmr.2016.5565. Epub 2016 Jul 27.
2016
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| 6 | IRF5, IRF8, TLR9
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| IRF5 and IRF8 modulate the CAL-1 human plasmacytoid dendritic cell line response following TLR9 ligation.
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| Steinhagen F, Rodriguez LG, Tross D, Tewary P, Bode C, Klinman DM.
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| Eur J Immunol 46(3):647-55. doi: 10.1002/eji.201545911. Epub 2015 Dec 17.
2016
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| 7 | IFNB1, IRF1, IRF5
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| Effects of IRF1 and IFN-β interaction on the M1 polarization of macrophages and its antitumor function.
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| Xie C, Liu C, Wu B, Lin Y, Ma T, Xiong H, Wang Q, Li Z, Ma C, Tu Z.
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| Int J Mol Med 38(1):148-60. doi: 10.3892/ijmm.2016.2583. Epub 2016 May 10.
2016
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| 8 | IRF5
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| IRF5 controls both acute and chronic inflammation.
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| Weiss M, Byrne AJ, Blazek K, Saliba DG, Pease JE, Perocheau D, Feldmann M, Udalova IA.
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| Proc Natl Acad Sci U S A 112(35):11001-6. doi: 10.1073/pnas.1506254112. Epub 2015 Aug 17.
2015
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| 9 | IRF5
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| Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity.
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| Dalmas E, Toubal A, Alzaid F, Blazek K, Eames HL, Lebozec K, Pini M, Hainault I, Montastier E, Denis RG, Ancel P, Lacombe A, Ling Y, Allatif O, Cruciani-Guglielmacci C, André S, Viguerie N, Poitou C, Stich V, Torcivia A, Foufelle F, Luquet S, Aron-Wisnewsky J, Langin D, Clément K, Udalova IA, Venteclef N.
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| Nat Med 21(6):610-8. doi: 10.1038/nm.3829. Epub 2015 May 4.
2015
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| 10 | IRF5, TNPO3
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| The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share.
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| Kottyan LC, Zoller EE, Bene J, Lu X, Kelly JA, Rupert AM, Lessard CJ, Vaughn SE, Marion M, Weirauch MT, Namjou B, Adler A, Rasmussen A, Glenn S, Montgomery CG, Hirschfield GM, Xie G, Coltescu C, Amos C, Li H, Ice JA, Nath SK, Mariette X, Bowman S; UK Primary Sjögren's Syndrome Registry, Rischmueller M, Lester S, Brun JG, Gřransson LG, Harboe E, Omdal R, Cunninghame-Graham DS, Vyse T, Miceli-Richard C, Brennan MT, Lessard JA, Wahren-Herlenius M, Kvarnström M, Illei GG, Witte T, Jonsson R, Eriksson P, Nordmark G, Ng WF; UK Primary Sjögren's Syndrome Registry, Anaya JM, Rhodus NL, Segal BM, Merrill JT, James JA, Guthridge JM, Scofield RH, Alarcon-Riquelme M, Bae SC, Boackle SA, Criswell LA, Gilkeson G, Kamen DL, Jacob CO, Kimberly R, Brown E, Edberg J, Alarcón GS, Reveille JD, Vilá LM, Petri M, Ramsey-Goldman R, Freedman BI, Niewold T, Stevens AM, Tsao BP, Ying J, Mayes MD, Gorlova OY, Wakeland W, Radstake T, Martin E, Martin J, Siminovitch K, Moser Sivils KL, Gaffney PM, Langefeld CD, Harley JB, Kaufman KM.
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| Hum Mol Genet 24(2):582-96. doi: 10.1093/hmg/ddu455. Epub 2014 Sep 8.
2015
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| 11 | IRF5, TLR7, TRIM21
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| TRIpartite motif 21 (TRIM21) differentially regulates the stability of interferon regulatory factor 5 (IRF5) isoforms.
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| Lazzari E, Korczeniewska J, Ní Gabhann J, Smith S, Barnes BJ, Jefferies CA.
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| PLoS One 9(8):e103609. doi: 10.1371/journal.pone.0103609. eCollection 2014.
2014
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| 12 | IRF5
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| Association of the IRF5 SNP rs2004640 with systemic sclerosis in Han Chinese.
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| Wang J, Yi L, Guo X, Liu M, Li H, Zou H, Gu Y, Tu W, Guo G, Yang L, Lai S, He D, Zhou X.
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| Int J Immunopathol Pharmacol 27(4):635-8.
2014
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| 13 | IKBKB, IRF5
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| IKKβ is an IRF5 kinase that instigates inflammation.
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| Ren J, Chen X, Chen ZJ.
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| Proc Natl Acad Sci U S A 111(49):17438-43. doi: 10.1073/pnas.1418516111. Epub 2014 Oct 17.
2014
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| 14 | IKBKB, IRF5, NFKB1
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| Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells.
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| Lopez-Pelaez M, Lamont DJ, Peggie M, Shpiro N, Gray NS, Cohen P.
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| Proc Natl Acad Sci U S A 111(49):17432-7. doi: 10.1073/pnas.1418399111. Epub 2014 Oct 17.
2014
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| 15 | IRF5
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| IRF5 is a specific marker of inflammatory macrophages in vivo.
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| Weiss M, Blazek K, Byrne AJ, Perocheau DP, Udalova IA.
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| Mediators Inflamm 2013:245804. doi: 10.1155/2013/245804. Epub 2013 Dec 23.
2013
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| 16 | IRF5
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| Interferon regulatory factor 5 and autoimmune lupus.
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| Xu WD, Pan HF, Xu Y, Ye DQ.
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| Expert Rev Mol Med 15:e6. doi: 10.1017/erm.2013.7. Review.
2013
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| 17 | IRF5, TRIM28
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| KAP1/TRIM28: an inhibitor of IRF5 function in inflammatory macrophages.
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| Eames HL, Saliba DG, Krausgruber T, Lanfrancotti A, Ryzhakov G, Udalova IA.
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| Immunobiology 217(12):1315-24. doi: 10.1016/j.imbio.2012.07.026. Epub 2012 Aug 11.
2012
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| 18 | IKZF1, IRF5
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| Unique contribution of IRF-5-Ikaros axis to the B-cell IgG2a response.
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| Fang CM, Roy S, Nielsen E, Paul M, Maul R, Paun A, Koentgen F, Raval FM, Szomolanyi-Tsuda E, Pitha PM.
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| Genes Immun 13(5):421-30. doi: 10.1038/gene.2012.10. Epub 2012 Apr 26.
2012
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| 19 | IRF5
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| Loss of interferon regulatory factor 5 (IRF5) expression in human ductal carcinoma correlates with disease stage and contributes to metastasis.
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| Bi X, Hameed M, Mirani N, Pimenta EM, Anari J, Barnes BJ.
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| Breast Cancer Res 13(6):R111. doi: 10.1186/bcr3053. Epub 2011 Nov 4.
2011
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| 20 | IRF5
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| Interferon regulatory factor 5 is critical for the development of lupus in MRL/lpr mice.
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| Tada Y, Kondo S, Aoki S, Koarada S, Inoue H, Suematsu R, Ohta A, Mak TW, Nagasawa K.
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| Arthritis Rheum 63(3):738-48. doi: 10.1002/art.30183.
2011
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| 21 | IRF4, IRF5, IRF8, PRDM1
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| Critical role of IRF-5 in regulation of B-cell differentiation.
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| Lien C, Fang CM, Huso D, Livak F, Lu R, Pitha PM.
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| Proc Natl Acad Sci U S A 107(10):4664-8. Epub 2010 Feb 22. 2010
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| 22 | IL12A, IRF5, SPIB, TNPO3
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| Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.
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| Liu X, Invernizzi P, Lu Y, Kosoy R, Lu Y, Bianchi I, Podda M, Xu C, Xie G, Macciardi F, Selmi C, Lupoli S, Shigeta R, Ransom M, Lleo A, Lee AT, Mason AL, Myers RP, Peltekian KM, Ghent CN, Bernuzzi F, Zuin M, Rosina F, Borghesio E, Floreani A, Lazzari R, Niro G, Andriulli A, Muratori L, Muratori P, Almasio PL, Andreone P, Margotti M, Brunetto M, Coco B, Alvaro D, Bragazzi MC, Marra F, Pisano A, Rigamonti C, Colombo M, Marzioni M, Benedetti A, Fabris L, Strazzabosco M, Portincasa P, Palmieri VO, Tiribelli C, Croce L, Bruno S, Rossi S, Vinci M, Prisco C, Mattalia A, Toniutto P, Picciotto A, Galli A, Ferrari C, Colombo S, Casella G, Morini L, Caporaso N, Colli A, Spinzi G, Montanari R, Gregersen PK, Heathcote EJ, Hirschfield GM, Siminovitch KA, Amos CI, Gershwin ME, Seldin MF.
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| Nat Genet 42(8):658-60. Epub 2010 Jul 18.PMID: 20639880 2010
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| 23 | IRF5, MMEL1, TNPO3
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| Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis.
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| Hirschfield GM, Liu X, Han Y, Gorlov IP, Lu Y, Xu C, Lu Y, Chen W, Juran BD, Coltescu C, Mason AL, Milkiewicz P, Myers RP, Odin JA, Luketic VA, Speiciene D, Vincent C, Levy C, Gregersen PK, Zhang J, Heathcote EJ, Lazaridis KN, Amos CI, Siminovitch KA.
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| Nat Genet 42(8):655-7. Epub 2010 Jul 18.PMID: 20639879 2010
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| 24 | CHUK, IRF5
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| IKKalpha negatively regulates IRF-5 function in a MyD88-TRAF6 pathway.
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| Balkhi MY, Fitzgerald KA, Pitha PM.
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| Cell Signal 22(1):117-27. Epub 2009 Sep 25.
2010
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| 25 | IRF5
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| IRF-5 is a mediator of the death receptor-induced apoptotic signaling pathway.
|
| Hu G, Barnes BJ.
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| J Biol Chem 284(5):2767-77. Epub 2008 Nov 20.
2009
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| 26 | BANK1, BLK, FCGR2A, FCGR3A, HLA-DR2, HLA-DR3, IRAK1, IRF5, ITGAM, PDCD1, PTPN22, PXK, TNFAIP3, TREX1, XKR6
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| Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies.
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| Harley IT, Kaufman KM, Langefeld CD, Harley JB, Kelly JA.
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| Nat Rev Genet 10(5):285-90.
2009
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| 27 | IRF5
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| Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus.
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| Sigurdsson S, Gšring HH, Kristjansdottir G, Milani L, Nordmark G, Sandling JK, Eloranta ML, Feng D, Sangster-Guity N, Gunnarsson I, Svenungsson E, Sturfelt G, Jšnsen A, Truedsson L, Barnes BJ, Alm G, Ršnnblom L, SyvŠnen AC.
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| Hum Mol Genet 17(6):872-81. Epub 2007 Dec 6. 2008
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| 28 | IRF5, IRF7
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| Interferon regulatory factors IRF5 and IRF7 inhibit growth and induce senescence in immortal Li-Fraumeni fibroblasts.
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| Li Q, Tang L, Roberts PC, Kraniak JM, Fridman AL, Kulaeva OI, Tehrani OS, Tainsky MA.
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| Mol Cancer Res 6(5):770-84.PMID: 18505922 2008
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| 29 | IRF5
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| Association of IRF5 in UK SLE families identifies a variant involved in polyadenylation.
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| Graham DS, Manku H, Wagner S, Reid J, Timms K, Gutin A, Lanchbury JS, Vyse TJ.
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| Hum Mol Genet 16(6):579-91. Epub 2006 Dec 22. 2007
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| 30 | IRF5
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| Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.
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| Graham RR, Kyogoku C, Sigurdsson S, Vlasova IA, Davies LR, Baechler EC, Plenge RM, Koeuth T, Ortmann WA, Hom G, Bauer JW, Gillett C, Burtt N, Cunninghame Graham DS, Onofrio R, Petri M, Gunnarsson I, Svenungsson E, Ronnblom L, Nordmark G, Gregersen PK, Moser K, Gaffney PM, Criswell LA, Vyse TJ, Syvanen AC, Bohjanen PR, Daly MJ, Behrens TW, Altshuler D.
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| Proc Natl Acad Sci U S A 104(16):6758-63. Epub 2007 Apr 5. 2007
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| 31 | IRF5
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| Genetic association of IRF5 with SLE in Mexicans: higher frequency of the risk haplotype and its homozygozity than Europeans.
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| Reddy MV, Velazquez-Cruz R, Baca V, Lima G, Granados J, Orozco L, Alarcon-Riquelme ME.
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| Hum Genet 121(6):721-7. Epub 2007 May 3. 2007
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| 32 | IRF5
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| An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases.
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| Dideberg V, Kristjansdottir G, Milani L, Libioulle C, Sigurdsson S, Louis E, Wiman AC, Vermeire S, Rutgeerts P, Belaiche J, Franchimont D, Van Gossum A, Bours V, SyvŠnen AC.
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| Hum Mol Genet 16(24):3008-16. Epub 2007 Sep 19. 2007
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| 33 | IRF5
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| A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus.
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| Graham RR, Kozyrev SV, Baechler EC, Reddy MV, Plenge RM, Bauer JW, Ortmann WA, Koeuth T, Escribano MF, Collaborative Groups TA, Pons-Estel B, Petri M, Daly M, Gregersen PK, Martin J, Altshuler D, Behrens TW, Alarcon-Riquelme ME.
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| Nat Genet 38(5):550-555. Epub 2006 Apr 16. 2006
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| 34 | IRF5
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| Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors.
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| Takaoka A, Yanai H, Kondo S, Duncan G, Negishi H, Mizutani T, Kano S, Honda K, Ohba Y, Mak TW, Taniguchi T.
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| Nature 434(7030):243-9. Epub 2005 Jan 23. 2005
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| 35 | IFNAR1, IRF5, TYK2
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| Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.
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| Sigurdsson S, Nordmark G, Goring HH, Lindroos K, Wiman AC, Sturfelt G, Jonsen A, Rantapaa-Dahlqvist S, Moller B, Kere J, Koskenmies S, Widen E, Eloranta ML, Julkunen H, Kristjansdottir H, Steinsson K, Alm G, Ronnblom L, Syvanen AC.
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| Am J Hum Genet 76(3):528-37. Epub 2005 Jan 18. 2005
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| 36 | IRF5
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| Two discrete promoters regulate the alternatively spliced human interferon regulatory factor-5 isoforms. Multiple isoforms with distinct cell type-specific expression, localization, regulation, and function.
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| Mancl ME, Hu G, Sangster-Guity N, Olshalsky SL, Hoops K, Fitzgerald-Bocarsly P, Pitha PM, Pinder K, Barnes BJ.
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| J Biol Chem 280(22):21078-90. Epub 2005 Mar 31. 2005
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| 37 | IRF5
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| Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes.
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| Barnes BJ, Kellum MJ, Field AE, Pitha PM.
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| Mol Cell Biol 22(16):5721-40. 2002
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| 38 | IRF5
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| Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes.
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| Barnes BJ, Moore PA, Pitha PM.
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| J Biol Chem 276(26):23382-90. Epub 2001 Apr 12. 2001
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| 39 | IRF5
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| Generation of mutant mice deficient in IRF5.
|
| Grossman A, et Al.
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| unpublished 1999
|