1 | CHCHD3, IMMT, SAMM50
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| Sub-mitochondrial localization of the genetic-tagged mitochondrial intermembrane space-bridging components Mic19, Mic60 and Sam50.
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| Sastri M, Darshi M, Mackey M, Ramachandra R, Ju S, Phan S, Adams S, Stein K, Douglas CR, Kim JJ, Ellisman MH, Taylor SS, Perkins GA.
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| J Cell Sci 2017
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2 | IMMT, PINK1, PRKACA, PRKN
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| PKA Regulates PINK1 Stability and Parkin Recruitment to Damaged Mitochondria through Phosphorylation of MIC60.
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| Akabane S, Uno M, Tani N, Shimazaki S, Ebara N, Kato H, Kosako H, Oka T.
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| Mol Cell 62(3):371-384. doi: 10.1016/j.molcel.2016.03.037.
2016
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3 | CHCHD3, IMMT, YME1L1
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| Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.
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| Li H, Ruan Y, Zhang K, Jian F, Hu C, Miao L, Gong L, Sun L, Zhang X, Chen S, Chen H, Liu D, Song Z.
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| Cell Death Differ 23(3):380-92. doi: 10.1038/cdd.2015.102. Epub 2015 Aug 7.
2016
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4 | CHCHD6, IMMT, SAMM50
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| Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure.
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| Ding C, Wu Z, Huang L, Wang Y, Xue J, Chen S, Deng Z, Wang L, Song Z, Chen S.
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| Sci Rep 5:16064. doi: 10.1038/srep16064.
2015
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5 | IMMT, TFAM, TFB2M
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| Suppression of Mic60 compromises mitochondrial transcription and oxidative phosphorylation.
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| Yang RF, Sun LH, Zhang R, Zhang Y, Luo YX, Zheng W, Zhang ZQ, Chen HZ, Liu DP.
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| Sci Rep 5:7990. doi: 10.1038/srep07990.
2015
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6 | CHCHD3, IMMT, SAMM50
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| Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits.
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| Ott C, Dorsch E, Fraunholz M, Straub S, Kozjak-Pavlovic V.
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| PLoS One 10(3):e0120213. doi: 10.1371/journal.pone.0120213. eCollection 2015.
2015
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7 | HMN6B, IMMT, SLC25A46
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| Mutations in SLC25A46, encoding a UGO1-like protein, cause an optic atrophy spectrum disorder
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| Abrams AJ, Hufnagel RB, Rebelo A, Zanna C, Patel N, Gonzalez MA, Campeanu IJ, Griffin LB, Groenewald S, Strickland AV, Tao F, Speziani F, Abreu L, Schüle R, Caporali L, La Morgia C, Maresca A, Liguori R, Lodi R, Ahmed ZM, Sund KL, Wang X, Krueger LA, Peng Y, Prada CE, Prows CA, Schorry EK, Antonellis A, Zimmerman HH, Abdul-Rahman OA, Yang Y, Downes SM, Prince J, Fontanesi F, Barrientos A, Németh AH, Carelli V, Huang T, Zuchner S, Dallman JE.
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| Nat Genet. Aug;47(8):926-32. doi: 10.1038/ng.3354. Epub 2015 Jul 13. 2015
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8 | IMMT
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| Overexpression of mitofilin in the mouse heart promotes cardiac hypertrophy in response to hypertrophic stimuli.
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| Zhang Y, Xu J, Luo YX, An XZ, Zhang R, Liu G, Li H, Chen HZ, Liu DP.
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| Antioxid Redox Signal 21(12):1693-707. doi: 10.1089/ars.2013.5438. Epub 2014 May 2.
2014
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9 | APOOL, IMMT, MINOS1, SAMM50
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| APOOL is a cardiolipin-binding constituent of the Mitofilin/MINOS protein complex determining cristae morphology in mammalian mitochondria.
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| Weber TA, Koob S, Heide H, Wittig I, Head B, van der Bliek A, Brandt U, Mittelbronn M, Reichert AS.
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| PLoS One 8(5):e63683. doi: 10.1371/journal.pone.0063683. Print 2013.
2013
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10 | CHCHD3, IMMT, MINOS1
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| STED super-resolution microscopy reveals an array of MINOS clusters along human mitochondria.
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| Jans DC, Wurm CA, Riedel D, Wenzel D, Stagge F, Deckers M, Rehling P, Jakobs S.
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| Proc Natl Acad Sci U S A 110(22):8936-41. doi: 10.1073/pnas.1301820110. Epub 2013 May 15.
2013
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11 | IMMT, MINOS1, SAMM50, TOMM40
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| Role of mitochondrial inner membrane organizing system in protein biogenesis of the mitochondrial outer membrane.
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| Bohnert M, Wenz LS, Zerbes RM, Horvath SE, Stroud DA, von der Malsburg K, Müller JM, Oeljeklaus S, Perschil I, Warscheid B, Chacinska A, Veenhuis M, van der Klei IJ, Daum G, Wiedemann N, Becker T, Pfanner N, van der Laan M.
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| Mol Biol Cell 23(20):3948-56. doi: 10.1091/mbc.E12-04-0295. Epub 2012 Aug 23.
2012
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12 | IMMT
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| Mitofilin regulates cytochrome c release during apoptosis by controlling mitochondrial cristae remodeling.
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| Yang RF, Zhao GW, Liang ST, Zhang Y, Sun LH, Chen HZ, Liu DP.
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| Biochem Biophys Res Commun 428(1):93-8. doi: 10.1016/j.bbrc.2012.10.012. Epub 2012 Oct 8.
2012
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13 | CHCHD6, IMMT
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| CHCM1/CHCHD6, novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology.
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| An J, Shi J, He Q, Lui K, Liu Y, Huang Y, Sheikh MS.
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| J Biol Chem 287(10):7411-26. doi: 10.1074/jbc.M111.277103. Epub 2012 Jan 6.
2012
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14 | DISC1, IMMT
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| Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin.
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| Park YU, Jeong J, Lee H, Mun JY, Kim JH, Lee JS, Nguyen MD, Han SS, Suh PG, Park SK.
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| Proc Natl Acad Sci U S A 107(41):17785-90. Epub 2010 Sep 28. 2010
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15 | IMMT
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| Caenorhabditis elegans mitofilin homologs control the morphology of mitochondrial cristae and influence reproduction and physiology.
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| Mun JY, Lee TH, Kim JH, Yoo BH, Bahk YY, Koo HS, Han SS.
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| J Cell Physiol 224(3):748-56.
2010
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16 | IMMT, PARP1
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| Mitochondrial localization of PARP-1 requires interaction with mitofilin and is involved in the maintenance of mitochondrial DNA integrity.
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| Rossi MN, Carbone M, Mostocotto C, Mancone C, Tripodi M, Maione R, Amati P.
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| J Biol Chem 284(46):31616-24. Epub 2009 Sep 17.
2009
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17 | IMMT, PINK1
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| Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking.
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| Weihofen A, Thomas KJ, Ostaszewski BL, Cookson MR, Selkoe DJ.
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| Biochemistry 48(9):2045-52.
2009
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18 | CHCHD6, DNAJC11, CHCHD3, SAMM50, IMMT, MTX1, MTX2
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| The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11.
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| Xie J, Marusich MF, Souda P, Whitelegge J, Capaldi RA.
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| FEBS Lett 581(18):3545-9. Epub 2007 Jun 27. 2007
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19 | IMMT
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| The mitochondrial inner membrane protein mitofilin controls cristae morphology.
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| John GB, Shang Y, Li L, Renken C, Mannella CA, Selker JM, Rangell L, Bennett MJ, Zha J.
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| Mol Biol Cell 16(3):1543-54. Epub 2005 Jan 12. 2005
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20 | IMMT
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| Mitofilin is a transmembrane protein of the inner mitochondrial membrane expressed as two isoforms.
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| Gieffers C, Korioth F, Heimann P, Ungermann C, Frey J.
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| Exp Cell Res 232(2):395-9. 1997
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21 | IMMT
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| A novel human gene that is preferentially transcribed in heart muscle.
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| Icho T, Ikeda T, Matsumoto Y, Hanaoka F, Kaji K, Tsuchida N.
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| Gene 144(2):301-6. 1994
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