| 1 | IRF1
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| IRF-1 mediates the suppressive effects of mTOR inhibition on arterial endothelium.
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| Peng K, Fan X, Li Q, Wang Y, Chen X, Xiao P, Passerini AG, Simon SI, Sun C.
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| J Mol Cell Cardiol 140:30-41. doi: 10.1016/j.yjmcc.2020.02.006. [Epub ahead of print]
2020
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| 2 | ATG10, IFNL2, IRF1
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| A new transcription factor ATG10S activates IFNL2 transcription by binding at an IRF1 site in HepG2 cells.
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| Zhang MQ, Zhao Q, Zhang JP.
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| Autophagy utophagy. 2020 Jan 29:1-13. doi: 10.1080/15548627.2020.1719681. [Epub ahead of print]
2020
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| 3 | IRF1, PARP1
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| Inhibition of PARP1 Increases IRF-dependent Gene Transcription in Jurkat Cells.
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| Wang C, Du M, Huang D, Huang K, Huang K.
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| Curr Med Sci 39(3):356-362. doi: 10.1007/s11596-019-2043-1. Epub 2019 Jun 17.
2019
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| 4 | IRF1, IRF2, TRIM14
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| TRIM14 expression is regulated by IRF-1 and IRF-2.
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| Cui J, Xu X, Li Y, Hu X, Xie Y, Tan J, Qiao W.
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| FEBS Open Bio 9(8):1413-1420. doi: 10.1002/2211-5463.12682. Epub 2019 Jul 1.
2019
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| 5 | FOXM1, IRF1
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| FOXM1c promotes oesophageal cancer metastasis by transcriptionally regulating IRF1 expression.
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| Zhou Y, Wang Q, Chu L, Dai W, Zhang X, Chen J, Zhang L, Ding P, Zhang X, Gu H, Zhang P, Li L, Zhang W, Li L, Lv X, Zhou D, Cai G, Chen L, Zhao K, Hu W.
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| Cell Prolif 52(2):e12553. doi: 10.1111/cpr.12553. Epub 2018 Nov 28.
2019
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| 6 | IRF1
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| Tumor suppressor Interferon Regulatory Factor 1 selectively blocks expression of endogenous retrovirus.
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| Stoltz KP, Jondle CN, Pulakanti K, Sylvester PA, Urrutia R, Rao S, Tarakanova VL.
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| Virology 526:52-60. doi: 10.1016/j.virol.2018.10.003. Epub 2018 Oct 17.
2019
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| 7 | CASP4, IRF1, IRF1
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| IRF1 and IRF2 regulate the non-canonical inflammasome.
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| Thygesen SJ, Stacey KJ.
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| EMBO Rep 20(9):e48891. doi: 10.15252/embr.201948891. Epub 2019 Aug 5.
2019
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| 8 | IRF1, XAF1
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| XAF1 forms a positive feedback loop with IRF-1 to drive apoptotic stress response and suppress tumorigenesis.
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| Jeong SI, Kim JW, Ko KP, Ryu BK, Lee MG, Kim HJ, Chi SG.
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| Cell Death Dis 9(8):806. doi: 10.1038/s41419-018-0867-4.
2018
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| 9 | IRF1
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| Deletion of interferon-regulatory factor-1 results in cognitive impairment.
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| Mogi M, Iwanami J, Wang XL, Tsukuda K, Kan-No H, Bai HY, Shan BS, Higaki A, Min LJ, Horiuchi M.
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| Hypertens Res 41(10):809-816. doi: 10.1038/s41440-018-0080-y. Epub 2018 Aug 6.
2018
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| 10 | IRF1, STAT1
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| IRF1 supports DNA binding of STAT1 by promoting its phosphorylation.
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| Zenke K, Muroi M, Tanamoto KI.
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| Immunol Cell Biol 96(10):1095-1103. doi: 10.1111/imcb.12185. Epub 2018 Jun 28.
2018
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| 11 | IRF1, STAT1
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| Frequent interferon regulatory factor 1 (IRF1) binding at remote elements without histone modification.
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| Abou El Hassan M, Huang K, Xu Z, Yu T, Bremner R.
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| J Biol Chem 293(26):10353-10362. doi: 10.1074/jbc.RA118.002889. Epub 2018 May 10.
2018
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| 12 | IRF1, NMI
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| Interferon activates promoter of Nmi gene via interferon regulator factor-1.
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| Xu X, Chai K, Chen Y, Lin Y, Zhang S, Li X, Qiao W, Tan J.
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| Mol Cell Biochem 441(1-2):165-171. doi: 10.1007/s11010-017-3182-y. Epub 2017 Sep 14.
2018
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| 13 | IRF1, VCAM1
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| Endothelial Interferon Regulatory Factor 1 Regulates Lipopolysaccharide-Induced VCAM-1 Expression Independent of NFκB.
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| Yan R, van Meurs M, Popa ER, Jongman RM, Zwiers PJ, Niemarkt AE, Kuiper T, Kamps JA, Heeringa P, Zijlstra JG, Molema G, Moser J.
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| J Innate Immun 9(6):546-560. doi: 10.1159/000477211. Epub 2017 Jun 29.
2017
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| 14 | IRF1
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| Activation of IRF1 in Human Adipocytes Leads to Phenotypes Associated with Metabolic Disease.
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| Friesen M, Camahort R, Lee YK, Xia F, Gerszten RE, Rhee EP, Deo RC, Cowan CA.
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| Stem Cell Reports 8(5):1164-1173. doi: 10.1016/j.stemcr.2017.03.014. Epub 2017 Apr 13.
2017
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| 15 | BATF, IRF1
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| Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation.
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| Karwacz K, Miraldi ER, Pokrovskii M, Madi A, Yosef N, Wortman I, Chen X, Watters A, Carriero N, Awasthi A, Regev A, Bonneau R, Littman D, Kuchroo VK.
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| Nat Immunol 18(4):412-421. doi: 10.1038/ni.3683. Epub 2017 Feb 6.
2017
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| 16 | IFNB1, IRF1, IRF5
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| Effects of IRF1 and IFN-β interaction on the M1 polarization of macrophages and its antitumor function.
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| Xie C, Liu C, Wu B, Lin Y, Ma T, Xiong H, Wang Q, Li Z, Ma C, Tu Z.
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| Int J Mol Med 38(1):148-60. doi: 10.3892/ijmm.2016.2583. Epub 2016 May 10.
2016
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| 17 | AGTR1, AGTR2, IRF1
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| Interferon regulatory factor 1 attenuates vascular remodeling; roles of angiotensin II type 2 receptor.
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| Nakaoka H, Mogi M, Suzuki J, Kan-No H, Min LJ, Iwanami J, Horiuchi M.
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| J Am Soc Hypertens 10(10):811-818. doi: 10.1016/j.jash.2016.07.005. Epub 2016 Aug 4.
2016
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| 18 | IRF1
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| The Transcription Factor Interferon Regulatory Factor-1 (IRF1) Plays a Key Role in the Terminal Effector Pathways of Human Preterm Labor.
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| Lim R, Tran HT, Liong S, Barker G, Lappas M.
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| Biol Reprod 94(2):32. doi: 10.1095/biolreprod.115.134726. Epub 2015 Dec 16.
2016
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| 19 | IRF1, PPARGC1A
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| PGC-1α regulates the expression and activity of IRF-1.
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| Lu H, Zhu L, Lian L, Chen M, Shi D, Wang K.
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| IUBMB Life 67(4):300-5. doi: 10.1002/iub.1369. Epub 2015 Apr 15.
2015
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| 20 | DIABLO, IRF1
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| Identification of IRF1 as critical dual regulator of Smac mimetic-induced apoptosis and inflammatory cytokine response.
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| Eckhardt I, Weigert A, Fulda S.
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| Cell Death Dis 5:e1562. doi: 10.1038/cddis.2014.498.
2014
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| 21 | IRF1, NOS2
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| Interferon regulatory factor 1 is required for cardiac remodeling in response to pressure overload.
|
| Jiang DS, Li L, Huang L, Gong J, Xia H, Liu X, Wan N, Wei X, Zhu X, Chen Y, Chen X, Zhang XD, Li H.
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| Hypertension 64(1):77-86. doi: 10.1161/HYPERTENSIONAHA.114.03229. Epub 2014 Apr 14.
2014
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| 22 | IRF1, IRF2
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| The roles of interferon regulatory factors 1 and 2 in the progression of human pancreatic cancer.
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| Sakai T, Mashima H, Yamada Y, Goto T, Sato W, Dohmen T, Kamada K, Yoshioka M, Uchinami H, Yamamoto Y, Ohnishi H.
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| Pancreas 43(6):909-16. doi: 10.1097/MPA.0000000000000116.
2014
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| 23 | IFNG, IRF1, OPTN
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| IRF-1-binding site in the first intron mediates interferon-γ-induced optineurin promoter activation.
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| Sudhakar C, Vaibhava V, Swarup G.
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| Biochem Biophys Res Commun 437(1):179-84. doi: 10.1016/j.bbrc.2013.06.065. Epub 2013 Jun 27.
2013
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| 24 | CASP8, IRF1, SMAD7
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| Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis.
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| Hong S, Kim HY, Kim J, Ha HT, Kim YM, Bae E, Kim TH, Lee KC, Kim SJ.
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| J Biol Chem 288(5):3560-70. doi: 10.1074/jbc.M112.400408. Epub 2012 Dec 19. 2013
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| 25 | IFI35, IRF1, IRF2
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| Interferon-γ upregulates expression of IFP35 gene in HeLa cells via interferon regulatory factor-1.
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| Yang W, Tan J, Liu R, Cui X, Ma Q, Geng Y, Qiao W.
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| PLoS One 7(12):e50932. doi: 10.1371/journal.pone.0050932. Epub 2012 Dec 4.
2012
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| 26 | IRF1, SMARCA4, TRIM22
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| BRG1 is indispensable for IFN-γ-induced TRIM22 expression, which is dependent on the recruitment of IRF-1.
|
| Wang Y, Gao B, Xu W, Xiong S.
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| Biochem Biophys Res Commun 410(3):549-54. Epub 2011 Jun 12. 2011
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| 27 | IRF1
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| IRF-1 expression is essential for natural killer cells to suppress metastasis.
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| Ksienzyk A, Neumann B, Nandakumar R, Finsterbusch K, Grashoff M, Zawatzky R, Bernhardt G, Hauser H, Kröger A.
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| Cancer Res 71(20):6410-8. doi: 10.1158/0008-5472.CAN-11-1565. Epub 2011 Sep 7.
2011
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| 28 | IL27, IRF1, IRF9
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| Critical role of the IFN-stimulated gene factor 3 complex in TLR-mediated IL-27p28 gene expression revealing a two-step activation process.
|
| Molle C, Goldman M, Goriely S.
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| J Immunol 184(4):1784-92. doi: 10.4049/jimmunol.0902005. Epub 2010 Jan 18.
2010
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| 29 | IRF1
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| Interaction between interferon regulatory factor-1 and human papillomavirus E7 oncogene in cervical cancer: an ontology study.
|
| Wiwanitkit V.
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| Taiwan J Obstet Gynecol 48(2):138-41.
2009
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| 30 | FANCJ, IRF1
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| A ChIP-chip approach reveals a novel role for transcription factor IRF1 in the DNA damage response.
|
| Frontini M, Vijayakumar M, Garvin A, Clarke N.
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| Nucleic Acids Res 37(4):1073-85. Epub 2009 Jan 7.PMID: 19129219 2009
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| 31 | IRF1
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| Role of the IRF-1 enhancer domain in signalling polyubiquitination and degradation.
|
| Pion E, Narayan V, Eckert M, Ball KL.
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| Cell Signal 21(10):1479-87. Epub 2009 May 18.PMID: 19450680 2009
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| 32 | IRF1
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| Frequent loss of heterozygosity at the interferon regulatory factor-1 gene locus in breast cancer.
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| Cavalli LR, Riggins RB, Wang A, Clarke R, Haddad BR.
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| Breast Cancer Res Treat reast Cancer Res Treat. 2009 Aug 21. [Epub ahead of print]PMID: 19697121 2009
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| 33 | IRF1, UBE2I
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| Ubc9-mediated sumoylation leads to transcriptional repression of IRF-1.
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| Kim EJ, Park JS, Um SJ.
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| Biochem Biophys Res Commun 377(3):952-6. Epub 2008 Oct 26.PMID: 18955028 2008
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| 34 | IRF1
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| IRF-1 promotes apoptosis in p53-damaged basal-type human mammary epithelial cells: a model for early basal-type mammary carcinogenesis.
|
| Bowie ML, Ibarra C, Seewalt VL.
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| Adv Exp Med Biol 617:367-74.PMID: 18497060 2008
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| 35 | IRF1
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| Associations between interferon regulatory factor-1 polymorphisms and Behçet's disease.
|
| Lee YJ, Kang SW, Song JK, Baek HJ, Choi HJ, Bae YD, Ryu HJ, Lee EY, Lee EB, Song YW.
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| Hum Immunol 68(9):770-8. Epub 2007 Jul 17.PMID: 17869652 2007
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| 36 | IRF1, PSMB8
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| IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome.
|
| Namiki S, Nakamura T, Oshima S, Yamazaki M, Sekine Y, Tsuchiya K, Okamoto R, Kanai T, Watanabe M.
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| FEBS Lett 579(13):2781-7. Epub 2005 Apr 20.
2005
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| 37 | IRF1
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| A central role of interferon regulatory factor-1 for the limitation of neointimal hyperplasia.
|
| Wessely R, Hengst L, Jaschke B, Wegener F, Richter T, Lupetti R, Paschalidis M, Schomig A, Brandl R, Neumann FJ.
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| Hum Mol Genet 12(2):177-87. 2003
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| 38 | IRF1, CDK2
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| The tumor suppressor interferon regulatory factor 1 interferes with SP1 activation to repress the human CDK2 promoter.
|
| Xie RL, Gupta S, Miele A, Shiffman D, Stein JL, Stein GS, van Wijnen AJ.
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| J Biol Chem 278(29):26589-96. Epub 2003 May 5. 2003
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| 39 | IRF1, PIAS3
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| PIAS3 induces SUMO-1 modification and transcriptional repression of IRF-1.
|
| Nakagawa K, Yokosawa H.
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| FEBS Lett 530(1-3):204-8. 2002
|
| 40 | CSF1R, FGF1, IRF1
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| Linkage and allelic association of chromosome 5 cytokine cluster genetic markers with atopy and asthma associated traits.
|
| Walley AJ, Wiltshire S, Ellis CM, Cookson WO.
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| Genomics 72(1):15-20. 2001
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| 41 | CSF2, IL13, IL3, IL4, IL4R, IL9, IRF1, TCF7
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| A second-generation association study of the 5q31 cytokine gene cluster and the interleukin-4 receptor in asthma.
|
| Kauppi P, Lindblad-Toh K, Sevon P, Toivonen HT, Rioux JD, Villapakkam A, Laitinen LA, Hudson TJ, Kere J, Laitinen T.
|
| Genomics 77(1/2):35-42. 2001
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| 42 | CD80, COMP, IL9R, IRF1, TNFRSF9
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| Identification of 142 single nucleotide polymorphisms in 41 candidate genes for rheumatoid arthritis in the Japanese population.
|
| Yamada R, Tanaka T, Ohnishi Y, Suematsu K, Minami M, Seki T, Yukioka M, Maeda A, Murata N, Saiki O, Teshima R, Kudo O, Ishikawa K, Ueyosi A, Tateishi H, Inaba M, Goto H, Nishizawa Y, Tohma S, Ochi T, Yamamoto K, Nakamura Y.
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| Hum Genet 106(3):293-7. 2000
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| 43 | IRF1
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| Cooperative activity between HER oncogenes and the tumor suppressor IRF-1 results in apoptosis.
|
| Kirchhoff S, et al.
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| Oncogene 18(25):3725-36 1999
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| 44 | IRF1, TSG5D
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| Functionally inactivating point mutation in the tumor-suppressor IRF-1 gene identified in human gastric cancer.
|
| Nozawa H, et al.
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| Int J Cancer 77 : 522-527. 1998
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| 45 | AFF4, ARAP3, CCNL1, FACLL, IL5, IRF1, KIF3A, P4HA2, PDLIM4, RAD50, SEPTIN8, SHROOM1
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| Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region.
|
| Frazer KA, Ueda Y, Zhu Y, Gifford VR, Garofalo MR, Mohandas N, Martin CH, Palazzolo MJ, Cheng JF, Rubin EM.
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| Genome Res 7 : 495-512. 1997
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| 46 | IRF1, IRF2
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| Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes : implications for a gene network in the interferon system.
|
| Harada H, et al.
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| Mol Cell Biol 14 : 1500-1509. 1994
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| 47 | IRF1
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| Allelic loss of IRF1 in myelodysplasia and acute myeloid leukemia : retention of IRF1 on the 5q-chromosome in some patients with the 5q-syndrome.
|
| Boultwood J, et al.
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| Blood 82 : 2611-2616. 1993
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| 48 | IRF1, IRF2
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| Anti-oncogenic and oncogenic potentials of interferon regulatory factors -1 and -2.
|
| Harada H, et al.
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| Science 259 : 971-974. 1993
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| 49 | IRF1
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| Dinucleotide repeat polymorphism in the interferon regulating factor 1 (IRF1) gene.
|
| Kroef MJPL, et al.
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| Hum Mol Genet 2 : 1748. 1993
|
| 50 | IRF1
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| Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia.
|
| Willman CL, et al.
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| Science 259 : 968-971. 1993
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| 51 | IRF1
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| Somatic cell hybrid mapping of human chromosome band 5q31 : a region important to hematopoiesis.
|
| Neuman WL, et al.
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| Cytogenet Cell Genet 61 : 103-106. 1992
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| 52 | IRF1
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| Assignment of the human interferon regulatory factor-1 (IRF1) gene to chromosome 5q23-q31.
|
| Itoh S, et al.
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| Genomics 10 : 1097-1099. 1991
|
| 53 | IRF1
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| Progress toward the identification of a leukemia suppressor gene on chromosome 5.
|
| Neuman WL, et al.
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| Am J Hum Genet 47 : A258. 1990
|