Citations for
1IRAK1BP1, MED1
SIMPL enhancement of tumor necrosis factor-α dependent p65-MED1 complex formation is required for mammalian hematopoietic stem and progenitor cell function.
Zhao W, Breese E, Bowers A, Hoggatt J, Pelus LM, Broxmeyer HE, Goebl M, Harrington MA.
PLoS One 8(4):e61123. doi: 10.1371/journal.pone.0061123. Print 2013. 2013
2IRAK1BP1
Loss of SIMPL compromises TNF-alpha-dependent survival of hematopoietic progenitors.
Benson EA, Goebl MG, Yang FC, Kapur R, McClintick J, Sanghani S, Clapp DW, Harrington MA.
Exp Hematol 38(2):71-81. Epub 2009 Nov 23.PMID: 19941935 2010
3IRAK1BP1
IRAK1BP1 inhibits inflammation by promoting nuclear translocation of NF-kappaB p50.
Conner JR, Smirnova II, Moseman AP, Poltorak A.
Proc Natl Acad Sci U S A 107(25):11477-82. Epub 2010 Jun 7.PMID: 20534545 2010
4IRAK1BP1
Forward genetic analysis of Toll-like receptor responses in wild-derived mice reveals a novel antiinflammatory role for IRAK1BP1.
Conner JR, Smirnova II, Poltorak A.
J Exp Med 205(2):305-14. Epub 2008 Feb 11.PMID: 18268037 2008
5IRAK1BP1
Phosphorylation of SIMPL modulates RelA-associated NF-kappaB-dependent transcription.
Luo Y, Kwon HJ, Montano S, Georgiadis M, Goebl MG, Harrington MA.
Am J Physiol Cell Physiol 292(3):C1013-23. Epub 2006 Nov 1.PMID: 17079333 2007
6IRAK1BP1
The disordered amino-terminus of SIMPL interacts with members of the 70-kDa heat-shock protein family.
Haag Breese E, Uversky VN, Georgiadis MM, Harrington MA.
DNA Cell Biol 25(12):704-14.PMID: 17233114 2006
7IRAK1BP1, RELA
Tumor necrosis factor alpha induction of NF-kappaB requires the novel coactivator SIMPL.
Kwon HJ, Breese EH, Vig-Varga E, Luo Y, Lee Y, Goebl MG, Harrington MA.
Mol Cell Biol 24(21):9317-26.PMID: 15485901 2004
8IRAK1BP1
SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity.
Vig E, Green M, Liu Y, Yu KY, Kwon HJ, Tian J, Goebl MG, Harrington MA.
J Biol Chem 276(11):7859-66. Epub 2000 Nov 28. 2001