Citations for
1IL12B
A Locus at 5q33.3 Confers Resistance to Tuberculosis in Highly Susceptible Individuals.
Sobota RS, Stein CM, Kodaman N, Scheinfeldt LB, Maro I, Wieland-Alter W, Igo RP Jr, Magohe A, Malone LL, Chervenak K, Hall NB, Modongo C, Zetola N, Matee M, Joloba M, Froment A, Nyambo TB, Moore JH, Scott WK, Lahey T, Boom WH, von Reyn CF, Tishkoff SA, Sirugo G, Williams SM.
Am J Hum Genet 98(3):514-24. doi: 10.1016/j.ajhg.2016.01.015. 2016
2CCL4, IL12B, IL1A, IL1B, STX3
An essential role of syntaxin 3 protein for granule exocytosis and secretion of IL-1α, IL-1β, IL-12b, and CCL4 from differentiated HL-60 cells.
Naegelen I, Plançon S, Nicot N, Kaoma T, Muller A, Vallar L, Tschirhart EJ, Bréchard S.
J Leukoc Biol 97(3):557-71. doi: 10.1189/jlb.3A0514-254RR. Epub 2014 Dec 29. 2015
3FCGR2A, FCGR3A, IL12B
Two Susceptibility Loci to Takayasu Arteritis Reveal a Synergistic Role of the IL12B and HLA-B Regions in a Japanese Population.
Terao C, Yoshifuji H, Kimura A, Matsumura T, Ohmura K, Takahashi M, Shimizu M, Kawaguchi T, Chen Z, Naruse TK, Sato-Otsubo A, Ebana Y, Maejima Y, Kinoshita H, Murakami K, Kawabata D, Wada Y, Narita I, Tazaki J, Kawaguchi Y, Yamanaka H, Yurugi K, Miura Y, Maekawa T, Ogawa S, Komuro I, Nagai R, Yamada R, Tabara Y, Isobe M, Mimori T, Matsuda F.
Am J Hum Genet m J Hum Genet. 2013 Jul 2. doi:pii: S0002-9297(13)00263-2. 10.1016/j.ajhg.2013.05.024. [Epub ahead of print] 2013
4IL12B
Inherited IL-12p40 deficiency: genetic, immunologic, and clinical features of 49 patients from 30 kindreds.
Prando C, Samarina A, Bustamante J, Boisson-Dupuis S, Cobat A, Picard C, AlSum Z, Al-Jumaah S, Al-Hajjar S, Frayha H, Alangari A, Al-Mousa H, Mobaireek KF, Ben-Mustapha I, Adimi P, Feinberg J, de Suremain M, Jannière L, Filipe-Santos O, Mansouri N, Stephan JL, Nallusamy R, Kumararatne DS, Bloorsaz MR, Ben-Ali M, Elloumi-Zghal H, Chemli J, Bouguila J, Bejaoui M, Alaki E, AlFawaz TS, Al Idrissi E, ElGhazali G, Pollard AJ, Murugasu B, Wah Lee B, Halwani R, Al-Zahrani M, Al Shehri MA, Al-Zahrani M, Bin-Hussain I, Mahdaviani SA, Parvaneh N, Abel L, Mansouri D, Barbouche R, Al-Muhsen S, Casanova JL.
Medicine (Baltimore) 92(2):109-22. doi: 10.1097/MD.0b013e31828a01f9. Erratum in: Medicine (Baltimore). 2013 May;92(3):190. Alangari, Abdullah A [adde 2013
5IL12A, IL12B
The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit: implications for improved IL-12 cytokine production.
Jalah R, Rosati M, Ganneru B, Pilkington GR, Valentin A, Kulkarni V, Bergamaschi C, Chowdhury B, Zhang GM, Beach RK, Alicea C, Broderick KE, Sardesai NY, Pavlakis GN, Felber BK.
J Biol Chem 288(9):6763-76. doi: 10.1074/jbc.M112.436675. Epub 2013 Jan 7. 2013
6IL12B, KLF10
Klf10 inhibits IL-12p40 production in macrophage colony-stimulating factor-induced mouse bone marrow-derived macrophages.
Zhang W, Wang X, Xia X, Liu X, Suo S, Guo J, Li M, Cao W, Cai Z, Hui Z, Subramaniam M, Spelsberg TC, Wang J, Wang L.
Eur J Immunol 43(1):258-69. doi: 10.1002/eji.201242697. Epub 2012 Nov 27. 2013
7IL12B
Regulation of cooperative function of the Il12b enhancer and promoter by the interferon regulatory factors 3 and 5.
Koshiba R, Yanai H, Matsuda A, Goto A, Nakajima A, Negishi H, Nishio J, Smale ST, Taniguchi T.
Biochem Biophys Res Commun 430(1):95-100. doi: 10.1016/j.bbrc.2012.11.006. Epub 2012 Nov 12. 2013
8HDAC3, IL10, IL12B
IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis.
Kobayashi T, Matsuoka K, Sheikh SZ, Russo SM, Mishima Y, Collins C, deZoeten EF, Karp CL, Ting JP, Sartor RB, Plevy SE.
J Immunol 189(4):1792-9. doi: 10.4049/jimmunol.1200042. Epub 2012 Jul 11. 2012
9IL12B
Analysis of IL12B gene variants in inflammatory bowel disease.
Glas J, Seiderer J, Wagner J, Olszak T, Fries C, Tillack C, Friedrich M, Beigel F, Stallhofer J, Steib C, Wetzke M, Göke B, Ochsenkühn T, Diegelmann J, Czamara D, Brand S.
PLoS One 7(3):e34349. doi: 10.1371/journal.pone.0034349. Epub 2012 Mar 30. 2012
10IL12A, IL12B, SIRT1
Sirtuin 1 is a key regulator of the interleukin-12 p70/interleukin-23 balance in human dendritic cells.
Alvarez Y, Rodríguez M, Municio C, Hugo E, Alonso S, Ibarrola N, Fernández N, Crespo MS.
J Biol Chem 287(42):35689-701. doi: 10.1074/jbc.M112.391839. Epub 2012 Aug 14. 2012
11IL10, IL12B, NFIL3
A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3.
Smith AM, Qualls JE, O'Brien K, Balouzian L, Johnson PF, Schultz-Cherry S, Smale ST, Murray PJ.
J Biol Chem 286(26):23582-90. doi: 10.1074/jbc.M111.249235. Epub 2011 May 12. 2011
12IL12B, NFIL3
NFIL3 is a regulator of IL-12 p40 in macrophages and mucosal immunity.
Kobayashi T, Matsuoka K, Sheikh SZ, Elloumi HZ, Kamada N, Hisamatsu T, Hansen JJ, Doty KR, Pope SD, Smale ST, Hibi T, Rothman PB, Kashiwada M, Plevy SE.
J Immunol 186(8):4649-55. doi: 10.4049/jimmunol.1003888. Epub 2011 Mar 7. 2011
13IL12B, IL18, NFKBIZ
IKBZ is essential for natural killer cell activation in response to IL-12 and IL-18.
Miyake T, Satoh T, Kato H, Matsushita K, Kumagai Y, Vandenbon A, Tani T, Muta T, Akira S, Takeuchi O.
Proc Natl Acad Sci U S A 107(41):17680-5. Epub 2010 Sep 27. 2010
14IL12B
Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease.
Wang K, Zhang H, Kugathasan S, Annese V, Bradfield JP, Russell RK, Sleiman PM, Imielinski M, Glessner J, Hou C, Wilson DC, Walters T, Kim C, Frackelton EC, Lionetti P, Barabino A, Van Limbergen J, Guthery S, Denson L, Piccoli D, Li M, Dubinsky M, Silverberg M, Griffiths A, Grant SF, Satsangi J, Baldassano R, Hakonarson H.
Am J Hum Genet 84(3):399-405. Epub 2009 Feb 26.PMID: 19249008 2009
15IL12B
Interleukin-12 Gene Polymorphism and Cervical Cancer Risk.
Kordi Tamandani DM, Shekari M, Suri V.
Am J Clin Oncol m J Clin Oncol. 2009 May 29. [Epub ahead of print]PMID: 19487916 2009
16IL12B
A functional promoter variant in IL12B predisposes to cerebral malaria.
Marquet S, Doumbo O, Cabantous S, Poudiougou B, Argiro L, Safeukui I, Konate S, Sissoko S, Chevereau E, Traore A, Keita MM, Chevillard C, Abel L, Dessein AJ.
Hum Mol Genet 17(14):2190-5. Epub 2008 Apr 15. 2008
17CDKAL1, IL12B, IL23R, PSORS1
Psoriasis is associated with pleiotropic susceptibility loci identified in type II diabetes and Crohn disease.
Wolf N, Quaranta M, Prescott NJ, Allen M, Smith R, Burden AD, Worthington J, Griffiths CE, Mathew CG, Barker JN, Capon F, Trembath RC.
J Med Genet 45(2):114-6. Epub 2007 Nov 9. 2008
18HCP5, IL12B, IL23R, PSORS1
A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.
Liu Y, Helms C, Liao W, Zaba LC, Duan S, Gardner J, Wise C, Miner A, Malloy MJ, Pullinger CR, Kane JP, Saccone S, Worthington J, Bruce I, Kwok PY, Menter A, Krueger J, Barton A, Saccone NL, Bowcock AM.
PLoS Genet 4(3):e1000041. 2008
19IL12B
The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12.
Lupardus PJ, Garcia KC.
J Mol Biol 382(4):931-41. Epub 2008 Jul 25.PMID: 18680750 2008
20IL12B, IL23A
The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12.
Lupardus PJ, Garcia KC.
J Mol Biol 382(4):931-41. doi: 10.1016/j.jmb.2008.07.051. Epub 2008 Jul 25. 2008
21IL12B, IL23R, PSORS1
A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.
Cargill M, Schrodi SJ, Chang M, Garcia VE, Brandon R, Callis KP, Matsunami N, Ardlie KG, Civello D, Catanese JJ, Leong DU, Panko JM, McAllister LB, Hansen CB, Papenfuss J, Prescott SM, White TJ, Leppert MF, Krueger GG, Begovich AB.
Am J Hum Genet 80(2):273-90. Epub 2006 Dec 21. 2007
22CSF2, IL1A, IL12B, IL15, IL17A, IL18, IL23A, IL6
Cytokines in the pathogenesis of rheumatoid arthritis.
McInnes IB, Schett G.
Nat Rev Immunol 7(6):429-42. Review. 2007
23ATF3, TLR4, IL6, IL12B
Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4.
Gilchrist M, Thorsson V, Li B, Rust AG, Korb M, Kennedy K, Hai T, Bolouri H, Aderem A.
Nature 441(7090):173-8. 2006
24IL12B
The IL12B Gene Is Associated with Asthma.
Randolph AG, Lange C, Silverman EK, Lazarus R, Silverman ES, Raby B, Brown A, Ozonoff A, Richter B, Weiss ST.
Am J Hum Genet 75(4):709-15. Epub 2004 Aug 20. 2004
25IL12B
Alleles of the IL12B 3'UTR associate with late onset of type 1 diabetes.
Windsor L, Morahan G, Huang D, McCann V, Jones T, James I, Christiansen FT, Price P.
Hum Immunol 65(12):1432-6. 2004
26IL12B
Inherited interleukin-12 deficiency: IL12B genotype and clinical phenotype of 13 patients from six kindreds.
Picard C, Fieschi C, Altare F, Al-Jumaah S, Al-Hajjar S, Feinberg J, Dupuis S, Soudais C, Al-Mohsen IZ, Genin E, Lammas D, Kumararatne DS, Leclerc T, Rafii A, Frayha H, Murugasu B, Wah LB, Sinniah R, Loubser M, Okamoto E, Al-Ghonaium A, Tufenkeji H, Abel L, Casanova JL.
Am J Hum Genet 70(2):336-48. 2002
27IL12A, IL12B
Requirement for both IL-12 and IFN-gamma signaling pathways in optimal IFN-gamma production by human T cells.
Losana G, Rigamonti L, Borghi I, Assenzio B, Ariotti S, Jouanguy E, Altare F, Forni G, Casanova JL, Novelli F.
Eur J Immunol 32(3):693-700. 2002
28IL12B
Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children.
Morahan G, Huang D, Wu M, Holt B, White G, Kendall G, Sly P, Holt P.
Lancet 360(9331):455. 2002
29IL12B, IMD29
Inherited interleukin-12 deficiency: IL12B genotype and clinical phenotype of 13 patients from six kindreds.
Picard C, Fieschi C, Altare F, Al-Jumaah S, Al-Hajjar S, Feinberg J, Dupuis S, Soudais C, Al-Mohsen IZ, Génin E, Lammas D, Kumararatne DS, Leclerc T, Rafii A, Frayha H, Murugasu B, Wah LB, Sinniah R, Loubser M, Okamoto E, Al-Ghonaium A, Tufenkeji H, Abel L, Casanova JL.
Am J Hum Genet 70(2):336-48. Epub 2001 Dec 17. 2002
30IL12B
A novel function of IL-12p40 as a chemotactic molecule for macrophages.
Ha SJ, Lee CH, Lee SB, Kim CM, Jang KL, Shin HS, Sung YC.
J Immunol 163(5):2902-8 1999
31CSF1R, D5S2360, D5S2908, D5S2909, D5S2910, D5S2911, D5S2912, D5S2913, D5S2914, D5S2915, D5S2916, D5S2917, D5S2918, D5S2919, D5S2920, D5S2921, D5S2923, D5S2924, GABRA1, GRIA1, IL12B, TCOF1
Integrated physical and transcript map of 5q31.3-qter.
Kostrzewa M, et al.
Eur J Hum Genet 6 : 266-274. 1998
32IL12B
Interleukin 12 deficiency associated with recurrent infections.
Haraguchi S, et al.
Proc Natl Acad Sci U S A 95 : 13125-13129. 1998
33IL12B
Inherited interleukin 12 deficiency in a child with bacille Calmette-Guerin and Salmonella enteritidis disseminated infection.
Altare F, Lammas D, Revy P, Jouanguy E, Doffinger R, Lamhamedi S, Drysdale P, Scheel-Toellner D, Girdlestone J, Darbyshire P, Wadhwa M, Dockrell H, Salmon M, Fischer A, Durandy A, Casanova JL, Kumararatne DS.
J Clin Invest 102 : 2035-2040. 1998
34IL12A, IL12B
Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5.
Sieburth D, et al.
Genomics 14 : 59-62. 1992
35IL12B
Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.
Wolf SF, et al.
J Immunol 146 : 3074-3081. 1991