Citations for
1AKT1, IFNA1, IL2, IL7
Interferon-α inhibits CD4 T cell responses to interleukin-7 and interleukin-2 and selectively interferes with Akt signaling.
Nguyen TP, Bazdar DA, Mudd JC, Lederman MM, Harding CV, Hardy GA, Sieg SF.
J Leukoc Biol 97(6):1139-46. doi: 10.1189/jlb.4A0714-345RR. Epub 2015 Mar 17. 2015
2ETS1, IL2, NFATC1, PRDM1
Ets-1 facilitates nuclear entry of NFAT proteins and their recruitment to the IL-2 promoter.
Tsao HW, Tai TS, Tseng W, Chang HH, Grenningloh R, Miaw SC, Ho IC.
Proc Natl Acad Sci U S A 110(39):15776-81. doi: 10.1073/pnas.1304343110. Epub 2013 Sep 9. 2013
3CSF2, IL2
NF-κB controls Il2 and Csf2 expression during T cell development and activation process.
Li Y, Ohms SJ, Sun C, Fan J.
Mol Biol Rep 40(2):1685-92. doi: 10.1007/s11033-012-2219-2. Epub 2012 Oct 20. 2013
4CREM, IL17A, IL2, ORMDL3
cAMP response element modulator α controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus.
Hedrich CM, Crispin JC, Rauen T, Ioannidis C, Apostolidis SA, Lo MS, Kyttaris VC, Tsokos GC.
Proc Natl Acad Sci U S A 109(41):16606-11. doi: 10.1073/pnas.1210129109. Epub 2012 Sep 26. 2012
5CD86, IL2, NFATC1
IL-2 upregulates CD86 expression on human CD4(+) and CD8(+) T cells.
Paine A, Kirchner H, Immenschuh S, Oelke M, Blasczyk R, Eiz-Vesper B.
J Immunol 188(4):1620-9. doi: 10.4049/jimmunol.1100181. Epub 2012 Jan 13. 2012
6DUSP4, IL2, STAT5B
DUSP4 deficiency enhances CD25 expression and CD4+ T-cell proliferation without impeding T-cell development.
Huang CY, Lin YC, Hsiao WY, Liao FH, Huang PY, Tan TH.
Eur J Immunol 42(2):476-88. doi: 10.1002/eji.201041295. Epub 2011 Dec 27. 2012
7CSF2, IL2
Depletion of c-Rel from cytokine gene promoters is required for chromatin reassembly and termination of gene responses to T cell activation.
Poke FS, Upcher WR, Sprod OR, Young A, Brettingham-Moore KH, Holloway AF.
PLoS One 7(7):e41734. doi: 10.1371/journal.pone.0041734. Epub 2012 Jul 30. 2012
8IL2, IL4, IRF4, REL
Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel.
Shindo H, Yasui K, Yamamoto K, Honma K, Yui K, Kohno T, Ma Y, Chua KJ, Kubo Y, Aihara H, Ito T, Nagayasu T, Matsuyama T, Hayashi H.
Cytokine 56(3):564-72. doi: 10.1016/j.cyto.2011.08.014. Epub 2011 Sep 3. 2011
9IL2, MAF
IL-2 regulates expression of C-MAF in human CD4 T cells.
Rani A, Afzali B, Kelly A, Tewolde-Berhan L, Hackett M, Kanhere AS, Pedroza-Pacheco I, Bowen H, Jurcevic S, Jenner RG, Cousins DJ, Ragheb JA, Lavender P, John S.
J Immunol 187(7):3721-9. doi: 10.4049/jimmunol.1002354. Epub 2011 Aug 29. 2011
10IL2, IL2RA, IL2RB
Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk.
Cavanillas ML, Alcina A, Núñez C, de las Heras V, Fernández-Arquero M, Bartolomé M, de la Concha EG, Fernández O, Arroyo R, Matesanz F, Urcelay E.
Eur J Hum Genet 18(7):794-9. Epub 2010 Feb 24.PMID: 20179739 2010
11IL15, IL2
Distinct roles for IL-2 and IL-15 in the differentiation and survival of CD8+ effector and memory T cells.
Mitchell DM, Ravkov EV, Williams MA.
J Immunol 184(12):6719-30. doi: 10.4049/jimmunol.0904089. Epub 2010 May 14. 2010
12IL2
IL-2 producing memory CD4+ T lymphocytes are closely associated with the generation of IgG-secreting plasma cells.
Litjens NH, Huisman M, Hijdra D, Lambrecht BM, Stittelaar KJ, Betjes MG.
J Immunol 181(5):3665-73. 2008
13IL2
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner VE, Gonzalez-Munoz A, Clark J, Veijola R, Cubbon R, Chen SL, Rosa R, Cumiskey AM, Serreze DV, Gregory S, Rogers J, Lyons PA, Healy B, Smink LJ, Todd JA, Peterson LB, Wicker LS, Santamaria P.
Nat Genet 39(3):329-37. Epub 2007 Feb 4. 2007
14ADAD1,IL2,IL21,KIAA1109
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.
van Heel DA, Franke L, Hunt KA, Gwilliam R, Zhernakova A, Inouye M, Wapenaar MC, Barnardo MC, Bethel G, Holmes GK, Feighery C, Jewell D, Kelleher D, Kumar P, Travis S, Walters JR, Sanders DS, Howdle P, Swift J, Playford RJ, McLaren WM, Mearin ML, Mulder CJ, McManus R, McGinnis R, Cardon LR, Deloukas P, Wijmenga C.
Nat Genet 39(7):827-9. Epub 2007 Jun 10. 2007
15MAP3K7, IL2
TAK1-mediated transcriptional activation of CD28-responsive element and AP-1-binding site within the IL-2 promoter in Jurkat T cells.
Sakurai H, Singhirunnusorn P, Shimotabira E, Chino A, Suzuki S, Koizumi K, Saiki I.
FEBS Lett 579(29):6641-6. Epub 2005 Nov 9. 2005
16IL2, MAP3K1, STK10
Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells.
Tao L, Wadsworth S, Mercer J, Mueller C, Lynn K, Siekierka J, August A.
Biochem J 363(Pt 1):175-82. 2002
17IFNG, IL2, NMI, STAT1, STAT5A
Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.
Zhu M, et al.
Cell 96(1):121-30. 1999
18IL2
Two novel biallelic polymorphisms in the IL-2 gene.
John S, et al.
Eur J Immunogenet 25(6):419-20. 1998
19FOXK2, IL2
Constitutive binding of the transcription factor interleukin-2 (IL-2) enhancer binding factor to the IL-2 promoter.
Nirula A, Moore DJ, Gaynor RB.
J Biol Chem 272(12):7736-45. 1997
20IL2, IL7, IL15
Role of interleukin-2 (IL-2), IL-7, and IL-15 in natural killer cell differentiation from cord blood hematopoietic progenitor cells and from gamma c transduced severe combined immunodeficiency X1 bone marrow cells.
Cavazzana-Calvo M, et al.
Blood 88 : 3901-3909. 1996
21IL2, IL5RA
Dinucleotide repeat polymorphism in the IL2 and IL5RA genes.
Epplen C, et al.
Hum Mol Genet 3 : 679. 1994
22IL2
Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn's disease but not ulcerative colitis.
Mullin GE, et al.
Gastroenterology 102 : 1620-1627. 1992
23IL5, IL2
Expression of interleukin 5 by the CD4+CD45Ro+ subset of human T cells.
Sewell WA, et al.
Growth Factors 6 : 295-302. 1992
24IL2, IL2R
Suppression of interleukin-2 and interleukin-2 receptor expression in Jurkat cells stably expressing the human immunodeficiency virus Tat protein.
Purvis SF, Georges DL, Williams TM, Lederman MM.
Cell Immunol 144(1):32-42. 1992
25IL2
Severe combined immunodeficiency due to a specific defect in the production of interleukin-2.
Weinberg K, et al.
N Engl J Med 322 : 1718-1723. 1990
26ADH@, ADH1A, ADH1B, ADH1C, ADH4, ADH5, IL2, RIEG1
Mapping of ADH3, EGF and IL2 in a patient with Riegers-like phenotype and 4q23-q27 deletion.
Shiang R, et al.
Am J Hum Genet 41 : A185. 1987
27IL2
Genetic localization of the structural gene for T-cell growth factor (interleukin-2) in normal and HTLV infected human genomes and in the domestic cat.
Seigel LS, et al.
(HGM7) Cytogenet Cell Genet 37 : 579-580. 1984
28IL2
Gene for T-cell growth factor : Location on human chromosome 4q and feline chromosome B1.
Seigel LJ, et al.
Science 223 : 175-178. 1984
29IL2
Interleukin 2 (IL2) is assigned to human chromosome 4.
Shows T, et al.
Somat Cell Mol Genet 10 : 315-318. 1984
30IL2
Human interleukin-2 (IL2) is on chromosome 4.
Shows TB, et al.
(HGM7) Cytogenet Cell Genet 37 : 583-584. 1984
31IL2
T-cell growth factor : complete nucleotide sequence and organization of the gene in normal and malignant cells.
Holbrook NJ, et al.
Proc Natl Acad Sci U S A 81 : 1634-1638. 1984