| 1 | IL12B
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| A Locus at 5q33.3 Confers Resistance to Tuberculosis in Highly Susceptible Individuals.
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| Sobota RS, Stein CM, Kodaman N, Scheinfeldt LB, Maro I, Wieland-Alter W, Igo RP Jr, Magohe A, Malone LL, Chervenak K, Hall NB, Modongo C, Zetola N, Matee M, Joloba M, Froment A, Nyambo TB, Moore JH, Scott WK, Lahey T, Boom WH, von Reyn CF, Tishkoff SA, Sirugo G, Williams SM.
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| Am J Hum Genet 98(3):514-24. doi: 10.1016/j.ajhg.2016.01.015.
2016
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| 2 | CCL4, IL12B, IL1A, IL1B, STX3
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| An essential role of syntaxin 3 protein for granule exocytosis and secretion of IL-1α, IL-1β, IL-12b, and CCL4 from differentiated HL-60 cells.
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| Naegelen I, Plançon S, Nicot N, Kaoma T, Muller A, Vallar L, Tschirhart EJ, Bréchard S.
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| J Leukoc Biol 97(3):557-71. doi: 10.1189/jlb.3A0514-254RR. Epub 2014 Dec 29.
2015
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| 3 | FCGR2A, FCGR3A, IL12B
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| Two Susceptibility Loci to Takayasu Arteritis Reveal a Synergistic Role of the IL12B and HLA-B Regions in a Japanese Population.
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| Terao C, Yoshifuji H, Kimura A, Matsumura T, Ohmura K, Takahashi M, Shimizu M, Kawaguchi T, Chen Z, Naruse TK, Sato-Otsubo A, Ebana Y, Maejima Y, Kinoshita H, Murakami K, Kawabata D, Wada Y, Narita I, Tazaki J, Kawaguchi Y, Yamanaka H, Yurugi K, Miura Y, Maekawa T, Ogawa S, Komuro I, Nagai R, Yamada R, Tabara Y, Isobe M, Mimori T, Matsuda F.
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| Am J Hum Genet m J Hum Genet. 2013 Jul 2. doi:pii: S0002-9297(13)00263-2. 10.1016/j.ajhg.2013.05.024. [Epub ahead of print]
2013
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| 4 | IL12B
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| Inherited IL-12p40 deficiency: genetic, immunologic, and clinical features of 49 patients from 30 kindreds.
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| Prando C, Samarina A, Bustamante J, Boisson-Dupuis S, Cobat A, Picard C, AlSum Z, Al-Jumaah S, Al-Hajjar S, Frayha H, Alangari A, Al-Mousa H, Mobaireek KF, Ben-Mustapha I, Adimi P, Feinberg J, de Suremain M, Janničre L, Filipe-Santos O, Mansouri N, Stephan JL, Nallusamy R, Kumararatne DS, Bloorsaz MR, Ben-Ali M, Elloumi-Zghal H, Chemli J, Bouguila J, Bejaoui M, Alaki E, AlFawaz TS, Al Idrissi E, ElGhazali G, Pollard AJ, Murugasu B, Wah Lee B, Halwani R, Al-Zahrani M, Al Shehri MA, Al-Zahrani M, Bin-Hussain I, Mahdaviani SA, Parvaneh N, Abel L, Mansouri D, Barbouche R, Al-Muhsen S, Casanova JL.
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| Medicine (Baltimore) 92(2):109-22. doi: 10.1097/MD.0b013e31828a01f9. Erratum in: Medicine (Baltimore). 2013 May;92(3):190. Alangari, Abdullah A [adde 2013
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| 5 | IL12A, IL12B
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| The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit: implications for improved IL-12 cytokine production.
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| Jalah R, Rosati M, Ganneru B, Pilkington GR, Valentin A, Kulkarni V, Bergamaschi C, Chowdhury B, Zhang GM, Beach RK, Alicea C, Broderick KE, Sardesai NY, Pavlakis GN, Felber BK.
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| J Biol Chem 288(9):6763-76. doi: 10.1074/jbc.M112.436675. Epub 2013 Jan 7.
2013
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| 6 | IL12B, KLF10
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| Klf10 inhibits IL-12p40 production in macrophage colony-stimulating factor-induced mouse bone marrow-derived macrophages.
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| Zhang W, Wang X, Xia X, Liu X, Suo S, Guo J, Li M, Cao W, Cai Z, Hui Z, Subramaniam M, Spelsberg TC, Wang J, Wang L.
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| Eur J Immunol 43(1):258-69. doi: 10.1002/eji.201242697. Epub 2012 Nov 27.
2013
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| 7 | IL12B
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| Regulation of cooperative function of the Il12b enhancer and promoter by the interferon regulatory factors 3 and 5.
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| Koshiba R, Yanai H, Matsuda A, Goto A, Nakajima A, Negishi H, Nishio J, Smale ST, Taniguchi T.
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| Biochem Biophys Res Commun 430(1):95-100. doi: 10.1016/j.bbrc.2012.11.006. Epub 2012 Nov 12.
2013
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| 8 | HDAC3, IL10, IL12B
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| IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis.
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| Kobayashi T, Matsuoka K, Sheikh SZ, Russo SM, Mishima Y, Collins C, deZoeten EF, Karp CL, Ting JP, Sartor RB, Plevy SE.
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| J Immunol 189(4):1792-9. doi: 10.4049/jimmunol.1200042. Epub 2012 Jul 11.
2012
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| 9 | IL12B
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| Analysis of IL12B gene variants in inflammatory bowel disease.
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| Glas J, Seiderer J, Wagner J, Olszak T, Fries C, Tillack C, Friedrich M, Beigel F, Stallhofer J, Steib C, Wetzke M, Göke B, Ochsenkühn T, Diegelmann J, Czamara D, Brand S.
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| PLoS One 7(3):e34349. doi: 10.1371/journal.pone.0034349. Epub 2012 Mar 30.
2012
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| 10 | IL12A, IL12B, SIRT1
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| Sirtuin 1 is a key regulator of the interleukin-12 p70/interleukin-23 balance in human dendritic cells.
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| Alvarez Y, Rodríguez M, Municio C, Hugo E, Alonso S, Ibarrola N, Fernández N, Crespo MS.
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| J Biol Chem 287(42):35689-701. doi: 10.1074/jbc.M112.391839. Epub 2012 Aug 14.
2012
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| 11 | IL10, IL12B, NFIL3
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| A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3.
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| Smith AM, Qualls JE, O'Brien K, Balouzian L, Johnson PF, Schultz-Cherry S, Smale ST, Murray PJ.
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| J Biol Chem 286(26):23582-90. doi: 10.1074/jbc.M111.249235. Epub 2011 May 12.
2011
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| 12 | IL12B, NFIL3
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| NFIL3 is a regulator of IL-12 p40 in macrophages and mucosal immunity.
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| Kobayashi T, Matsuoka K, Sheikh SZ, Elloumi HZ, Kamada N, Hisamatsu T, Hansen JJ, Doty KR, Pope SD, Smale ST, Hibi T, Rothman PB, Kashiwada M, Plevy SE.
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| J Immunol 186(8):4649-55. doi: 10.4049/jimmunol.1003888. Epub 2011 Mar 7.
2011
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| 13 | IL12B, IL18, NFKBIZ
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| IKBZ is essential for natural killer cell activation in response to IL-12 and IL-18.
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| Miyake T, Satoh T, Kato H, Matsushita K, Kumagai Y, Vandenbon A, Tani T, Muta T, Akira S, Takeuchi O.
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| Proc Natl Acad Sci U S A 107(41):17680-5. Epub 2010 Sep 27. 2010
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| 14 | IL12B
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| Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease.
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| Wang K, Zhang H, Kugathasan S, Annese V, Bradfield JP, Russell RK, Sleiman PM, Imielinski M, Glessner J, Hou C, Wilson DC, Walters T, Kim C, Frackelton EC, Lionetti P, Barabino A, Van Limbergen J, Guthery S, Denson L, Piccoli D, Li M, Dubinsky M, Silverberg M, Griffiths A, Grant SF, Satsangi J, Baldassano R, Hakonarson H.
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| Am J Hum Genet 84(3):399-405. Epub 2009 Feb 26.PMID: 19249008 2009
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| 15 | IL12B
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| Interleukin-12 Gene Polymorphism and Cervical Cancer Risk.
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| Kordi Tamandani DM, Shekari M, Suri V.
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| Am J Clin Oncol m J Clin Oncol. 2009 May 29. [Epub ahead of print]PMID: 19487916 2009
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| 16 | IL12B
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| A functional promoter variant in IL12B predisposes to cerebral malaria.
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| Marquet S, Doumbo O, Cabantous S, Poudiougou B, Argiro L, Safeukui I, Konate S, Sissoko S, Chevereau E, Traore A, Keita MM, Chevillard C, Abel L, Dessein AJ.
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| Hum Mol Genet 17(14):2190-5. Epub 2008 Apr 15.
2008
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| 17 | CDKAL1, IL12B, IL23R, PSORS1
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| Psoriasis is associated with pleiotropic susceptibility loci identified in type II diabetes and Crohn disease.
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| Wolf N, Quaranta M, Prescott NJ, Allen M, Smith R, Burden AD, Worthington J, Griffiths CE, Mathew CG, Barker JN, Capon F, Trembath RC.
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| J Med Genet 45(2):114-6. Epub 2007 Nov 9.
2008
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| 18 | HCP5, IL12B, IL23R, PSORS1
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| A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.
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| Liu Y, Helms C, Liao W, Zaba LC, Duan S, Gardner J, Wise C, Miner A, Malloy MJ, Pullinger CR, Kane JP, Saccone S, Worthington J, Bruce I, Kwok PY, Menter A, Krueger J, Barton A, Saccone NL, Bowcock AM.
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| PLoS Genet 4(3):e1000041.
2008
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| 19 | IL12B
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| The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12.
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| Lupardus PJ, Garcia KC.
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| J Mol Biol 382(4):931-41. Epub 2008 Jul 25.PMID: 18680750 2008
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| 20 | IL12B, IL23A
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| The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12.
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| Lupardus PJ, Garcia KC.
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| J Mol Biol 382(4):931-41. doi: 10.1016/j.jmb.2008.07.051. Epub 2008 Jul 25.
2008
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| 21 | IL12B, IL23R, PSORS1
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| A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.
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| Cargill M, Schrodi SJ, Chang M, Garcia VE, Brandon R, Callis KP, Matsunami N, Ardlie KG, Civello D, Catanese JJ, Leong DU, Panko JM, McAllister LB, Hansen CB, Papenfuss J, Prescott SM, White TJ, Leppert MF, Krueger GG, Begovich AB.
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| Am J Hum Genet 80(2):273-90. Epub 2006 Dec 21. 2007
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| 22 | CSF2, IL1A, IL12B, IL15, IL17A, IL18, IL23A, IL6
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| Cytokines in the pathogenesis of rheumatoid arthritis.
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| McInnes IB, Schett G.
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| Nat Rev Immunol 7(6):429-42. Review. 2007
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| 23 | ATF3, TLR4, IL6, IL12B
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| Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4.
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| Gilchrist M, Thorsson V, Li B, Rust AG, Korb M, Kennedy K, Hai T, Bolouri H, Aderem A.
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| Nature 441(7090):173-8. 2006
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| 24 | IL12B
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| The IL12B Gene Is Associated with Asthma.
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| Randolph AG, Lange C, Silverman EK, Lazarus R, Silverman ES, Raby B, Brown A, Ozonoff A, Richter B, Weiss ST.
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| Am J Hum Genet 75(4):709-15. Epub 2004 Aug 20. 2004
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| 25 | IL12B
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| Alleles of the IL12B 3'UTR associate with late onset of type 1 diabetes.
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| Windsor L, Morahan G, Huang D, McCann V, Jones T, James I, Christiansen FT, Price P.
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| Hum Immunol 65(12):1432-6. 2004
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| 26 | IL12B
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| Inherited interleukin-12 deficiency: IL12B genotype and clinical phenotype of 13 patients from six kindreds.
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| Picard C, Fieschi C, Altare F, Al-Jumaah S, Al-Hajjar S, Feinberg J, Dupuis S, Soudais C, Al-Mohsen IZ, Genin E, Lammas D, Kumararatne DS, Leclerc T, Rafii A, Frayha H, Murugasu B, Wah LB, Sinniah R, Loubser M, Okamoto E, Al-Ghonaium A, Tufenkeji H, Abel L, Casanova JL.
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| Am J Hum Genet 70(2):336-48. 2002
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| 27 | IL12A, IL12B
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| Requirement for both IL-12 and IFN-gamma signaling pathways in optimal IFN-gamma production by human T cells.
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| Losana G, Rigamonti L, Borghi I, Assenzio B, Ariotti S, Jouanguy E, Altare F, Forni G, Casanova JL, Novelli F.
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| Eur J Immunol 32(3):693-700. 2002
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| 28 | IL12B
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| Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children.
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| Morahan G, Huang D, Wu M, Holt B, White G, Kendall G, Sly P, Holt P.
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| Lancet 360(9331):455. 2002
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| 29 | IL12B, IMD29
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| Inherited interleukin-12 deficiency: IL12B genotype and clinical phenotype of 13 patients from six kindreds.
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| Picard C, Fieschi C, Altare F, Al-Jumaah S, Al-Hajjar S, Feinberg J, Dupuis S, Soudais C, Al-Mohsen IZ, Génin E, Lammas D, Kumararatne DS, Leclerc T, Rafii A, Frayha H, Murugasu B, Wah LB, Sinniah R, Loubser M, Okamoto E, Al-Ghonaium A, Tufenkeji H, Abel L, Casanova JL.
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| Am J Hum Genet 70(2):336-48. Epub 2001 Dec 17.
2002
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| 30 | IL12B
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| A novel function of IL-12p40 as a chemotactic molecule for macrophages.
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| Ha SJ, Lee CH, Lee SB, Kim CM, Jang KL, Shin HS, Sung YC.
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| J Immunol 163(5):2902-8 1999
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| 31 | CSF1R, D5S2360, D5S2908, D5S2909, D5S2910, D5S2911, D5S2912, D5S2913, D5S2914, D5S2915, D5S2916, D5S2917, D5S2918, D5S2919, D5S2920, D5S2921, D5S2923, D5S2924, GABRA1, GRIA1, IL12B, TCOF1
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| Integrated physical and transcript map of 5q31.3-qter.
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| Kostrzewa M, et al.
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| Eur J Hum Genet 6 : 266-274. 1998
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| 32 | IL12B
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| Interleukin 12 deficiency associated with recurrent infections.
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| Haraguchi S, et al.
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| Proc Natl Acad Sci U S A 95 : 13125-13129. 1998
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| 33 | IL12B
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| Inherited interleukin 12 deficiency in a child with bacille Calmette-Guerin and Salmonella enteritidis disseminated infection.
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| Altare F, Lammas D, Revy P, Jouanguy E, Doffinger R, Lamhamedi S, Drysdale P, Scheel-Toellner D, Girdlestone J, Darbyshire P, Wadhwa M, Dockrell H, Salmon M, Fischer A, Durandy A, Casanova JL, Kumararatne DS.
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| J Clin Invest 102 : 2035-2040. 1998
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| 34 | IL12A, IL12B
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| Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5.
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| Sieburth D, et al.
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| Genomics 14 : 59-62. 1992
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| 35 | IL12B
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| Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.
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| Wolf SF, et al.
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| J Immunol 146 : 3074-3081. 1991
|