Citations for
1DUOX1, iL4
Duox1 Regulates Primary B Cell Function under the Influence of IL-4 through BCR-Mediated Generation of Hydrogen Peroxide.
Sugamata R, Donko A, Murakami Y, Boudreau HE, Qi CF, Kwon J, Leto TL.
J Immunol 202(2):428-440. doi: 10.4049/jimmunol.1601395. Epub 2018 Dec 17. 2019
2BCL6, IL21, IL4
IL4 and IL21 cooperate to induce the high Bcl6 protein level required for germinal center formation.
Chevrier S, Kratina T, Emslie D, Tarlinton DM, Corcoran LM.
Immunol Cell Biol 95(10):925-932. doi: 10.1038/icb.2017.71. Epub 2017 Oct 3. 2017
3IL4, iL7R
IL-7Rα Expression Regulates Murine Dendritic Cell Sensitivity to Thymic Stromal Lymphopoietin.
Kummola L, Ortutay Z, Chen X, Caucheteux S, Hämäläinen S, Aittomäki S, Yagi R, Zhu J, Pesu M, Paul WE, Junttila IS.
J Immunol 198(10):3909-3918. doi: 10.4049/jimmunol.1600753. Epub 2017 Apr 12. 2017
4CCL26, IL13, IL4
Eotaxin-3 (CCL26) Expression in Human Pancreatic Myofibroblasts.
Fujimoto T, Imaeda H, Takahashi K, Nishida A, Shioya M, Inatomi O, Bamba S, Shiomi H, Tani M, Andoh A.
Pancreas Mar;45(3):420-4. doi: 10.1097/MPA.0000000000000480 2016
Interleukin-4 and melatonin ameliorate high glucose and interleukin-1β stimulated inflammatory reaction in human retinal endothelial cells and retinal pigment epithelial cells.
Xie M, Hu A, Luo Y, Sun W, Hu X, Tang S.
Mol Vis 20:921-8. eCollection 2014. 2014
6IL4, STAT6, iL19
Interleukin-4 up-regulation of epidermal interleukin-19 expression in keratinocytes involves the binding of signal transducer and activator of transcription 6 (Stat6) to the imperfect Stat6 sites.
Bao L, Alexander JB, Shi VY, Mohan GC, Chan LS.
Immunology 143(4):601-8. doi: 10.1111/imm.12339. 2014
7BCL2L11, IL4
IL-4 regulates Bim expression and promotes B cell maturation in synergy with BAFF conferring resistance to cell death at negative selection checkpoints.
Granato A, Hayashi EA, Baptista BJ, Bellio M, Nobrega A.
J Immunol 192(12):5761-75. doi: 10.4049/jimmunol.1300749. Epub 2014 May 16. 2014
8IL4, KLF13, MAF
KLF13 cooperates with c-Maf to regulate IL-4 expression in CD4+ T cells.
Kwon SJ, Crespo-Barreto J, Zhang W, Wang T, Kim DS, Krensky A, Clayberger C.
J Immunol 192(12):5703-9. doi: 10.4049/jimmunol.1302830. Epub 2014 May 12. 2014
Inducible costimulator facilitates T-dependent B cell activation by augmenting IL-4 translation.
Gigoux M, Lovato A, Leconte J, Leung J, Sonenberg N, Suh WK.
Mol Immunol 59(1):46-54. doi: 10.1016/j.molimm.2014.01.008. Epub 2014 Jan 31. 2014
10IL4, iL31
Human Th2 but not Th9 cells release IL-31 in a STAT6/NF-κB-dependent way.
Maier E, Werner D, Duschl A, Bohle B, Horejs-Hoeck J.
J Immunol 193(2):645-54. doi: 10.4049/jimmunol.1301836. Epub 2014 Jun 18. 2014
11ERN1, IL4
The serine-threonine kinase inositol-requiring enzyme 1α (IRE1α) promotes IL-4 production in T helper cells.
Kemp KL, Lin Z, Zhao F, Gao B, Song J, Zhang K, Fang D.
J Biol Chem 288(46):33272-82. doi: 10.1074/jbc.M113.493171. Epub 2013 Oct 7. 2013
12IL4, STAT6
Reprogramming of lysosomal gene expression by interleukin-4 and Stat6.
Brignull LM, Czimmerer Z, Saidi H, Daniel B, Villela I, Bartlett NW, Johnston SL, Meira LB, Nagy L, Nohturfft A.
BMC Genomics 14:853. doi: 10.1186/1471-2164-14-853. 2013
13CSF1, IL4
IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1.
Jenkins SJ, Ruckerl D, Thomas GD, Hewitson JP, Duncan S, Brombacher F, Maizels RM, Hume DA, Allen JE.
J Exp Med 210(11):2477-91. doi: 10.1084/jem.20121999. Epub 2013 Oct 7. 2013
IL-4 attenuates Th1-associated chemokine expression and Th1 trafficking to inflamed tissues and limits pathogen clearance.
Lazarski CA, Ford J, Katzman SD, Rosenberg AF, Fowell DJ.
PLoS One 8(8):e71949. doi: 10.1371/journal.pone.0071949. eCollection 2013. 2013
15IL4, IL4R
IL-4 and IL-4 receptor expression is dispensable for the development and function of natural killer T cells.
Sharma A, Berga-Bolanos R, Sultana DA, Sen JM.
PLoS One 8(8):e71872. doi: 10.1371/journal.pone.0071872. eCollection 2013. 2013
16IL4, PTPN6
Shp1 regulates T cell homeostasis by limiting IL-4 signals.
Johnson DJ, Pao LI, Dhanji S, Murakami K, Ohashi PS, Neel BG.
J Exp Med 210(7):1419-31. 2013
High association of IL-4 gene intron 3 VNTR polymorphism with diabetic peripheral neuropathy.
Basol N, Inanir A, Yigit S, Karakus N, Kaya SU.
J Mol Neurosci 51(2):437-41. doi: 10.1007/s12031-013-0048-y. Epub 2013 Jun 16. 2013
18IL4, IL4R
Eosinophils secrete IL-4 to facilitate liver regeneration.
Goh YP, Henderson NC, Heredia JE, Red Eagle A, Odegaard JI, Lehwald N, Nguyen KD, Sheppard D, Mukundan L, Locksley RM, Chawla A.
Proc Natl Acad Sci U S A 110(24):9914-9. doi: 10.1073/pnas.1304046110. Epub 2013 May 28. 2013
Thyroid hydrogen peroxide production is enhanced by the Th2 cytokines, IL-4 and IL-13, through increased expression of the dual oxidase 2 and its maturation factor DUOXA2.
Raad H, Eskalli Z, Corvilain B, Miot F, De Deken X.
Free Radic Biol Med 56:216-25. doi: 10.1016/j.freeradbiomed.2012.09.003. Epub 2012 Sep 23. 2013
20IL13, IL4, STAT1, STAT6, TYK2
IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages.
Bhattacharjee A, Shukla M, Yakubenko VP, Mulya A, Kundu S, Cathcart MK.
Free Radic Biol Med ree Radic Biol Med. 2012 Nov 1. doi:pii: S0891-5849(12)01795-9. 10.1016/j.freeradbiomed.2012.10.553. [Epub ahead of print] 2012
21IL13, IL4
Interleukin-4 and interleukin-13 prime migrational responses of haemopoietic progenitor cells to stromal cell-derived factor-1α.
Punia N, Smith S, Thomson JV, Irshad A, Nair P, Sehmi R.
Clin Exp Allergy 42(2):255-64. doi: 10.1111/j.1365-2222.2011.03889.x. Epub 2011 Oct 13. 2012
22IL4, KLRK1
Negative regulation of NKG2D expression by IL-4 in memory CD8 T cells.
Ventre E, Brinza L, Schicklin S, Mafille J, Coupet CA, Marçais A, Djebali S, Jubin V, Walzer T, Marvel J.
J Immunol 189(7):3480-9. Epub 2012 Aug 31. 2012
IL-4 in the brain: a cytokine to remember.
Gadani SP, Cronk JC, Norris GT, Kipnis J.
J Immunol 189(9):4213-9. doi: 10.4049/jimmunol.1202246. Review. 2012
24IL4, MAF
Tyrosine phosphorylation of c-Maf enhances the expression of IL-4 gene.
Lai CY, Lin SY, Wu CK, Yeh LT, Sytwu HK, Miaw SC.
J Immunol 189(4):1545-50. doi: 10.4049/jimmunol.1200405. Epub 2012 Jul 13. 2012
25IL2, IL4, IRF4, REL
Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel.
Shindo H, Yasui K, Yamamoto K, Honma K, Yui K, Kohno T, Ma Y, Chua KJ, Kubo Y, Aihara H, Ito T, Nagayasu T, Matsuyama T, Hayashi H.
Cytokine 56(3):564-72. doi: 10.1016/j.cyto.2011.08.014. Epub 2011 Sep 3. 2011
26IL4, TNFSF11
Interleukin-4 inhibits RANKL-induced NFATc1 expression via STAT6: a novel mechanism mediating its blockade of osteoclastogenesis.
Cheng J, Liu J, Shi Z, Xu D, Luo S, Siegal GP, Feng X, Wei S.
J Cell Biochem 112(11):3385-92. doi: 10.1002/jcb.23269. 2011
Alternatively spliced variants of interleukin-4 promote inflammation differentially.
Luzina IG, Lockatell V, Todd NW, Highsmith K, Keegan AD, Hasday JD, Atamas SP.
J Leukoc Biol 89(5):763-70. doi: 10.1189/jlb.0510271. Epub 2011 Feb 1. 2011
28DUOX1, IL13, IL4
Dual oxidase 1 induced by Th2 cytokines promotes STAT6 phosphorylation via oxidative inactivation of protein tyrosine phosphatase 1B in human epidermal keratinocytes.
Hirakawa S, Saito R, Ohara H, Okuyama R, Aiba S.
J Immunol 186(8):4762-70. doi: 10.4049/jimmunol.1000791. Epub 2011 Mar 16. 2011
Short-term memory in gene induction reveals the regulatory principle behind stochastic IL-4 expression.
Mariani L, Schulz EG, Lexberg MH, Helmstetter C, Radbruch A, Löhning M, Höfer T.
Mol Syst Biol 6:359.PMID: 20393579 2010
30IL4, MAF
SUMOylation attenuates c-Maf-dependent IL-4 expression.
Lin BS, Tsai PY, Hsieh WY, Tsao HW, Liu MW, Grenningloh R, Wang LF, Ho IC, Miaw SC.
Eur J Immunol 40(4):1174-84.PMID: 20127678 2010
31IL4, STAT6
Differential requirements for IL-4/STAT6 signalling in CD4 T-cell fate determination and Th2-immune effector responses.
Forbes E, van Panhuys N, Min B, Le Gros G.
Immunol Cell Biol 88(3):240-3. Epub 2009 Dec 15. Review.PMID: 20010912 2010
32CLCA1, IL13, IL4, IL9
Effect of Th2 type cytokines on hCLCA1 and mucus expression in cystic fibrosis airways.
Hauber HP, Lavigne F, Hung HL, Levitt RC, Hamid Q.
J Cyst Fibros 9(4):277-9. doi: 10.1016/j.jcf.2010.05.002. Epub 2010 Jun 9. 2010
33CCL26, CCR3, CX3CL1, CX3CR1, IL13, IL4
Eotaxin-3/CC chemokine ligand 26 is a functional ligand for CX3CR1.
Nakayama T, Watanabe Y, Oiso N, Higuchi T, Shigeta A, Mizuguchi N, Katou F, Hashimoto K, Kawada A, Yoshie O.
J Immunol. Dec 1;185(11):6472-9. doi: 10.4049/jimmunol.0904126. Epub 2010 Oct 25 2010
Sequencing the IL4 locus in African Americans implicates rare noncoding variants in asthma susceptibility.
Haller G, Torgerson DG, Ober C, Thompson EE.
J Allergy Clin Immunol 124(6):1204-9.e9. Epub .PMID: 19910025 2009
Mina, an Il4 repressor, controls T helper type 2 bias.
Okamoto M, Van Stry M, Chung L, Koyanagi M, Sun X, Suzuki Y, Ohara O, Kitamura H, Hijikata A, Kubo M, Bix M.
Nat Immunol 10(8):872-9. Epub 2009 Jun 28.PMID: 19561615 2009
STAT6 activation confers upon T helper cells resistance to suppression by regulatory T cells.
Pillemer BB, Qi Z, Melgert B, Oriss TB, Ray P, Ray A.
J Immunol 183(1):155-63. Epub 2009 Jun 17.PMID: 19535633 2009
Differential expression of nuclear receptors in T helper cells.
Hwang SS, Kim YU, Lee W, Lee GR.
J Microbiol Biotechnol 19(2):208-14.PMID: 19307772 2009
Elevating calcium in Th2 cells activates multiple pathways to induce IL-4 transcription and mRNA stabilization.
Guo L, Urban JF, Zhu J, Paul WE.
J Immunol 181(6):3984-93.PMID: 18768853 2008
39IL13, IL13RA1, IL4, IL4R
Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis.
Munitz A, Brandt EB, Mingler M, Finkelman FD, Rothenberg ME.
Proc Natl Acad Sci U S A 105(20):7240-5. doi: 10.1073/pnas.0802465105. Epub 2008 May 14. 2008
Suppression of early IL-4 production underlies the failure of CD4 T cells activated by TLR-stimulated dendritic cells to differentiate into Th2 cells.
Sun J, Pearce EJ.
J Immunol 178(3):1635-44. 2007
Expansion of Vdelta1 T lymphocytes producing IL-4 in low-grade non-Hodgkin lymphomas expressing UL-16-binding proteins.
Catellani S, Poggi A, Bruzzone A, Dadati P, Ravetti JL, Gobbi M, Zocchi MR.
Blood 109(5):2078-85. Epub 2006 Sep 14. 2007
42IL4, IL13
Inhibition of matrix metalloproteinase-3 synthesis in human conjunctival fibroblasts by interleukin-4 or interleukin-13.
Fukuda K, Fujitsu Y, Kumagai N, Nishida T.
Invest Ophthalmol Vis Sci 47(7):2857-64. 2006
Pro-atherogenic effect of interleukin-4 in endothelial cells: modulation of oxidative stress, nitric oxide and monocyte chemoattractant protein-1 expression.
Walch L, Massade L, Dufilho M, Brunet A, Rendu F.
Atherosclerosis 187(2):285-91. Epub 2005 Oct 24. 2006
44IL4, HIF1A
IL-4 enhances hypoxia induced HIF-1alpha protein levels in human transformed intestinal cells.
Scharte M, Jurk K, Kehrel B, Zarbock A, Van Aken H, Singbartl K.
FEBS Lett 580(27):6399-404. Epub 2006 Nov 3. 2006
Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis.
Zee RY, Cook NR, Cheng S, Reynolds R, Erlich HA, Lindpaintner K, Ridker PM.
Hum Mol Genet 13(4):389-96. Epub 2003 Dec 17. 2004
46STAT6, GATA3, KIF3A, IL4, IL13, RAD50
Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA3.
Lee DU, Rao A.
Proc Natl Acad Sci U S A 101(45):16010-5. Epub 2004 Oct 26. 2004
A complete screening of the IL4 gene: novel polymorphisms and their association with asthma and IgE in childhood.
Kabesch M, Tzotcheva I, Carr D, Hšfler C, Weiland SK, Fritzsch C, von Mutius E, Martinez FD.
J Allergy Clin Immunol 112(5):893-8. 2003
Germinal center B cells constitute a predominant physiological source of IL-4: implication for Th2 development in vivo.
Johansson-Lindbom B, Borrebaeck CA.
J Immunol 168(7):3165-72. 2002
49CCR5, CD4, IL10, IL4
Regulation of CC chemokine receptor 5 and CD4 expression and human immunodeficiency virus type 1 replication in human macrophages and microglia by T helper type 2 cytokines.
Wang J, Crawford K, Yuan M, Wang H, Gorry PR, Gabuzda D.
J Infect Dis 185(7):885-97. 2002
IL-4 is a potent modulator of ion transport in the human bronchial epithelium in vitro.
Galietta LJ, Pagesy P, Folli C, Caci E, Romio L, Costes B, Nicolis E, Cabrini G, Goossens M, Ravazzolo R, Zegarra-Moran O.
J Immunol 168(2):839-45. 2002
51CSF2, IL13, IL3, IL4, IL4R, IL9, IRF1, TCF7
A second-generation association study of the 5q31 cytokine gene cluster and the interleukin-4 receptor in asthma.
Kauppi P, Lindblad-Toh K, Sevon P, Toivonen HT, Rioux JD, Villapakkam A, Laitinen LA, Hudson TJ, Kere J, Laitinen T.
Genomics 77(1/2):35-42. 2001
52CD320, IL10, IL4
The distinct roles of T cell-derived cytokines and a novel follicular dendritic cell-signaling molecule 8D6 in germinal center-B cell differentiation.
Zhang X, Li L, Jung J, Xiang S, Hollmann C, Choi YS.
J Immunol 167(1):49-56. 2001
53IL13, IL4, IL5
Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons.
Loots GG, Locksley RM, Blankespoor CM, Wang ZE, Miller W, Rubin EM, Frazer KA.
Science 288(5463):136-40. 2000
54ICAM1, IL4
Intercellular adhesion molecule-1 inhibits interleukin 4 production by naive T cells.
Luksch CR, et al.
Proc Natl Acad Sci U S A 96(6):3023-8. 1999
55APY10, IL4
Linkage and association of an interleukin 4 gene polymorphism with atopic dermatitis in Japanese families.
Kawashima T, et al.
J Med Genet 35 : 502-504. 1998
56APY10, IL4, IL13
Requirement for IL-13 independently of IL-4 in experimental asthma.
Grunig G, et al.
Science 282(5397):2261-3. 1998
57APY10, IL4, IL13
Interleukin-13: central mediator of allergic asthma.
Wills-Karp M, et al.
Science 282(5397):2258-61. 1998
58IL4, IL13RA1, STAT6
Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex.
Miloux B, Laurent P, Bonnin O, Lupker J, Caput D, Vita N, Ferrara P.
FEBS Lett 401(2-3):163-6. 1997
59IL4, ZFP36L1
Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene, Berg36.
Ning ZQ, Norton JD, Li J, Murphy JJ.
Eur J Immunol 26(10):2356-63. 1996
An alternatively spliced interleukin 4 form in lymphoid cells.
Klein SC, Golverdingen JG, Bouwens AG, Tilanus MG, de Weger RA.
Immunogenetics 41(1):57. No abstract available. 1995
61IL3, IL4, IL9
SSC polymorphisms in interleukin genes.
Borish L, et al.
Hum Mol Genet 3 : 1710. 1994
Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations.
Marsh DG, et al.
Science 264 : 1152-1156. 1994
63IL13RA1, IL4, STAT6
An interleukin-4-induced transcription factor: IL-4 Stat.
Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, McKnight SL.
Science 265(5179):1701-6. 1994
64IL4, IL5
Characterization of yeast artificial chromosomes containing interleukin genes on human chromosome 5.
Stock W, et al.
Cytogenet Cell Genet 61 : 263-265. 1992
Interleukin-4 enhances in vitro mineralization in human osteoblast-like cells.
Ueno K, et al.
Biochem Biophys Res Commun 189 : 1521-1526. 1992
Interleukin 4 receptor expression and growth inhibition of gastric carcinoma cells by interleukin 4.
Morisaki T, et al.
Cancer Res 52 : 6059-6065. 1992
Repeat polymorphisms in the interleukin-4 gene (IL4).
Mout R, et al.
Nucleic Acids Res 19 : 3763. 1991
68IL4, IL5
A long-range restriction map of the interleukin-4 and interleukin-5 group on chromosome 5.
Chandrasekharappa SC, et al.
Genomics 6 : 94-99. 1990
69IL4, IL5
Interleukin-4 and interleukin-5 map to human chromosome-5 in a region encoding growth factors and receptors and are deleted in myeloid leukemias with a del(5q).
Le Beau MM, et al.
Blood 73 : 647-650. 1989
Complete nucleotide sequence of the chromosomal gene for human IL-4 and its expression.
Arai N, Nomura D, Villaret D, DeWaal Malefijt R, Seiki M, Yoshida M, Minoshima S, Fukuyama R, Maekawa M, Kudoh J, et al.
J Immunol 142(1):274-82. 1989
71IL4, IL6
Interleukin 4 is at 5q31 and interleukin 6 is at 7p15.
Sutherland GR, Baker E, Callen DF, Hyland VJ, Wong G, Clark S, Jones SS, Eglinton LK, Shannon MF, Lopez AF, et al.
Hum Genet 79(4):335-7 1988