Citations for
1IL1A, S100A7
Human S100A7 Induces Mature Interleukin1α Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis.
Lei H, Li X, Jing B, Xu H, Wu Y.
PLoS One 12(1):e0169788. doi: 10.1371/journal.pone.0169788. eCollection 2017. 2017
2IL1A
Cutting edge: IL-1α is a crucial danger signal triggering acute myocardial inflammation during myocardial infarction.
Lugrin J, Parapanov R, Rosenblatt-Velin N, Rignault-Clerc S, Feihl F, Waeber B, Mller O, Vergely C, Zeller M, Tardivel A, Schneider P, Pacher P, Liaudet L.
J Immunol 194(2):499-503. doi: 10.4049/jimmunol.1401948. Epub 2014 Dec 10. 2015
3IL1A
IL-1α induces CD11b(low) alveolar macrophage proliferation and maturation during granuloma formation.
Huaux F, Lo Re S, Giordano G, Uwambayinema F, Devosse R, Yakoub Y, Panin N, Palmai-Pallag M, Rabolli V, Delos M, Marbaix E, Dauguet N, Couillin I, Ryffel B, Renauld JC, Lison D.
J Pathol 235(5):698-709. doi: 10.1002/path.4487. Epub 2015 Jan 20. 2015
4IL1A, IL1B
Requirement for interleukin-1 to drive brain inflammation reveals tissue-specific mechanisms of innate immunity.
Giles JA, Greenhalgh AD, Davies CL, Denes A, Shaw T, Coutts G, Rothwell NJ, McColl BW, Allan SM.
Eur J Immunol 45(2):525-30. doi: 10.1002/eji.201444748. Epub 2014 Nov 24. 2015
5IL1A, IL1B
Dendritic cell IL-1α and IL-1β are polyubiquitinated and degraded by the proteasome.
Ainscough JS, Frank Gerberick G, Zahedi-Nejad M, Lopez-Castejon G, Brough D, Kimber I, Dearman RJ.
J Biol Chem 289(51):35582-92. doi: 10.1074/jbc.M114.595686. Epub 2014 Nov 4. 2014
6IL1A, IL1B
Interleukin-1 deficiency prolongs ovarian lifespan in mice.
Uri-Belapolsky S, Shaish A, Eliyahu E, Grossman H, Levi M, Chuderland D, Ninio-Many L, Hasky N, Shashar D, Almog T, Kandel-Kfir M, Harats D, Shalgi R, Kamari Y.
Proc Natl Acad Sci U S A 111(34):12492-7. doi: 10.1073/pnas.1323955111. Epub 2014 Aug 11. 2014
7IL1A, IL1B
Release of interleukin-1α or interleukin-1β depends on mechanism of cell death.
England H, Summersgill HR, Edye ME, Rothwell NJ, Brough D.
J Biol Chem 289(23):15942-50. doi: 10.1074/jbc.M114.557561. Epub 2014 Apr 30. 2014
8IL1A, SDC2
Interleukin-1α promotes extracellular shedding of syndecan-2 via induction of matrix metalloproteinase-7 expression.
Kwon MJ, Hong E, Choi Y, Kang DH, Oh ES.
Biochem Biophys Res Commun 446(2):487-92. doi: 10.1016/j.bbrc.2014.02.142. Epub 2014 Mar 12. 2014
9IL1A, IL1R1, IL23A, MYD88
MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling.
Chang J, Burkett PR, Borges CM, Kuchroo VK, Turka LA, Chang CH.
Proc Natl Acad Sci U S A 110(6):2270-5. doi: 10.1073/pnas.1206048110. Epub 2013 Jan 22. 2013
10CXCL1, CXCL10, ICAM1, IL1A
IL-1 alpha regulates CXCL1, CXCL10 and ICAM1 in network form in oral keratinocytes.
Wu T, Du R, Hong Y, Jia L, Zeng Q, Cheng B.
Clin Lab 59(9-10):1105-11. 2013
11IL1A
Redox control of the senescence regulator interleukin-1α and the secretory phenotype.
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA.
J Biol Chem 288(45):32149-59. doi: 10.1074/jbc.M113.493841. Epub 2013 Sep 23. 2013
12IL1A
Redox-control of the alarmin, Interleukin-1α.
McCarthy DA, Ranganathan A, Subbaram S, Flaherty NL, Patel N, Trebak M, Hempel N, Melendez JA.
Redox Biol 1:218-25. doi: 10.1016/j.redox.2013.03.001. eCollection 2013. 2013
13IL1A
Endogenous IL-1α is a chromatin-associated protein in mouse macrophages.
Lamacchia C, Rodriguez E, Palmer G, Gabay C.
Cytokine 63(2):135-44. doi: 10.1016/j.cyto.2013.04.010. Epub 2013 May 14. 2013
14IL1A, IL1B, IL23A
Autophagy regulates IL-23 secretion and innate T cell responses through effects on IL-1 secretion.
Peral de Castro C, Jones SA, N Cheallaigh C, Hearnden CA, Williams L, Winter J, Lavelle EC, Mills KH, Harris J.
J Immunol 189(8):4144-53. doi: 10.4049/jimmunol.1201946. Epub 2012 Sep 12. 2012
15IL1A
Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1.
Gross O, Yazdi AS, Thomas CJ, Masin M, Heinz LX, Guarda G, Quadroni M, Drexler SK, Tschopp J.
Immunity 36(3):388-400. doi: 10.1016/j.immuni.2012.01.018. 2012
16IL1A
Functional polymorphism of IL-1 alpha and its potential role in obesity in humans and mice.
Um JY, Rim HK, Kim SJ, Kim HL, Hong SH.
PLoS One 6(12):e29524. doi: 10.1371/journal.pone.0029524. Epub 2011 Dec 27. 2011
17IL1A, IL1B
Inflammasome activation and IL-1β target IL-1α for secretion as opposed to surface expression.
Fettelschoss A, Kistowska M, LeibundGut-Landmann S, Beer HD, Johansen P, Senti G, Contassot E, Bachmann MF, French LE, Oxenius A, Kndig TM.
Proc Natl Acad Sci U S A 108(44):18055-60. doi: 10.1073/pnas.1109176108. Epub 2011 Oct 17. 2011
18IL1A, IL1B
IL-1α and IL-1β recruit different myeloid cells and promote different stages of sterile inflammation.
Rider P, Carmi Y, Guttman O, Braiman A, Cohen I, Voronov E, White MR, Dinarello CA, Apte RN.
J Immunol 187(9):4835-43. doi: 10.4049/jimmunol.1102048. Epub 2011 Sep 19. 2011
19IL1A
Interleukin-1alpha is a regulator of the blood-testis barrier.
Lie PP, Cheng CY, Mruk DD.
FASEB J 25(4):1244-53. doi: 10.1096/fj.10-169995. Epub 2010 Dec 29. 2011
20IL1A, IL1B
Association of IL1A and IL1B loci with primary open angle glaucoma.
Mookherjee S, Banerjee D, Chakraborty S, Banerjee A, Mukhopadhyay I, Sen A, Ray K.
BMC Med Genet 11:99. doi: 10.1186/1471-2350-11-99. 2010
21IL1A
Platelet interleukin-1alpha drives cerebrovascular inflammation.
Thornton P, McColl BW, Greenhalgh A, Denes A, Allan SM, Rothwell NJ.
Blood 115(17):3632-9. doi: 10.1182/blood-2009-11-252643. Epub 2010 Mar 3. 2010
22IL1A
Differential release of chromatin-bound IL-1alpha discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation.
Cohen I, Rider P, Carmi Y, Braiman A, Dotan S, White MR, Voronov E, Martin MU, Dinarello CA, Apte RN.
Proc Natl Acad Sci U S A 107(6):2574-9. doi: 10.1073/pnas.0915018107. Epub 2010 Jan 25. 2010
23IL1A
Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network.
Orjalo AV, Bhaumik D, Gengler BK, Scott GK, Campisi J.
Proc Natl Acad Sci U S A 106(40):17031-6. doi: 10.1073/pnas.0905299106. Epub 2009 Sep 28. 2009
24IL1A, IL1B, IL6, TNF
Interleukin-1alpha stimulates proinflammatory cytokine expression in human cardiac myofibroblasts.
Turner NA, Das A, Warburton P, O'Regan DJ, Ball SG, Porter KE.
Am J Physiol Heart Circ Physiol 297(3):H1117-27. doi: 10.1152/ajpheart.00372.2009. Epub 2009 Jul 31. 2009
25IL1A
Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells.
Eigenbrod T, Park JH, Harder J, Iwakura Y, Nez G.
J Immunol 181(12):8194-8. 2008
26IL1A
Antiviral and immunoregulatory activities of IFN-gamma depend on constitutively expressed IL-1alpha.
Hurgin V, Novick D, Werman A, Dinarello CA, Rubinstein M.
Proc Natl Acad Sci U S A 104(12):5044-9. Epub 2007 Mar 8. 2007
27CSF2, IL1A, IL12B, IL15, IL17A, IL18, IL23A, IL6
Cytokines in the pathogenesis of rheumatoid arthritis.
McInnes IB, Schett G.
Nat Rev Immunol 7(6):429-42. Review. 2007
28IL1A,S100A13
Molecular cloning, overexpression and characterization of human interleukin 1alpha.
Rajalingam D, Kacer D, Prudovsky I, Kumar TK.
Biochem Biophys Res Commun 360(3):604-8. Epub 2007 Jun 28. 2007
29MAP3K8, IL1A
Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62.
Stafford MJ, Morrice NA, Peggie MW, Cohen P.
FEBS Lett 580(16):4010-4. Epub 2006 Jun 15. 2006
30EPO,IL1A
Erythropoietin production: Molecular mechanisms of the antagonistic actions of cyclic adenosine monophosphate and interleukin-1.
Batmunkh C, Krajewski J, Jelkmann W, Hellwig-Burgel T.
FEBS Lett 580(13):3153-60. Epub 2006 May 2. 2006
31IL1A, MAPK14
p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes.
Radons J, Bosserhoff AK, Grssel S, Falk W, Schubert TE.
Int J Mol Med 17(4):661-8. 2006
32IL1A
Nucleotide variation, haplotype structure, and association with end-stage renal disease of the human interleukin-1 gene cluster.
Bensen JT, Langefeld CD, Hawkins GA, Green LE, Mychaleckyj JC, Brewer CS, Kiger DS, Binford SM, Colicigno CJ, Allred DC, Freedman BI, Bowden DW.
Genomics 82(2):194-217. 2003
33ADRA2A, ADRB1, AGTR1, CAFG, CD36, CETP, CSF1, CSF2, CYP11B2, ECE1, EDN1, EDNRA, EDNRB, EGR1, F2R, FGA, FGB, FHBL1, HGF, ICAM1, IGF1, IL1A, IL6, LPA, MGP, MSR1, MTTP, NOS2, NOS3, PDGFA, PDGFRA, SELP, TGFB1, TNF, VCAM1, VDR
Sequence diversity in 36 candidate genes for cardiovascular disorders.
Cambien F, Poirier O, Nicaud V, Herrmann SM, Mallet C, Ricard S, Behague I, Hallet V, Blanc H, Loukaci V, Thillet J, Evans A, Ruidavets JB, Arveiler D, Luc G, Tiret L.
Am J Hum Genet 65(1):183-91. 1999
34IDDM7, IDDM12, IDDM13, IL1A, IL1B, SLC11A1
Genetic analysis of chromosome 2 in type 1 diabetes. Analysis of putative loci IDDM7, IDDM12, and IDDM13 and candidate genes NRAMP1 and IA-2 and the interleukin-1 gene cluster.
Esposito L, Hill NJ, Pritchard LE, Cucca F, Muxworthy C, Merriman ME, Wilson A, Julier C, Delepine M, Tuomilehto J, Tuomilehto-Wolf E, Ionesco-Tirgoviste C, Nistico' L, Buzzetti R, Pozzilli P, Ferrari M, Bosi E, Pociot F, Nerup J, Bain SC, Todd JA.
Diabetes 47 : 1797-1799. 1998
35IL1A, IL1B, IL1RN
Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13.
Nothwang HG, Strahm B, Denich D, Kubler M, Schwabe J, Gingrich JC, Jauch A, Cox A, Nicklin MJ, Kurnit DM, Hildebrandt F.
Genomics 41(3):370-8. 1997
36IL1A, IL1B, IL1RN
A physical map of the region encompassing the human interleukin-1alpha, interleukin-1beta, and interleukin-1 receptor antagonist genes.
Nicklin MJH, et al.
Genomics 19 : 382-384. 1994
37IL1A
Dinucleotide repeat polymorphism in the human IL1A gene.
Epplen C, et al.
Hum Mol Genet 3 : 1710. 1994
38IL1A
Polymorphic tandem repeat region in interleukin-1-alpha intron 6.
Bailly S, et al.
Hum Genet 91 : 85-86. 1993
39IL1A
Amino acid dimorphism in IL1A is detectable by PCR amplification.
van der Velden PA, et al.
Hum Mol Genet 2 : 1753. 1993
40IL1A, IL1B
Expression of interleukin 1-inducible genes and production of interleukin 1 by aging human fibroblasts.
Kumar S, et al.
Proc Natl Acad Sci U S A 89 : 4683-4687. 1992
41IL1A, IL6, IL8, TNFRSF1A
Heterogeneity among human nasopharyngeal carcinoma cell lines for inflammatory cytokines mRNA expression levels.
Mahe Y, Hirose K, Clausse B, Chouaib S, Tursz T, Mariame B.
Biochem Biophys Res Commun 187(1):121-6. 1992
42IL1A
Dinucleotide repeat polymorphism in the human interleukin 1, alpha gene (IL1A).
Todd S, et al.
Nucleic Acids Res 19 : 3756. 1991
43IL1A
The human interleukin-1alpha gene is located on the long arm of chromosome 2 at band q13.
Lafage M, et al.
Blood 73 : 104-107. 1989
44IL1A, IL1B
Chromosomal localization of the human interleukin 1 (IL-1) gene.
Modi WS, et al.
Genomics 2 : 310-314. 1988
45IL1A, IL1B
Interleukin-1 gene (IL1) assigned to long arm of human chromosome 2.
Webb AC, Collins KL, Auron PE, Eddy RL, Nakai H, Byers MG, Haley LL, Henry WM, Shows TB.
Lymphokine Res 5 : 77-85. 1986