Citations for
1IL21, PTPN11
Protein Tyrosine Phosphatase SHP-2 Is Involved in the Interleukin-21-Induced Activation of Extracellular Signal-Regulated Kinase 1/2.
Jin L, Nara H, Rahman M, Takeda Y, Araki A, Asao H.
Tohoku J Exp Med 244(3):187-193. doi: 10.1620/tjem.244.187. 2018
2BCL6, IL21, IL4
IL4 and IL21 cooperate to induce the high Bcl6 protein level required for germinal center formation.
Chevrier S, Kratina T, Emslie D, Tarlinton DM, Corcoran LM.
Immunol Cell Biol 95(10):925-932. doi: 10.1038/icb.2017.71. Epub 2017 Oct 3. 2017
3IL21
Evidence of Interleukin 21 Reduction in Osteosarcoma Patients Due to PD-1/PD-L1-Mediated Suppression of Follicular Helper T Cell Functionality.
Gao W, Zhou J, Ji B.
DNA Cell Biol 36(9):794-800. doi: 10.1089/dna.2017.3669. Epub 2017 Jun 26. 2017
4IL21
IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2.
Jandl C, Liu SM, Cañete PF, Warren J, Hughes WE, Vogelzang A, Webster K, Craig ME, Uzel G, Dent A, Stepensky P, Keller B, Warnatz K, Sprent J, King C.
Nat Commun 8:14647. doi: 10.1038/ncomms14647. 2017
5IL21
Dual role of IL-21 in megakaryopoiesis and platelet homeostasis.
Benbarche S, Strassel C, Angénieux C, Mallo L, Freund M, Gachet C, Lanza F, de la Salle H.
Haematologica 102(4):637-646. doi: 10.3324/haematol.2016.143958. Epub 2017 Jan 5. 2017
6IL21, IL21R
IL-21 signaling is essential for optimal host resistance against Mycobacterium tuberculosis infection.
Booty MG, Barreira-Silva P, Carpenter SM, Nunes-Alves C, Jacques MK, Stowell BL, Jayaraman P, Beamer G, Behar SM.
Sci Rep 6:36720. doi: 10.1038/srep36720. 2016
7IL21, IL6
IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21-producing B helper CD8+ T cells.
Yang R, Masters AR, Fortner KA, Champagne DP, Yanguas-Casás N, Silberger DJ, Weaver CT, Haynes L, Rincon M.
J Exp Med 213(11):2281-2291. Epub 2016 Sep 26. 2016
8IL21
A Context-Dependent Role for IL-21 in Modulating the Differentiation, Distribution, and Abundance of Effector and Memory CD8 T Cell Subsets.
Tian Y, Cox MA, Kahan SM, Ingram JT, Bakshi RK, Zajac AJ.
J Immunol 196(5):2153-66. doi: 10.4049/jimmunol.1401236. Epub 2016 Jan 29. 2016
9IL21
Therapeutic utility of the newly discovered properties of interleukin-21.
Al-Chami E, Tormo A, Khodayarian F, Rafei M.
Cytokine 82:33-7. doi: 10.1016/j.cyto.2015.12.018. Epub 2015 Dec 31. Review. 2016
10IL21
Biological effects of IL-21 on different immune cells and its role in autoimmune diseases.
Gharibi T, Majidi J, Kazemi T, Dehghanzadeh R, Motallebnezhad M, Babaloo Z.
Immunobiology 221(2):357-67. doi: 10.1016/j.imbio.2015.09.021. Epub 2015 Oct 1. Review. 2016
11IL21
Association between IL-21 polymorphism and systemic lupus erythematosus: a meta-analysis.
Qi JH, Qi J, Xiang LN, Nie G.
Genet Mol Res 14(3):9595-603. doi: 10.4238/2015.August.14.22. 2015
12IL21, STAT1, STAT3
Opposing roles of STAT1 and STAT3 in IL-21 function in CD4+ T cells.
Wan CK, Andraski AB, Spolski R, Li P, Kazemian M, Oh J, Samsel L, Swanson PA 2nd, McGavern DB, Sampaio EP, Freeman AF, Milner JD, Holland SM, Leonard WJ.
Proc Natl Acad Sci U S A 112(30):9394-9. doi: 10.1073/pnas.1511711112. Epub 2015 Jul 13. 2015
13IL21
Involvement of interleukin-21 in the pathophysiology of aplastic anemia.
Zhang J, Wu Q, Shi J, Ge M, Li X, Shao Y, Yao J, Zheng Y.
Eur J Haematol 95(1):44-51. doi: 10.1111/ejh.12471. Epub 2015 Mar 12. 2015
14IL21
Interleukin-21 suppresses the differentiation and functions of T helper 2 cells.
Lin PY, Jen HY, Chiang BL, Sheu F, Chuang YH.
Immunology 144(4):668-76. doi: 10.1111/imm.12419. 2015
15CVID11, IL21
Early-onset inflammatory bowel disease and common variable immunodeficiency-like disease caused by IL-21 deficiency.
Salzer E, Kansu A, Sic H, Májek P, Ikincioğullari A, Dogu FE, Prengemann NK, Santos-Valente E, Pickl WF, Bilic I, Ban SA, Kuloğlu Z, Demir AM, Ensari A, Colinge J, Rizzi M, Eibel H, Boztug K.
J Allergy Clin Immunol 133(6):1651-9.e12. doi: 10.1016/j.jaci.2014.02.034. Epub 2014 Apr 17. 2014
16CD86, IL21
IL-21 promotes CD4 T cell responses by phosphatidylinositol 3-kinase-dependent upregulation of CD86 on B cells.
Attridge K, Kenefeck R, Wardzinski L, Qureshi OS, Wang CJ, Manzotti C, Okkenhaug K, Walker LS.
J Immunol 192(5):2195-201. doi: 10.4049/jimmunol.1302082. Epub 2014 Jan 27. 2014
17IL21, IL22
IL-21 induces IL-22 production in CD4+ T cells.
Yeste A, Mascanfroni ID, Nadeau M, Burns EJ, Tukpah AM, Santiago A, Wu C, Patel B, Kumar D, Quintana FJ.
Nat Commun 5:3753. doi: 10.1038/ncomms4753. 2014
18CD40LG, IL21, PRDM1
IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells.
Ding BB, Bi E, Chen H, Yu JJ, Ye BH.
J Immunol 190(4):1827-36. doi: 10.4049/jimmunol.1201678. Epub 2013 Jan 16. 2013
19IL21, TBX21
IL-21 promotes CD8+ CTL activity via the transcription factor T-bet.
Sutherland AP, Joller N, Michaud M, Liu SM, Kuchroo VK, Grusby MJ.
J Immunol 190(8):3977-84. doi: 10.4049/jimmunol.1201730. 2013
20CSF2, IL21
The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells.
Wan CK, Oh J, Li P, West EE, Wong EA, Andraski AB, Spolski R, Yu ZX, He J, Kelsall BL, Leonard WJ.
Immunity 38(3):514-27. doi: 10.1016/j.immuni.2013.02.011. Epub 2013 Feb 28. 2013
21IL21, IL21R
Caspase-8 cleavage of the interleukin-21 (IL-21) receptor is a negative feedback regulator of IL-21 signaling.
Akagi T, Shimizu K, Takahama S, Iwasaki T, Sakamaki K, Endo Y, Sawasaki T.
FEBS Lett 585(12):1835-40. Epub 2011 Apr 20. 2011
22IL21, IL21R
IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain.
Tzartos JS, Craner MJ, Friese MA, Jakobsen KB, Newcombe J, Esiri MM, Fugger L.
Am J Pathol 178(2):794-802. 2011
23IL21, IL21R
IL-21 receptor is critical for the development of memory B cell responses.
Rankin AL, MacLeod H, Keegan S, Andreyeva T, Lowe L, Bloom L, Collins M, Nickerson-Nutter C, Young D, Guay H.
J Immunol 186(2):667-74. Epub 2010 Dec 17. 2011
24IL21, REL
Regulation of the IL-21 gene by the NF-kappaB transcription factor c-Rel.
Chen G, Hardy K, Bunting K, Daley S, Ma L, Shannon MF.
J Immunol 185(4):2350-9. Epub 2010 Jul 16. 2010
25IL21
Cutting edge: IL-21 and TLR signaling regulate germinal center responses in a B cell-intrinsic manner.
Bessa J, Kopf M, Bachmann MF.
J Immunol 184(9):4615-9. Epub 2010 Apr 5. 2010
26IL21
A vital role for interleukin-21 in the control of a chronic viral infection.
Yi JS, Du M, Zajac AJ.
Science 324(5934):1572-6. Epub 2009 May 14. 2009
27IL21, IL21R
Il-21 enhances NK cell activation and cytolytic activity and induces Th17 cell differentiation in inflammatory bowel disease.
Liu Z, Yang L, Cui Y, Wang X, Guo C, Huang Z, Kan Q, Liu Z, Liu Y.
Inflamm Bowel Dis 15(8):1133-44. 2009
28IL21, IL21R
IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo.
Sonderegger I, Kisielow J, Meier R, King C, Kopf M.
Eur J Immunol 38(7):1833-8. 2008
29CCL20,IL21
A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells.
Caruso R, Fina D, Peluso I, Stolfi C, Fantini MC, Gioia V, Caprioli F, Del Vecchio Blanco G, Paoluzi OA, Macdonald TT, Pallone F, Monteleone G.
Gastroenterology 132(1):166-75. Epub 2006 Oct 1. 2007
30ADAD1,IL2,IL21,KIAA1109
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.
van Heel DA, Franke L, Hunt KA, Gwilliam R, Zhernakova A, Inouye M, Wapenaar MC, Barnardo MC, Bethel G, Holmes GK, Feighery C, Jewell D, Kelleher D, Kumar P, Travis S, Walters JR, Sanders DS, Howdle P, Swift J, Playford RJ, McLaren WM, Mearin ML, Mulder CJ, McManus R, McGinnis R, Cardon LR, Deloukas P, Wijmenga C.
Nat Genet 39(7):827-9. Epub 2007 Jun 10. 2007
31IL21, IL21R
IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo.
Fröhlich A, Marsland BJ, Sonderegger I, Kurrer M, Hodge MR, Harris NL, Kopf M.
Blood 109(5):2023-31. Epub 2006 Oct 31. 2007
32IL21
Identification of cellular intermediates and molecular pathways induced by IL-21 in human B cells.
Konforte D, Paige CJ.
J Immunol 177(12):8381-92. 2006
33IL21
Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation.
Leonard WJ, Spolski R.
Nat Rev Immunol 5(9):688-98. Review. 2005
34IL21, IL21R
Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity.
Wu Z, Kim HP, Xue HH, Liu H, Zhao K, Leonard WJ.
Mol Cell Biol 25(22):9741-52. 2005
35IL21, IL21R
Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function.
Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, Gross JA, Johnston J, Madden K, Xu W, West J, Schrader S, Burkhead S, Heipel M, Brandt C, Kuijper JL, Kramer J, Conklin D, Presnell SR, Berry J, Shiota F, Bort S, Hambly K, Mudri S, Clegg C, Moore M, Grant FJ, Lofton-Day C, Gilbert T, Rayond F, Ching A, Yao L, Smith D, Webster P, Whitmore T, Maurer M, Kaushansky K, Holly RD, Foster D.
Nature 408(6808):57-63. 2000