| 1 | DHCR7, INSIG2, iNSIG1
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| Disruption of Dhcr7 and Insig1/2 in cholesterol metabolism causes defects in bone formation and homeostasis through primary cilium formation.
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| Suzuki A, Ogata K, Yoshioka H, Shim J, Wassif CA, Porter FD, Iwata J.
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| Bone Res 8:1. doi: 10.1038/s41413-019-0078-3. eCollection 2020.
2020
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| 2 | INSIG1, INSIG2, PCK1
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| The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.
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| Xu D, Wang Z, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee JH, Du L, Zheng Y, Lv G, Leu JS, Wang H, Xing D, Liang T, Hung MC, Lu Z.
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| Nature Apr;580(7804):530-535. doi: 10.1038/s41586-020-2183-2. Epub 2020 Apr 8 2020
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| 3 | INSIG1, INSIG2, SREBF2
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| Insig proteins mediate feedback inhibition of cholesterol synthesis in the intestine.
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| McFarlane MR, Liang G, Engelking LJ.
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| J Biol Chem 289(4):2148-56. doi: 10.1074/jbc.M113.524041. Epub 2013 Dec 11. 2014
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| 4 | INSIG2
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| INSIG2 variants, dietary patterns and metabolic risk in Samoa.
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| Baylin A, Deka R, Tuitele J, Viali S, Weeks DE, McGarvey ST.
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| Eur J Clin Nutr 67(1):101-7. doi: 10.1038/ejcn.2012.124. Epub 2012 Sep 12.
2013
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| 5 | AMFR, INSIG1, INSIG2, RNF139
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| Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.
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| Jo Y, Lee PC, Sguigna PV, DeBose-Boyd RA.
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| Proc Natl Acad Sci U S A 108(51):20503-8. doi: 10.1073/pnas.1112831108. Epub 2011 Dec 5.
2011
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| 6 | INSIG2
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| Characterization of the human insulin-induced gene 2 (INSIG2) promoter: the role of Ets-binding motifs.
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| Fernández-Alvarez A, Soledad Alvarez M, Cucarella C, Casado M.
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| J Biol Chem 285(16):11765-74. Epub 2010 Feb 9.PMID: 20145255 2010
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| 7 | GLI2, INHBB, INSIG2, SHFLD3
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| Characterization of two ectrodactyly-associated translocation breakpoints separated by 2.5 Mb on chromosome 2q14.1-q14.2.
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| David D, Marques B, Ferreira C, Vieira P, Corona-Rivera A, Ferreira JC, van Bokhoven H.
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| Eur J Hum Genet 17(8):1024-33. Epub 2009 Feb 18.
2009
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| 8 | INSIG1, INSIG2
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| Silibinin attenuates adipogenesis in 3T3-L1 preadipocytes through a potential upregulation of the insig pathway.
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| Ka SO, Kim KA, Kwon KB, Park JW, Park BH.
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| Int J Mol Med 23(5):633-7.
2009
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| 9 | INSIG2
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| INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese.
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| Hotta K, Nakamura M, Nakata Y, Matsuo T, Kamohara S, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Miyazaki S, Tokunaga K, Kawamoto M, Funahashi T, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Tanaka K, Kamatani N, Nakamura Y.
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| J Hum Genet 53(9):857-62. Epub 2008 Jul 10.
2008
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| 10 | INSIG2
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| Insig2 is associated with colon tumorigenesis and inhibits Bax-mediated apoptosis.
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| Li CG, Gruidl M, Eschrich S, McCarthy S, Wang HG, Alexandrow MG, Yeatman TJ.
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| Int J Cancer 123(2):273-82. 2008
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| 11 | INSIG2
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| Insulin-induced gene 2 involvement in human adipocyte metabolism and body weight regulation.
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| Krapivner S, Popov S, Chernogubova E, HellŽnius ML, Fisher RM, Hamsten A, van't Hooft FM.
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| J Clin Endocrinol Metab 93(5):1995-2001. Epub 2008 Mar 4. 2008
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| 12 | INSIG2, PFKP
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| Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes.
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| Andreasen CH, Mogensen MS, Borch-Johnsen K, Sandbaek A, Lauritzen T, Sørensen TI, Hansen L, Almind K, Jørgensen T, Pedersen O, Hansen T.
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| PLoS One 3(8):e2872.
2008
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| 13 | INSIG2
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| Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.
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| Yabe D, Brown MS, Goldstein JL.
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| Proc Natl Acad Sci U S A 99(20):12753-8. 2002
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