Citations for
1CHCHD3, IMMT, SAMM50
Sub-mitochondrial localization of the genetic-tagged mitochondrial intermembrane space-bridging components Mic19, Mic60 and Sam50.
Sastri M, Darshi M, Mackey M, Ramachandra R, Ju S, Phan S, Adams S, Stein K, Douglas CR, Kim JJ, Ellisman MH, Taylor SS, Perkins GA.
J Cell Sci 2017
2IMMT, PINK1, PRKACA, PRKN
PKA Regulates PINK1 Stability and Parkin Recruitment to Damaged Mitochondria through Phosphorylation of MIC60.
Akabane S, Uno M, Tani N, Shimazaki S, Ebara N, Kato H, Kosako H, Oka T.
Mol Cell 62(3):371-384. doi: 10.1016/j.molcel.2016.03.037. 2016
3CHCHD3, IMMT, YME1L1
Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.
Li H, Ruan Y, Zhang K, Jian F, Hu C, Miao L, Gong L, Sun L, Zhang X, Chen S, Chen H, Liu D, Song Z.
Cell Death Differ 23(3):380-92. doi: 10.1038/cdd.2015.102. Epub 2015 Aug 7. 2016
4CHCHD6, IMMT, SAMM50
Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure.
Ding C, Wu Z, Huang L, Wang Y, Xue J, Chen S, Deng Z, Wang L, Song Z, Chen S.
Sci Rep 5:16064. doi: 10.1038/srep16064. 2015
5IMMT, TFAM, TFB2M
Suppression of Mic60 compromises mitochondrial transcription and oxidative phosphorylation.
Yang RF, Sun LH, Zhang R, Zhang Y, Luo YX, Zheng W, Zhang ZQ, Chen HZ, Liu DP.
Sci Rep 5:7990. doi: 10.1038/srep07990. 2015
6CHCHD3, IMMT, SAMM50
Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits.
Ott C, Dorsch E, Fraunholz M, Straub S, Kozjak-Pavlovic V.
PLoS One 10(3):e0120213. doi: 10.1371/journal.pone.0120213. eCollection 2015. 2015
7HMN6B, IMMT, SLC25A46
Mutations in SLC25A46, encoding a UGO1-like protein, cause an optic atrophy spectrum disorder
Abrams AJ, Hufnagel RB, Rebelo A, Zanna C, Patel N, Gonzalez MA, Campeanu IJ, Griffin LB, Groenewald S, Strickland AV, Tao F, Speziani F, Abreu L, Schüle R, Caporali L, La Morgia C, Maresca A, Liguori R, Lodi R, Ahmed ZM, Sund KL, Wang X, Krueger LA, Peng Y, Prada CE, Prows CA, Schorry EK, Antonellis A, Zimmerman HH, Abdul-Rahman OA, Yang Y, Downes SM, Prince J, Fontanesi F, Barrientos A, Németh AH, Carelli V, Huang T, Zuchner S, Dallman JE.
Nat Genet. Aug;47(8):926-32. doi: 10.1038/ng.3354. Epub 2015 Jul 13. 2015
8IMMT
Overexpression of mitofilin in the mouse heart promotes cardiac hypertrophy in response to hypertrophic stimuli.
Zhang Y, Xu J, Luo YX, An XZ, Zhang R, Liu G, Li H, Chen HZ, Liu DP.
Antioxid Redox Signal 21(12):1693-707. doi: 10.1089/ars.2013.5438. Epub 2014 May 2. 2014
9APOOL, IMMT, MINOS1, SAMM50
APOOL is a cardiolipin-binding constituent of the Mitofilin/MINOS protein complex determining cristae morphology in mammalian mitochondria.
Weber TA, Koob S, Heide H, Wittig I, Head B, van der Bliek A, Brandt U, Mittelbronn M, Reichert AS.
PLoS One 8(5):e63683. doi: 10.1371/journal.pone.0063683. Print 2013. 2013
10CHCHD3, IMMT, MINOS1
STED super-resolution microscopy reveals an array of MINOS clusters along human mitochondria.
Jans DC, Wurm CA, Riedel D, Wenzel D, Stagge F, Deckers M, Rehling P, Jakobs S.
Proc Natl Acad Sci U S A 110(22):8936-41. doi: 10.1073/pnas.1301820110. Epub 2013 May 15. 2013
11IMMT, MINOS1, SAMM50, TOMM40
Role of mitochondrial inner membrane organizing system in protein biogenesis of the mitochondrial outer membrane.
Bohnert M, Wenz LS, Zerbes RM, Horvath SE, Stroud DA, von der Malsburg K, Müller JM, Oeljeklaus S, Perschil I, Warscheid B, Chacinska A, Veenhuis M, van der Klei IJ, Daum G, Wiedemann N, Becker T, Pfanner N, van der Laan M.
Mol Biol Cell 23(20):3948-56. doi: 10.1091/mbc.E12-04-0295. Epub 2012 Aug 23. 2012
12IMMT
Mitofilin regulates cytochrome c release during apoptosis by controlling mitochondrial cristae remodeling.
Yang RF, Zhao GW, Liang ST, Zhang Y, Sun LH, Chen HZ, Liu DP.
Biochem Biophys Res Commun 428(1):93-8. doi: 10.1016/j.bbrc.2012.10.012. Epub 2012 Oct 8. 2012
13CHCHD6, IMMT
CHCM1/CHCHD6, novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology.
An J, Shi J, He Q, Lui K, Liu Y, Huang Y, Sheikh MS.
J Biol Chem 287(10):7411-26. doi: 10.1074/jbc.M111.277103. Epub 2012 Jan 6. 2012
14DISC1, IMMT
Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin.
Park YU, Jeong J, Lee H, Mun JY, Kim JH, Lee JS, Nguyen MD, Han SS, Suh PG, Park SK.
Proc Natl Acad Sci U S A 107(41):17785-90. Epub 2010 Sep 28. 2010
15IMMT
Caenorhabditis elegans mitofilin homologs control the morphology of mitochondrial cristae and influence reproduction and physiology.
Mun JY, Lee TH, Kim JH, Yoo BH, Bahk YY, Koo HS, Han SS.
J Cell Physiol 224(3):748-56. 2010
16IMMT, PARP1
Mitochondrial localization of PARP-1 requires interaction with mitofilin and is involved in the maintenance of mitochondrial DNA integrity.
Rossi MN, Carbone M, Mostocotto C, Mancone C, Tripodi M, Maione R, Amati P.
J Biol Chem 284(46):31616-24. Epub 2009 Sep 17. 2009
17IMMT, PINK1
Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking.
Weihofen A, Thomas KJ, Ostaszewski BL, Cookson MR, Selkoe DJ.
Biochemistry 48(9):2045-52. 2009
18CHCHD6, DNAJC11, CHCHD3, SAMM50, IMMT, MTX1, MTX2
The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11.
Xie J, Marusich MF, Souda P, Whitelegge J, Capaldi RA.
FEBS Lett 581(18):3545-9. Epub 2007 Jun 27. 2007
19IMMT
The mitochondrial inner membrane protein mitofilin controls cristae morphology.
John GB, Shang Y, Li L, Renken C, Mannella CA, Selker JM, Rangell L, Bennett MJ, Zha J.
Mol Biol Cell 16(3):1543-54. Epub 2005 Jan 12. 2005
20IMMT
Mitofilin is a transmembrane protein of the inner mitochondrial membrane expressed as two isoforms.
Gieffers C, Korioth F, Heimann P, Ungermann C, Frey J.
Exp Cell Res 232(2):395-9. 1997
21IMMT
A novel human gene that is preferentially transcribed in heart muscle.
Icho T, Ikeda T, Matsumoto Y, Hanaoka F, Kaji K, Tsuchida N.
Gene 144(2):301-6. 1994