| 1 | IRAK1, IRAK4
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| The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists.
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| Vollmer S, Strickson S, Zhang T, Gray N, Lee KL, Rao VR, Cohen P.
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| Biochem J 474(12):2027-2038. doi: 10.1042/BCJ20170097.
2017
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| 2 | IRAK1, IRAK4, MYD88
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| Oncogenically active MYD88 mutations in human lymphoma.
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| Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, Lim KH, Kohlhammer H, Xu W, Yang Y, Zhao H, Shaffer AL, Romesser P, Wright G, Powell J, Rosenwald A, Muller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Staudt LM.
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| Nature 470(7332):115-9. Epub 2010 Dec 22.
2011
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| 3 | IRAK1, IRAK4, MYD88, TIRAP
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| IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal).
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| Dunne A, Carpenter S, Brikos C, Gray P, Strelow A, Wesche H, Morrice N, O'Neill LA.
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| J Biol Chem 285(24):18276-82. Epub 2010 Apr 16. 2010
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| 4 | IRAK1, IRAK4, PELI1, PELI2, PELI3
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| Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4.
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| Smith H, Peggie M, Campbell DG, Vandermoere F, Carrick E, Cohen P.
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| Proc Natl Acad Sci U S A 106(12):4584-90. Epub 2009 Mar 5.
2009
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| 5 | IRAK1
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| Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus.
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| Jacob CO, Zhu J, Armstrong DL, Yan M, Han J, Zhou XJ, Thomas JA, Reiff A, Myones BL, Ojwang JO, Kaufman KM, Klein-Gitelman M, McCurdy D, Wagner-Weiner L, Silverman E, Ziegler J, Kelly JA, Merrill JT, Harley JB, Ramsey-Goldman R, Vila LM, Bae SC, Vyse TJ, Gilkeson GS, Gaffney PM, Moser KL, Langefeld CD, Zidovetzki R, Mohan C.
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| Proc Natl Acad Sci U S A 106(15):6256-61. Epub 2009 Mar 27.
2009
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| 6 | BANK1, BLK, FCGR2A, FCGR3A, HLA-DR2, HLA-DR3, IRAK1, IRF5, ITGAM, PDCD1, PTPN22, PXK, TNFAIP3, TREX1, XKR6
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| Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies.
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| Harley IT, Kaufman KM, Langefeld CD, Harley JB, Kelly JA.
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| Nat Rev Genet 10(5):285-90.
2009
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| 7 | IRAK1, IRAK4
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| The kinase activities of interleukin-1 receptor associated kinase (IRAK)-1 and 4 are redundant in the control of inflammatory cytokine expression in human cells.
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| Song KW, Talamas FX, Suttmann RT, Olson PS, Barnett JW, Lee SW, Thompson KD, Jin S, Hekmat-Nejad M, Cai TZ, Manning AM, Hill RJ, Wong BR.
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| Mol Immunol 46(7):1458-66. Epub 2009 Jan 31.
2009
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| 8 | IRAK1, MAP3K8, TNIP2
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| IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2.
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| Handoyo H, Stafford MJ, McManus E, Baltzis D, Peggie M, Cohen P.
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| Biochem J 424(1):109-18.
2009
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| 9 | IRAK1, IRAK4
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| IRAK-4-dependent degradation of IRAK-1 is a negative feedback signal for TLR-mediated NF-kappaB activation.
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| Kubo-Murai M, Hazeki K, Nigorikawa K, Omoto T, Inoue N, Hazeki O.
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| J Biochem 143(3):295-302. Epub 2007 Dec 13.
2008
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| 10 | IRAK1
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| IRAK1: a critical signaling mediator of innate immunity.
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| Gottipati S, Rao NL, Fung-Leung WP.
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| Cell Signal 20(2):269-76. Epub 2007 Aug 23. Review.PMID: 17890055 2008
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| 11 | IRAK1, IRAK2, IRAK4
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| IRAK1: a critical signaling mediator of innate immunity.
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| Gottipati S, Rao NL, Fung-Leung WP.
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| Cell Signal 20(2):269-76. Epub 2007 Aug 23. Review. 2008
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| 12 | IRAK1
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| Differential regulation of interleukin-1 receptor associated kinase 1 (IRAK1) splice variants.
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| Su J, Richter K, Zhang C, Gu Q, Li L.
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| Mol Immunol 44(5):900-5. Epub 2006 May 9. 2007
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| 13 | TNFAIP3, TAX1BP1, TRAF6, IRAK1
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| Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling.
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| Shembade N, Harhaj NS, Liebl DJ, Harhaj EW.
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| EMBO J 26(17):3910-22. Epub 2007 Aug 16. 2007
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| 14 | PELI1, PELI2, PELI3, IRAK1, IRAK4
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| Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases.
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| Butler MP, Hanly JA, Moynagh PN.
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| J Biol Chem 282(41):29729-37. Epub 2007 Aug 3. 2007
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| 15 | IRAK1, IRAK2, IRAK4, PELI1, PELI2, PELI3
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| Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases.
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| Butler MP, Hanly JA, Moynagh PN.
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| J Biol Chem 282(41):29729-37. Epub 2007 Aug 3.
2007
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| 16 | PELI1, PELI2, PELI3, IRAK1
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| Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases.
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| Schauvliege R, Janssens S, Beyaert R.
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| FEBS Lett 580(19):4697-702. Epub 2006 Jul 24. 2006
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| 17 | NLRP12, MYD88, IRAK1
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| The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals.
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| Williams KL, Lich JD, Duncan JA, Reed W, Rallabhandi P, Moore C, Kurtz S, Coffield VM, Accavitti-Loper MA, Su L, Vogel SN, Braunstein M, Ting JP.
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| J Biol Chem 280(48):39914-24. Epub 2005 Oct 3. 2005
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| 18 | IRAK1, STAT3
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| IRAK1 serves as a novel regulator essential for lipopolysaccharide-induced interleukin-10 gene expression.
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| Huang Y, Li T, Sane DC, Li L.
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| J Biol Chem 279(49):51697-703. Epub 2004 Oct 1. 2004
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| 19 | PELI2, IRAK1, IRAK4
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| Characterization of Pellino2, a substrate of IRAK1 and IRAK4.
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| Strelow A, Kollewe C, Wesche H.
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| FEBS Lett 547(1-3):157-61. 2003
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| 20 | IRAK1
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| Divergence of bacterial lipopolysaccharide pro-apoptotic signaling downstream of IRAK-1.
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| Bannerman DD, Tupper JC, Erwert RD, Winn RK, Harlan JM.
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| J Biol Chem 277(10):8048-53. 2002
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| 21 | IRAK1
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| Identification of threonine 66 as a functionally critical residue of the interleukin-1 receptor-associated kinase.
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| Ross K, Yang L, Dower S, Volpe F, Guesdon F.
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| J Biol Chem 277(40):37414-21. 2002
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| 22 | IRAK1, MAP3K7
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| Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol.
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| Jiang Z, Ninomiya-Tsuji J, Qian Y, Matsumoto K, Li X.
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| Mol Cell Biol 22(20):7158-67. 2002
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| 23 | IRAK1
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| IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability.
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| Jensen LE, Whitehead AS.
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| J Biol Chem 276(31):29037-44. 2001
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| 24 | IRAK1, IKBKG
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| Functional analysis of the interleukin-1-receptor-associated kinase (IRAK-1) in interleukin-1 beta-stimulated nuclear factor kappa B (NF-kappa B) pathway activation: IRAK-1 associates with the NF-kappa B essential modulator (NEMO) upon receptor stimulation.
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| Cooke EL, Uings IJ, Xia CL, Woo P, Ray KP.
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| Biochem J 359(Pt 2):403-10. 2001
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| 25 | IRAK1, TRAF6
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| IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B.
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| Qian Y, Commane M, Ninomiya-Tsuji J, Matsumoto K, Li X.
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| J Biol Chem 276(45):41661-7. 2001
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| 26 | IRAK1, MAP3K7
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| IRAK and TAK1 are required for IL-18-mediated signaling.
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| Wald D, Commane M, Stark GR, Li X.
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| Eur J Immunol 31(12):3747-54. 2001
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| 27 | IRAK1, MECP2, RTT
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| Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions.
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| Reichwald K, Thiesen J, Wiehe T, Weitzel J, Poustka WA, Rosenthal A, Platzer M, Stratling WH, Kioschis P.
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| Mamm Genome 11(3):182-90. 2000
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| 28 | IL1R1, IRAK1, TOLLIP
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| Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.
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| Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, Lewis A, Ray K, Tschopp J, Volpe F.
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| Nat Cell Biol 2(6):346-51. 2000
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| 29 | IRAK1, IRAK2, IRAK4
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| Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB.
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| Maschera B, Ray K, Burns K, Volpe F.
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| Biochem J 339 ( Pt 2):227-31. 1999
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| 30 | IL1R1, IRAK1, IRAK2
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| The IL1 receptor accessory protein is responsible for the recruitment of the interleukin-1 receptor associated kinase to the IL1/IL1 receptor I complex.
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| Volpe F, Clatworthy J, Kaptein A, Maschera B, Griffin AM, Ray K.
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| FEBS Lett 419(1):41-4. 1997
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| 31 | IRAK1
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| Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein.
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| Huang J, Gao X, Li S, Cao Z.
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| Proc Natl Acad Sci U S A 94(24):12829-32.PMID: 9371760 1997
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| 32 | IRAK1
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| IRAK : a kinase associated with the interleukin-1 receptor.
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| Cao Z, et al.
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| Science 271 : 1128-1131. 1996
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| 33 | IL1B, IRAK1, TRAF6
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| TRAF6 is a signal transducer for interleukin-1.
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| Cao Z, Xiong J, Takeuchi M, Kurama T, Goeddel DV.
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| Nature 383(6599):443-6 1996
|