Citations for
1IL17A, IL17RA, TAOK1
TAOK1 negatively regulates IL-17-mediated signaling and inflammation.
Zhang Z, Tang Z, Ma X, Sun K, Fan L, Fang J, Pan J, Wang X, An H, Zhou J.
Cell Mol Immunol 15(8):794-802. doi: 10.1038/cmi.2017.158. Epub 2018 Feb 5. Erratum in: Cell Mol Immunol. 2018 May 29;:. 2018
2CASP5, IL17A, NLRP1
Th17 micro-milieu regulates NLRP1-dependent caspase-5 activity in skin autoinflammation.
Zwicker S, Hattinger E, Bureik D, Batycka-Baran A, Schmidt A, Gerber PA, Rothenfusser S, Gilliet M, Ruzicka T, Wolf R.
PLoS One 12(4):e0175153. doi: 10.1371/journal.pone.0175153. eCollection 2017. 2017
3IL17A, RORC
Inhibition of the Nuclear Receptor RORγ and Interleukin-17A Suppresses Neovascular Retinopathy: Involvement of Immunocompetent Microglia.
Talia DM, Deliyanti D, Agrotis A, Wilkinson-Berka JL.
Arterioscler Thromb Vasc Biol 36(6):1186-96. doi: 10.1161/ATVBAHA.115.307080. Epub 2016 Apr 7. 2016
4CD14, IL17A, IL1B
New roles for CD14 and IL-β linking inflammatory dendritic cells to IL-17 production in memory CD4+ T cells.
Ilarregui JM, van Beelen AJ, Fehres CM, Bruijns SC, García-Vallejo JJ, van Kooyk Y.
Immunol Cell Biol 94(10):907-916. doi: 10.1038/icb.2016.66. Epub 2016 Aug 23. 2016
5IL17A, IL17RA
Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis.
Wang K, Kim MK, Di Caro G, Wong J, Shalapour S, Wan J, Zhang W, Zhong Z, Sanchez-Lopez E, Wu LW, Taniguchi K, Feng Y, Fearon E, Grivennikov SI, Karin M.
Immunity 41(6):1052-63. doi: 10.1016/j.immuni.2014.11.009. Epub 2014 Nov 25. 2014
6CTCF, IL17A, POU2F1
Oct-1 regulates IL-17 expression by directing interchromosomal associations in conjunction with CTCF in T cells.
Kim LK, Esplugues E, Zorca CE, Parisi F, Kluger Y, Kim TH, Galjart NJ, Flavell RA.
Mol Cell 54(1):56-66. doi: 10.1016/j.molcel.2014.02.004. Epub 2014 Mar 6. 2014
7IL17A, IL33
Expression of IL-33 in the epidermis: The mechanism of induction by IL-17.
Meephansan J, Komine M, Tsuda H, Karakawa M, Tominaga S, Ohtsuki M.
J Dermatol Sci 71(2):107-14. doi: 10.1016/j.jdermsci.2013.04.014. Epub 2013 Apr 19. 2013
8IL17A, IL23A
Increased IL-23 and IL-17 expression by peripheral blood cells of patients with primary biliary cirrhosis.
Qian C, Jiang T, Zhang W, Ren C, Wang Q, Qin Q, Chen J, Deng A, Zhong R.
Cytokine 64(1):172-80. doi: 10.1016/j.cyto.2013.07.005. Epub 2013 Jul 31. 2013
9CREM, IL17A, IL2, ORMDL3
cAMP response element modulator α controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus.
Hedrich CM, Crispin JC, Rauen T, Ioannidis C, Apostolidis SA, Lo MS, Kyttaris VC, Tsokos GC.
Proc Natl Acad Sci U S A 109(41):16606-11. doi: 10.1073/pnas.1210129109. Epub 2012 Sep 26. 2012
10IL15, IL17A
The role of IL-15 in activating STAT5 and fine-tuning IL-17A production in CD4 T lymphocytes.
Pandiyan P, Yang XP, Saravanamuthu SS, Zheng L, Ishihara S, O'Shea JJ, Lenardo MJ.
J Immunol 189(9):4237-46. doi: 10.4049/jimmunol.1201476. Epub 2012 Sep 19. 2012
11IL17A, IL17RA
The IL-17A/IL-17RA axis plays a proatherogenic role via the regulation of aortic myeloid cell recruitment.
Butcher MJ, Gjurich BN, Phillips T, Galkina EV.
Circ Res 110(5):675-87. doi: 10.1161/CIRCRESAHA.111.261784. Epub 2012 Feb 2. 2012
12IL17A, TBK1, TRAF3IP2, TRAF6
TRAF6-dependent Act1 phosphorylation by the IκB kinase-related kinases suppresses interleukin-17-induced NF-κB activation.
Qu F, Gao H, Zhu S, Shi P, Zhang Y, Liu Y, Jallal B, Yao Y, Shi Y, Qian Y.
Mol Cell Biol 32(19):3925-37. doi: 10.1128/MCB.00268-12. Epub 2012 Jul 30. 2012
13IL17A, LY9, RORC, SLAMF6
CD3-T cell receptor co-stimulation through SLAMF3 and SLAMF6 receptors enhances RORγt recruitment to the IL17A promoter in human T lymphocytes.
Chatterjee M, Hedrich CM, Rauen T, Ioannidis C, Terhorst C, Tsokos GC.
J Biol Chem 287(45):38168-77. doi: 10.1074/jbc.M112.415067. Epub 2012 Sep 18. 2012
14IL17A, VEGFA
IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma.
Liu J, Duan Y, Cheng X, Chen X, Xie W, Long H, Lin Z, Zhu B.
Biochem Biophys Res Commun 407(2):348-54. Epub 2011 Mar 9. 2011
15IL17A, TRAF3IP2, TRAF6
IL-17-induced NF-kappaB activation via CIKS/Act1: physiologic significance and signaling mechanisms.
Sønder SU, Saret S, Tang W, Sturdevant DE, Porcella SF, Siebenlist U.
J Biol Chem 286(15):12881-90. Epub 2011 Feb 18. 2011
16IL17A, IL23A
Interleukin-17 and interleukin-23 in patients with polymyositis and dermatomyositis.
Shen H, Xia L, Lu J, Xiao W.
Scand J Rheumatol 40(3):217-20. doi: 10.3109/03009742.2010.517215. Epub 2011 Jan 13. 2011
17CXCL1, IL17A
IL-17 regulates CXCL1 mRNA stability via an AUUUA/tristetraprolin-independent sequence.
Datta S, Novotny M, Pavicic PG Jr, Zhao C, Herjan T, Hartupee J, Hamilton T.
J Immunol 184(3):1484-91. Epub 2009 Dec 30.PMID: 20042592 2010
18IL17A
Innate IL-17-producing cells: the sentinels of the immune system.
Cua DJ, Tato CM.
Nat Rev Immunol. 10(7):479-89. 2010
19IL17A
IL-23 and IL-17A, but not IL-12 and IL-22, are required for optimal skin host defense against Candida albicans.
Kagami S, Rizzo HL, Kurtz SE, Miller LS, Blauvelt A.
J Immunol. 185(9):5453-62. 2010
20IL17A, IL22
Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A.
Sonnenberg GF, Nair MG, Kirn TJ, Zaph C, Fouser LA, Artis D.
J Exp Med 207(6):1293-305. Epub 2010 May 24. 2010
21IL17A, IL17RA, IL17RB, IL17RC, IL17RD, IL17RE
Structure and signalling in the IL-17 receptor family.
Gaffen SL.
Nat Rev Immunol 9(8):556-67. Epub 2009 Jul 3. Review. Erratum in: Nat Rev Immunol. 2009 Oct;9(10):747. PMID: 19575028 2009
22IL17A
Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis.
Lin Y, Ritchea S, Logar A, Slight S, Messmer M, Rangel-Moreno J, Guglani L, Alcorn JF, Strawbridge H, Park SM, Onishi R, Nyugen N, Walter MJ, Pociask D, Randall TD, Gaffen SL, Iwakura Y, Kolls JK, Khader SA.
Immunity. 31(5):799-810. 2009
23IL17A, IL23A
Monocyte derived interleukin (IL)-23 is an important determinant of synovial IL-17A expression in rheumatoid arthritis.
Stamp LK, Easson A, Pettersson L, Highton J, Hessian PA.
J Rheumatol 36(11):2403-8. doi: 10.3899/jrheum.081304. Epub 2009 Oct 1. 2009
24CCR6, IL17A
Human T cells that are able to produce IL-17 express the chemokine receptor CCR6.
Singh SP, Zhang HH, Foley JF, Hedrick MN, Farber JM.
J Immunol 180(1):214-21. 2008
25IL17A, IL17RA
Immunolocalization of IL-17A, IL-17B, and their receptors in chondrocytes during fracture healing.
Kokubu T, Haudenschild DR, Moseley TA, Rose L, Reddi AH.
J Histochem Cytochem 56(2):89-95. Epub 2007 Sep 6. 2008
26CSF2, IL1A, IL12B, IL15, IL17A, IL18, IL23A, IL6
Cytokines in the pathogenesis of rheumatoid arthritis.
McInnes IB, Schett G.
Nat Rev Immunol 7(6):429-42. Review. 2007
27IL17RC, IL17A, IL17F
Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F.
Kuestner RE, Taft DW, Haran A, Brandt CS, Brender T, Lum K, Harder B, Okada S, Ostrander CD, Kreindler JL, Aujla SJ, Reardon B, Moore M, Shea P, Schreckhise R, Bukowski TR, Presnell S, Guerra-Lewis P, Parrish-Novak J, Ellsworth JL, Jaspers S, Lewis KE, Appleby M, Kolls JK, Rixon M, West JW, Gao Z, Levin SD.
J Immunol 179(8):5462-73. 2007
28IL17A, IL17RA
Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression.
Maitra A, Shen F, Hanel W, Mossman K, Tocker J, Swart D, Gaffen SL.
Proc Natl Acad Sci U S A 104(18):7506-11. Epub 2007 Apr 24.PMID: 17456598 2007
29IL17A
IL-17A promotes the growth of airway epithelial cells through ERK-dependent signaling pathway.
Inoue D, Numasaki M, Watanabe M, Kubo H, Sasaki T, Yasuda H, Yamaya M, Sasaki H.
Biochem Biophys Res Commun 347(4):852-8. Epub 2006 Jun 30. 2006
30IL17A
The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models.
Lubberts E, Koenders MI, van den Berg WB.
Arthritis Res Ther 7(1):29-37. Epub 2004 Nov 30. Review. 2005
31IL17A
Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice.
Nakae S, Nambu A, Sudo K, Iwakura Y.
J Immunol. 171(11):6173-7. 2003
32IL17A
Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses.
Nakae S, Komiyama Y, Nambu A, Sudo K, Iwase M, Homma I, Sekikawa K, Asano M, Iwakura Y.
17(3):375-87. 2002
33IL17A
IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages.
Jovanovic DV, et al.
J Immunol 160 : 3513-3521. 1998
34IL17A
Yao Z, Spriggs MK, Derry JM, Strockbine L, Park LS, VandenBos T, Zappone JD, Painter SL, Armitage RJ.
Molecular characterization of the human interleukin (IL)-17 receptor.
Cytokine. 9(11):794-800. 1997
35IL17A
Human IL-17: a novel cytokine derived from T cells.
Yao Z, Painter SL, Fanslow WC, Ulrich D, Macduff BM, Spriggs MK, Armitage RJ.
J Immunol. 155(12):5483-6. 1995
36IL17A
CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpes virus saimiri gene.
Rouvier E, et al.
J Immunol 150 : 5445-5456. 1993