| 1 | INSIG1, SREBF1
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| Sterol regulatory element binding protein-1 (SREBP1) activation in motor neurons in excitotoxicity and amyotrophic lateral sclerosis (ALS): Indip, a potential therapeutic peptide.
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| Taghibiglou C, Lu J, Mackenzie IR, Wang YT, Cashman NR.
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| Biochem Biophys Res Commun 413(2):159-63. Epub 2011 Aug 19.
2011
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| 2 | INSIG1, SREBF1
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| Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c.
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| Chen K, Jin P, He HH, Xie YH, Xie XY, Mo ZH.
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| J Biomed Sci 18:57.
2011
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| 3 | INSIG1, INSIG2
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| Silibinin attenuates adipogenesis in 3T3-L1 preadipocytes through a potential upregulation of the insig pathway.
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| Ka SO, Kim KA, Kwon KB, Park JW, Park BH.
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| Int J Mol Med 23(5):633-7.
2009
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| 4 | INSIG1
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| The INSIG1 gene, not the INSIG2 gene, associated with coronary heart disease: tagSNPs and haplotype-based association study. The Beijing Atherosclerosis Study.
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| Liu X, Li Y, Wang L, Zhao Q, Lu X, Huang J, Fan Z, Gu D.
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| Thromb Haemost 100(5):886-92.
2008
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| 5 | INSIG1
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| Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step.
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| Lee JN, Zhang X, Feramisco JD, Gong Y, Ye J.
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| J Biol Chem 283(48):33772-83. Epub 2008 Oct 3.
2008
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| 6 | INSIG1
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| Human evidence for the involvement of insulin-induced gene 1 in the regulation of plasma glucose concentration.
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| Krapivner S, Chernogubova E, Ericsson M, Ahlbeck-Glader C, Hamsten A, van 't Hooft FM.
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| Diabetologia 50(1):94-102. Epub 2006 Nov 15.
2007
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| 7 | TFE3, IRS2, HK2, INSIG1
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| TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes.
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| Nakagawa Y, Shimano H, Yoshikawa T, Ide T, Tamura M, Furusawa M, Yamamoto T, Inoue N, Matsuzaka T, Takahashi A, Hasty AH, Suzuki H, Sone H, Toyoshima H, Yahagi N, Yamada N.
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| Nat Med 12(1):107-13. Epub 2005 Dec 4. 2006
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| 8 | INSIG1, SCAP
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| Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78.
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| Lee JN, Song B, DeBose-Boyd RA, Ye J.
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| J Biol Chem 281(51):39308-15. Epub 2006 Oct 16.PMID: 17043353 2006
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| 9 | AMFR,INSIG1
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| Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase.
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| Song BL, Sever N, DeBose-Boyd RA.
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| Mol Cell 19(6):829-40. 2005
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| 10 | INSIG1, SCAP
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| Membrane topology of human insig-1, a protein regulator of lipid synthesis.
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| Feramisco JD, Goldstein JL, Brown MS.
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| J Biol Chem 279(9):8487-96. Epub 2003 Dec 5. 2004
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| 11 | INSIG1
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| Cloning, human chromosomal assignment, and adipose and hepatic expression of the CL-6/INSIG1 gene.
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| Peng Y, Schwarz EJ, Lazar MA, Genin A, Spinner NB, Taub R.
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| Genomics 43(3):278-84. 1997
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| 12 | GPC3, INSIG1, SRSF5
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| Novel delayed-early and highly insulin-induced growth response genes. Identification of HRS, a potential regulator of alternative pre-mRNA splicing.
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| Diamond RH, et al.
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| J Biol Chem 268(20):15185-92 1993
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