| 1 | IDSSAH, IQSEC1, IQSEC2, IQSEC3, MRX1
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| Bi-allelic Variants in IQSEC1 Cause Intellectual Disability, Developmental Delay, and Short Stature.
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| Ansar M, Chung HL, Al-Otaibi A, Elagabani MN, Ravenscroft TA, Paracha SA, Scholz R, Abdel Magid T, Sarwar MT, Shah SF, Qaisar AA, Makrythanasis P, Marcogliese PC, Kamsteeg EJ, Falconnet E, Ranza E, Santoni FA, Aldhalaan H, Al-Asmari A, Faqeih EA, Ahmed J, Kornau HC, Bellen HJ, Antonarakis SE.
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| Am J Hum Genet 105(5):907-920. doi: 10.1016/j.ajhg.2019.09.013. Epub 2019 Oct 10.
2019
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| 2 | IQSEC1, IQSEC2, IQSEC3
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| Synaptic functions of the IQSEC family of ADP-ribosylation factor guanine nucleotide exchange factors.
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| Um JW.
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| Neurosci Res 116:54-59. doi: 10.1016/j.neures.2016.06.007. Epub 2016 Jun 28. Review.
2017
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| 3 | ARF6, IQSEC1
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| BRAG2a, a Guanine Nucleotide Exchange Factor for Arf6, Is a Component of the Dystrophin-Associated Glycoprotein Complex at the Photoreceptor Terminal.
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| Sakagami H, Katsumata O, Hara Y, Sasaoka T, Fukaya M.
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| Invest Ophthalmol Vis Sci 58(9):3795-3803. doi: 10.1167/iovs.17-21746.
2017
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| 4 | IQSEC1, IQSEC2
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| Subunit-selective N-Methyl-d-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation.
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| Elagabani MN, Briševac D, Kintscher M, Pohle J, Köhr G, Schmitz D, Kornau HC.
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| J Biol Chem 291(17):9105-18. doi: 10.1074/jbc.M115.691717. Epub 2016 Feb 16.
2016
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| 5 | MAP4K4, iQSEC1
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| Microtubules regulate focal adhesion dynamics through MAP4K4.
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| Yue J, Xie M, Gou X, Lee P, Schneider MD, Wu X.
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| Dev Cell 31(5):572-85. doi: 10.1016/j.devcel.2014.10.025.
2014
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| 6 | IQSEC1
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| Brag2 differentially regulates β1- and β3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis.
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| Manavski Y, Carmona G, Bennewitz K, Tang Z, Zhang F, Sakurai A, Zeiher AM, Gutkind JS, Li X, Kroll J, Dimmeler S, Chavakis E.
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| Basic Res Cardiol 109(2):404. doi: 10.1007/s00395-014-0404-2. Epub 2014 Feb 13.
2014
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| 7 | IQSEC1, IQSEC2, IQSEC3
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| Distinct synaptic localization patterns of brefeldin A-resistant guanine nucleotide exchange factors BRAG2 and BRAG3 in the mouse retina.
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| Sakagami H, Katsumata O, Hara Y, Tamaki H, Watanabe M, Harvey RJ, Fukaya M.
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| J Comp Neurol 521(4):860-76. doi: 10.1002/cne.23206.
2013
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| 8 | ARF4, ARF5, ARF6, IQSEC1
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| BRAG2/GEP100/IQSec1 interacts with clathrin and regulates α5β1 integrin endocytosis through activation of ADP ribosylation factor 5 (Arf5).
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| Moravec R, Conger KK, D'Souza R, Allison AB, Casanova JE.
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| J Biol Chem 287(37):31138-47. doi: 10.1074/jbc.M112.383117. Epub 2012 Jul 19.
2012
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| 9 | IQSEC1
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| Down-regulation of GEP100 causes increase in E-cadherin levels and inhibits pancreatic cancer cell invasion.
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| Xie CG, Wei SM, Chen JM, Xu XF, Cai JT, Chen QY, Jia LT.
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| PLoS One 7(5):e37854. doi: 10.1371/journal.pone.0037854. Epub 2012 May 25.
2012
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| 10 | IQSEC1
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| The pleckstrin homology (PH) domain of the Arf exchange factor Brag2 is an allosteric binding site.
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| Jian X, Gruschus JM, Sztul E, Randazzo PA.
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| J Biol Chem 287(29):24273-83. doi: 10.1074/jbc.M112.368084. Epub 2012 May 21.
2012
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| 11 | ARF6, ASAP1, IQSEC1
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| GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis.
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| Hashimoto A, Hashimoto S, Ando R, Noda K, Ogawa E, Kotani H, Hirose M, Menju T, Morishige M, Manabe T, Toda Y, Ishida S, Sabe H.
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| PLoS One 6(8):e23359. doi: 10.1371/journal.pone.0023359. Epub 2011 Aug 15.
2011
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| 12 | IQSEC1, SEMA3E
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| Phosphatidylinositol-4-phosphate 5-kinase and GEP100/Brag2 protein mediate antiangiogenic signaling by semaphorin 3E-plexin-D1 through Arf6 protein.
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| Sakurai A, Jian X, Lee CJ, Manavski Y, Chavakis E, Donaldson J, Randazzo PA, Gutkind JS.
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| J Biol Chem 286(39):34335-45. doi: 10.1074/jbc.M111.259499. Epub 2011 Jul 27.
2011
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| 13 | IQSEC1
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| The guanine nucleotide exchange protein for ADP-ribosylation factor 6, ARF-GEP100/BRAG2, regulates phagocytosis of monocytic phagocytes in an ARF6-dependent process.
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| Someya A, Moss J, Nagaoka I.
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| J Biol Chem 285(40):30698-707. doi: 10.1074/jbc.M110.107458. Epub 2010 Jul 2.
2010
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| 14 | ARF6, ASAP1, IQSEC1
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| The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis.
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| Sabe H, Hashimoto S, Morishige M, Ogawa E, Hashimoto A, Nam JM, Miura K, Yano H, Onodera Y.
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| Traffic 10(8):982-93. doi: 10.1111/j.1600-0854.2009.00917.x. Epub 2009 Apr 21. Review.
2009
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| 15 | IQSEC1, ARF6
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| GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion.
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| Morishige M, Hashimoto S, Ogawa E, Toda Y, Kotani H, Hirose M, Wei S, Hashimoto A, Yamada A, Yano H, Mazaki Y, Kodama H, Nio Y, Manabe T, Wada H, Kobayashi H, Sabe H.
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| Nat Cell Biol 10(1):85-92. Epub 2007 Dec 16. 2008
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| 16 | IQSEC1
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| GEP100/BRAG2: activator of ADP-ribosylation factor 6 for regulation of cell adhesion and actin cytoskeleton via E-cadherin and alpha-catenin.
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| Hiroi T, Someya A, Thompson W, Moss J, Vaughan M.
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| Proc Natl Acad Sci U S A 103(28):10672-7. Epub 2006 Jun 28. 2006
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