Citations for
1AMFR, CISD2, INSIG1
The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING.
Wang Q, Liu X, Cui Y, Tang Y, Chen W, Li S, Yu H, Pan Y, Wang C.
Immunity 41(6):919-33. doi: 10.1016/j.immuni.2014.11.011. Epub 2014 Nov 28. 2014
2INSIG1, INSIG2, SREBF2
Insig proteins mediate feedback inhibition of cholesterol synthesis in the intestine.
McFarlane MR, Liang G, Engelking LJ.
J Biol Chem 289(4):2148-56. doi: 10.1074/jbc.M113.524041. Epub 2013 Dec 11. 2014
3AMFR, INSIG1, RNF139
Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system.
Tsai YC, Leichner GS, Pearce MM, Wilson GL, Wojcikiewicz RJ, Roitelman J, Weissman AM.
Mol Biol Cell 23(23):4484-94. doi: 10.1091/mbc.E12-08-0631. Epub 2012 Oct 19. 2012
4INSIG1, SREBF1
Sterol regulatory element binding protein-1 (SREBP1) activation in motor neurons in excitotoxicity and amyotrophic lateral sclerosis (ALS): Indip, a potential therapeutic peptide.
Taghibiglou C, Lu J, Mackenzie IR, Wang YT, Cashman NR.
Biochem Biophys Res Commun 413(2):159-63. Epub 2011 Aug 19. 2011
5INSIG1, SREBF1
Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c.
Chen K, Jin P, He HH, Xie YH, Xie XY, Mo ZH.
J Biomed Sci 18:57. 2011
6AMFR, INSIG1, INSIG2, RNF139
Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.
Jo Y, Lee PC, Sguigna PV, DeBose-Boyd RA.
Proc Natl Acad Sci U S A 108(51):20503-8. doi: 10.1073/pnas.1112831108. Epub 2011 Dec 5. 2011
7INSIG1, INSIG2
Silibinin attenuates adipogenesis in 3T3-L1 preadipocytes through a potential upregulation of the insig pathway.
Ka SO, Kim KA, Kwon KB, Park JW, Park BH.
Int J Mol Med 23(5):633-7. 2009
8INSIG1
The INSIG1 gene, not the INSIG2 gene, associated with coronary heart disease: tagSNPs and haplotype-based association study. The Beijing Atherosclerosis Study.
Liu X, Li Y, Wang L, Zhao Q, Lu X, Huang J, Fan Z, Gu D.
Thromb Haemost 100(5):886-92. 2008
9INSIG1
Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step.
Lee JN, Zhang X, Feramisco JD, Gong Y, Ye J.
J Biol Chem 283(48):33772-83. Epub 2008 Oct 3. 2008
10INSIG1
Human evidence for the involvement of insulin-induced gene 1 in the regulation of plasma glucose concentration.
Krapivner S, Chernogubova E, Ericsson M, Ahlbeck-Glader C, Hamsten A, van 't Hooft FM.
Diabetologia 50(1):94-102. Epub 2006 Nov 15. 2007
11TFE3, IRS2, HK2, INSIG1
TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes.
Nakagawa Y, Shimano H, Yoshikawa T, Ide T, Tamura M, Furusawa M, Yamamoto T, Inoue N, Matsuzaka T, Takahashi A, Hasty AH, Suzuki H, Sone H, Toyoshima H, Yahagi N, Yamada N.
Nat Med 12(1):107-13. Epub 2005 Dec 4. 2006
12INSIG1, SCAP
Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78.
Lee JN, Song B, DeBose-Boyd RA, Ye J.
J Biol Chem 281(51):39308-15. Epub 2006 Oct 16.PMID: 17043353 2006
13AMFR,INSIG1
Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase.
Song BL, Sever N, DeBose-Boyd RA.
Mol Cell 19(6):829-40. 2005
14INSIG1, SCAP
Membrane topology of human insig-1, a protein regulator of lipid synthesis.
Feramisco JD, Goldstein JL, Brown MS.
J Biol Chem 279(9):8487-96. Epub 2003 Dec 5. 2004
15INSIG1
Cloning, human chromosomal assignment, and adipose and hepatic expression of the CL-6/INSIG1 gene.
Peng Y, Schwarz EJ, Lazar MA, Genin A, Spinner NB, Taub R.
Genomics 43(3):278-84. 1997
16GPC3, INSIG1, SRSF5
Novel delayed-early and highly insulin-induced growth response genes. Identification of HRS, a potential regulator of alternative pre-mRNA splicing.
Diamond RH, et al.
J Biol Chem 268(20):15185-92 1993