1 | IL21, PTPN11
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| Protein Tyrosine Phosphatase SHP-2 Is Involved in the Interleukin-21-Induced Activation of Extracellular Signal-Regulated Kinase 1/2.
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| Jin L, Nara H, Rahman M, Takeda Y, Araki A, Asao H.
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| Tohoku J Exp Med 244(3):187-193. doi: 10.1620/tjem.244.187.
2018
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2 | BCL6, IL21, IL4
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| IL4 and IL21 cooperate to induce the high Bcl6 protein level required for germinal center formation.
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| Chevrier S, Kratina T, Emslie D, Tarlinton DM, Corcoran LM.
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| Immunol Cell Biol 95(10):925-932. doi: 10.1038/icb.2017.71. Epub 2017 Oct 3.
2017
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3 | IL21
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| Evidence of Interleukin 21 Reduction in Osteosarcoma Patients Due to PD-1/PD-L1-Mediated Suppression of Follicular Helper T Cell Functionality.
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| Gao W, Zhou J, Ji B.
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| DNA Cell Biol 36(9):794-800. doi: 10.1089/dna.2017.3669. Epub 2017 Jun 26.
2017
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4 | IL21
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| IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2.
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| Jandl C, Liu SM, Cañete PF, Warren J, Hughes WE, Vogelzang A, Webster K, Craig ME, Uzel G, Dent A, Stepensky P, Keller B, Warnatz K, Sprent J, King C.
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| Nat Commun 8:14647. doi: 10.1038/ncomms14647.
2017
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5 | IL21
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| Dual role of IL-21 in megakaryopoiesis and platelet homeostasis.
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| Benbarche S, Strassel C, Angénieux C, Mallo L, Freund M, Gachet C, Lanza F, de la Salle H.
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| Haematologica 102(4):637-646. doi: 10.3324/haematol.2016.143958. Epub 2017 Jan 5.
2017
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6 | IL21, IL21R
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| IL-21 signaling is essential for optimal host resistance against Mycobacterium tuberculosis infection.
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| Booty MG, Barreira-Silva P, Carpenter SM, Nunes-Alves C, Jacques MK, Stowell BL, Jayaraman P, Beamer G, Behar SM.
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| Sci Rep 6:36720. doi: 10.1038/srep36720.
2016
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7 | IL21, IL6
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| IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21-producing B helper CD8+ T cells.
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| Yang R, Masters AR, Fortner KA, Champagne DP, Yanguas-Casás N, Silberger DJ, Weaver CT, Haynes L, Rincon M.
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| J Exp Med 213(11):2281-2291. Epub 2016 Sep 26.
2016
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8 | IL21
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| A Context-Dependent Role for IL-21 in Modulating the Differentiation, Distribution, and Abundance of Effector and Memory CD8 T Cell Subsets.
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| Tian Y, Cox MA, Kahan SM, Ingram JT, Bakshi RK, Zajac AJ.
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| J Immunol 196(5):2153-66. doi: 10.4049/jimmunol.1401236. Epub 2016 Jan 29.
2016
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9 | IL21
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| Therapeutic utility of the newly discovered properties of interleukin-21.
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| Al-Chami E, Tormo A, Khodayarian F, Rafei M.
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| Cytokine 82:33-7. doi: 10.1016/j.cyto.2015.12.018. Epub 2015 Dec 31. Review.
2016
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10 | IL21
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| Biological effects of IL-21 on different immune cells and its role in autoimmune diseases.
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| Gharibi T, Majidi J, Kazemi T, Dehghanzadeh R, Motallebnezhad M, Babaloo Z.
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| Immunobiology 221(2):357-67. doi: 10.1016/j.imbio.2015.09.021. Epub 2015 Oct 1. Review.
2016
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11 | IL21
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| Association between IL-21 polymorphism and systemic lupus erythematosus: a meta-analysis.
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| Qi JH, Qi J, Xiang LN, Nie G.
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| Genet Mol Res 14(3):9595-603. doi: 10.4238/2015.August.14.22.
2015
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12 | IL21, STAT1, STAT3
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| Opposing roles of STAT1 and STAT3 in IL-21 function in CD4+ T cells.
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| Wan CK, Andraski AB, Spolski R, Li P, Kazemian M, Oh J, Samsel L, Swanson PA 2nd, McGavern DB, Sampaio EP, Freeman AF, Milner JD, Holland SM, Leonard WJ.
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| Proc Natl Acad Sci U S A 112(30):9394-9. doi: 10.1073/pnas.1511711112. Epub 2015 Jul 13.
2015
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13 | IL21
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| Involvement of interleukin-21 in the pathophysiology of aplastic anemia.
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| Zhang J, Wu Q, Shi J, Ge M, Li X, Shao Y, Yao J, Zheng Y.
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| Eur J Haematol 95(1):44-51. doi: 10.1111/ejh.12471. Epub 2015 Mar 12.
2015
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14 | IL21
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| Interleukin-21 suppresses the differentiation and functions of T helper 2 cells.
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| Lin PY, Jen HY, Chiang BL, Sheu F, Chuang YH.
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| Immunology 144(4):668-76. doi: 10.1111/imm.12419.
2015
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15 | CVID11, IL21
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| Early-onset inflammatory bowel disease and common variable immunodeficiency-like disease caused by IL-21 deficiency.
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| Salzer E, Kansu A, Sic H, Májek P, Ikincioğullari A, Dogu FE, Prengemann NK, Santos-Valente E, Pickl WF, Bilic I, Ban SA, Kuloğlu Z, Demir AM, Ensari A, Colinge J, Rizzi M, Eibel H, Boztug K.
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| J Allergy Clin Immunol 133(6):1651-9.e12. doi: 10.1016/j.jaci.2014.02.034. Epub 2014 Apr 17.
2014
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16 | CD86, IL21
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| IL-21 promotes CD4 T cell responses by phosphatidylinositol 3-kinase-dependent upregulation of CD86 on B cells.
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| Attridge K, Kenefeck R, Wardzinski L, Qureshi OS, Wang CJ, Manzotti C, Okkenhaug K, Walker LS.
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| J Immunol 192(5):2195-201. doi: 10.4049/jimmunol.1302082. Epub 2014 Jan 27.
2014
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17 | IL21, IL22
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| IL-21 induces IL-22 production in CD4+ T cells.
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| Yeste A, Mascanfroni ID, Nadeau M, Burns EJ, Tukpah AM, Santiago A, Wu C, Patel B, Kumar D, Quintana FJ.
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| Nat Commun 5:3753. doi: 10.1038/ncomms4753.
2014
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18 | CD40LG, IL21, PRDM1
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| IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells.
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| Ding BB, Bi E, Chen H, Yu JJ, Ye BH.
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| J Immunol 190(4):1827-36. doi: 10.4049/jimmunol.1201678. Epub 2013 Jan 16.
2013
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19 | IL21, TBX21
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| IL-21 promotes CD8+ CTL activity via the transcription factor T-bet.
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| Sutherland AP, Joller N, Michaud M, Liu SM, Kuchroo VK, Grusby MJ.
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| J Immunol 190(8):3977-84. doi: 10.4049/jimmunol.1201730.
2013
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20 | CSF2, IL21
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| The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells.
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| Wan CK, Oh J, Li P, West EE, Wong EA, Andraski AB, Spolski R, Yu ZX, He J, Kelsall BL, Leonard WJ.
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| Immunity 38(3):514-27. doi: 10.1016/j.immuni.2013.02.011. Epub 2013 Feb 28.
2013
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21 | IL21, IL21R
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| Caspase-8 cleavage of the interleukin-21 (IL-21) receptor is a negative feedback regulator of IL-21 signaling.
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| Akagi T, Shimizu K, Takahama S, Iwasaki T, Sakamaki K, Endo Y, Sawasaki T.
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| FEBS Lett 585(12):1835-40. Epub 2011 Apr 20.
2011
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22 | IL21, IL21R
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| IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain.
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| Tzartos JS, Craner MJ, Friese MA, Jakobsen KB, Newcombe J, Esiri MM, Fugger L.
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| Am J Pathol 178(2):794-802.
2011
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23 | IL21, IL21R
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| IL-21 receptor is critical for the development of memory B cell responses.
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| Rankin AL, MacLeod H, Keegan S, Andreyeva T, Lowe L, Bloom L, Collins M, Nickerson-Nutter C, Young D, Guay H.
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| J Immunol 186(2):667-74. Epub 2010 Dec 17.
2011
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24 | IL21, REL
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| Regulation of the IL-21 gene by the NF-kappaB transcription factor c-Rel.
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| Chen G, Hardy K, Bunting K, Daley S, Ma L, Shannon MF.
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| J Immunol 185(4):2350-9. Epub 2010 Jul 16.
2010
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25 | IL21
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| Cutting edge: IL-21 and TLR signaling regulate germinal center responses in a B cell-intrinsic manner.
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| Bessa J, Kopf M, Bachmann MF.
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| J Immunol 184(9):4615-9. Epub 2010 Apr 5.
2010
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26 | IL21
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| A vital role for interleukin-21 in the control of a chronic viral infection.
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| Yi JS, Du M, Zajac AJ.
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| Science 324(5934):1572-6. Epub 2009 May 14.
2009
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27 | IL21, IL21R
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| Il-21 enhances NK cell activation and cytolytic activity and induces Th17 cell differentiation in inflammatory bowel disease.
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| Liu Z, Yang L, Cui Y, Wang X, Guo C, Huang Z, Kan Q, Liu Z, Liu Y.
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| Inflamm Bowel Dis 15(8):1133-44.
2009
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28 | IL21, IL21R
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| IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo.
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| Sonderegger I, Kisielow J, Meier R, King C, Kopf M.
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| Eur J Immunol 38(7):1833-8.
2008
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29 | CCL20,IL21
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| A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells.
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| Caruso R, Fina D, Peluso I, Stolfi C, Fantini MC, Gioia V, Caprioli F, Del Vecchio Blanco G, Paoluzi OA, Macdonald TT, Pallone F, Monteleone G.
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| Gastroenterology 132(1):166-75. Epub 2006 Oct 1. 2007
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30 | ADAD1,IL2,IL21,KIAA1109
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| A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.
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| van Heel DA, Franke L, Hunt KA, Gwilliam R, Zhernakova A, Inouye M, Wapenaar MC, Barnardo MC, Bethel G, Holmes GK, Feighery C, Jewell D, Kelleher D, Kumar P, Travis S, Walters JR, Sanders DS, Howdle P, Swift J, Playford RJ, McLaren WM, Mearin ML, Mulder CJ, McManus R, McGinnis R, Cardon LR, Deloukas P, Wijmenga C.
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| Nat Genet 39(7):827-9. Epub 2007 Jun 10. 2007
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31 | IL21, IL21R
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| IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo.
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| Fröhlich A, Marsland BJ, Sonderegger I, Kurrer M, Hodge MR, Harris NL, Kopf M.
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| Blood 109(5):2023-31. Epub 2006 Oct 31.
2007
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32 | IL21
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| Identification of cellular intermediates and molecular pathways induced by IL-21 in human B cells.
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| Konforte D, Paige CJ.
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| J Immunol 177(12):8381-92. 2006
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33 | IL21
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| Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation.
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| Leonard WJ, Spolski R.
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| Nat Rev Immunol 5(9):688-98. Review. 2005
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34 | IL21, IL21R
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| Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity.
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| Wu Z, Kim HP, Xue HH, Liu H, Zhao K, Leonard WJ.
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| Mol Cell Biol 25(22):9741-52.
2005
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35 | IL21, IL21R
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| Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function.
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| Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, Gross JA, Johnston J, Madden K, Xu W, West J, Schrader S, Burkhead S, Heipel M, Brandt C, Kuijper JL, Kramer J, Conklin D, Presnell SR, Berry J, Shiota F, Bort S, Hambly K, Mudri S, Clegg C, Moore M, Grant FJ, Lofton-Day C, Gilbert T, Rayond F, Ching A, Yao L, Smith D, Webster P, Whitmore T, Maurer M, Kaushansky K, Holly RD, Foster D.
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| Nature 408(6808):57-63. 2000
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