| 1 | CASP4, CTSG, IL1A
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| Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts.
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| Jun HK, Jung YJ, Ji S, An SJ, Choi BK.
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| Cell Death Differ 25(2):380-391. doi: 10.1038/cdd.2017.167. Epub 2017 Oct 27.
2018
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| 2 | IL1A, S100A7
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| Human S100A7 Induces Mature Interleukin1α Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis.
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| Lei H, Li X, Jing B, Xu H, Wu Y.
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| PLoS One 12(1):e0169788. doi: 10.1371/journal.pone.0169788. eCollection 2017.
2017
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| 3 | IL1A
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| Cutting edge: IL-1α is a crucial danger signal triggering acute myocardial inflammation during myocardial infarction.
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| Lugrin J, Parapanov R, Rosenblatt-Velin N, Rignault-Clerc S, Feihl F, Waeber B, Müller O, Vergely C, Zeller M, Tardivel A, Schneider P, Pacher P, Liaudet L.
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| J Immunol 194(2):499-503. doi: 10.4049/jimmunol.1401948. Epub 2014 Dec 10.
2015
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| 4 | IL1A
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| IL-1α induces CD11b(low) alveolar macrophage proliferation and maturation during granuloma formation.
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| Huaux F, Lo Re S, Giordano G, Uwambayinema F, Devosse R, Yakoub Y, Panin N, Palmai-Pallag M, Rabolli V, Delos M, Marbaix E, Dauguet N, Couillin I, Ryffel B, Renauld JC, Lison D.
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| J Pathol 235(5):698-709. doi: 10.1002/path.4487. Epub 2015 Jan 20.
2015
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| 5 | IL1A, IL1B
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| Requirement for interleukin-1 to drive brain inflammation reveals tissue-specific mechanisms of innate immunity.
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| Giles JA, Greenhalgh AD, Davies CL, Denes A, Shaw T, Coutts G, Rothwell NJ, McColl BW, Allan SM.
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| Eur J Immunol 45(2):525-30. doi: 10.1002/eji.201444748. Epub 2014 Nov 24.
2015
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| 6 | CASP4, CASP5, IL1A, IL1B
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| Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes.
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| Viganò E, Diamond CE, Spreafico R, Balachander A, Sobota RM, Mortellaro A.
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| Nat Commun 6:8761. doi: 10.1038/ncomms9761.
2015
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| 7 | CCL4, IL12B, IL1A, IL1B, STX3
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| An essential role of syntaxin 3 protein for granule exocytosis and secretion of IL-1α, IL-1β, IL-12b, and CCL4 from differentiated HL-60 cells.
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| Naegelen I, Plançon S, Nicot N, Kaoma T, Muller A, Vallar L, Tschirhart EJ, Bréchard S.
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| J Leukoc Biol 97(3):557-71. doi: 10.1189/jlb.3A0514-254RR. Epub 2014 Dec 29.
2015
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| 8 | IL1A, IL1B
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| Dendritic cell IL-1α and IL-1β are polyubiquitinated and degraded by the proteasome.
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| Ainscough JS, Frank Gerberick G, Zahedi-Nejad M, Lopez-Castejon G, Brough D, Kimber I, Dearman RJ.
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| J Biol Chem 289(51):35582-92. doi: 10.1074/jbc.M114.595686. Epub 2014 Nov 4.
2014
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| 9 | IL1A, IL1B
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| Interleukin-1 deficiency prolongs ovarian lifespan in mice.
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| Uri-Belapolsky S, Shaish A, Eliyahu E, Grossman H, Levi M, Chuderland D, Ninio-Many L, Hasky N, Shashar D, Almog T, Kandel-Kfir M, Harats D, Shalgi R, Kamari Y.
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| Proc Natl Acad Sci U S A 111(34):12492-7. doi: 10.1073/pnas.1323955111. Epub 2014 Aug 11.
2014
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| 10 | IL1A, IL1B
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| Release of interleukin-1α or interleukin-1β depends on mechanism of cell death.
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| England H, Summersgill HR, Edye ME, Rothwell NJ, Brough D.
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| J Biol Chem 289(23):15942-50. doi: 10.1074/jbc.M114.557561. Epub 2014 Apr 30.
2014
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| 11 | IL1A, SDC2
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| Interleukin-1α promotes extracellular shedding of syndecan-2 via induction of matrix metalloproteinase-7 expression.
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| Kwon MJ, Hong E, Choi Y, Kang DH, Oh ES.
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| Biochem Biophys Res Commun 446(2):487-92. doi: 10.1016/j.bbrc.2014.02.142. Epub 2014 Mar 12.
2014
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| 12 | IL1A, IL1R1, IL23A, MYD88
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| MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling.
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| Chang J, Burkett PR, Borges CM, Kuchroo VK, Turka LA, Chang CH.
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| Proc Natl Acad Sci U S A 110(6):2270-5. doi: 10.1073/pnas.1206048110. Epub 2013 Jan 22.
2013
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| 13 | CXCL1, CXCL10, ICAM1, IL1A
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| IL-1 alpha regulates CXCL1, CXCL10 and ICAM1 in network form in oral keratinocytes.
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| Wu T, Du R, Hong Y, Jia L, Zeng Q, Cheng B.
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| Clin Lab 59(9-10):1105-11.
2013
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| 14 | IL1A
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| Redox control of the senescence regulator interleukin-1α and the secretory phenotype.
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| McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA.
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| J Biol Chem 288(45):32149-59. doi: 10.1074/jbc.M113.493841. Epub 2013 Sep 23.
2013
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| 15 | IL1A
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| Redox-control of the alarmin, Interleukin-1α.
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| McCarthy DA, Ranganathan A, Subbaram S, Flaherty NL, Patel N, Trebak M, Hempel N, Melendez JA.
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| Redox Biol 1:218-25. doi: 10.1016/j.redox.2013.03.001. eCollection 2013.
2013
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| 16 | IL1A
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| Endogenous IL-1α is a chromatin-associated protein in mouse macrophages.
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| Lamacchia C, Rodriguez E, Palmer G, Gabay C.
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| Cytokine 63(2):135-44. doi: 10.1016/j.cyto.2013.04.010. Epub 2013 May 14.
2013
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| 17 | IL1A, IL1B, IL23A
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| Autophagy regulates IL-23 secretion and innate T cell responses through effects on IL-1 secretion.
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| Peral de Castro C, Jones SA, Ní Cheallaigh C, Hearnden CA, Williams L, Winter J, Lavelle EC, Mills KH, Harris J.
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| J Immunol 189(8):4144-53. doi: 10.4049/jimmunol.1201946. Epub 2012 Sep 12.
2012
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| 18 | IL1A
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| Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1.
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| Gross O, Yazdi AS, Thomas CJ, Masin M, Heinz LX, Guarda G, Quadroni M, Drexler SK, Tschopp J.
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| Immunity 36(3):388-400. doi: 10.1016/j.immuni.2012.01.018.
2012
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| 19 | IL1A
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| Functional polymorphism of IL-1 alpha and its potential role in obesity in humans and mice.
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| Um JY, Rim HK, Kim SJ, Kim HL, Hong SH.
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| PLoS One 6(12):e29524. doi: 10.1371/journal.pone.0029524. Epub 2011 Dec 27.
2011
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| 20 | IL1A, IL1B
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| Inflammasome activation and IL-1β target IL-1α for secretion as opposed to surface expression.
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| Fettelschoss A, Kistowska M, LeibundGut-Landmann S, Beer HD, Johansen P, Senti G, Contassot E, Bachmann MF, French LE, Oxenius A, Kündig TM.
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| Proc Natl Acad Sci U S A 108(44):18055-60. doi: 10.1073/pnas.1109176108. Epub 2011 Oct 17.
2011
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| 21 | IL1A, IL1B
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| IL-1α and IL-1β recruit different myeloid cells and promote different stages of sterile inflammation.
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| Rider P, Carmi Y, Guttman O, Braiman A, Cohen I, Voronov E, White MR, Dinarello CA, Apte RN.
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| J Immunol 187(9):4835-43. doi: 10.4049/jimmunol.1102048. Epub 2011 Sep 19.
2011
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| 22 | IL1A
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| Interleukin-1alpha is a regulator of the blood-testis barrier.
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| Lie PP, Cheng CY, Mruk DD.
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| FASEB J 25(4):1244-53. doi: 10.1096/fj.10-169995. Epub 2010 Dec 29.
2011
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| 23 | IL1A, IL1B
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| Association of IL1A and IL1B loci with primary open angle glaucoma.
|
| Mookherjee S, Banerjee D, Chakraborty S, Banerjee A, Mukhopadhyay I, Sen A, Ray K.
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| BMC Med Genet 11:99. doi: 10.1186/1471-2350-11-99.
2010
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| 24 | IL1A
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| Platelet interleukin-1alpha drives cerebrovascular inflammation.
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| Thornton P, McColl BW, Greenhalgh A, Denes A, Allan SM, Rothwell NJ.
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| Blood 115(17):3632-9. doi: 10.1182/blood-2009-11-252643. Epub 2010 Mar 3.
2010
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| 25 | IL1A
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| Differential release of chromatin-bound IL-1alpha discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation.
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| Cohen I, Rider P, Carmi Y, Braiman A, Dotan S, White MR, Voronov E, Martin MU, Dinarello CA, Apte RN.
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| Proc Natl Acad Sci U S A 107(6):2574-9. doi: 10.1073/pnas.0915018107. Epub 2010 Jan 25.
2010
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| 26 | IL1A
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| Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network.
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| Orjalo AV, Bhaumik D, Gengler BK, Scott GK, Campisi J.
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| Proc Natl Acad Sci U S A 106(40):17031-6. doi: 10.1073/pnas.0905299106. Epub 2009 Sep 28.
2009
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| 27 | IL1A, IL1B, IL6, TNF
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| Interleukin-1alpha stimulates proinflammatory cytokine expression in human cardiac myofibroblasts.
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| Turner NA, Das A, Warburton P, O'Regan DJ, Ball SG, Porter KE.
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| Am J Physiol Heart Circ Physiol 297(3):H1117-27. doi: 10.1152/ajpheart.00372.2009. Epub 2009 Jul 31.
2009
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| 28 | IL1A
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| Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells.
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| Eigenbrod T, Park JH, Harder J, Iwakura Y, Núñez G.
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| J Immunol 181(12):8194-8.
2008
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| 29 | IL1A
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| Antiviral and immunoregulatory activities of IFN-gamma depend on constitutively expressed IL-1alpha.
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| Hurgin V, Novick D, Werman A, Dinarello CA, Rubinstein M.
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| Proc Natl Acad Sci U S A 104(12):5044-9. Epub 2007 Mar 8. 2007
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| 30 | CSF2, IL1A, IL12B, IL15, IL17A, IL18, IL23A, IL6
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| Cytokines in the pathogenesis of rheumatoid arthritis.
|
| McInnes IB, Schett G.
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| Nat Rev Immunol 7(6):429-42. Review. 2007
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| 31 | IL1A,S100A13
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| Molecular cloning, overexpression and characterization of human interleukin 1alpha.
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| Rajalingam D, Kacer D, Prudovsky I, Kumar TK.
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| Biochem Biophys Res Commun 360(3):604-8. Epub 2007 Jun 28. 2007
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| 32 | MAP3K8, IL1A
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| Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62.
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| Stafford MJ, Morrice NA, Peggie MW, Cohen P.
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| FEBS Lett 580(16):4010-4. Epub 2006 Jun 15. 2006
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| 33 | EPO,IL1A
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| Erythropoietin production: Molecular mechanisms of the antagonistic actions of cyclic adenosine monophosphate and interleukin-1.
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| Batmunkh C, Krajewski J, Jelkmann W, Hellwig-Burgel T.
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| FEBS Lett 580(13):3153-60. Epub 2006 May 2. 2006
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| 34 | IL1A, MAPK14
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| p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes.
|
| Radons J, Bosserhoff AK, GrŠssel S, Falk W, Schubert TE.
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| Int J Mol Med 17(4):661-8. 2006
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| 35 | IL1A
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| Nucleotide variation, haplotype structure, and association with end-stage renal disease of the human interleukin-1 gene cluster.
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| Bensen JT, Langefeld CD, Hawkins GA, Green LE, Mychaleckyj JC, Brewer CS, Kiger DS, Binford SM, Colicigno CJ, Allred DC, Freedman BI, Bowden DW.
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| Genomics 82(2):194-217. 2003
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| 36 | ADRA2A, ADRB1, AGTR1, CAFG, CD36, CETP, CSF1, CSF2, CYP11B2, ECE1, EDN1, EDNRA, EDNRB, EGR1, F2R, FGA, FGB, FHBL1, HGF, ICAM1, IGF1, IL1A, IL6, LPA, MGP, MSR1, MTTP, NOS2, NOS3, PDGFA, PDGFRA, SELP, TGFB1, TNF, VCAM1, VDR
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| Sequence diversity in 36 candidate genes for cardiovascular disorders.
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| Cambien F, Poirier O, Nicaud V, Herrmann SM, Mallet C, Ricard S, Behague I, Hallet V, Blanc H, Loukaci V, Thillet J, Evans A, Ruidavets JB, Arveiler D, Luc G, Tiret L.
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| Am J Hum Genet 65(1):183-91. 1999
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| 37 | IDDM7, IDDM12, IDDM13, IL1A, IL1B, SLC11A1
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| Genetic analysis of chromosome 2 in type 1 diabetes. Analysis of putative loci IDDM7, IDDM12, and IDDM13 and candidate genes NRAMP1 and IA-2 and the interleukin-1 gene cluster.
|
| Esposito L, Hill NJ, Pritchard LE, Cucca F, Muxworthy C, Merriman ME, Wilson A, Julier C, Delepine M, Tuomilehto J, Tuomilehto-Wolf E, Ionesco-Tirgoviste C, Nistico' L, Buzzetti R, Pozzilli P, Ferrari M, Bosi E, Pociot F, Nerup J, Bain SC, Todd JA.
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| Diabetes 47 : 1797-1799. 1998
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| 38 | IL1A, IL1B, IL1RN
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| Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13.
|
| Nothwang HG, Strahm B, Denich D, Kubler M, Schwabe J, Gingrich JC, Jauch A, Cox A, Nicklin MJ, Kurnit DM, Hildebrandt F.
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| Genomics 41(3):370-8. 1997
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| 39 | IL1A, IL1B, IL1RN
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| A physical map of the region encompassing the human interleukin-1alpha, interleukin-1beta, and interleukin-1 receptor antagonist genes.
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| Nicklin MJH, et al.
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| Genomics 19 : 382-384. 1994
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| 40 | IL1A
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| Dinucleotide repeat polymorphism in the human IL1A gene.
|
| Epplen C, et al.
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| Hum Mol Genet 3 : 1710. 1994
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| 41 | IL1A
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| Polymorphic tandem repeat region in interleukin-1-alpha intron 6.
|
| Bailly S, et al.
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| Hum Genet 91 : 85-86. 1993
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| 42 | IL1A
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| Amino acid dimorphism in IL1A is detectable by PCR amplification.
|
| van der Velden PA, et al.
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| Hum Mol Genet 2 : 1753. 1993
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| 43 | IL1A, IL1B
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| Expression of interleukin 1-inducible genes and production of interleukin 1 by aging human fibroblasts.
|
| Kumar S, et al.
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| Proc Natl Acad Sci U S A 89 : 4683-4687. 1992
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| 44 | IL1A, IL6, IL8, TNFRSF1A
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| Heterogeneity among human nasopharyngeal carcinoma cell lines for inflammatory cytokines mRNA expression levels.
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| Mahe Y, Hirose K, Clausse B, Chouaib S, Tursz T, Mariame B.
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| Biochem Biophys Res Commun 187(1):121-6. 1992
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| 45 | IL1A
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| Dinucleotide repeat polymorphism in the human interleukin 1, alpha gene (IL1A).
|
| Todd S, et al.
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| Nucleic Acids Res 19 : 3756. 1991
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| 46 | IL1A
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| The human interleukin-1alpha gene is located on the long arm of chromosome 2 at band q13.
|
| Lafage M, et al.
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| Blood 73 : 104-107. 1989
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| 47 | IL1A, IL1B
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| Chromosomal localization of the human interleukin 1î (IL-1î) gene.
|
| Modi WS, et al.
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| Genomics 2 : 310-314. 1988
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| 48 | IL1A, IL1B
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| Interleukin-1 gene (IL1) assigned to long arm of human chromosome 2.
|
| Webb AC, Collins KL, Auron PE, Eddy RL, Nakai H, Byers MG, Haley LL, Henry WM, Shows TB.
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| Lymphokine Res 5 : 77-85. 1986
|