| 1 | IL1B, NLRC4, NLRP12
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| Epigenetic hypomethylation and upregulation of NLRC4 and NLRP12 in Kawasaki disease.
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| Huang YH, Lo MH, Cai XY, Kuo HC.
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| Oncotarget 9(27):18939-18948. doi: 10.18632/oncotarget.24851. eCollection 2018 Apr 10.
2018
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| 2 | CASP1, CASP4, IL1B
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| Involvement of caspase-4 in IL-1 beta production and pyroptosis in human macrophages during dengue virus infection.
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| Cheung KT, Sze DM, Chan KH, Leung PH.
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| Immunobiology 223(4-5):356-364. doi: 10.1016/j.imbio.2017.10.044. Epub 2017 Oct 26.
2018
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| 3 | AMTN, IL1B
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| Transcriptional regulation of human amelotin gene by interleukin-1β
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| Yamazaki M, Mezawa M, Noda K, Iwai Y, Matsui S, Takai H, Nakayama Y, Ogata Y.
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| FEBS Open Bio. May 14;8(6):974-985. doi: 10.1002/2211-5463.12434 2018
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| 4 | IL1B, RSPO3
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| RSPO3 impairs barrier function of human vascular endothelial monolayers and synergizes with pro-inflammatory IL-1
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| Skaria T, Bachli E, Schoedon G.
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| Mol Med. Aug 29;24(1):45. doi: 10.1186/s10020-018-0048-z. 2018
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| 5 | CASP1, IL1B
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| The Atypical Ubiquitin E2 Conjugase UBE2L3 Is an Indirect Caspase-1 Target and Controls IL-1β Secretion by Inflammasomes.
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| Eldridge MJG, Sanchez-Garrido J, Hoben GF, Goddard PJ, Shenoy AR.
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| Cell Rep 18(5):1285-1297. doi: 10.1016/j.celrep.2017.01.015.
2017
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| 6 | IL1B, NLRC4
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| Involvement of the NLRC4-Inflammasome in Diabetic Nephropathy.
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| Yuan F, Kolb R, Pandey G, Li W, Sun L, Liu F, Sutterwala FS, Liu Y, Zhang W.
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| PLoS One 11(10):e0164135. doi: 10.1371/journal.pone.0164135. eCollection 2016.
2016
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| 7 | CD14, IL17A, IL1B
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| New roles for CD14 and IL-β linking inflammatory dendritic cells to IL-17 production in memory CD4+ T cells.
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| Ilarregui JM, van Beelen AJ, Fehres CM, Bruijns SC, García-Vallejo JJ, van Kooyk Y.
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| Immunol Cell Biol 94(10):907-916. doi: 10.1038/icb.2016.66. Epub 2016 Aug 23.
2016
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| 8 | IL1A, IL1B
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| Requirement for interleukin-1 to drive brain inflammation reveals tissue-specific mechanisms of innate immunity.
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| Giles JA, Greenhalgh AD, Davies CL, Denes A, Shaw T, Coutts G, Rothwell NJ, McColl BW, Allan SM.
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| Eur J Immunol 45(2):525-30. doi: 10.1002/eji.201444748. Epub 2014 Nov 24.
2015
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| 9 | IL1B, IL36G
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| Interleukin (IL)-1β Is a Strong Inducer of IL-36γ Expression in Human Colonic Myofibroblasts.
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| Takahashi K, Nishida A, Shioya M, Imaeda H, Bamba S, Inatomi O, Shimizu T, Kitoh K, Andoh A.
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| PLoS One 10(11):e0138423. doi: 10.1371/journal.pone.0138423. eCollection 2015.
2015
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| 10 | ADAMTS9, IL1B, NFKB1
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| Interleukin-1β induced nuclear factor-κB binds to a disintegrin-like and metalloproteinase with thrombospondin type 1 motif 9 promoter in human chondrosarcoma cells.
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| Altuntas A, Halacli SO, Cakmak O, Erden G, Akyol S, Ugurcu V, Hirohata S, Demircan K.
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| Mol Med Rep 12(1):595-600. doi: 10.3892/mmr.2015.3444. Epub 2015 Mar 6.
2015
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| 11 | CASP1, IL1B, NLRP3, PLIN2
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| PLIN2 inhibits insulin-induced glucose uptake in myoblasts through the activation of the NLRP3 inflammasome.
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| Cho KA, Kang PB.
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| Int J Mol Med 36(3):839-44. doi: 10.3892/ijmm.2015.2276. Epub 2015 Jul 8.
2015
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| 12 | CASP1, CASP8, IL1B
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| Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling.
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| Antonopoulos C, Russo HM, El Sanadi C, Martin BN, Li X, Kaiser WJ, Mocarski ES, Dubyak GR.
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| J Biol Chem 290(33):20167-84. doi: 10.1074/jbc.M115.652321. Epub 2015 Jun 22.
2015
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| 13 | DNASE1, IL1B
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| TNFα Amplifies DNaseI Expression in Renal Tubular Cells while IL-1β Promotes Nuclear DNaseI Translocation in an Endonuclease-Inactive Form.
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| Thiyagarajan D, Rekvig OP, Seredkina N.
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| PLoS One 10(6):e0129485. doi: 10.1371/journal.pone.0129485. eCollection 2015.
2015
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| 14 | CASP4, CASP5, IL1A, IL1B
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| Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes.
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| Viganò E, Diamond CE, Spreafico R, Balachander A, Sobota RM, Mortellaro A.
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| Nat Commun 6:8761. doi: 10.1038/ncomms9761.
2015
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| 15 | CCL4, IL12B, IL1A, IL1B, STX3
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| An essential role of syntaxin 3 protein for granule exocytosis and secretion of IL-1α, IL-1β, IL-12b, and CCL4 from differentiated HL-60 cells.
|
| Naegelen I, Plançon S, Nicot N, Kaoma T, Muller A, Vallar L, Tschirhart EJ, Bréchard S.
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| J Leukoc Biol 97(3):557-71. doi: 10.1189/jlb.3A0514-254RR. Epub 2014 Dec 29.
2015
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| 16 | IL1B, NOTCH1, NOTCH4
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| Activation of an endothelial Notch1-Jagged1 circuit induces VCAM1 expression, an effect amplified by interleukin-1β.
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| Verginelli F, Adesso L, Limon I, Alisi A, Gueguen M, Panera N, Giorda E, Raimondi L, Ciarapica R, Campese AF, Screpanti I, Stifani S, Kitajewski J, Miele L, Rota R, Locatelli F.
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| Oncotarget Dec 22;6(41):43216-29. doi: 10.18632/oncotarget.6456 2015
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| 17 | IL1A, IL1B
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| Dendritic cell IL-1α and IL-1β are polyubiquitinated and degraded by the proteasome.
|
| Ainscough JS, Frank Gerberick G, Zahedi-Nejad M, Lopez-Castejon G, Brough D, Kimber I, Dearman RJ.
|
| J Biol Chem 289(51):35582-92. doi: 10.1074/jbc.M114.595686. Epub 2014 Nov 4.
2014
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| 18 | IL1A, IL1B
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| Interleukin-1 deficiency prolongs ovarian lifespan in mice.
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| Uri-Belapolsky S, Shaish A, Eliyahu E, Grossman H, Levi M, Chuderland D, Ninio-Many L, Hasky N, Shashar D, Almog T, Kandel-Kfir M, Harats D, Shalgi R, Kamari Y.
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| Proc Natl Acad Sci U S A 111(34):12492-7. doi: 10.1073/pnas.1323955111. Epub 2014 Aug 11.
2014
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| 19 | IL1A, IL1B
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| Release of interleukin-1α or interleukin-1β depends on mechanism of cell death.
|
| England H, Summersgill HR, Edye ME, Rothwell NJ, Brough D.
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| J Biol Chem 289(23):15942-50. doi: 10.1074/jbc.M114.557561. Epub 2014 Apr 30.
2014
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| 20 | IL1B, MYLK
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| Non-muscle Mlck is required for β-catenin- and FoxO1-dependent downregulation of Cldn5 in IL-1β-mediated barrier dysfunction in brain endothelial cells.
|
| Beard RS Jr, Haines RJ, Wu KY, Reynolds JJ, Davis SM, Elliott JE, Malinin NL, Chatterjee V, Cha BJ, Wu MH, Yuan SY.
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| J Cell Sci 127(Pt 8):1840-53. doi: 10.1242/jcs.144550. Epub 2014 Feb 12.
2014
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| 21 | CASP4, IL1B, TLR3
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| TLR3 mediates release of IL-1β and cell death in keratinocytes in a caspase-4 dependent manner.
|
| Grimstad Ø, Husebye H, Espevik T.
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| J Dermatol Sci 72(1):45-53. doi: 10.1016/j.jdermsci.2013.05.006. Epub 2013 Jun 12.
2013
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| 22 | IL1A, IL1B, IL23A
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| Autophagy regulates IL-23 secretion and innate T cell responses through effects on IL-1 secretion.
|
| Peral de Castro C, Jones SA, Ní Cheallaigh C, Hearnden CA, Williams L, Winter J, Lavelle EC, Mills KH, Harris J.
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| J Immunol 189(8):4144-53. doi: 10.4049/jimmunol.1201946. Epub 2012 Sep 12.
2012
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| 23 | IL1B, IL1RN
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| Analysis of IL1 gene polymorphisms and transcript levels in periodontal and chronic kidney disease.
|
| Braosi AP, de Souza CM, Luczyszyn SM, Dirschnabel AJ, Claudino M, Olandoski M, Probst CM, Garlet GP, Pecoits-Filho R, Trevilatto PC.
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| Cytokine 60(1):76-82. doi: 10.1016/j.cyto.2012.06.006. Epub 2012 Jul 13.
2012
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| 24 | AKR1C1, AKR1C2, IL1B
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| Interleukin 1β regulates progesterone metabolism in human cervical fibroblasts.
|
| Roberson AE, Hyatt K, Kenkel C, Hanson K, Myers DA.
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| Reprod Sci 19(3):271-81. doi: 10.1177/1933719111419246. Epub 2011 Nov 7. Erratum in: Reprod Sci. 2012 Jun;19(6):666.
2012
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| 25 | FOXO1, IL1B, SMPD3
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| Interleukin 1β regulation of FoxO1 protein content and localization: evidence for a novel ceramide-dependent mechanism.
|
| Dobierzewska A, Shi L, Karakashian AA, Nikolova-Karakashian MN.
|
| J Biol Chem 287(53):44749-60. doi: 10.1074/jbc.M112.378836. Epub 2012 Oct 26.
2012
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| 26 | IL1A, IL1B
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| Inflammasome activation and IL-1β target IL-1α for secretion as opposed to surface expression.
|
| Fettelschoss A, Kistowska M, LeibundGut-Landmann S, Beer HD, Johansen P, Senti G, Contassot E, Bachmann MF, French LE, Oxenius A, Kündig TM.
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| Proc Natl Acad Sci U S A 108(44):18055-60. doi: 10.1073/pnas.1109176108. Epub 2011 Oct 17.
2011
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| 27 | IL1A, IL1B
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| IL-1α and IL-1β recruit different myeloid cells and promote different stages of sterile inflammation.
|
| Rider P, Carmi Y, Guttman O, Braiman A, Cohen I, Voronov E, White MR, Dinarello CA, Apte RN.
|
| J Immunol 187(9):4835-43. doi: 10.4049/jimmunol.1102048. Epub 2011 Sep 19.
2011
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| 28 | IL1B, SMAD7
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| IL1B induced Smad 7 negatively regulates gastrin expression.
|
| Datta De D, Bhattacharjya S, Maitra M, Datta A, Choudhury A, Dhali GK, Roychoudhury S.
|
| PLoS One 6(3):e14775. doi: 10.1371/journal.pone.0014775.
2011
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| 29 | IL1A, IL1B
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| Association of IL1A and IL1B loci with primary open angle glaucoma.
|
| Mookherjee S, Banerjee D, Chakraborty S, Banerjee A, Mukhopadhyay I, Sen A, Ray K.
|
| BMC Med Genet 11:99. doi: 10.1186/1471-2350-11-99.
2010
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| 30 | IL1B, STEAP4
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| Interleukin-1beta is a positive regulator of TIARP/STAMP2 gene and protein expression in adipocytes in vitro.
|
| Kralisch S, Sommer G, Weise S, Lipfert J, Lossner U, Kamprad M, Schröck K, Bluher M, Stumvoll M, Fasshauer M.
|
| FEBS Lett 583(7):1196-200. Epub 2009 Mar 14.
2009
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| 31 | IL1B
|
| Association of variation in the interleukin-1 gene family with diabetes and glucose homeostasis.
|
| Luotola K, Pääkkönen R, Alanne M, Lanki T, Moilanen L, Surakka I, Pietilä A, Kähönen M, Nieminen MS, Kesäniemi YA, Peters A, Jula A, Perola M, Salomaa V; Health 2000 AIRGENE Study Groups.
|
| J Clin Endocrinol Metab 94(11):4575-83. doi: 10.1210/jc.2009-0666. Epub 2009 Oct 9.
2009
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| 32 | IL1A, IL1B, IL6, TNF
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| Interleukin-1alpha stimulates proinflammatory cytokine expression in human cardiac myofibroblasts.
|
| Turner NA, Das A, Warburton P, O'Regan DJ, Ball SG, Porter KE.
|
| Am J Physiol Heart Circ Physiol 297(3):H1117-27. doi: 10.1152/ajpheart.00372.2009. Epub 2009 Jul 31.
2009
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| 33 | IL1B
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| Interleukin-1alpha regulates substance P expression and release in adult sensory neurons.
|
| Skoff AM, Zhao C, Adler JE.
|
| Exp Neurol 217(2):395-400. doi: 10.1016/j.expneurol.2009.03.022. Epub 2009 Mar 31.
2009
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| 34 | APOE, COMT, DAO, DRD1, DRD2, DRD4, DTNBP1, GABRB2, GRIN2B, HP, IL1B, MTHFR, PLXNA2, SCZD23, SLC6A4, TP53, TPH1
|
| Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
|
| Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ, Tanzi RE, Bertram L.
|
| Nat Genet 40(7):827-34. 2008
|
| 35 | IL1B, IL10, IL6, TGFB1
|
| [Genetic markers of predisposition to an aggressive course of chronic C hepatitis]
|
| Abdullaev SM, Tselishcheva IuI, Samokhodskaia LM, Kvasovka VV, Ignatova TM, Krasnova TN, Bochkov VN, Mukhin NA.
|
| Vestn Ross Akad Med Nauk (1):8-13. Russian. 2007
|
| 36 | IL1B, IL1RN
|
| Genetic association of interleukin-1beta (-511C/T) and interleukin-1 receptor antagonist (86 bp repeat) polymorphisms with Type 2 diabetes mellitus in North Indians.
|
| Achyut BR, Srivastava A, Bhattacharya S, Mittal B.
|
| Clin Chim Acta 377(1-2):163-9. Epub 2006 Oct 27. 2007
|
| 37 | IL1B, IL6
|
| Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities.
|
| Rieder F, Cheng L, Harnett KM, Chak A, Cooper GS, Isenberg G, Ray M, Katz JA, Catanzaro A, O'Shea R, Post AB, Wong R, Sivak MV, McCormick T, Phillips M, West GA, Willis JE, Biancani P, Fiocchi C.
|
| Gastroenterology 132(1):154-65. Epub 2006 Oct 12. 2007
|
| 38 | ADAMTS1, TGFB1, IL1B
|
| Differential effects of interleukin-1beta and transforming growth factor-beta1 on the expression of the inflammation-associated protein, ADAMTS-1, in human decidual stromal cells in vitro.
|
| Ng YH, Zhu H, Pallen CJ, Leung PC, MacCalman CD.
|
| Hum Reprod 21(8):1990-9. Epub 2006 May 4. 2006
|
| 39 | IL1B
|
| Speed of tooth movement is related to stress and IL-1 gene polymorphisms.
|
| Iwasaki LR, Gibson CS, Crouch LD, Marx DB, Pandey JP, Nickel JC.
|
| Am J Orthod Dentofacial Orthop 130(6):698.e1-9. 2006
|
| 40 | IL1B, TCIM, TNF
|
| TC1(C8orf4) is upregulated by IL-1beta/TNF-alpha and enhances proliferation of human follicular dendritic cells.
|
| Kim Y, Kim J, Park J, Bang S, Jung Y, Choe J, Song K, Lee I.
|
| FEBS Lett 580(14):3519-24. Epub 2006 May 22. 2006
|
| 41 | IL1B
|
| The IL-1 gene family and bone involvement in celiac disease.
|
| Moreno ML, Crusius JB, Chernavsky A, Sugai E, Sambuelli A, Vazquez H, Maurino E, Pena AS, Bai JC.
|
| Immunogenetics 57(8):618-20. Epub 2005 Sep 29. 2005
|
| 42 | IL1B, IL1R1
|
| Interleukin-1 cluster is associated with genetic risk for schizophrenia and bipolar disorder.
|
| Papiol S, Rosa A, Gutierrez B, Martin B, Salgado P, Catalan R, Arias B, Fananas L.
|
| J Med Genet 41(3):219-23. No abstract available. 2004
|
| 43 | IL1B
|
| IL-1beta expression in IgM monoclonal gammopathy and its relationship to multiple myeloma.
|
| Donovan KA, Lacy MQ, Gertz MA, Lust JA.
|
| Leukemia 16(3):382-5. 2002
|
| 44 | IL1B
|
| Increased frequency of interleukin-1beta (-511) allele 2 in febrile seizures.
|
| Virta M, Hurme M, Helminen M.
|
| Pediatr Neurol 26(3):192-5. 2002
|
| 45 | IL1B
|
| The IL-1beta genotype carries asthma susceptibility only in men.
|
| Karjalainen J, Nieminen MM, Aromaa A, Klaukka T, Hurme M.
|
| J Allergy Clin Immunol 109(3):514-6. 2002
|
| 46 | CEBPB, IL1B
|
| Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6.
|
| Xie Y, Chen C, Stevenson MA, Auron PE, Calderwood SK.
|
| J Biol Chem 277(14):11802-10. 2002
|
| 47 | IL1B, SLAMF1
|
| Signaling lymphocytic activation molecule is expressed on mature CD83+ dendritic cells and is up-regulated by IL-1 beta.
|
| Kruse M, Meinl E, Henning G, Kuhnt C, Berchtold S, Berger T, Schuler G, Steinkasserer A.
|
| J Immunol 167(4):1989-95. 2001
|
| 48 | IL1B
|
| Interleukin-1 polymorphisms associated with increased risk of gastric cancer.
|
| El-Omar EM, Carrington M, Chow WH, McColl KE, Bream JH, Young HA, Herrera J, Lissowska J, Yuan CC, Rothman N, Lanyon G, Martin M, Fraumeni JF Jr, Rabkin CS.
|
| Nature 404(6776):398-402. 2000
|
| 49 | IL1B
|
| Interleukin (IL)1beta, IL-1alpha, and IL-1 receptor antagonist gene polymorphisms in patients with temporal lobe epilepsy.
|
| Kanemoto K, Kawasaki J, Miyamoto T, Obayashi H, Nishimura M.
|
| Ann Neurol 47(5):571-4. 2000
|
| 50 | IL1B
|
| IL1B gene polymorphisms influence the course and severity of inflammatory bowel disease.
|
| Nemetz A, et al.
|
| Immunogenetics 49(6):527-31. 1999
|
| 51 | IL1B, TNFRSF11B, TNFSF11
|
| Interleukin-1beta and tumor necrosis factor-alpha, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells.
|
| Hofbauer LC, Lacey DL, Dunstan CR, Spelsberg TC, Riggs BL, Khosla S.
|
| Bone 25(3):255-9 1999
|
| 52 | IDDM7, IDDM12, IDDM13, IL1A, IL1B, SLC11A1
|
| Genetic analysis of chromosome 2 in type 1 diabetes. Analysis of putative loci IDDM7, IDDM12, and IDDM13 and candidate genes NRAMP1 and IA-2 and the interleukin-1 gene cluster.
|
| Esposito L, Hill NJ, Pritchard LE, Cucca F, Muxworthy C, Merriman ME, Wilson A, Julier C, Delepine M, Tuomilehto J, Tuomilehto-Wolf E, Ionesco-Tirgoviste C, Nistico' L, Buzzetti R, Pozzilli P, Ferrari M, Bosi E, Pociot F, Nerup J, Bain SC, Todd JA.
|
| Diabetes 47 : 1797-1799. 1998
|
| 53 | IL1A, IL1B, IL1RN
|
| Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13.
|
| Nothwang HG, Strahm B, Denich D, Kubler M, Schwabe J, Gingrich JC, Jauch A, Cox A, Nicklin MJ, Kurnit DM, Hildebrandt F.
|
| Genomics 41(3):370-8. 1997
|
| 54 | IL1B, IRAK1, TRAF6
|
| TRAF6 is a signal transducer for interleukin-1.
|
| Cao Z, Xiong J, Takeuchi M, Kurama T, Goeddel DV.
|
| Nature 383(6599):443-6 1996
|
| 55 | IL1A, IL1B, IL1RN
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| A physical map of the region encompassing the human interleukin-1alpha, interleukin-1beta, and interleukin-1 receptor antagonist genes.
|
| Nicklin MJH, et al.
|
| Genomics 19 : 382-384. 1994
|
| 56 | IL1B
|
| Single base polymorphism at -511 in the human interleukin-1beta gene (IL1beta).
|
| di Giovine FS, et al.
|
| Hum Mol Genet 1 : 450. 1992
|
| 57 | IL1A, IL1B
|
| Expression of interleukin 1-inducible genes and production of interleukin 1 by aging human fibroblasts.
|
| Kumar S, et al.
|
| Proc Natl Acad Sci U S A 89 : 4683-4687. 1992
|
| 58 | IL6, IL1B, TNF
|
| Tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 expression in inflammatory bowel disease.
|
| Stevens C, Walz G, Singaram C, Lipman ML, Zanker B, Muggia A, Antonioli D, Peppercorn MA, Strom TB.
|
| Dig Dis Sci 37(6):818-26. 1992
|
| 59 | IL1B
|
| Detection of alveolar macrophage-derived IL-1 beta in asthma. Inhibition with corticosteroids.
|
| Borish L, et al.
|
| J Immunol 149 : 3078-3082. 1992
|
| 60 | IL1A, IL1B
|
| Chromosomal localization of the human interleukin 1î (IL-1î) gene.
|
| Modi WS, et al.
|
| Genomics 2 : 310-314. 1988
|
| 61 | IL1B
|
| Human interleukin-1 beta gene.
|
| Bensi G, et al.
|
| Gene 52 : 95-101. 1987
|
| 62 | IL1A, IL1B
|
| Interleukin-1 gene (IL1) assigned to long arm of human chromosome 2.
|
| Webb AC, Collins KL, Auron PE, Eddy RL, Nakai H, Byers MG, Haley LL, Henry WM, Shows TB.
|
| Lymphokine Res 5 : 77-85. 1986
|