| 1 | DHCR7, INSIG2, iNSIG1
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| Disruption of Dhcr7 and Insig1/2 in cholesterol metabolism causes defects in bone formation and homeostasis through primary cilium formation.
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| Suzuki A, Ogata K, Yoshioka H, Shim J, Wassif CA, Porter FD, Iwata J.
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| Bone Res 8:1. doi: 10.1038/s41413-019-0078-3. eCollection 2020.
2020
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| 2 | INSIG1, INSIG2, PCK1
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| The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.
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| Xu D, Wang Z, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee JH, Du L, Zheng Y, Lv G, Leu JS, Wang H, Xing D, Liang T, Hung MC, Lu Z.
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| Nature Apr;580(7804):530-535. doi: 10.1038/s41586-020-2183-2. Epub 2020 Apr 8 2020
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| 3 | AMFR, INSIG1, STING1
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| The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING.
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| Wang Q, Liu X, Cui Y, Tang Y, Chen W, Li S, Yu H, Pan Y, Wang C.
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| Immunity 41(6):919-33. doi: 10.1016/j.immuni.2014.11.011. Epub 2014 Nov 28. 2014
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| 4 | INSIG1, INSIG2, SREBF2
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| Insig proteins mediate feedback inhibition of cholesterol synthesis in the intestine.
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| McFarlane MR, Liang G, Engelking LJ.
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| J Biol Chem 289(4):2148-56. doi: 10.1074/jbc.M113.524041. Epub 2013 Dec 11. 2014
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| 5 | AMFR, HMGCR, INSIG1, RNF139
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| Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system.
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| Tsai YC, Leichner GS, Pearce MM, Wilson GL, Wojcikiewicz RJ, Roitelman J, Weissman AM.
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| Mol Biol Cell 23(23):4484-94. doi: 10.1091/mbc.E12-08-0631. Epub 2012 Oct 19. 2012
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| 6 | INSIG1, SREBF1
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| Sterol regulatory element binding protein-1 (SREBP1) activation in motor neurons in excitotoxicity and amyotrophic lateral sclerosis (ALS): Indip, a potential therapeutic peptide.
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| Taghibiglou C, Lu J, Mackenzie IR, Wang YT, Cashman NR.
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| Biochem Biophys Res Commun 413(2):159-63. Epub 2011 Aug 19.
2011
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| 7 | INSIG1, SREBF1
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| Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c.
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| Chen K, Jin P, He HH, Xie YH, Xie XY, Mo ZH.
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| J Biomed Sci 18:57.
2011
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| 8 | AMFR, INSIG1, INSIG2, RNF139
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| Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.
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| Jo Y, Lee PC, Sguigna PV, DeBose-Boyd RA.
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| Proc Natl Acad Sci U S A 108(51):20503-8. doi: 10.1073/pnas.1112831108. Epub 2011 Dec 5.
2011
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| 9 | INSIG1, INSIG2
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| Silibinin attenuates adipogenesis in 3T3-L1 preadipocytes through a potential upregulation of the insig pathway.
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| Ka SO, Kim KA, Kwon KB, Park JW, Park BH.
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| Int J Mol Med 23(5):633-7.
2009
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| 10 | INSIG1
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| The INSIG1 gene, not the INSIG2 gene, associated with coronary heart disease: tagSNPs and haplotype-based association study. The Beijing Atherosclerosis Study.
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| Liu X, Li Y, Wang L, Zhao Q, Lu X, Huang J, Fan Z, Gu D.
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| Thromb Haemost 100(5):886-92.
2008
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| 11 | INSIG1
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| Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step.
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| Lee JN, Zhang X, Feramisco JD, Gong Y, Ye J.
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| J Biol Chem 283(48):33772-83. Epub 2008 Oct 3.
2008
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| 12 | INSIG1
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| Human evidence for the involvement of insulin-induced gene 1 in the regulation of plasma glucose concentration.
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| Krapivner S, Chernogubova E, Ericsson M, Ahlbeck-Glader C, Hamsten A, van 't Hooft FM.
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| Diabetologia 50(1):94-102. Epub 2006 Nov 15.
2007
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| 13 | TFE3, IRS2, HK2, INSIG1
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| TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes.
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| Nakagawa Y, Shimano H, Yoshikawa T, Ide T, Tamura M, Furusawa M, Yamamoto T, Inoue N, Matsuzaka T, Takahashi A, Hasty AH, Suzuki H, Sone H, Toyoshima H, Yahagi N, Yamada N.
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| Nat Med 12(1):107-13. Epub 2005 Dec 4. 2006
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| 14 | INSIG1, SCAP
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| Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78.
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| Lee JN, Song B, DeBose-Boyd RA, Ye J.
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| J Biol Chem 281(51):39308-15. Epub 2006 Oct 16.PMID: 17043353 2006
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| 15 | AMFR,INSIG1
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| Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase.
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| Song BL, Sever N, DeBose-Boyd RA.
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| Mol Cell 19(6):829-40. 2005
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| 16 | INSIG1, SCAP
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| Membrane topology of human insig-1, a protein regulator of lipid synthesis.
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| Feramisco JD, Goldstein JL, Brown MS.
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| J Biol Chem 279(9):8487-96. Epub 2003 Dec 5. 2004
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| 17 | INSIG1
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| Cloning, human chromosomal assignment, and adipose and hepatic expression of the CL-6/INSIG1 gene.
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| Peng Y, Schwarz EJ, Lazar MA, Genin A, Spinner NB, Taub R.
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| Genomics 43(3):278-84. 1997
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| 18 | GPC3, INSIG1, SRSF5
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| Novel delayed-early and highly insulin-induced growth response genes. Identification of HRS, a potential regulator of alternative pre-mRNA splicing.
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| Diamond RH, et al.
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| J Biol Chem 268(20):15185-92 1993
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