1 | AKT1, IFNA1, IL2, IL7
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| Interferon-α inhibits CD4 T cell responses to interleukin-7 and interleukin-2 and selectively interferes with Akt signaling.
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| Nguyen TP, Bazdar DA, Mudd JC, Lederman MM, Harding CV, Hardy GA, Sieg SF.
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| J Leukoc Biol 97(6):1139-46. doi: 10.1189/jlb.4A0714-345RR. Epub 2015 Mar 17.
2015
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2 | ETS1, IL2, NFATC1, PRDM1
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| Ets-1 facilitates nuclear entry of NFAT proteins and their recruitment to the IL-2 promoter.
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| Tsao HW, Tai TS, Tseng W, Chang HH, Grenningloh R, Miaw SC, Ho IC.
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| Proc Natl Acad Sci U S A 110(39):15776-81. doi: 10.1073/pnas.1304343110. Epub 2013 Sep 9. 2013
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3 | CSF2, IL2
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| NF-κB controls Il2 and Csf2 expression during T cell development and activation process.
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| Li Y, Ohms SJ, Sun C, Fan J.
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| Mol Biol Rep 40(2):1685-92. doi: 10.1007/s11033-012-2219-2. Epub 2012 Oct 20.
2013
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4 | CREM, IL17A, IL2, ORMDL3
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| cAMP response element modulator α controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus.
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| Hedrich CM, Crispin JC, Rauen T, Ioannidis C, Apostolidis SA, Lo MS, Kyttaris VC, Tsokos GC.
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| Proc Natl Acad Sci U S A 109(41):16606-11. doi: 10.1073/pnas.1210129109. Epub 2012 Sep 26. 2012
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5 | CD86, IL2, NFATC1
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| IL-2 upregulates CD86 expression on human CD4(+) and CD8(+) T cells.
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| Paine A, Kirchner H, Immenschuh S, Oelke M, Blasczyk R, Eiz-Vesper B.
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| J Immunol 188(4):1620-9. doi: 10.4049/jimmunol.1100181. Epub 2012 Jan 13.
2012
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6 | DUSP4, IL2, STAT5B
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| DUSP4 deficiency enhances CD25 expression and CD4+ T-cell proliferation without impeding T-cell development.
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| Huang CY, Lin YC, Hsiao WY, Liao FH, Huang PY, Tan TH.
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| Eur J Immunol 42(2):476-88. doi: 10.1002/eji.201041295. Epub 2011 Dec 27.
2012
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7 | CSF2, IL2
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| Depletion of c-Rel from cytokine gene promoters is required for chromatin reassembly and termination of gene responses to T cell activation.
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| Poke FS, Upcher WR, Sprod OR, Young A, Brettingham-Moore KH, Holloway AF.
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| PLoS One 7(7):e41734. doi: 10.1371/journal.pone.0041734. Epub 2012 Jul 30.
2012
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8 | IL2, IL4, IRF4, REL
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| Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel.
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| Shindo H, Yasui K, Yamamoto K, Honma K, Yui K, Kohno T, Ma Y, Chua KJ, Kubo Y, Aihara H, Ito T, Nagayasu T, Matsuyama T, Hayashi H.
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| Cytokine 56(3):564-72. doi: 10.1016/j.cyto.2011.08.014. Epub 2011 Sep 3.
2011
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9 | IL2, MAF
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| IL-2 regulates expression of C-MAF in human CD4 T cells.
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| Rani A, Afzali B, Kelly A, Tewolde-Berhan L, Hackett M, Kanhere AS, Pedroza-Pacheco I, Bowen H, Jurcevic S, Jenner RG, Cousins DJ, Ragheb JA, Lavender P, John S.
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| J Immunol 187(7):3721-9. doi: 10.4049/jimmunol.1002354. Epub 2011 Aug 29.
2011
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10 | IL2, IL2RA, IL2RB
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| Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk.
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| Cavanillas ML, Alcina A, Núñez C, de las Heras V, Fernández-Arquero M, Bartolomé M, de la Concha EG, Fernández O, Arroyo R, Matesanz F, Urcelay E.
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| Eur J Hum Genet 18(7):794-9. Epub 2010 Feb 24.PMID: 20179739 2010
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11 | IL15, IL2
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| Distinct roles for IL-2 and IL-15 in the differentiation and survival of CD8+ effector and memory T cells.
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| Mitchell DM, Ravkov EV, Williams MA.
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| J Immunol 184(12):6719-30. doi: 10.4049/jimmunol.0904089. Epub 2010 May 14.
2010
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12 | IL2
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| IL-2 producing memory CD4+ T lymphocytes are closely associated with the generation of IgG-secreting plasma cells.
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| Litjens NH, Huisman M, Hijdra D, Lambrecht BM, Stittelaar KJ, Betjes MG.
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| J Immunol 181(5):3665-73.
2008
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13 | IL2
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| Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
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| Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner VE, Gonzalez-Munoz A, Clark J, Veijola R, Cubbon R, Chen SL, Rosa R, Cumiskey AM, Serreze DV, Gregory S, Rogers J, Lyons PA, Healy B, Smink LJ, Todd JA, Peterson LB, Wicker LS, Santamaria P.
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| Nat Genet 39(3):329-37. Epub 2007 Feb 4. 2007
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14 | ADAD1,IL2,IL21,KIAA1109
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| A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.
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| van Heel DA, Franke L, Hunt KA, Gwilliam R, Zhernakova A, Inouye M, Wapenaar MC, Barnardo MC, Bethel G, Holmes GK, Feighery C, Jewell D, Kelleher D, Kumar P, Travis S, Walters JR, Sanders DS, Howdle P, Swift J, Playford RJ, McLaren WM, Mearin ML, Mulder CJ, McManus R, McGinnis R, Cardon LR, Deloukas P, Wijmenga C.
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| Nat Genet 39(7):827-9. Epub 2007 Jun 10. 2007
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15 | MAP3K7, IL2
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| TAK1-mediated transcriptional activation of CD28-responsive element and AP-1-binding site within the IL-2 promoter in Jurkat T cells.
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| Sakurai H, Singhirunnusorn P, Shimotabira E, Chino A, Suzuki S, Koizumi K, Saiki I.
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| FEBS Lett 579(29):6641-6. Epub 2005 Nov 9. 2005
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16 | IL2, MAP3K1, STK10
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| Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells.
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| Tao L, Wadsworth S, Mercer J, Mueller C, Lynn K, Siekierka J, August A.
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| Biochem J 363(Pt 1):175-82.
2002
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17 | IFNG, IL2, NMI, STAT1, STAT5A
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| Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.
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| Zhu M, et al.
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| Cell 96(1):121-30. 1999
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18 | IL2
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| Two novel biallelic polymorphisms in the IL-2 gene.
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| John S, et al.
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| Eur J Immunogenet 25(6):419-20. 1998
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19 | FOXK2, IL2
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| Constitutive binding of the transcription factor interleukin-2 (IL-2) enhancer binding factor to the IL-2 promoter.
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| Nirula A, Moore DJ, Gaynor RB.
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| J Biol Chem 272(12):7736-45.
1997
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20 | IL2, IL7, IL15
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| Role of interleukin-2 (IL-2), IL-7, and IL-15 in natural killer cell differentiation from cord blood hematopoietic progenitor cells and from gamma c transduced severe combined immunodeficiency X1 bone marrow cells.
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| Cavazzana-Calvo M, et al.
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| Blood 88 : 3901-3909. 1996
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21 | IL2, IL5RA
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| Dinucleotide repeat polymorphism in the IL2 and IL5RA genes.
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| Epplen C, et al.
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| Hum Mol Genet 3 : 679. 1994
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22 | IL2
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| Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn's disease but not ulcerative colitis.
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| Mullin GE, et al.
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| Gastroenterology 102 : 1620-1627. 1992
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23 | IL5, IL2
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| Expression of interleukin 5 by the CD4+CD45Ro+ subset of human T cells.
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| Sewell WA, et al.
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| Growth Factors 6 : 295-302. 1992
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24 | IL2, IL2R
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| Suppression of interleukin-2 and interleukin-2 receptor expression in Jurkat cells stably expressing the human immunodeficiency virus Tat protein.
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| Purvis SF, Georges DL, Williams TM, Lederman MM.
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| Cell Immunol 144(1):32-42.
1992
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25 | IL2
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| Severe combined immunodeficiency due to a specific defect in the production of interleukin-2.
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| Weinberg K, et al.
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| N Engl J Med 322 : 1718-1723. 1990
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26 | ADH@, ADH1A, ADH1B, ADH1C, ADH4, ADH5, IL2, RIEG1
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| Mapping of ADH3, EGF and IL2 in a patient with Riegers-like phenotype and 4q23-q27 deletion.
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| Shiang R, et al.
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| Am J Hum Genet 41 : A185. 1987
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27 | IL2
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| Genetic localization of the structural gene for T-cell growth factor (interleukin-2) in normal and HTLV infected human genomes and in the domestic cat.
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| Seigel LS, et al.
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| (HGM7) Cytogenet Cell Genet 37 : 579-580. 1984
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28 | IL2
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| Gene for T-cell growth factor : Location on human chromosome 4q and feline chromosome B1.
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| Seigel LJ, et al.
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| Science 223 : 175-178. 1984
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29 | IL2
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| Interleukin 2 (IL2) is assigned to human chromosome 4.
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| Shows T, et al.
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| Somat Cell Mol Genet 10 : 315-318. 1984
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30 | IL2
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| Human interleukin-2 (IL2) is on chromosome 4.
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| Shows TB, et al.
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| (HGM7) Cytogenet Cell Genet 37 : 583-584. 1984
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31 | IL2
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| T-cell growth factor : complete nucleotide sequence and organization of the gene in normal and malignant cells.
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| Holbrook NJ, et al.
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| Proc Natl Acad Sci U S A 81 : 1634-1638. 1984
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