| 1 | BRD7, INSR
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| BRD7 improves glucose homeostasis independent of IRS proteins.
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| Kim Y, Lee JM, Han Y, Tao R, White MF, Liu R, Park SW.
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| J Endocrinol. Aug 14;258(3):e230119. doi: 10.1530/JOE-23-0119. 2023
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| 2 | BUB1B, INSR, MAD2L1BP
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| Mitotic Checkpoint Regulators Control Insulin Signaling and Metabolic Homeostasis.
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| Choi E, Zhang X, Xing C, Yu H.
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| Cell 166(3):567-581. doi: 10.1016/j.cell.2016.05.074. Epub 2016 Jun 30.
2016
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| 3 | INSR, SORL1
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| SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.
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| Schmidt V, Schulz N, Yan X, Schürmann A, Kempa S, Kern M, Blüher M, Poy MN, Olivecrona G, Willnow TE.
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| J Clin Invest. Jul 1;126(7):2706-20. doi: 10.1172/JCI84708. Epub 2016 Jun 20 2016
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| 4 | GLS, INSR, NCALD
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| Genes involved in muscle contractility and nutrient signaling pathways within celiac disease risk loci show differential mRNA expression.
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| Montén C, Gudjonsdottir AH, Browaldh L, Arnell H, Nilsson S, Agardh D, Naluai ÅT.
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| BMC Med Genet 16:44. doi: 10.1186/s12881-015-0190-1.
2015
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| 5 | INSR, IRS1
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| Fatty acylated caveolin-2 is a substrate of insulin receptor tyrosine kinase for insulin receptor substrate-1-directed signaling activation.
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| Kwon H, Lee J, Jeong K, Jang D, Pak Y.
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| Biochim Biophys Acta 1853(5):1022-34. doi: 10.1016/j.bbamcr.2015.02.002. Epub 2015 Feb 7.
2015
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| 6 | ATIC, HACD3, INSR
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| The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network.
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| Boutchueng-Djidjou M, Collard-Simard G, Fortier S, Hébert SS, Kelly I, Landry CR, Faure RL.
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| Mol Cell Proteomics 14(4):1079-92. doi: 10.1074/mcp.M114.047159. Epub 2015 Feb 16. 2015
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| 7 | GRB14, INSR
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| Phosphorylation of Grb14 BPS domain by GSK-3 correlates with complex forming of Grb14 and insulin receptor.
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| Taira J, Higashimoto Y.
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| J Biochem 155(6):353-60. doi: 10.1093/jb/mvu011.
2014
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| 8 | APPL1, INSR, IRS1, IRS2
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| APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor.
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| Ryu J, Galan AK, Xin X, Dong F, Abdul-Ghani MA, Zhou L, Wang C, Li C, Holmes BM, Sloane LB, Austad SN, Guo S, Musi N, DeFronzo RA, Deng C, White MF, Liu F, Dong LQ.
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| Cell Rep 7(4):1227-38. doi: 10.1016/j.celrep.2014.04.006. Epub 2014 May 10.
2014
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| 9 | FABP2, INSR
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| Single-nucleotide polymorphisms inside microRNA target sites influence the susceptibility to type 2 diabetes.
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| Zhao X, Ye Q, Xu K, Cheng J, Gao Y, Li Q, Du J, Shi H, Zhou L.
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| J Hum Genet 58(3):135-41. doi: 10.1038/jhg.2012.146. Epub 2013 Jan 10.
2013
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| 10 | INSR, LMBRD1
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| LMBD1 protein serves as a specific adaptor for insulin receptor internalization.
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| Tseng LT, Lin CL, Tzen KY, Chang SC, Chang MF.
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| J Biol Chem 288(45):32424-32. doi: 10.1074/jbc.M113.479527. Epub 2013 Sep 27.
2013
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| 11 | HMGA1, INSR, POU2F1, POU2F2
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| Transcriptional regulation of the HMGA1 gene by octamer-binding proteins Oct-1 and Oct-2.
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| Chiefari E, Arcidiacono B, Possidente K, Iiritano S, Ventura V, Pandolfo R, Brunetti FS, Greco M, Foti D, Brunetti A.
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| PLoS One 8(12):e83969. doi: 10.1371/journal.pone.0083969. eCollection 2013.
2013
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| 12 | INSR, MBNL1
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| Muscleblind-like 1 (Mbnl1) promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic enhancer.
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| Sen S, Talukdar I, Liu Y, Tam J, Reddy S, Webster NJ.
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| J Biol Chem 285(33):25426-37. Epub 2010 Jun 2. 2010
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| 13 | INSR
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| Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition.
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| Fulzele K, Riddle RC, DiGirolamo DJ, Cao X, Wan C, Chen D, Faugere MC, Aja S, Hussain MA, Brüning JC, Clemens TL.
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| Cell 142(2):309-19.PMID: 20655471 2010
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| 14 | IGF1R, INSR
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| Insulin receptor and IGF1R are not required for oocyte growth, differentiation, and maturation in mice.
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| Pitetti JL, Torre D, Conne B, Papaioannou MD, Cederroth CR, Xuan S, Kahn R, Parada LF, Vassalli JD, Efstratiadis A, Nef S.
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| Sex Dev 3(5):264-72. Epub 2009 Oct 23.PMID: 19851056 2009
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| 15 | CHN2, INSR
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| Severe insulin resistance and intrauterine growth deficiency associated with haploinsufficiency for INSR and CHN2: new insights into synergistic pathways involved in growth and metabolism.
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| Suliman SG, Stanik J, McCulloch LJ, Wilson N, Edghill EL, Misovicova N, Gasperikova D, Sandrikova V, Elliott KS, Barak L, Ellard S, Volpi EV, Klimes I, Gloyn AL.
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| Diabetes 58(12):2954-61. Epub 2009 Aug 31.PMID: 19720790 2009
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| 16 | INSR
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| The human insulin receptor mRNA contains a functional internal ribosome entry segment.
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| Spriggs KA, Cobbold LC, Ridley SH, Coldwell M, Bottley A, Bushell M, Willis AE, Siddle K.
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| Nucleic Acids Res 37(17):5881-93. Epub 2009 Aug 4.PMID: 19654240 2009
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| 17 | INSR
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| Insulin receptor signaling regulates actin cytoskeletal organization in developing photoreceptors.
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| Rajala RV, Rajala A, Brush RS, Rotstein NP, Politi LE.
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| J Neurochem 110(5):1648-60. Epub 2009 Jul 2.PMID: 19575708 2009
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| 18 | INSR, RMS
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| Two novel mutations in the insulin binding subunit of the insulin receptor gene without insulin binding impairment in a patient with Rabson-Mendenhall syndrome.
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| Thiel CT, Knebel B, Knerr I, Sticht H, Müller-Wieland D, Zenker M, Reis A, Dörr HG, Rauch A.
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| Mol Genet Metab 94(3):356-62. Epub 2008 Apr 14.
2008
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| 19 | INSR
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| Protein tyrosine phosphatase regulation in fibroblasts from patients with an insulin receptor gene mutation.
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| Seki N, Yagi S, Suzuki Y, Shimada F, Taira M, Makino H, Amano K, Yagui K, Saito Y, Hashimoto N.
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| Horm Metab Res 40(12):833-7. Epub 2008 Oct 16.PMID: 18925540 2008
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| 20 | INSR
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| N-linked glycans of the human insulin receptor and their distribution over the crystal structure.
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| Sparrow LG, Lawrence MC, Gorman JJ, Strike PM, Robinson CP, McKern NM, Ward CW.
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| Proteins 71(1):426-39.PMID: 17957771 2008
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| 21 | INSR, INSRDA
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| A clinical approach to severe insulin resistance.
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| Savage DB, Semple RK, Chatterjee VK, Wales JK, Ross RJ, O'Rahilly S.
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| Endocr Dev 11:122-32. Review.
2007
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| 22 | INSR
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| Insulin pathway related genes and risk of colorectal cancer: INSR promoter polymorphism shows a protective effect.
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| Pechlivanis S, Pardini B, Bermejo JL, Wagner K, Naccarati A, Vodickova L, Novotny J, Hemminki K, Vodicka P, Försti A.
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| Endocr Relat Cancer 14(3):733-40.PMID: 17914103 2007
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| 23 | INSR, INSRDA
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| Acanthosis Nigricans, insulin resistance (HOMA) and dyslipidemia among Native American children.
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| Copeland K, Pankratz K, Cathey V, Immohotichey P, Maddox J, Felton B, McIntosh R, Parker D, Burgin C, Blackett P.
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| J Okla State Med Assoc 99(1):19-24.
2006
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| 24 | HMGA1, INSR
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| Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice.
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| Foti D, Chiefari E, Fedele M, Iuliano R, Brunetti L, Paonessa F, Manfioletti G, Barbetti F, Brunetti A, Croce CM, Fusco A, Brunetti A.
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| Nat Med 11(7):765-773. Epub 2005 May 29. 2005
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| 25 | DM1, DM2, INSR
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| Insulin receptor splicing alteration in myotonic dystrophy type 2.
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| Savkur RS, Philips AV, Cooper TA, Dalton JC, Moseley ML, Ranum LP, Day JW.
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| Am J Hum Genet 74(6):1309-13. Epub 2004 Apr 26. 2004
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| 26 | HHF5, INSR
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| A novel syndrome of autosomal-dominant hyperinsulinemic hypoglycemia linked to a mutation in the human insulin receptor gene.
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| Hojlund K, Hansen T, Lajer M, Henriksen JE, Levin K, Lindholm J, Pedersen O, Beck-Nielsen H.
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| Diabetes 53(6):1592-8. 2004
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| 27 | INSR, INSRDA
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| Acanthosis nigricans associated with insulin resistance : pathophysiology and management.
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| Hermanns-Lê T, Scheen A, Piérard GE.
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| Am J Clin Dermatol 5(3):199-203. Review.
2004
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| 28 | INSR, INSRDA
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| Prevalence of mutations in the insulin receptor gene in subjects with features of the type A syndrome of insulin resistance.
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| Moller DE, Cohen O, Yamaguchi Y, Assiz R, Grigorescu F, Eberle A, Morrow LA, Moses AC, Flier JS.
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| Diabetes 43(2):247-55.
1994
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| 29 | INSR
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| The functions of the human insulin receptor are affected in different ways by mutation of each of the four N-glycosylation sites in the beta subunit.
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| Leconte I, Carpentier JL, Clauser E.
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| J Biol Chem 269(27):18062-71.PMID: 8027066 1994
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| 30 | INSR
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| Five mutant alleles of the insulin receptor gene in patients with genetic forms of insulin resistance.
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| Kadowaki T, et al.
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| J Clin Invest 86 : 254-264. 1990
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| 31 | INSR, RMS
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| Substitution of lysine for asparagine at position 15 in the alpha-subunit of the human insulin receptor. A mutation that impairs transport of receptors to the cell surface and decreases the affinity of insulin binding.
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| Kadowaki T, Kadowaki H, Accili D, Taylor SI.
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| J Biol Chem 265(31):19143-50.
1990
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| 32 | INSR
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| Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes.
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| Ullrich A, Bell JR, Chen EY, Herrera R, Petruzzelli LM, Dull TJ, Gray A,Coussens L, Liao YC, Tsubokawa M, et al.
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| Nature 313(6005):756-61. 1985
|