| 1 | IL5, IL6, IL8
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| An inter-correlated cytokine network identified at the center of cytokine storm predicted COVID-19 prognosis
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| Liu Y, Chen D, Hou J, Li H, Cao D, Guo M, Ling Y, Gao M, Zhou Y, Wan Y, Zhu Z.
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| Cytokine. Feb;138:155365. doi: 10.1016/j.cyto.2020.155365. Epub 2020 Nov 9. 2021
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| 2 | F2RL1, IL8, TMPRSS11D
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| Human airway trypsin-like protease enhances interleukin-8 synthesis in bronchial epithelial cells by activating protease-activated receptor 2.
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| Miki M, Yasuoka S, Tsutsumi R, Nakamura Y, Hajime M, Takeuchi Y, Miki K, Kitada S, Maekura R.
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| Arch Biochem Biophys 664:167-173. doi: 10.1016/j.abb.2019.01.019. Epub 2019 Jan 21.
2019
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| 3 | CXCR1, IL8
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| Dynamics-Derived Insights into Complex Formation between the CXCL8 Monomer and CXCR1 N-Terminal Domain: An NMR Study.
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| Joseph PRB, Spyracopoulos L, Rajarathnam K.
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| Molecules 23(11). pii: E2825. doi: 10.3390/molecules23112825.
2018
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| 4 | CNOT1, CNOT7, ICAM1, IL8
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| CNOT1 is involved in TTP‑mediated ICAM‑1 and IL‑8 mRNA decay.
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| Shi JX, Li JS, Hu R, Zhao XC, Liang CC, Li XM, Wang H, Shi Y, Su X.
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| Mol Med Rep 18(2):2321-2327. doi: 10.3892/mmr.2018.9213. Epub 2018 Jun 22.
2018
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| 5 | CXCR1, IL8
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| Interaction of Monomeric Interleukin-8 with CXCR1 Mapped by Proton-Detected Fast MAS Solid-State NMR.
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| Park SH, Berkamp S, Radoicic J, De Angelis AA, Opella SJ.
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| Biophys J 113(12):2695-2705. doi: 10.1016/j.bpj.2017.09.041.
2017
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| 6 | CXCR1, IL8
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| Structure of monomeric Interleukin-8 and its interactions with the N-terminal Binding Site-I of CXCR1 by solution NMR spectroscopy.
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| Berkamp S, Park SH, De Angelis AA, Marassi FM, Opella SJ.
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| J Biomol NMR 69(3):111-121. doi: 10.1007/s10858-017-0128-3. Epub 2017 Nov 15.
2017
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| 7 | CXCL1, IL8, STAT3
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| Endoplasmic Reticulum Stress and Chemokine Production in Cystic Fibrosis Airway Cells: Regulation by STAT3 Modulation.
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| Tang AC, Saferali A, He G, Sandford AJ, Strug LJ, Turvey SE.
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| J Infect Dis 215(2):293-302. doi: 10.1093/infdis/jiw516.
2017
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| 8 | GPR68, IL8
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| Extracellular acidification stimulates GPR68 mediated IL-8 production in human pancreatic β cells.
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| Chandra V, Karamitri A, Richards P, Cormier F, Ramond C, Jockers R, Armanet M, Albagli-Curiel O, Scharfmann R.
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| Sci Rep 6:25765. doi: 10.1038/srep25765.
2016
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| 9 | CXCR1, IL8
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| Solution NMR characterization of WT CXCL8 monomer and dimer binding to CXCR1 N-terminal domain.
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| Joseph PR, Rajarathnam K.
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| Protein Sci 24(1):81-92. doi: 10.1002/pro.2590. Epub 2014 Nov 28.
2015
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| 10 | BTC, IL8
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| Regulatory mechanisms of betacellulin in CXCL8 production from lung cancer cells.
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| Shi L, Wang L, Wang B, Cretoiu SM, Wang Q, Wang X, Chen C.
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| J Transl Med 12:70. doi: 10.1186/1479-5876-12-70.
2014
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| 11 | CXCR1, IL8
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| The IL-8/CXCR1 axis is associated with cancer stem cell-like properties and correlates with clinical prognosis in human pancreatic cancer cases.
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| Chen L, Fan J, Chen H, Meng Z, Chen Z, Wang P, Liu L.
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| Sci Rep 4:5911. doi: 10.1038/srep05911.
2014
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| 12 | CXCR1, IL8
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| The dynamics of interleukin-8 and its interaction with human CXC receptor I peptide.
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| Kendrick AA, Holliday MJ, Isern NG, Zhang F, Camilloni C, Huynh C, Vendruscolo M, Armstrong G, Eisenmesser EZ.
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| Protein Sci 23(4):464-80. doi: 10.1002/pro.2430. Epub 2014 Feb 12.
2014
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| 13 | IL1RL1, IL33, IL6, IL8, TMED1
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| The GOLD domain-containing protein TMED1 is involved in interleukin-33 signaling.
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| Connolly DJ, O'Neill LA, McGettrick AF.
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| J Biol Chem 288(8):5616-23. doi: 10.1074/jbc.M112.403899. Epub 2013 Jan 14.
2013
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| 14 | CENPA, CENPB, IL8
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| Nap1 regulates proper CENP-B binding to nucleosomes.
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| Tachiwana H, Miya Y, Shono N, Ohzeki J, Osakabe A, Otake K, Larionov V, Earnshaw WC, Kimura H, Masumoto H, Kurumizaka H.
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| Nucleic Acids Res 41(5):2869-80. doi: 10.1093/nar/gks1464. Epub 2013 Jan 15.
2013
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| 15 | ANO1, CFTR, IL8
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| Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia.
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| Veit G, Bossard F, Goepp J, Verkman AS, Galietta LJ, Hanrahan JW, Lukacs GL.
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| Mol Biol Cell 23(21):4188-202. doi: 10.1091/mbc.E12-06-0424. Epub 2012 Sep 12.
2012
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| 16 | IL8, SLC16A1
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| Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis.
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| Végran F, Boidot R, Michiels C, Sonveaux P, Feron O.
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| Cancer Res 71(7):2550-60. Epub 2011 Feb 7.
2011
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| 17 | ENTPD1, IL8
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| NTPDase1 controls IL-8 production by human neutrophils.
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| Kukulski F, Bahrami F, Ben Yebdri F, Lecka J, Martín-Satué M, Lévesque SA, Sévigny J.
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| J Immunol 187(2):644-53. Epub 2011 Jun 13.
2011
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| 18 | IL8
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| IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells.
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| Fernando RI, Castillo MD, Litzinger M, Hamilton DH, Palena C.
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| Cancer Res 71(15):5296-306. Epub 2011 Jun 8.
2011
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| 19 | IL8, SNAI1
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| SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells.
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| Hwang WL, Yang MH, Tsai ML, Lan HY, Su SH, Chang SC, Teng HW, Yang SH, Lan YT, Chiou SH, Wang HW.
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| Gastroenterology 141(1):279-91, 291.e1-5. Epub 2011 Apr 16.
2011
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| 20 | IL8
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| Interleukin-8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models.
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| Ning Y, Manegold PC, Hong YK, Zhang W, Pohl A, Lurje G, Winder T, Yang D, LaBonte MJ, Wilson PM, Ladner RD, Lenz HJ.
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| Int J Cancer 128(9):2038-49. doi: 10.1002/ijc.25562.
2011
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| 21 | IL8
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| CXCL8 protects human neurons from amyloid-β-induced neurotoxicity: relevance to Alzheimer's disease.
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| Ashutosh, Kou W, Cotter R, Borgmann K, Wu L, Persidsky R, Sakhuja N, Ghorpade A.
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| Biochem Biophys Res Commun 412(4):565-71. Epub 2011 Aug 5.
2011
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| 22 | CXCL13, IL8
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| IL8 and CXCL13 are potent chemokines for the recruitment of human neural precursor cells across brain endothelial cells.
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| Weiss N, Deboux C, Chaverot N, Miller F, Baron-Van Evercooren A, Couraud PO, Cazaubon S.
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| J Neuroimmunol 223(1-2):131-4. Epub 2010 Apr 18.PMID: 20400187 2010
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| 23 | IL8
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| The Chemokine IL8 Is Up-Regulated in Bovine Endometrial Stromal Cells by the BoHV-4 IE2 Gene Product, ORF50/Rta: A Step Ahead Toward a Mechanism for BoHV-4 Induced Endometritis.
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| Donofrio G, Capocefalo A, Franceschi V, Price S, Cavirani S, Sheldon M.
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| Biol Reprod iol Reprod. 2010 Aug 18. [Epub ahead of print]PMID: 20720165 2010
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| 24 | DEFA1, IL8
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| Differential effects of human neutrophil peptide-1 on growth factor and interleukin-8 production by human lung fibroblasts and epithelial cells.
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| Amenomori M, Mukae H, Ishimatsu Y, Sakamoto N, Kakugawa T, Hara A, Hara S, Fujita H, Ishimoto H, Hayashi T, Kohno S.
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| Exp Lung Res 36(7):411-9. 2010
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| 25 | IL8
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| IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis.
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| Reeves EP, Williamson M, Byrne B, Bergin DA, Smith SG, Greally P, O'Kennedy R, O'Neill SJ, McElvaney NG.
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| J Immunol 184(3):1642-52. Epub 2009 Dec 21.
2010
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| 26 | IL8, PXN
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| Cell migration to the chemokine CXCL8: paxillin is activated and regulates adhesion and cell motility.
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| Cohen-Hillel E, Mintz R, Meshel T, Garty BZ, Ben-Baruch A.
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| Cell Mol Life Sci 66(5):884-99.
2009
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| 27 | CCL4, CXCL1, IL8, PROK1
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| Prokineticin 1 induces CCL4, CXCL1 and CXCL8 in human monocytes but not in macrophages and dendritic cells.
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| Monnier J, Quillien V, Piquet-Pellorce C, Leberre C, Preisser L, Gascan H, Samson M.
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| Eur Cytokine Netw 19(4):166-75.PMID: 19103522 2008
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| 28 | IL8
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| Interleukin-8 is a molecular determinant of androgen independence and progression in prostate cancer.
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| Araki S, Omori Y, Lyn D, Singh RK, Meinbach DM, Sandman Y, Lokeshwar VB, Lokeshwar BL.
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| Cancer Res 67(14):6854-62. 2007
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| 29 | PYCARD, IL8
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| Regulation of the ASC expression in response to LPS stimulation is related to IL-8 secretion in the human intestinal mucosa.
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| Masumoto J, Kobayashi H, Nakamura T, Kaneko Y, Ota H, Hasegawa M, Kobayashi Y, Suzuki T, Matsuda K, Sano K, Katsuyama T, Inohara N.
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| Biochem Biophys Res Commun 346(3):968-73. Epub 2006 Jun 9. 2006
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| 30 | CXCR1, CXCR2, IL8
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| The N- and C-terminal peptides of hIL8/CXCL8 are ligands for hCXCR1 and hCXCR2.
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| Li QJ, Yao M, Wong W, Parpura V, Martins-Green M.
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| FASEB J 18(6):776-8. Epub 2004 Feb 6. 2004
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| 31 | TMPRSS11D, F2RL1, IL8
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| Human airway trypsin-like protease induces PAR-2-mediated IL-8 release in psoriasis vulgaris.
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| Iwakiri K, Ghazizadeh M, Jin E, Fujiwara M, Takemura T, Takezaki S, Kawana S, Yasuoka S, Kawanami O.
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| J Invest Dermatol 122(4):937-44. 2004
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| 32 | IL8, CXCL1
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| IL-8/CXCL8 and growth-related oncogene alpha/CXCL1 induce chondrocyte hypertrophic differentiation.
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| Merz D, Liu R, Johnson K, Terkeltaub R.
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| J Immunol 171(8):4406-15. 2003
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| 33 | IL8, LTBR, TRAF2, TRAF3, TRAF5
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| Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation.
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| Chang YH, Hsieh SL, Chen MC, Lin WW.
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| Exp Cell Res 278(2):166-74. 2002
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| 34 | IL8
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| Interleukin 8: an autocrine growth factor for malignant mesothelioma.
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| Galffy G, et al.
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| Cancer Res 59(2):367-71. 1999
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| 35 | IER3, DUSP1, HIF1A, IL8,TNF, GIMAP4, AGPAT4
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| Cloning of ARE-containing genes by AU-motif-directed display.
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| Dominguez O, Ashhab Y, Sabater L, Belloso E, Caro P, Pujol-Borrell R.
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| Genomics 54(2):278-86. 1998
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| 36 | IL1A, IL6, IL8, TNFRSF1A
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| Heterogeneity among human nasopharyngeal carcinoma cell lines for inflammatory cytokines mRNA expression levels.
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| Mahe Y, Hirose K, Clausse B, Chouaib S, Tursz T, Mariame B.
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| Biochem Biophys Res Commun 187(1):121-6. 1992
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| 37 | IL8
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| Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8) resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily.
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| Modi WS, et al.
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| Hum Genet 84 : 185-187. 1990
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| 38 | IL8
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| Chromosome mapping and RFLP analyses of monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8).
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| Modi WS, et al.
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| (HGM10) Cytogenet Cell Genet 51 : 1046. 1989
|