1 | IL18, TICAM2
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| Polymorphisms in TICAM2 and IL1B are associated with TB.
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| Hall NB, Igo RP Jr, Malone LL, Truitt B, Schnell A, Tao L, Okware B, Nsereko M, Chervenak K, Lancioni C, Hawn TR, Mayanja-Kizza H, Joloba ML, Boom WH, Stein CM; Tuberculosis Research Unit (TBRU).
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| Genes Immun 16(2):127-133. doi: 10.1038/gene.2014.77. Epub 2014 Dec 18.
2015
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2 | IL18, IL22
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| Interleukin-22 induces interleukin-18 expression from epithelial cells during intestinal infection.
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| Muñoz M, Eidenschenk C, Ota N, Wong K, Lohmann U, Kühl AA, Wang X, Manzanillo P, Li Y, Rutz S, Zheng Y, Diehl L, Kayagaki N, van Lookeren-Campagne M, Liesenfeld O, Heimesaat M, Ouyang W.
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| Immunity 42(2):321-331. doi: 10.1016/j.immuni.2015.01.011. Epub 2015 Feb 10.
2015
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3 | IL18, MYD88, TICAM2
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| TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88.
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| Ohnishi H, Tochio H, Kato Z, Kawamoto N, Kimura T, Kubota K, Yamamoto T, Funasaka T, Nakano H, Wong RW, Shirakawa M, Kondo N.
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| PLoS One 7(6):e38423. doi: 10.1371/journal.pone.0038423. Epub 2012 Jun 7.
2012
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4 | CASP1, IL18, NLRP6, PYCARD
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| NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis.
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| Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ, Peaper DR, Bertin J, Eisenbarth SC, Gordon JI, Flavell RA.
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| Cell 145(5):745-57. Epub 2011 May 12.
2011
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5 | IL12B, IL18, NFKBIZ
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| IKBZ is essential for natural killer cell activation in response to IL-12 and IL-18.
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| Miyake T, Satoh T, Kato H, Matsushita K, Kumagai Y, Vandenbon A, Tani T, Muta T, Akira S, Takeuchi O.
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| Proc Natl Acad Sci U S A 107(41):17680-5. Epub 2010 Sep 27. 2010
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6 | IL18, NLRP3
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| The inflammasome sensor, NLRP3, regulates CNS inflammation and demyelination via caspase-1 and interleukin-18.
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| Jha S, Srivastava SY, Brickey WJ, Iocca H, Toews A, Morrison JP, Chen VS, Gris D, Matsushima GK, Ting JP.
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| J Neurosci 30(47):15811-20.
2010
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7 | IL18
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| IL-18 promoter polymorphisms confer susceptibility to Behçet's disease, particularly to the mucocutaneous form, in a Turkish population.
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| Keskin F, Pay S, Musabak U, Sagkan RI, Erdem H, Simsek I, Kose O, Dinc A, Sengul A.
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| Clin Exp Rheumatol 27(2 Suppl 53):S108-9. No abstract available. PMID: 19796548 2009
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8 | IL18
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| IL-18 activity in systemic lupus erythematosus.
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| Favilli F, Anzilotti C, Martinelli L, Quattroni P, De Martino S, Pratesi F, Neumann D, Beermann S, Novick D, Dinarello CA, Boraschi D, Migliorini P.
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| Ann N Y Acad Sci 1173:301-9.PMID: 19758166 2009
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9 | IL18
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| Identification of a new putative functional IL18 gene variant through an association study in systemic lupus erythematosus.
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| Sánchez E, Palomino-Morales RJ, Ortego-Centeno N, Jiménez-Alonso J, González-Gay MA, López-Nevot MA, Sánchez-Román J, de Ramón E, González-Escribano MF, Pons-Estel BA, D'Alfonso S, Sebastiani GD; Italian collaborative group, Alarcón-Riquelme ME, Martín J.
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| Hum Mol Genet 18(19):3739-48. Epub 2009 Jul 7.PMID: 19584085 2009
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10 | IL18
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| Possible role of nerve growth factor and interleukin-18 in pathogenesis of eczematous lesions of atopic dermatitis.
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| Shaker OG, El-Komy M, Tawfic SO, Zeidan N, Tomairek RH.
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| J Dermatol Sci 53(2):153-4. Epub 2008 Oct 15. No abstract available. PMID: 18922682 2009
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11 | IL18
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| Autocrine role of endogenous interleukin-18 on inflammatory cytokine generation by human neutrophils.
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| Fortin CF, Ear T, McDonald PP.
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| FASEB J 23(1):194-203. Epub 2008 Sep 9.PMID: 18780764 2009
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12 | IL18, PTH
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| Interleukin-18 is regulated by parathyroid hormone and is required for its bone anabolic actions.
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| Raggatt LJ, Qin L, Tamasi J, Jefcoat SC Jr, Shimizu E, Selvamurugan N, Liew FY, Bevelock L, Feyen JH, Partridge NC.
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| J Biol Chem 283(11):6790-8. Epub 2007 Dec 28. 2008
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13 | CSF2, IL1A, IL12B, IL15, IL17A, IL18, IL23A, IL6
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| Cytokines in the pathogenesis of rheumatoid arthritis.
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| McInnes IB, Schett G.
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| Nat Rev Immunol 7(6):429-42. Review. 2007
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14 | IL12A, IL18
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| Expression and significance of intratumoral interleukin-12 and interleukin-18 in human gastric carcinoma.
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| Ye ZB, Ma T, Li H, Jin XL, Xu HM.
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| World J Gastroenterol 13(11):1747-51. 2007
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15 | IL18
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| IL-18 gene polymorphisms affect IL-18 production capability by monocytes.
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| Arimitsu J, Hirano T, Higa S, Kawai M, Naka T, Ogata A, Shima Y, Fujimoto M, Yamadori T, Hagiwara K, Ohgawara T, Kuwabara Y, Kawase I, Tanaka T.
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| Biochem Biophys Res Commun 342(4):1413-6. Epub 2006 Feb 28. 2006
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16 | IL18
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| Expression and alternative processing of IL-18 in human neutrophils.
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| Robertson SE, Young JD, Kitson S, Pitt A, Evans J, Roes J, Karaoglu D, Santora L, Ghayur T, Liew FY, Gracie JA, McInnes IB.
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| Eur J Immunol 36(3):722-31. 2006
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17 | IL18
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| Association of interleukin-18 expression with enhanced levels of both interleukin-1beta and tumor necrosis factor alpha in knee synovial tissue of patients with rheumatoid arthritis.
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| Joosten LA, Radstake TR, Lubberts E, van den Bersselaar LA, van Riel PL, van Lent PL, Barrera P, van den Berg WB.
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| Arthritis Rheum 48(2):339-47. 2003
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18 | IL18
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| Increased expression of DC-SIGN+IL-12+IL-18+ and CD83+IL-12-IL-18- dendritic cell populations in the colonic mucosa of patients with Crohn's disease.
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| te Velde AA, van Kooyk Y, Braat H, Hommes DW, Dellemijn TA, Slors JF, van Deventer SJ, Vyth-Dreese FA.
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| Eur J Immunol 33(1):143-51. 2003
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19 | IL18
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| Identification of amino acid residues critical for biological activity in human interleukin-18.
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| Kim SH, Azam T, Novick D, Yoon DY, Reznikov LL, Bufler P, Rubinstein M, Dinarello CA.
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| J Biol Chem 277(13):10998-1003. 2002
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20 | IL18
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| Immunoregulatory functions of interleukin 18 and its role in defense against bacterial pathogens.
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| Biet F, Locht C, Kremer L.
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| J Mol Med 80(3):147-62. Review. 2002
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21 | IL18
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| Interleukin-18 promoter polymorphisms in type 1 diabetes.
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| Kretowski A, Mironczuk K, Karpinska A, Bojaryn U, Kinalski M, Puchalski Z, Kinalska I.
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| Diabetes 51(11):3347-9. 2002
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22 | IL18
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| Physiological levels of interleukin-18 stimulate multiple neutrophil functions through p38 MAP kinase activation.
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| Wyman TH, Dinarello CA, Banerjee A, Gamboni-Robertson F, Hiester AA, England KM, Kelher M, Silliman CC.
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| J Leukoc Biol 72(2):401-9. 2002
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23 | IL18
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| Elevated production of interleukin-18 is associated with renal disease in patients with systemic lupus erythematosus.
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| Wong CK, Ho CY, Li EK, Tam LS, Lam CW.
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| Clin Exp Immunol 130(2):345-51. 2002
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24 | IL18
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| Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin-18-induced vascular cell adhesion molecule-1 expression.
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| Morel JC, Park CC, Zhu K, Kumar P, Ruth JH, Koch AE.
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| J Biol Chem 277(38):34679-91. 2002
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25 | IL18
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| Genomic organization and regulation of the human interleukin-18 gene.
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| Kalina U, Ballas K, Koyama N, Kauschat D, Miething C, Arnemann J, Martin H, Hoelzer D, Ottmann OG.
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| Scand J Immunol 52(6):525-30. 2000
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26 | IL18
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| The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci.
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| Nolan KF, et al.
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| Genomics 51 : 161-163. 1998
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27 | IL18
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| Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein.
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| Ushio S, Namba M, Okura T, Hattori K, Nukada Y, Akita K, Tanabe F, Konishi K, Micallef M, Fujii M, Torigoe K, Tanimoto T, Fukuda S, Ikeda M, Okamura H, Kurimoto M.
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| J Immunol 156(11):4274-9.PMID: 8666798 1996
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