| 1 | HAVCR2, IL10, IL27, NFIL3
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| An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction.
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| Zhu C, Sakuishi K, Xiao S, Sun Z, Zaghouani S, Gu G, Wang C, Tan DJ, Wu C, Rangachari M, Pertel T, Jin HT, Ahmed R, Anderson AC, Kuchroo VK.
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| Nat Commun 6:6072. doi: 10.1038/ncomms7072. Erratum in: Nat Commun. 2015;6:7657.
2015
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| 2 | IL27
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| Association of single nucleotide polymorphisms in the IL27 gene with rheumatoid arthritis.
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| Paradowska-Gorycka A, Raszkiewicz B, Jurkowska M, Felis-Giemza A, Romanowska-Próchnicka K, Mańczak M, Olesinska M.
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| Scand J Immunol cand J Immunol. 2014 Jul 8. doi: 10.1111/sji.12209. [Epub ahead of print]
2014
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| 3 | IL27
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| IL-27 limits central nervous system viral clearance by promoting IL-10 and enhances demyelination.
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| de Aquino MT, Kapil P, Hinton DR, Phares TW, Puntambekar SS, Savarin C, Bergmann CC, Stohlman SA.
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| J Immunol 193(1):285-94. doi: 10.4049/jimmunol.1400058. Epub 2014 Jun 2.
2014
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| 4 | IL27
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| Interleukin-27 Mediates Inflammation During Chronic Disease.
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| Wynick C, Petes C, Gee K.
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| J Interferon Cytokine Res Interferon Cytokine Res. 2014 May 5. [Epub ahead of print]
2014
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| 5 | IL27
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| Modulation of inflammation by interleukin-27.
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| Bosmann M, Ward PA.
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| J Leukoc Biol 94(6):1159-65. doi: 10.1189/jlb.0213107. Epub 2013 Jul 31. Review.
2013
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| 6 | IL27
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| Interleukin 27 inhibits atherosclerosis via immunoregulation of macrophages in mice.
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| Hirase T, Hara H, Miyazaki Y, Ide N, Nishimoto-Hazuku A, Fujimoto H, Saris CJ, Yoshida H, Node K.
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| Am J Physiol Heart Circ Physiol 305(3):H420-9. doi: 10.1152/ajpheart.00198.2013. Epub 2013 May 31.
2013
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| 7 | IL22, IL27
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| IL-27 suppresses the production of IL-22 in human CD4(+) T cells by inducing the expression of SOCS1.
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| Wang H, Li Z, Yang B, Yu S, Wu C.
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| Immunol Lett 152(2):96-103. doi: 10.1016/j.imlet.2013.05.001. Epub 2013 May 29.
2013
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| 8 | IL27
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| Neonatal macrophages express elevated levels of interleukin-27 that oppose immune responses.
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| Kraft JD, Horzempa J, Davis C, Jung JY, Peña MM, Robinson CM.
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| Immunology 139(4):484-93. doi: 10.1111/imm.12095.
2013
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| 9 | IL27
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| IL-27 inhibits lymphatic endothelial cell proliferation by STAT1-regulated gene expression.
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| Nielsen SR, Hammer T, Gibson J, Pepper MS, Nisato RE, Dissing S, Tritsaris K.
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| Microcirculation 20(6):555-64. doi: 10.1111/micc.12055.
2013
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| 10 | BST2, IL27
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| IL-27 increases BST-2 expression in human monocytes and T cells independently of type I IFN.
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| Guzzo C, Jung M, Graveline A, Banfield BW, Gee K.
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| Sci Rep 2:974. doi: 10.1038/srep00974. Epub 2012 Dec 13.
2012
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| 11 | CFH, IL27
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| Interleukin 27 induces the expression of complement factor H (CFH) in the retina.
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| Amadi-Obi A, Yu CR, Dambuza I, Kim SH, Marrero B, Egwuagu CE.
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| PLoS One 7(9):e45801. doi: 10.1371/journal.pone.0045801. Epub 2012 Sep 20.
2012
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| 12 | IL27
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| A role for IL-27 in limiting T regulatory cell populations.
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| Wojno ED, Hosken N, Stumhofer JS, O'Hara AC, Mauldin E, Fang Q, Turka LA, Levin SD, Hunter CA.
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| J Immunol 187(1):266-73. doi: 10.4049/jimmunol.1004182. Epub 2011 May 27.
2011
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| 13 | IL27
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| Decreased expression of interleukin-27 in immune thrombocytopenia.
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| Liu XG, Ren J, Yu Y, Sun L, Shi Y, Qin P, Yang L, Ma SH, Dong XY, Ma DX, Qu X, Guo CS, Chen CY, Hou M, Peng J.
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| Br J Haematol 153(2):259-67. doi: 10.1111/j.1365-2141.2011.08614.x. Epub 2011 Mar 8.
2011
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| 14 | IFNG, IL27, SPP1
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| Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation.
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| Murugaiyan G, Mittal A, Weiner HL.
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| Proc Natl Acad Sci U S A 107(25):11495-500. Epub 2010 Jun 7.PMID: 20534530 2010
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| 15 | EBI3, IL27
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| IL-27 structural analysis demonstrates similarities with ciliary neurotrophic factor (CNTF) and leads to the identification of antagonistic variants.
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| Rousseau F, Basset L, Froger J, Dinguirard N, Chevalier S, Gascan H.
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| Proc Natl Acad Sci U S A 107(45):19420-5. Epub 2010 Oct 25.
2010
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| 16 | IL27, IRF1, IRF9
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| Critical role of the IFN-stimulated gene factor 3 complex in TLR-mediated IL-27p28 gene expression revealing a two-step activation process.
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| Molle C, Goldman M, Goriely S.
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| J Immunol 184(4):1784-92. doi: 10.4049/jimmunol.0902005. Epub 2010 Jan 18.
2010
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| 17 | IL10, IL17, IL27
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| IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells.
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| Murugaiyan G, Mittal A, Lopez-Diego R, Maier LM, Anderson DE, Weiner HL.
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| J Immunol 183(4):2435-43. doi: 10.4049/jimmunol.0900568. Epub 2009 Jul 22.
2009
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| 18 | IL27
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| Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population.
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| Chae SC, Li CS, Kim KM, Yang JY, Zhang Q, Lee YC, Yang YS, Chung HT.
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| J Hum Genet 52(4):355-61. Epub 2007 Feb 22. 2007
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| 19 | IL27
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| Antiangiogenic and antitumor activities of IL-27.
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| Shimizu M, Shimamura M, Owaki T, Asakawa M, Fujita K, Kudo M, Iwakura Y, Takeda Y, Luster AD, Mizuguchi J, Yoshimoto T.
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| J Immunol 176(12):7317-24. 2006
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| 20 | IL27
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| IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms.
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| Lucas S, Ghilardi N, Li J, de Sauvage FJ.
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| Proc Natl Acad Sci U S A 100(25):15047-52. Epub 2003 Dec 01. 2003
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| 21 | IL27, IL27RA
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| Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment.
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| Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, Yoshimura A, Yoshida H.
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| J Immunol 170(10):4886-90. 2003
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| 22 | IL27
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| IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells.
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| Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, Hibbert L, Churakova T, Travis M, Vaisberg E, Blumenschein WM, Mattson JD, Wagner JL, To W, Zurawski S, McClanahan TK, Gorman DM, Bazan JF, de Waal Malefyt R, Rennick D, Kastelein RA.
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| Immunity 16(6):779-90. 2002
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