| 1 | IL1R1, PIK3AP1
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| BCAP links IL-1R to the PI3K-mTOR pathway and regulates pathogenic Th17 cell differentiation.
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| Deason K, Troutman TD, Jain A, Challa DK, Mandraju R, Brewer T, Ward ES, Pasare C.
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| J Exp Med 215(9):2413-2428. doi: 10.1084/jem.20171810. Epub 2018 Aug 9.
2018
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| 2 | IL1A, IL1R1, IL23A, MYD88
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| MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling.
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| Chang J, Burkett PR, Borges CM, Kuchroo VK, Turka LA, Chang CH.
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| Proc Natl Acad Sci U S A 110(6):2270-5. doi: 10.1073/pnas.1206048110. Epub 2013 Jan 22.
2013
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| 3 | IL1R1, PDX1
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| Neutralizing interleukin-1beta (IL-1beta) induces beta-cell survival by maintaining PDX1 protein nuclear localization.
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| Ardestani A, Sauter NS, Paroni F, Dharmadhikari G, Cho JH, Lupi R, Marchetti P, Oberholzer J, Conte JK, Maedler K.
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| J Biol Chem 286(19):17144-55. doi: 10.1074/jbc.M110.210526. Epub 2011 Mar 10.
2011
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| 4 | FREM1, IL1R1, MYD88
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| TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control Ras-dependent amplification of NF-kappaB.
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| Zhang X, Shephard F, Kim HB, Palmer IR, McHarg S, Fowler GJ, O'Neill LA, Kiss-Toth E, Qwarnstrom EE.
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| J Biol Chem 285(10):7222-32. Epub 2009 Nov 25. Erratum in: J Biol Chem. 2010 Jun 4;285(23):18122. 2010
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| 5 | IL1R1
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| Expression and function of TNF and IL-1 receptors on human regulatory T cells.
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| Mercer F, Kozhaya L, Unutmaz D.
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| PLoS One 5(1):e8639.PMID: 20066156 2010
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| 6 | IL1R1
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| Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane proteolysis.
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| Elzinga BM, Twomey C, Powell JC, Harte F, McCarthy JV.
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| J Biol Chem 284(3):1394-409. Epub 2008 Nov 7.PMID: 18996842 2009
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| 7 | IL1R1, TOLLIP, TOM1
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| Intracellular trafficking of interleukin-1 receptor I requires Tollip.
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| Brissoni B, Agostini L, Kropf M, Martinon F, Swoboda V, Lippens S, Everett H, Aebi N, Janssens S, Meylan E, Felberbaum-Corti M, Hirling H, Gruenberg J, Tschopp J, Burns K.
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| Curr Biol 16(22):2265-70.PMID: 17113392 2006
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| 8 | IL1R1
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| Central IL-1 receptor signaling regulates bone growth and mass.
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| Bajayo A, Goshen I, Feldman S, Csernus V, Iverfeldt K, Shohami E, Yirmiya R, Bab I.
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| Proc Natl Acad Sci U S A 102(36):12956-61. Epub 2005 Aug 26. 2005
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| 9 | IL1B, IL1R1
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| Interleukin-1 cluster is associated with genetic risk for schizophrenia and bipolar disorder.
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| Papiol S, Rosa A, Gutierrez B, Martin B, Salgado P, Catalan R, Arias B, Fananas L.
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| J Med Genet 41(3):219-23. No abstract available. 2004
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| 10 | IL1R1
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| Osteoporotic fractures are associated with an 86-base pair repeat polymorphism in the interleukin-1--receptor antagonist gene but not with polymorphisms in the interleukin-1beta gene.
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| Langdahl BL, Lokke E, Carstens M, Stenkjaer LL, Eriksen EF.
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| J Bone Miner Res 15(3):402-14. 2000
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| 11 | IL1R1, IRAK1, TOLLIP
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| Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.
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| Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, Lewis A, Ray K, Tschopp J, Volpe F.
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| Nat Cell Biol 2(6):346-51. 2000
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| 12 | IL1R1
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| Cotranscription and intergenic splicing of human galactose-1-phosphate uridylyltransferase and interleukin-11 receptor alpha-chain genes generate a fusion mRNA in normal cells. Implication for the production of multidomain proteins during evolution.
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| Magrangeas F, Pitiot G, Dubois S, Bragado-Nilsson E, Cherel M, Jobert S, Lebeau B, Boisteau O, Lethe B, Mallet J, Jacques Y, Minvielle S.
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| J Biol Chem 273(26):16005-10. 1998
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| 13 | IL1R1, IRAK1, IRAK2
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| The IL1 receptor accessory protein is responsible for the recruitment of the interleukin-1 receptor associated kinase to the IL1/IL1 receptor I complex.
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| Volpe F, Clatworthy J, Kaptein A, Maschera B, Griffin AM, Ray K.
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| FEBS Lett 419(1):41-4. 1997
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| 14 | IL1R1, IL1R2
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| Genomic organization of the type I and type II IL-1 receptors.
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| Sims JE, et al.
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| Cytokine 7 : 483-490. 1995
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| 15 | IL1R1
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| Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat.
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| Tarlow JK, et al.
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| Hum Genet 91 : 403-404. 1993
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| 16 | IL1R1
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| Chromosomal location of murine and human IL-1 receptor genes.
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| Copeland NG, et al.
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| Genomics 9 : 44-50. 1991
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| 17 | IL1R1, IL1R2
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| A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.
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| McMahan CJ, et al.
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| EMBO J 10 : 2821-2832. 1991
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| 18 | IL1-2@, IL1R1, IL1R@
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| Two high-affinity interleukin 1 receptors represent separate gene products.
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| Chizzonite R, et al.
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| Proc Natl Acad Sci U S A 86 : 8029-8033. 1989
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